Abstract: An electrode array which is able to be inserted to a desired depth within the cochlea to provide useful percepts for the recipient which will also preferably not cause damage to the sensitive structures of the cochlea. The electrode array is insertable through an opening in the cochlea and into at least the basal region of the cochlea and comprises an elongate carrier having a proximal end, a distal end, and a plurality of electrodes supported by the carrier at respective spaced locations thereon in a region between the proximal end and the distal end. A stabilising collar extends outwardly from the elongate carrier at or adjacent a proximal end thereof and has an abutment surface adapted to abut a portion of the cochlea surface around the cochleostomy and at least substantially prevent movement of the carrier following completion of insertion of the array into the cochlea.

Abstract: In one embodiment, a system for manipulation of a micro component includes a gripper subsystem for lifting, holding, and releasing a micro component. The gripper subsystem includes a base substrate having a work side and an opposing side, a positive electrode secured to the work side of the base substrate, a negative electrode suitably spaced from the positive electrode and secured to the work side of the base substrate, a dielectric layer formed over the work side of the base substrate and the positive and negative electrodes, and a hydrophobic layer comprising a hydrophobic material with predictable electrowetting behavior formed over the dielectric layer such that the dielectric layer is between the work side of the base substrate and the hydrophobic layer. A method for manipulation of a micro component is also provided as well as a method of manufacturing the system for manipulation of a micro component.

Abstract: Methods of identifying subjects having, or at risk of developing, diabetes, obesity, and/or hypertension are disclosed, as well as methods of identifying biomarkers for diabetes, obesity, and/or hypertension, and biomarkers identified by such methods.

Abstract: The invention relates to the polynucleotide sequence of a nontypeable stain of Haemophilus influenzae (NTHi) and polypeptides encoded by the polynucleotides and uses thereof. The invention also relates to NTHi genes which are upregulated during or in response to NTHi infection of the middle ear and/or the nasopharynx.

Abstract: A light emitting diode including a substrate, a first semiconductor layer, an active layer, and a second semiconductor layer is provided. The first semiconductor layer includes a first surface and a second surface, and the first surface is connected to the substrate. The active layer and the second semiconductor layer are stacked on the second surface in that order, and a surface of the second semiconductor layer away from the active layer is configured as the light emitting surface. A first electrode electrically is connected with the first semiconductor layer. A second electrode is electrically connected with the second semiconductor layer. A number of three-dimensional nano-structures are located on the surface of the first surface of the first semiconductor layer and the light emitting surface, and a cross section of each of the three-dimensional nano-structures is M-shaped.

Abstract: A game system 1 related to the present invention includes: slot machines 3A to 3J in each of which a base game is executed with a game value being bet; a shared display 201 which displays predetermined content; and a lighting device 120. The lighting device 120 related to the present invention includes: an LED 135 which emits light; a cover 121 which is positioned so as to receive light emitted from the LED 135, and has a hemispherical shape and translucency; and an aluminum layer serving as a metal layer which is vapor-deposited onto the cover 121, and transmits a predetermined amount of light emitted from the LED 135.

Abstract: The invention provides isolated and at least partially-purified dicamba-degrading enzymes, isolated DNA molecules coding for dicamba-degrading enzymes, DNA constructs coding for dicamba-degrading enzymes, transgenic host cells comprising DNA coding for dicamba-degrading enzymes, and transgenic plants and plant parts comprising one or more cells comprising DNA coding for dicamba-degrading enzymes. Expression of the dicamba-degrading enzymes results in the production of dicamba-degrading organisms, including dicamba-tolerant plants. Finally, the invention provides a method of selecting transformed plants and plant cells based on dicamba tolerance and a method of selecting or screening transformed host cells, intact organisms and parts of organisms based on the fluorescence of 3,6-dichlorosalicylic acid produced as a result of dicamba degradation.

Abstract: Provided are methods of simulating tissue healing. The methods comprise using a mechanistic computer model of the interrelated effects of inflammation, tissue damage or dysfunction and tissue healing to predict an outcome of healing of damaged tissue in vivo, thereby predicting the outcome of healing of damaged tissue in vivo. Implementations of these methods on a computing device also are provided. Non-limiting examples of diseases and/or conditions that are amenable to simulation according to the methods described herein include: a diabetes, diabetic foot ulcers, necrotizing enterocolitis, ulcerative colitis, Crohn's disease, inflammatory bowel disease, restenosis (post-angioplasty or stent implantation), incisional wounding, excisional wounding, surgery, accidental trauma, pressure ulcer, stasis ulcer, tendon rupture, vocal fold phonotrauma, otitis media and pancreatitis.

Abstract: A self-closing invisible hinge for returning a door to its closed position from its opened position including a self-closing structure in which the closing force can be selectively adjusted externally at the hinge and in which the self-closing structure is compact. The self-closing invisible hinge further having an embedded wiring system for providing electrical communication between an area on or in the door and an area adjacent a mounting structure supporting the door, such as a building electrical and/or communication system.

Abstract: Provided herein is an endothelial scaffold comprising, consisting of, or consisting essentially of decellularized corneal stroma. In some embodiments, the scaffold has cultured endothelial cells seeded thereon. Methods of treating a patient in need of corneal endothelial transplant are also provided, including implanting the scaffold as described herein onto a cornea of the patient (e.g., by deep keratectomy).

Abstract: A bi-directional electrostatic microvalve includes a membrane electrode that is controlled by application of voltage to fixed electrodes disposed on either side of the membrane electrode. Dielectric insulating layers separate the electrodes. One of the fixed electrodes defines a microcavity. Microfluidic channels formed into the electrodes provide fluid to the microcavity. A central pad defined in the microcavity places a portion of the second electrode close to the membrane electrode to provide a quick actuation while the microcavity reduces film squeezing pressure of the membrane electrode. In preferred embodiment microvalves, low surface energy and low surface charge trapping coatings, such as fluorocarbon films made from cross-linked carbon di-fluoride monomers or surface monolayers made from fluorocarbon terminated silanol compounds coatings coat the electrode low bulk charge trapping dielectric layers limit charge trapping and other problems and increase device lifetime operation.

Abstract: Photonic integrated circuits on silicon are disclosed. By bonding a wafer of compound semiconductor material as an active region to silicon and removing the substrate, the lasers, amplifiers, modulators, and other devices can be processed using standard photolithographic techniques on the silicon substrate. A silicon laser intermixed integrated device in accordance with one or more embodiments of the present invention comprises a silicon-on-insulator substrate, comprising at least one waveguide in a top surface, and a compound semiconductor substrate comprising a gain layer, the compound semiconductor substrate being subjected to a quantum well intermixing process, wherein the upper surface of the compound semiconductor substrate is bonded to the top surface of the silicon-on-insulator substrate.

Abstract: The invention provides a method for the observation, identification, and detection of blood cells, which comprises a label-free third harmonic generation (THG) tomography having a property of least injury. Submicron morphologies and granularities of blood cells can be revealed and reflected through this method. Leukocytes with different granularities can thus be identified from the intensity and distribution of third harmonic generation signals generated within cells. Furthermore, the method of the present invention is capable of performing a noninvasive sectioning microscopy image in vivo. Without cell and tissue damage, label-free third harmonic generation microscopy can real-time observe the morphology and dynamics of blood cells flowing in vessels or trafficking in tissues; Red blood cells and leukocytes have different morphology in blood flow and can thus be distinguished by in vivo third harmonic generation microscopy.

Abstract: The present invention relates to a pol I promoter derived from Vero cells and a recombinant vector containing the same. When the pol I promoter derived from Vero cells according to the present invention is utilized, viruses can be manufactured efficiently, and consequently, the manufacture of both seasonal influenza vaccine and pandemic vaccine can be prepared more quickly to usefully address either situation.

Abstract: An integrated circuit includes one or more portions having error detection and error correction circuits and which is operated with operating parameters giving finite non-zero error rate as well as one or more portions formed and operated to provide a zero error rate.

Abstract: An optical fuse device adapted to be placed in between ends of lead-in fibers of an optical fiber line. The optical fuse device has a destructible region having a core, the destructible region including a light absorbing material adapted to heat and destroy the core upon application of a light intensity greater than a predetermined threshold. Optical fiber lines including the optical fuse device and methods of manufacturing the optical fuse device are provided. Numerous other aspects are provided.

Abstract: Novel metal complexes containing silyl substitution are provided. Depending on the location of the substitution, compounds that emit in the yellow or green portions of the spectrum can be produced. These compounds are useful as components of OLED devices.

Abstract: The present invention provides methods of treating diseases and disorders associated with aberrant erythropoiesis. Specifically, the present invention provides a method for treating polycythemia in a subject by administering an inhibitor of miR-451. Methods of increasing red blood cell count and treating anemia in a subject by administering miR-451 mimetics are also disclosed.

Abstract: A fluid drainage system configured for draining a basin impounding fluid and sediment, solids or the like of varying density and turbidity. The system includes a first conduit and a second conduit within or adjacent to the first conduit to form a fluid receiving chamber between the first and second conduits, each conduit having apertures therethrough, with the apertures of the first and second conduits being sized and arranged relative to one another and so configured as to preferentially discharge fluid from the top of a basin, thus providing flow conditions which inhibit the entry of sediment into the system so as to maximize the retention of sediment within the basin and reduce turbidity and Total Suspended Sediment in the discharged fluid.

Abstract: An organic light emitting device that includes an anode, a cathode, an enhancement layer, and an emissive layer that includes homoleptic iridium complexes containing phenyl-imidazole ligands, which include at least one fused substituent. The enhancement layer also includes a new dibenzothiophene and dibenzofuran-containing compound that is useful as a material in an enhancement layer.