Abstract: The invention provides compositions and methods for ameliorating, treating, reversing or preventing pathology or inflammation in the central nervous system (CNS), or the brain, caused or mediated by NFkB, IL-6, IL-6-R, NADPH oxidase (Nox), and/or superoxide and/or hydrogen peroxide production by a NADPH oxidase, including for example ameliorating, treating, reversing or preventing schizophrenia, psychosis, delirium, e.g., post-operative delirium, drug-induced psychosis, psychotic features associated with frailty syndrome (FS), aging, depression, dementias; traumatic war neurosis, post traumatic stress disorder (PTSD) or post-traumatic stress syndrome (PTSS), Amyotrophic Lateral Sclerosis (ALS, or Lou Gehrig's Disease), and/or Multiple Sclerosis (MS). The invention also provides methods for purifying a C60 fullerene, C3 (tris malonic acid C60) or malonic acid derivatives.
Type:
Grant
Filed:
October 18, 2008
Date of Patent:
January 24, 2017
Assignee:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventors:
Laura L. Dugan, Maria Margarita Behrens, Sameh S. Ali
Abstract: Described herein are vitamin C prodrugs of Formula (I), (II), or (III), and pharmaceutically acceptable salts thereof. Also provided are pharmaceutical compositions, cosmetic or personal care composition, neutraceutical composition, and medical food composition thereof. Methods of using the compounds or compositions thereof for treating diseases are also provided.
Type:
Grant
Filed:
September 24, 2014
Date of Patent:
January 24, 2017
Assignee:
University of Florida Research Foundation, Inc.
Abstract: Techniques are disclosed relating to wide towing of marine survey signal sources. In one embodiment, an apparatus includes a signal source and a wing coupled to the signal source. In this embodiment, the wing is configured to impart a force to the signal source when towed through a body of water by a survey vessel. In this embodiment, the force includes a lateral component and a vertical component. The wing may be configured to impart the force based on a shape of the wing and an orientation of the wing. The wing may extend over at least a third of a length of a keel of the apparatus. At least a majority of a top surface of the wing may be oriented within 20 degrees of parallel to a surface of the body of water. The wing may include a plurality of wing sections.
Type:
Grant
Filed:
March 13, 2013
Date of Patent:
January 24, 2017
Assignees:
PGS Geophysical AS, National University of Singapore
Abstract: There are provided compounds and methods for the detection of amyloids and treatment of diseases related to amyloids including Alzheimer's disease and other related amyloid-based neurodegenerative diseases.
Type:
Grant
Filed:
December 16, 2014
Date of Patent:
January 24, 2017
Assignee:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Abstract: A compressive sensing system for dynamic video acquisition. The system includes a video signal interface including a compressive imager configured to acquire compressive sensed video frame data from an object, a video processing unit including a processor and memory. The video processing unit is configured to receive the compressive sensed video frame data from the video signal interface. The memory comprises computer readable instructions that when executed by the processor cause the processor to generate a motion estimate from the compressive sensed video frame data and generate dynamical video frame data from the motion estimate and the compressive sensed video frame data. The dynamical video frame data may be output.
Type:
Grant
Filed:
July 26, 2013
Date of Patent:
January 24, 2017
Assignee:
William Marsh Rice University
Inventors:
Jianing V. Shi, Aswin C. Sankaranarayanan, Christoph Emanuel Studer, Richard G. Baraniuk
Abstract: Disclosed are negative allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
Type:
Grant
Filed:
October 2, 2015
Date of Patent:
January 24, 2017
Assignee:
Vanderbilt University
Inventors:
Kyle A. Emmitte, Craig W. Lindsley, P. Jeffrey Conn, Andrew S. Felts, Katrina A. Smith
Abstract: The present invention relates to the field of virology. More specifically, the present invention provides methods and compositions useful for treating human cytomegalovirus using Wnt pathway modulators. In a specific embodiment, a method for treating human cytomegalovirus (HCMV) in a patient in need thereof comprises administering an effective amount of Wnt pathway modulator.
Abstract: A terminal apparatus included in a contents centric network and a communication method thereof are provided, the communication method including receiving an interest packet regarding a specific content from an external terminal apparatus, adjusting a window size of the interest packet based on at least one of a requesting frequency of the specific content corresponding to the interest packet and a communication status, and after adjusting the window size, transmitting the interest packet to surrounding terminal apparatuses.
Type:
Grant
Filed:
August 7, 2014
Date of Patent:
January 24, 2017
Assignees:
SAMSUNG ELECTRONICS CO., LTD., INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY
Inventors:
Jaehong Kim, Seok-hwan Kong, Jae-yong Lee, Honguk Woo, Sungwon Han
Abstract: Embodiments of the invention relate to a self-adaptive network control transmission method and system based on TCP. By creating network coding layer between transmission layer and IP layer on both the sending and receiving nodes, we can add network-coding headers which contains specific variables in the coding packets and ACK packets, transmit and refresh those variables through network-coding packets and ACK packets, and adjust redundancy factor R according to the variables. This method can strengthen the resistance to burst loss and maintain the redundancy factor R at the optimum value, thus raise the network throughputs.
Type:
Grant
Filed:
July 19, 2011
Date of Patent:
January 24, 2017
Assignee:
PEKING UNIVERSITY SHENZHEN GRADUATE SCHOOL
Inventors:
Hui Li, Sicong Song, Kai Pan, Shuoyan Li, Xudong Fan, Ruiyuan Li
Abstract: The present application discloses methods and systems for incrementally collecting replies in a forum and belongs to the technical field of collecting network information. The method comprises periodically determining whether there is a newly-established post and a post having new replies in all forum list pages needed to be collected: if yes, extracting a main post and reply information from the newly-established post, and extracting the information of the new replies from the post having new replies. The system comprises a determining device (11) for periodically determining whether there is a newly-established post and a post having new replies in all forum list pages needed to be collected; and an extracting device (12) for extracting a main post and reply information from the newly-established post, and extracting the information of the new replies from the post having new replies.
Type:
Grant
Filed:
December 22, 2011
Date of Patent:
January 24, 2017
Assignees:
Peking University Founder Group Co., Ltd., Peking University Founder R & D Center, Beijing Founder Electronics Co., Ltd., Peking University
Abstract: A microprotrusion array for use in transport of a material across a biological barrier, wherein said array comprises a plurality of microprotusions composed of a swellable polymer composition.
Type:
Grant
Filed:
September 29, 2008
Date of Patent:
January 24, 2017
Assignee:
THE QUEEN'S UNIVERSITY OF BELFAST
Inventors:
A. David Woolfson, Desmond Ian John Morrow, Anthony Morrissey, Ryan F. Donnelly, Paul A. McCarron
Abstract: A highly thermally conductive printed circuit board prevents electrochemical migration by inhibiting elution of copper ions. The printed circuit board is a metal-base printed circuit board including a metal base plate having an insulating resin layer and a copper foil layer stacked thereon in this order. In the printed circuit board, the insulating resin layer contains a first inorganic filler made of inorganic particles having particle diameters of 0.1 nm to 600 nm with an average particle diameter (D50) of 1 nm to 300 nm, and a second inorganic filler made of inorganic particles having particle diameters of 100 nm to 100 ?m with an average particle diameter (D50) of 500 nm to 20 ?m, and the first inorganic filler and the second inorganic filler are uniformly dispersed in the insulating resin layer.
Type:
Grant
Filed:
August 1, 2013
Date of Patent:
January 24, 2017
Assignees:
Waseda University, Fuji Electric Co., Ltd.
Abstract: The invention is directed to a Ca2+ precipitable polypeptide tags and cassettes useful for purification of molecules from heterogeneous samples. The invention also relates to methods for bioseparation of molecules comprising Ca2+ precipitable tags and cassettes.
Type:
Grant
Filed:
October 11, 2013
Date of Patent:
January 24, 2017
Assignee:
The Trustees of Columbia University in the City of New York
Abstract: The present invention encompasses methods and compositions for detecting pathogenic bacteria. Additionally, the present invention encompasses methods and compositions for catalyzing the dismutation of superoxide radicals. Further, the present invention encompasses methods for determining the antibiotic susceptibility of pathogenic bacteria.
Type:
Grant
Filed:
April 17, 2015
Date of Patent:
January 24, 2017
Assignee:
WASHINGTON UNIVERSITY
Inventors:
Jeffrey P. Henderson, Chia Hung, Kaveri Chaturvedi
Abstract: A transparent electromagnetic interference shield includes a first transparent substrate and an electromagnetic interference shielding layer. The electromagnetic interference shielding layer includes a transparent conductive polymer film which is formed on the first transparent substrate, and a plurality of metallic warp and weft lines which are laid on the transparent conductive polymer film. The warp lines and the weft lines cross one another.
Abstract: Described herein are methods for treating inflammation in a subject comprising administering to the subject an effective amount of a modified hyaluronan or a pharmaceutically acceptable salt or ester thereof, wherein said hyaluronan or its pharmaceutically acceptable salt or ester comprises at least one sulfate group and the primary C-6 hydroxyl proton of at least one N-acetyl-glucosamine residue is substituted with a C1-C10 unsubstituted alkyl group or fluoroalkyl group.
Type:
Grant
Filed:
February 4, 2015
Date of Patent:
January 24, 2017
Assignee:
University of Utah Research Foundation
Inventors:
Glenn Prestwich, Jianxing Zhang, Thomas P. Kennedy, Narayanam Rao
Abstract: The invention provides a novel composite bone graft system utilizing a porous collagen scaffold having a matrix impregnated with calcium phosphate particles and more than one bioactive agent, one of which is conjugated to the matrix. The graft system exhibits increased mechanical strength and osteogenic properties by providing sites for tissue attachment and propagation. The bioactive agents are delivered to the scaffold via different mechanisms to enable sequential and sustained release of the bioactive agents over time.
Type:
Grant
Filed:
August 5, 2014
Date of Patent:
January 24, 2017
Assignee:
University of Notre Dame Du Lac
Inventors:
Ryan K. Roeder, Matthew J. Meagher, Robert J. Kane
Abstract: A manufacturing method for a high-temperature-resistant metal-packaged fiber Bragg grating sensor includes using a regenerated fiber Bragg grating obtained via high-temperature annealing as a sensitive element so that the grating will not be erased when used at high temperature. The method also includes using a magnetron sputtering method which makes an optical fiber and metal combine better to form on the surface of the optical fiber an adhesive layer and a conductive layer, thereby causing little damage to optical fiber because of the absence of the processes of coarsening, sensitization, etc. of electroless plating and the fact that the method is performed in an anhydrous environment. After magnetron sputtering, the method includes using an electroplating method to thicken and deposit a protective layer, and embedding the optical fiber in a flexible-structure metallic substrate through the electroplating method to achieve the all-metal package.
Type:
Grant
Filed:
November 19, 2012
Date of Patent:
January 24, 2017
Assignee:
East China University of Science and Technology
Abstract: Certain embodiments are directed to methods of treating a metabolic disease in a subject using a fully implantable electrical stimulation system to provide or administer a therapy. In certain aspects a stimulation lead is implanted proximally to a stomach acupoint, the stimulation lead being coupled to an implantable signal generator; and stimulating the acupoints using the signal generator to treat the metabolic disease.
Type:
Grant
Filed:
August 15, 2013
Date of Patent:
January 24, 2017
Assignee:
THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM