Patents Assigned to University
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Publication number: 20140010757Abstract: Engineered peptides that bind with high affinity (low equilibrium dissociation constant (Kd)) to the cell surface receptors of fibronectin (?5?1) or vitronectin (?v?3 and ?v?5 integrins) are disclosed as useful as imaging tissue. These peptides are based on a molecular scaffold into which a subsequence containing the RGD integrin-binding motif has been inserted. The subsequence (RGD mimic) comprises about 9-13 amino acids, and the RGD contained within the subsequence can be flanked by a variety of amino acids, the sequence of which was determined by sequential rounds of selection (in vitro evolution). The molecular scaffold is preferably based on a knottin, e.g., EETI (Trypsin inhibitor 2 (Trypsin inhibitor II) (EETI-II) [Ecballium elaterium (Jumping cucumber)], AgRP (Agouti-related protein), and Agatoxin IVB, which peptides have a rigidly defined three-dimensional conformation. It is demonstrated that EETI tolerates mutations in other loops and that the present peptides may be used as imaging agents.Type: ApplicationFiled: September 16, 2013Publication date: January 9, 2014Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Jennifer R. Cochran, Richard Kimura, Sanjiv S. Gambhir, Zhen Cheng
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Publication number: 20140008639Abstract: Organic light emitting devices are described wherein the emissive layer comprises a host material containing an emissive molecule, which molecule is adapted to luminesce when a voltage is applied across the heterostructure, and the emissive molecule is selected from the group of phosphorescent organometallic complexes, including cyclometallated platinum, iridium and osmium complexes. The organic light emitting devices optionally contain an exciton blocking layer. Furthermore, improved electroluminescent efficiency in organic light emitting devices is obtained with an emitter layer comprising organometallic complexes of transition metals of formula L2MX, wherein L and X are distinct bidentate ligands. Compounds of this formula can be synthesized more facilely than in previous approaches and synthetic options allow insertion of fluorescent molecules into a phosphorescent complex, ligands to fine tune the color of emission, and ligands to trap carriers.Type: ApplicationFiled: August 29, 2013Publication date: January 9, 2014Applicants: The University of Southern California, The Trustees of Princeton UniversityInventors: Mark E. Thompson, Peter Djurovich, Sergey Lamansky, Drew Murphy, Raymond Kwong, Feras Abdel-Razzaq, Stephen R. Forrest, Marc A. Baldo, Paul A. Burrows
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Publication number: 20140010285Abstract: Apparatuses and techniques relating to encoding a video are provided. An encoding device includes a motion coding module configured to determine a coding block level for processing an image data, and further configured to determine a block formation for a motion coding of the image data according to the coding block level; and a texture coding module configured to determine a block size for a texture coding of the image data according to the block formation to thereby generate a coded bit stream.Type: ApplicationFiled: September 9, 2013Publication date: January 9, 2014Applicant: University-Industry Cooperation Group of Kyung Hee UniversityInventor: Gwang Hoon PARK
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Publication number: 20140011329Abstract: Disclosed is a method for manufacturing a self-aligned metal oxide thin film transistor. According to the present invention, a metal oxide semiconductor layer having a high carrier concentration is formed, and then a channel region which is self-aligned with a gate electrode is oxidized by a plasma having oxidbillity so that the channel region has a low carrier concentration and the source and drain regions have high carrier concentrations while the resulting transistor has a self-aligned structure. In addition, the threshold voltage of the transistor is controlled by the conditions under which the channel region of the transistor is subsequently oxidized by plasma having oxidbillity at a low temperature. Therefore, the controllability of the characteristics of the transistor is improved significantly, and the manufacturing process is simplified.Type: ApplicationFiled: June 13, 2011Publication date: January 9, 2014Applicant: Peking University Shenzhen Graduate SchoolInventors: Shengdong Zhang, Xin He, Yi Wang, Dedong Han, Ruqi Han
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Publication number: 20140012224Abstract: Provided are novel nanostructures comprising hollow nanospheres (HGNs) and nanotubes for use as chemical sensors, molecular specific photothermal coupling agents, and photothermal ablation compounds. The nanostructures can be used in electromagnetic radiation-induced phototherapy for treatment of cancer and other disorders. The nanostructures can also be used as a sensor that detects molecules. The nanostructures are of particular use in the fields of clinical diagnosis, clinical therapy, clinical treatment, and clinical evaluation of various diseases and disorders, manufacture of compositions for use in the treatment of various diseases and disorders, for use in molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof.Type: ApplicationFiled: August 21, 2013Publication date: January 9, 2014Applicant: The Regents of the University of CaliforniaInventors: Jin Z. Zhang, Adam Schwartzberg, Tammy Y. Olson
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Publication number: 20140011103Abstract: A proton conductor includes a metal ion, an oxoanion, and a molecule capable of undergoing protonation or deprotonation, in which the oxoanion and/or the molecule capable of undergoing protonation or deprotonation coordinates to the metal ion to form a coordination polymer. The oxoanion is preferably a monomer. The oxoanion is exemplified by at least one selected from the group consisting of phosphate ion, hydrogenphosphate ion, and dihydrogenphosphate ion. The molecule capable of undergoing protonation or deprotonation is exemplified by at least one selected from the group consisting of imidazole, triazole, benzimidazole, benzotriazole, and derivatives of them.Type: ApplicationFiled: April 11, 2013Publication date: January 9, 2014Applicants: Kyoto University, DENSON CORPORATIONInventors: DENSON CORPORATION, Kyoto University
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Publication number: 20140011755Abstract: The invention provides methods for treating inflammatory and autoimmune diseases by administering to the subject an effective amount of a cardiac glycoside, where the dose is effective to suppress or prevent initiation, progression, or relapses of the disease, including the progression of established disease. In some embodiments, the methods of the invention comprise administering to a subject determined to have rheumatoid arthritis or systemic lupus, or a pre-clinical disease state thereof, an effective amount of a cardiac glycoside, to suppress or prevent activity of the disease. In other embodiments, the methods of the invention comprise administering to a subject determined to have insufficient endogenous cardiac glycosides, an effective amount as a supplement to counteract the effects of cardiac glycoside deficiency.Type: ApplicationFiled: December 13, 2011Publication date: January 9, 2014Applicants: Department of Veterans Affairs, The Board of Trustees of the Leland Stanford Junior UniversityInventors: Emily A. Stein, William H. Robinson, Ricardo T. Paniagua
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Publication number: 20140011274Abstract: A small percentage of cells within an established solid tumor have the properties of stem cells. These solid tumor stem cells give rise to both more tumor stem cells and to the majority of cells in the tumor that have lost the capacity for extensive proliferation and the ability to give rise to new tumors. Thus, solid tumor heterogeneity reflects the presence of tumor cell progeny arising from a solid tumor stem cell. We have developed a xenograft model in which we have been able to establish tumors from primary tumors via injection of tumors in the mammary gland of severely immunodeficient mice. These xenograft assay have allowed us to do biological and molecular assays to characterize clonogenic solid tumor stem cells. We have also developed evidence that strongly implicates the Notch pathway, especially Notch 4, as playing a central pathway in carcinogenesis.Type: ApplicationFiled: December 14, 2012Publication date: January 9, 2014Applicant: The Regents of the University of MichiganInventors: Michael F. Clarke, Sean J. Morrison, Max S. Wicha, Muhammad Al-Hajj
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Publication number: 20140011952Abstract: An RTV anti-pollution flashover coating, and preparation method, includes components of the following weight parts: polydimethylsiloxane 100 parts, a reinforcing filler 4 to 10 parts, a catalyst 0.1 to 1 part, a crosslinking agent 1 to 5 parts, a hydrophobic agent 3 to 6 parts, a pigment 1 to 2 parts, decabromodiphenyl ether 1 to 2 parts, and toluene 30 to 40 parts. The hydrophobic agent is a mixture of a substance having a structure represented by Formula I and any one or more of a low-molecular weight silicone oil, dihydroxydiphenyl silane, fluorine-containing silicone oil and white oil. In Formula I, R is any one of acetoxy CH3COO—, methoxy CH3O—, ketoximo MeEtCNO—, an amide group AcMeN—, amino C6H11NH— and acetonyl H2C?CMeO; R1—Si is a polysiloxane group or a fluorine-containing siloxane group, and has a structural formula represented by Formula II, where n=1 to 4, and R2 is CH3— or CF3—.Type: ApplicationFiled: September 9, 2013Publication date: January 9, 2014Applicants: Shanxi Jincheng Power Supply Company, State Grid Corporation of China, Wuhan University, Taiyuan Zhongtianxing Electric Power Technology Co. Ltd.Inventors: Shengming Wang, Ronghua Huang, Dong Zhang, Xiaohong Yan, Xinliang Kang, Guangxu Jiao, Minying Yu, Xinbao Li, Wei Xiu, Jing Liang, Jianguo Ma, Leilei Chang
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Publication number: 20140007796Abstract: Disclosed are encapsulated zinc compounds, together with methods for preparing and use the same. Also disclosed are methods for mixing the encapsulated zinc mixtures with a cement, and the resulting concrete compositions.Type: ApplicationFiled: March 23, 2012Publication date: January 9, 2014Applicants: Kansas State University Research Foundation, Board of Regents of the University of Texas SystemInventors: Maria C.G. Juenger, Sarah Clare Taylor Lange, Kyle Riding
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Publication number: 20140010834Abstract: A high level replication fowl adenovirus (FAdV) isolate capable of reaching a viral titer of at least 3 log 10 is described. Said FAdV is a non-pathogenic strain of fowl adenovirus serotype 4, identified as FAdV-4 ON1. Additionally, the present disclosure also provides a viral vector comprising the fowl adenovirus, which has inserted an exogenous nucleotide sequence coding for at least one antigenic site of a disease of concern, as well as a method for obtaining said viral vector and an immunogenic composition comprising the same.Type: ApplicationFiled: March 16, 2012Publication date: January 9, 2014Applicant: University of GuelphInventors: Éva Nagy, Bryan Griffin, Helena Grgic, Davor Ojkic
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Publication number: 20140011955Abstract: The present invention includes compositions and methods for synthesis of composite materials involving gas phase plasma polymerization to covalently plasma graft an organic molecule onto inorganic particles; covalently binding an organic monomer to the functionalized inorganic particles; and, polymerizing the organic monomers into inorganic/organic hybrid polymer composite materials.Type: ApplicationFiled: September 11, 2013Publication date: January 9, 2014Applicant: Board of Regents, The University of Texas SystemInventors: Richard B. Timmons, Dattatray Wavhal, Dhiman Bhattacharyya, Narayan Mukherjee
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Publication number: 20140011228Abstract: Disclosed herein is a set of E. coli single-protein production (SPP) technologies with protein NMR (SPP-NMR) for (i) using isotope-enriched membrane proteins produced with the SPP system in screening detergent conditions suitable for purification and/or three-dimensional structure analysis without the requirement for protein purification, (ii) producing 2H, 13C, 15N enriched proteins suitable for high throughput and membrane protein NMR studies, and (iii) labeling with 13C—15N specific peptide bonds in proteins (referred to herein as SPP-PBL).Type: ApplicationFiled: May 24, 2013Publication date: January 9, 2014Applicant: University of Medicine and Dentistry of New JerseyInventors: Gaetano T. Montelione, Masayori Inoue, Yuefeng Tang, Mouica Roth, William Schneider
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Publication number: 20140011836Abstract: Provided are methods for using bis-quaternary ammonium compounds to treat inflammatory pain, neuropathic pain and nociceptive pain.Type: ApplicationFiled: September 6, 2013Publication date: January 9, 2014Applicant: University of Kentucky Research FoundationInventors: Joseph R. HOLTMAN, Peter Anthony CROOKS, Linda P. DWOSKIN, J. Michael MCINTOSH, Elzbieta Pogonowska WALA
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Publication number: 20140013470Abstract: Compositions and methods are disclosed for modulating disease resistance in plants.Type: ApplicationFiled: December 3, 2012Publication date: January 9, 2014Applicant: Rutgers, The State University of New JerseyInventors: Nilgun Ereken Tumer, John Edward McLaughlin, Mohamed Anwar Bin-Umer
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Publication number: 20140011785Abstract: The present invention relates to antiandrogenic compounds which may be administered for the treatment of androgen excess in the skin and by way of consequence, the treatment of acne, baldness or hirsuitism in subject or patient.Type: ApplicationFiled: September 6, 2013Publication date: January 9, 2014Applicant: Yale UniversityInventor: Richard Hochberg
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Publication number: 20140011215Abstract: The present invention relates to the field of immunology and hyperproliferative diseases. More specifically, the present invention relates to a method of detecting and monitoring therapeutic antibody:antigen complex, soluble antigen and soluble therapeutic antibody, wherein a patient has undergone at least one course of immunotherapy. Yet further, levels of therapeutic antibody:antigen complexes, soluble antigens or soluble therapeutic antibodies may be measured and used to stage or monitor a hyperproliferative disease.Type: ApplicationFiled: July 3, 2013Publication date: January 9, 2014Applicant: Board of Regents, The University of Texas SystemInventors: Maher ALBITAR, Michael J. KEATING, Taghi MANSHOURI
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Publication number: 20140007956Abstract: This invention relates to a catheter for use in post-mortem angiography and a method for post-mortem in-situ cardiac angiography of a human or animal body. The catheter comprises (a) a proximal end for insertion into a human or animal body, (b) a distal end which remains outside the body during normal use, (c) a tube for delivering an imaging agent to the body, and (d) a marker for insertion into the body, the marker being positioned at a predetermined distance from the proximal end and comprising a substance such that its position once inserted into the body is detectable from outside the body.Type: ApplicationFiled: February 17, 2012Publication date: January 9, 2014Applicant: University of LeicesterInventors: Guy Rutty, Sarah Saunders, Bruno Morgan, Vimal Raj
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Publication number: 20140011004Abstract: Disclosed herein are methods of using inkjet printing for high resolution patterning of conductive fabric in the preparation of electrochromic devices. The process finds utility in the preparation of wearable electronic garments and other electrochromic devices.Type: ApplicationFiled: December 19, 2012Publication date: January 9, 2014Applicant: The University of ConnecticutInventors: Gregory Allen Sotzing, Yujie Ding
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Publication number: 20140008447Abstract: Microstrip patch antenna (46), feed structure (48), and matching circuit (50) designs for an RFID tag (10). A balanced feed design using balanced feeds coupled by a shorting stub (56) to create a virtual short between the two feeds so as to eliminate the need for physically connecting the substrate to the ground plane. A dual feed structure design using a four-terminal IC can be connected to two antennas (46a,46b) resonating at different frequencies so as to provide directional and polarization diversity. A combined near-field/far-field design using a microstrip antenna providing electromagnetic coupling for far-field operation, and a looping matching circuit providing inductive coupling for near-field operation. A dual-antenna design using first and second microstrip antennas providing directional diversity when affixed to a cylindrical or conical object, and a protective superstrate (66). An annular antenna (46c) design for application to the top of a metal cylinder around a stem.Type: ApplicationFiled: September 12, 2013Publication date: January 9, 2014Applicant: The University of KansasInventors: Daniel D. DEAVOURS, Mutharasu SIVAKUMAR