Abstract: The invention discloses a method for tuning nano-scale analog-circuit designs in order to reduce random-device mismatches and optimize said design, where nano-scale devices potentially have large-scale process variations. The method includes providing a tunable circuit topology, wherein each nano-scale device comprises a single component or comprises multiple parallel components. Each component is decomposed into multiple discrete sub-components, wherein each said sub-component either operates in parallel with other like components to effectively operate like one bigger component. The sub-components are subjected to a dynamic-programming process to adaptively select the sub-components to be kept operational, while configuring the nonselected sub-components to be nonoperational, based on the measurement of at least one operational parameter.

Abstract: There is provided an anti-microbial composition comprising a cationic peptide and a glycineglycine endopeptidase. The composition has been found to be synergistic against bacteria, especially Gram positive bacteria such as Staphylococcus aureus MSSA or MRSA. In one embodiment the composition comprises ranalexin, dermaseptin, magainin or mixtures thereof together with lysostaphin. The composition is useful for treating surfaces, including a wound surface in a patient or surfaces of an object (e.g. surgical instrument) or room.

Abstract: The electrical conductivity of DNA and other oligonucleotide constructs is dependent on its conformational state. Such a dependence may be harnessed for the electronic sensing of external analytes, for instance, adenosine. Such a DNA sensor incorporates an analyte receptor, whose altered conformation in the presence of bound analyte switches the conformation, and hence, the conductive path between two oligonucleotide stems, such as double-helical DNA. Two distinct designs for such sensors are described that permit significant electrical conduction through a first or “detector” double-helical stem only in the presence of the bound analyte. In the first design, current flows through the analyte receptor itself whereas, in the second, current flows in a path adjacent to the receptor.

Abstract: A peptide-coated nanoparticle that includes a nanocrystal core surrounded by a graded shell that is composed of at least two different semiconductor molecules. At least one peptide is attached to the surface of the graded shell to render the nanoparticle biocompatible. The nanocrystal core and graded shell are optionally annealed with ultra violet radiation prior to and/or after attachment of the peptide(s).

Abstract: A thermal storage system includes a thermal storage device that includes an aqueous slurry of micro-encapsulated phase change material, a thermal collector in a heat exchange relationship with the thermal storage device through a first heat exchanger, and a thermal service device in a heat exchange relationship with the thermal storage device through a second heat exchanger. The aqueous slurry of micro-encapsulated phase change material is configured to convert between solid and liquid states.

Abstract: The present invention relates to the field of immunology and hyperproliferative diseases. More specifically, the present invention relates to a method of detecting and monitoring therapeutic antibody:antigen complex, soluble antigen and soluble therapeutic antibody, wherein a patient has undergone at least one course of immunotherapy. Yet further, levels of therapeutic antibody:antigen complexes, soluble antigens or soluble therapeutic antibodies may be measured and used to stage or monitor a hyperproliferative disease.

Abstract: The present invention relates to novel antineoplastic agents and cancer diagnostic agents that specifically target neo-plastic cells via the GLUT transportation system. More specifically, the invention relates to conjugates of 2-deoxyglucose, wherein a linker, which includes a covalent bond, is attached to 2-deoxyglucose at the 2 position, and the linker is attached to a therapeutic or diagnostic agent. The invention also relates to methods of treating tumor disease and methods of making the novel compounds of the present invention. The agents of the present invention are superior to previous agents as they are targeted via GLUT transporters.

Abstract: A single fiber full-field optical coherence tomography (OCT) imaging probe (300) includes a hollow tube (301), and a single fiber (305) disposed within the tube for transmitting light received from a broadband light source to a beam splitter (350) in the tube optically coupled to the single fiber (305). The beam splitter (350) splits the light into a first and a second optical beam, wherein the first beam is optically coupled to a reference arm including a MEMS reference micromirror (335) which provides axial scanning and the second beam is optically coupled to a sample arm for probing a sample to be imaged. Both the reference arm and the sample ami are disposed in the tube. A photodetector array (315) is preferably disposed inside the tube (301) optically coupled to the beam splitter (350). The photodetector array (315) receives a reflected beam from the MEMS reference micromirror (335) and a scattered beam from the sample to form an image of the sample.

Abstract: There is provided a zero-voltage switching high-frequency inverter capable of supplying a current of a large amplitude operation to a load, while suppressing a main switch current. The zero-voltage switching high-frequency inverter according to the present invention comprises: a first switch S1 and a second switch S2 that are connected in series between power sources Ed; a first capacitor C1, an impedance element R, and an inductor element L that are connected in series between a connecting path connecting the first switch S1 and the second switch S2 and one end of the power sources Ed; and a second capacitor C2 connected in parallel to the impedance element R and the inductor element L that are connected in series.

Abstract: The present invention provides systems and methods for automatically mining massive intelligence databases to discover sequential patterns therein using a novel combination of forward and reverse temporal processing techniques as an enhancement to well known pattern discovery algorithms.

Abstract: Disclosed are a method and a device for security-inspection of liquid articles with dual-energy CT imaging. The method comprises the steps of obtaining one or more CT images including physical attributes of liquid article to be inspected by CT scanning and a dual-energy reconstruction method; acquiring the physical attributes of each liquid article from the CT image; and determining whether there are drugs concealed in the inspected liquid article based on the difference between the acquired physical attributes and reference physical attributes of the inspected liquid article. The CT scanning can be implemented by a normal CT scanning technique, or a spiral CT scanning technique. In the normal CT scanning technique, the scan position can be preset, or set by the operator with a DR image, or set by automatic analysis of the DR image.

Abstract: The subject invention pertains to pentafluorosulfonyl (SF5) substituted pyrroles, thiophenes, 3-pyrrolines and 2,5-dihydrothiophenes, as well as methods for their synthesis.

Abstract: Compounds and methods useful for the treatment of cancer in subjects in need of such treatment. The compounds are metabolites of the compound FK228 which have been identified as possessing HDAC inhibitory activity and anticancer properties. Further provided are compounds and methods for inducing apoptosis in cancer cells. Further provided are compounds and methods for inhibiting HDAC in cancer cells.

Abstract: The present invention is in the field of soybean genetics. More specifically, the invention relates to nucleic acid molecules from regions in the soybean genome, which are associated with soybean Phytophthora resistance. The invention also relates to methods of transforming soybean with constructs containing nucleic acid molecules encoding proteins for Phytophthora resistance, to produce modified or transgenic plants and plant cells having enhanced disease resistance.

Abstract: A resonant element that causes a signal input from an input terminal to resonate at a predetermined resonance frequency and outputs it to an output terminal is provided. The element has a transmission line series including a plurality of transmission lines connected in series with each other and intersecting with a hotline connecting the input terminal and the output terminal and a plurality of switches. At least one of one end and the other end of the transmission line series is a grounded end. The resonant element having first and second end side, each end side having a first transmission line and a second transmission line connected to a switch having a grounded end. The resonance frequency is switched by turning on/off the switch to change the sum of the lengths of the transmission lines through which the signal passes.

Abstract: An item is organized and presented by displaying a table, wherein the table displays a plurality of data comprising DNA profile analysis results including an observation characterizing the at least one item, and wherein an analysis result is based on a decision made by an expert system according to a rule base. An observation comprises one of concordance, a locus having a concordance error, an off-ladder peak, a peak height imbalance and a peak falling in an overlap region between loci. The rule base comprises rules related to background noise, spike, broad peak, duplicate allele, bleed-through peak, pull-up peak, stutter peak, ?A peak and global filter rules.

Abstract: The present invention relates, in general, to tissue engineering and, in particular, to a method of extending the lifespan of cells suitable for use in vascular engineering.

Abstract: A surface plasmon resonance biosensor device and system are provided. The simplicity of SPR biosensor design allows easy integration with both QCM and electrochemistry techniques, not found in current SPR biosensor devices. In some embodiments, the surface plasmon resonance biosensor device has a dual SPR/QCM sample holder which allows simultaneous detection by both surface plasmon resonance and also quartz crystal microbalance (QCM) techniques. In additional embodiments, the surface plasmon resonance biosensor device and/or the dual SPR/QCM technique can be integrated with electrochemistry techniques by incorporate reference and counter electrodes in the SPR or SPR/QCM sample holder. Methods of using the device and system to determine whether an analyte of interest is present in a sample are also provided.

Abstract: Curable polyorganosiloxanes are provided that cure in the absence of a hydrosilylation catalyst. The cured polyorganosiloxanes have increased stability and can be used as encapsulation resin is at a temperature far lower than 300° C., have excellent light transmission properties (colorless transparency. in a wavelength region of from ultraviolet light to visible light, light resistance, heat resistance, resistance to moist heat and UV resistance, and do not generate cracks and peeling even in use over a long period of time.

Abstract: A method for self-assembling a plurality of microstructures onto a substrate comprising using a bonding material to make the microstructure assembled onto the substrate by a physical attraction force. The microstructures are self-aligned with the substrate, and further permanently fixed on and electrical connection with the substrate by the solder bumps between the microstructures and the substrate, which is formed by the solder bumps via reflow process. There is no need for the using of the conventional pick-and-place device in the present method. The present method could be applied to light emitting diodes, RFID tags, micro-integrated circuits or other types of microstructures.