Abstract: The present invention discloses a two-light flux interference exposure device comprising: a laser light source provided in a laser resonator; a single harmonic generation device provided in the laser resonator for converting laser light output by the laser light source to higher harmonics; an etalon provided in the laser resonator so as to serve as a narrowband wavelength filter; a beam splitter dividing laser light output outside the laser resonator into two light fluxes; and an interference optic system causing the light fluxes to interfere with each other on a target to be exposed.

Abstract: Stress-related nucleic acid molecules and polypeptides and fragments and variants thereof are disclosed in the current invention. In addition, stress-related fusion proteins, antigenic peptides, and anti-stress-related antibodies are encompassed. The invention also provides recombinant expression vectors containing a nucleic acid molecule of the invention and cells into which the expression vectors have been introduced. Methods for producing the polypeptides and methods of use for the polypeptides of the invention are further disclosed.

Abstract: A reconfigurable processor including a plurality of reconfigurable execution units, a memory, an instruction queue, a configuration selection unit, and a configuration loader. The memory stores a plurality of steering vector processing hardware configurations for configuring the reconfigurable execution units. The instruction queue stores a plurality of instructions to be executed by at least one of the reconfigurable execution units. The configuration selection unit analyzes the instructions stored in the instruction queue and chooses one of the steering vector processing hardware configurations. The configuration loader determines whether one of the reconfigurable slots is available and reconfigures at least one of the reconfigurable slots with at least a part of the chosen steering vector processing hardware configuration responsive to at least one of the reconfigurable slots being available.

Abstract: Compositions and methods useful in the reduction of localized fat deposits in patients in need thereof using pharmacologically active detergents are disclosed. The pharmacologically active detergent compositions can additionally include anti-inflammatory agents, analgesics, dispersion or anti-dispersion agents and pharmaceutically acceptable excipients. The pharmacologically active detergent compositions are useful for treating localized accumulations of fat including, for example, lower eyelid fat herniation, lipodystrophy and fat deposits associated with cellulite and do not require surgical procedures such as liposuction.

Abstract: The present invention provides a method of, and apparatus for, utilizing ultrasonic energy so as to mechanically disrupt the collagenous architecture of biological matrices in a controlled manner so that the tissue can be rapidly recellularized in continuous form. The present invention also provides for the production of tissue matrices with improved recellularization properties, cell stratification or patterning.

Abstract: A method for forming polyolefin/clay composites by olefin polymerization which can be used as flame retardants in which at least one filler is combined with an early or late transition metal first catalyst component that becomes activated for olefin polymerization when in contact with the treated filler. An olefin is contacted by the activated catalyst-filler combination either (a) in the absence of an alkylaluminum second catalyst component or (b) in the presence an alkylaluminum second catalyst component when the first catalyst component is an early transition metal catalyst, whereby to form an clay-polyolefin composite incorporating platelets of said filler. The filler is preferably clay, exemplified by montmorillonite and chlorite. The first catalyst component is preferably a non-metallocene catalyst. A predetermined amount of one or more olefinic polymers can also be blended with a masterbatch to obtain a composite having a desired amount of loading.

Abstract: Described is a technique to exhaustively enumerate the thermodynamic properties of the water molecules solvating the active site of a protein in its apostate and calculate the relative binding affinities of congeneric compounds that bind to this protein. The subject matter includes sampling the configurations of the solvating water in the active site; extracting the thermodynamic information about the solvating water from these configurations by clustering the observed water configurations into regions of high water occupancy (e.g.

Abstract: Disclosed is a method for detection of ligand-cell membrane protein binding by solid state NMR spectroscopy. The method starts by forming a lipid bilayer inside nanopores of an anodic aluminum oxide (AAO) substrate, the lipid bilayer containing a membrane protein sample. The AAO substrate is treated with multiple candidate ligands having potential binding affinity for the membrane protein. Solid-state NMR analysis is performed on the treated AAO/lipid preparation so as to generate an NMR spectrum for the treated membrane protein. The solid-state NMR spectrum of the treated membrane protein is compared with the spectrum of the same preparation of membrane protein in the absence of the ligands. It is then determined whether the solid-state NMR spectrum of the treated membrane protein has shifted from the NMR spectrum of the untreated membrane protein, a shift being indicative of protein binding by the candidate ligand.

Abstract: A channel estimation method in a Multiple Input Multiple Output (MIMO) mobile communication system having a plurality of transmission antennas and a plurality of reception antennas is provided. In a method of transmitting, by a transmitter, channel estimation signals for channel estimation at a receiver, the transmission antennas transmit the same channel estimation signals for a first frame transmission duration, and transmit predetermined channel estimation signals corresponding to the number of the transmission antennas for a second frame transmission duration.

Abstract: A gaming machine having a display device for variably displaying and stopping symbols during a game; a memory storing a lottery table having interrelated random number ranges, threshold target values (an accumulatively counted number of times the game has been played) and payouts; and a processor (a) to extract a random number, (b) to determine from the lottery table the random number range to which the random number belongs, (c) to determine the threshold target value corresponding to the determined random number range, (d) to accumulatively count a total number of times the game has been played while games are continuously conducted, (e) to determine whether or not the total number of game plays equals the determined threshold target value, and (f) to determine from the lottery table and give the related payout when the total number of game plays equals with the determined threshold target value.

Abstract: The present invention relates to methods of alleviating and inhibiting a lymphoproliferative disorder in a mammal, the method comprising administering one or more rapamycin derivatives (including rapamycin) to the mammal. Further, the invention provides a method for identifying agents which are useful for alleviating and inhibiting a lymphoproliferative disorders, as well as a method for identifying agents which are capable of inhibiting metastasis of lymphatic tumors in a mammal.

Abstract: A phase detector is described, comprising a pair of output-latched half-transparent (OLHT) module each receiving two input terminals with an inverse connection relationship with respect to two input signals as compared to each other, wherein each OLHT module of the pair comprises two stages of logic operation unit connected in series and a latch circuit electrically connected to a latter one of the two stages of logic operation unit and latching and output an output signal.

Abstract: An improved delivery system for antisense oligonucleotides involves a liposomal composition, comprising a liposome which consists essentially of neutral phospholipids and an antisense oligonucleotide that is entrapped in the liposome and is selected from the group consisting of phosphodiester oligonucleotides, phosphorothioate oligonucleotides, and p-ethoxy oligonucleotides.

Abstract: This invention provides a method of detecting pathogens comprising the steps of: (a) contacting a sufficient amount of biofunctional magnetic nanoparticles with an appropriate sample for an appropriate period of time to permit the formation of complexes between the pathogens in the sample and the nanoparticles; (b) using a magnetic field to aggregate said complexes; and (c) detecting said complexes. The method may further comprise the additional step of removing said complexes. The biofunctional magnetic nanoparticles are preferably a conjugate of vancomycin and FePt. The pathogens may be bacteria or viruses, and the sample may be a solid, liquid, or gas. Detection may involve conventional fluorescence assay, enzyme-linked immunosorbent assay (ELISA), optical microscope, electron microscope, or a combination thereof. The sensitivity of detection for the method is at least as low as 10 colony forming units (cfu) of the pathogens in one milliliter of solution within one hour.

Abstract: A triacetone triperoxide cloud associated with a triacetone triperoxide explosive attached to a hard target is remotely detected by operating differential-absorption lidar lasers to transmit a laser beam toward the hard target at differing wavelengths. A backscattered laser beam reflected from the lidar target (hard target, person, aerosols, clouds, buildings) is detected because a cloud of triacetone triperoxide in front of the lidar target and between the lidar target and the differential-absorption lidar system produces a differential-absorption signal having characteristics that identify the triacetone triperoxide. In a second embodiment, a triacetone triperoxide cloud that is absorbing optical radiation from its ambient environment and which is attached to a hard target is detected from a location remote from the triacetone triperoxide explosive by detecting an optical radiation absorption signature characterized by triacetone triperoxide absorption lines.

Abstract: This application describes the discovery that, in a pregnant woman, certain genes (such as RASSF1A, APC, CASP8, RARB, SCGB3A1, DAB2IP, PTPN6, THY1, TMEFF2, and PYCARD) originated from a fetus are highly methylated, whereas the same genes of maternal origin are unmethylated. This discovery allows the easy detection of one or more of these methylated fetal genes in a biological sample from a pregnant woman, serving as a universal indicator of the presence of fetal DNA in the sample. These fetal methylation markers are particularly useful as positive controls for a non-invasive analytical process during which the quality and quantity of fetal DNA are monitored. These newly identified fetal markers can also be measured directly for diagnosis of certain pregnancy-related conditions.

Abstract: This invention involves methods and materials for conferring a direct proliferative advantage on a genetically modified subpopulation of cells. Selection is then accomplished by exerting a positive selective stimulus on the engineered cells rather than a negative pressure on nonengineered cells.

Abstract: The present invention provides sphingosine-1-phosphate analogs that are potent, and selective agonists at one or more S1P receptors, specifically the S1P1 receptor type. The compounds invention include compounds having a phosphate moiety as well as compounds with hydrolysis-resistant phosphate surrogates such as phosphonates, alpha-substituted phosphonates, and phosphothionates.

Abstract: An optical functional waveguide having a small size, used with stored energy, controlling the phase of light at high speed, and adjusting the optical path length. The optical functional waveguide includes a substrate (11), a quartz waveguide clad (12), a quartz waveguide core (13), groove structures (14), a filling material (15), and heater electrode (16). The filling material (15) placed in the groove structures (14) is, e.g., a resin transparent to the wavelength region of the guided light, and the refractive index temperature coefficient is about 10 to 100 times that of quartz. The heater electrode (16) is interposed between the groove structures (14) provided along the optical path. Therefore, the temperature of the filling material (15) can be varied sharply and quickly with little energy expended.

Abstract: Files can be reassembled from fragments by (a) accepting adjacency scores for each pair of fragments from a set of fragments, (b) identifying header fragments from the set of fragments, and (c) for each of the header fragments, (i) setting a current fragment to the identified header fragment, (ii) selecting, from any of the fragments not identified as a header fragment, a fragment with a best adjacency score with the current fragment, (iii) determining if the selected fragment has a better adjacency score with any of the other fragments not identified as a header than with the current fragment, (iv) if so, then (A) selecting another fragment, from any of the fragments not identified as a header fragment, a fragment with a next best adjacency score with the current fragment, and continuing, and otherwise (A) adding the selected fragment to a reassembly path started with the identified header fragment, and (B) setting the current fragment to the selected fragment, and continuing until the file is reconstructed.