Abstract: The invention in some aspects relates to isolated nucleic acids, compositions, and kits useful for identifying adeno-associated viruses in cells. In some aspects, the invention provides kits and methods for producing somatic transgenic animal models using recombinant AAV (rAAV) to an animal having at least one transgene that expresses a small interfering nucleic acid or at least one binding site for a miRNA.

Abstract: Follicular thyroid adenoma (FTA) is distinguished from follicular thyroid carcinoma (FTC) by comparing amount of an expression product of at least one gene selected from the group consisting of DDIT3, ARG2, ITM1, C1orf24, TARSH, and ACO1 in a test follicular thyroid specimen to a normal control thyroid specimen. The test follicular thyroid specimen is identified as FTA if the amount of expression product of TARSH is equal to or greater in the test follicular thyroid specimen than in the normal control thyroid specimen. The test follicular thyroid specimen is identified as FTC if the amount of expression product of DDIT3, ARG2, ITM1, C1orf24, or ACO1 is greater in the test follicular thyroid specimen than in the normal control thyroid specimen.

Abstract: The present invention relates to retroviral vectors, particularly lentiviral vectors, pseudotyped with Sindbis envelope and targeted to specific cell types via a targeting moiety linked to the envelope.

Abstract: The present invention describes a novel recombinant NADH recycling system that is used as a process for producing reduced compounds. In a specific embodiment, the reduced compounds include ethanol, succinate, lactate, a vitamin, a pharmaceutical and a biodegraded organic molecule. The NADH recycling system effects metabolic flux of reductive pathways in aerobic and anaerobic environments.

Abstract: A method of treating a central nervous system (CNS) disorder, comprises the steps of inserting into a patient's body first and second conduits so that distal ends of the first and second conduits open to a portion of the patient's CNS with direct access to cerebrospinal fluid (CSF) and a proximal end of the first conduit opens into a first reservoir of material to be introduced into the CSF and a proximal end of the second conduit opens to drain CSF withdrawn from the CNS in combination with the steps of detecting and analyzing brain activity of a patient and determining a chemical imbalance present in the CSF by one of a microassay of a sample of CSF withdrawn from the second reservoir and the detected and analyzed brain activity. Based on the determined chemical imbalance, the patient is treated by one of supplying an agent to the CSF via the first conduit and withdrawing a quantity CSF via the second conduit.

Abstract: An image interpolating method and apparatus, in which horizontal and vertical Differences of Absolute Inter-channel Differences (DAIDs) are calculated from a color filter array (CFA) image, and an unknown pixel is interpolated in horizontal and vertical directions estimated in consideration of the DAIDs of R, G, and B pixels. Therefore, the image interpolating method and apparatus provide a large Peak Signal and Noise Ratio (PSNR), a Structural Similarity (SSIM), and high visual quality images.

Abstract: Disclosed is a designed and implemented 12-bit 70 Msps pipeline analog-to-digital converter. Two adjacent blocks operate at opposite clock phases to reduce the chip size and power consumption. Since the opposite clock phases are designed to be provided by external devices, the timing between these two clock phases must be accurate. Note that the architecture of pipeline ADC consists of four stages, divided into two groups, wherein two adjacent stages in each group share one 3-bit flash ADC, hence only two 3-bit flash ADCs are required in this scheme. Therefore, there are 6-bit signal produced from each 3-bit flash ADC within one clock phase which consists of two opposite clock phases. And within the same period, the total output of the pipeline analog-to-digital converter would be 12-bit. From the simulation results, when the sampling rate is 70 Msps, this converter consumes 155 mW (TBV) at a ±1.8 V supply.

Abstract: A lane departure warning method and system thereof are provided. First a driver model is established, wherein the driver model is established according to a lateral position error of a vehicle being driven and a steering angle generated by a driver for controlling the vehicle. Next, a system identification process is performed on the lateral position error and the steering angle, so as to obtain specific information of the driver model. An estimation process is performed on the specific information and a plurality of raw statistical data, so as to obtain a time to lane crossing (TLC). A decision process is performed on the TLC and a driver drowsiness index, so as to obtain a lane departure warning strategy.

Abstract: A garment for electrically stimulating muscles is provided to be used for, e.g., rehabilitation or exercise whereby an electrode can be conveniently provided at such a position as allowing the electrode to stimulate the nerve-muscular junction of a muscle to be moved in toning up the muscle through electrical stimulation on the muscle by taking advantage of the muscular contraction caused by electrically stimulating the muscle.

Abstract: Disclosed are methods and compositions related to riboswitches that control alternative splicing.

Abstract: A two-ring optical buffer comprising a first ring operatively connected to a waveguide and a second ring, the second ring being operatively connected to only the first ring, the second ring and the first ring having a circumferential ratio substantially equal to 2m, where m is an integer. A ratio of resonance splitting over resonance broadening may be approximately 0.6.

Abstract: The present invention relates to novel proteins, referred to herein as amidated glial cell line-derived neurotrophic factor (GDNF) peptides (or “Amidated Dopamine Neuron Stimulating peptides (ADNS peptides)”), that are useful for treating brain diseases and injuries that result in dopaminergic deficiencies.

Abstract: Provided is a tag identification method in an RFID system. A tag identification method generates a query tree according to a query and a response between an RFID reader and a tag to identify the tag. In the method, a query message is transmitted from the RFID reader to the tag. A response message for the query message is received from the tag. Herein, the query tree is generated in the reverse order of a string owned by the tag. The query tree is generated in the reverse order of the tag IDs in the query tree-based protocol to reduce the frequency of collisions between the tags, thereby making it possible to reduce the time taken to identify all the tags within the recognizable range of the RFID reader.

Abstract: Novel stable, concentrated, biologically active and ready-to-use lipid-comprising drug delivery complexes and methods for their production are described. The biological activity of the complexes produced are comparable to the formulations prepared according to the prior art admixture method and upon purification, the complexes produced by the method of this invention are 50 to 500 fold more concentrated than the complexes formed by admixture. The method described herein provides for the large scale production of lipid-comprising drug delivery systems useful for gene therapy and other applications.

Abstract: A method and corresponding system for providing a uniform nanowire array including uniform nanowires composed of at least three elements is presented. An embodiment of the method includes growing an array of two-element nanowires, and thereafter uniformly doping or alloying each two-element nanowire, with respect to each other two-element nanowire, with at least one doping or alloying element through a wet chemical synthesis with a precursor solution, to produce the uniform array of nanowires composed of at least three elements. The two-element nanowire can include Zn and O, and the at least one doping or alloying element can be Mg, Cd, Mn, Cu, Be, Fe, and Co. Applications of the three-element nanowire array include solar cells and light emitting diodes with improved efficiencies over existing technologies.

Abstract: An X-ray condensing method and its device are provided with an X-ray mirror that has a wavefront adjustable function to finely adjust a wavefront of a reflecting X-ray, measure an X-ray intensity distribution in the vicinity of a focus, measure an X-ray intensity distribution in the vicinity of the X-ray mirror or use a known X-ray intensity distribution of an incident X-ray, calculate a complex amplitude distribution at the reflective surface by using a phase restoration method from the X-ray intensity distribution in the vicinity of the focus and the X-ray intensity distribution in the vicinity of the reflective surface, calculate a wavefront aberration of an X-ray condensing optical system from the complex amplitude distribution, and control the reflective surface of the X-ray mirror with the wavefront adjustable function so that the wavefront aberration is minimized.

Abstract: The present invention includes compositions and methods for making and using a rapid dissolving, high potency, substantially amorphous nanostructured aggregate for pulmonary delivery of tacrolimus and a stabilizer matrix comprising, optionally, a polymeric or non-polymeric surfactant, a polymeric or non-polymeric saccharide or both, wherein the aggregate comprises a surface area greater than 5 m2/g as measured by BET analysis and exhibiting supersaturation for at least 0.5 hours when 11-15-times the aqueous crystalline solubility of tacrolimus is added to simulated lung fluid.

Abstract: A biopsy device is described. In one aspect, the biopsy device includes a scoop-shaped blade with a distal, pointed tip. A handle is operatively coupled to a proximal end of the scoop-shaped blade. The scoop-shaped blade and handle combination of the biopsy device are configured to provide a tissue biopsy to a practitioner responsive to a manually directed biopsy operation on a patient.

Abstract: A shared key management method for a Supervisory Control And Data Acquisition (SCADA) system in which a master terminal unit (MTU), a plurality of sub master terminal units (SUB-MTUs), and a plurality of remote terminal units (RTUs) are configured in a sequential hierarchy, is provided.

Abstract: The present invention provides an NAT (Network Address Translator) traversal method in Session Initiation Protocol (SIP) for solving the problems of SIP in Internet phone (VoIP) under current Internet environment. In other words, the present invention solves the SIP problems caused by NAT (Network Address Translator) that P2P (Peer to Peer) transmission cannot traverse the NAT firewall directly.