Abstract: The present invention provides systems and methods for improving the efficiency of a transient gene delivery system to differentiating embryonic stem (ES) cells by serum starving the targeted cells for one to three days prior to transfection. Such a serum starvation surprisingly resulted in increased expression of a constitutively-controlled plasmid from 50.4% to 83.2% of the population and increased expression of a promoter/enhancer controlled plasmid from ˜1.4% to ˜3.7% of the population.
Type:
Application
Filed:
September 22, 2009
Publication date:
July 22, 2010
Applicant:
Rutgers, the State University
Inventors:
Martin L. Yarmush, Eric J. Wallenstein, Rene S. Schloss
Abstract: The present invention relates to a cell culture device which includes: a cell culture container comprising a container body and a neck connecting to the container body wherein the container contains a top wall, a bottom wall having a first opening, and at least one side wall to define a cell culture zone, and an end of the neck has a second opening for cells or culture media being injected into the cell culture zone; a biosensor chip having a detective surface which faces the top wall of the cell culture container; and a fastening component for the biosensor chip being fastened in the first opening of the bottom wall. The cell culture of the present invention can be used for real-time detection of the cell growth and further for drug screening.
Type:
Application
Filed:
July 30, 2009
Publication date:
July 22, 2010
Applicants:
Tatung University, Tatung Company
Inventors:
Tsong-Rong Yan, Hung-Che Chou, Chao-Fa Lee
Abstract: The present invention relates to methods and compositions for treating and/or preventing inflammation associated with viral infection and solid organ transplant rejection. In particular, the present invention provides therapeutics for impairing the expansion and function of autoreactive T cells, NK cells and/or NKT cells, by modulating NKG2D.
Type:
Application
Filed:
May 4, 2007
Publication date:
July 22, 2010
Applicant:
Regents of the University of California
Inventors:
Jody L. Baron, Sang-Mo Kang, Lewis L. Lanier
Abstract: A field electron emitter includes a thin film layer including a carbon nanotube (“CNT”) disposed on a substrate, wherein the thin film layer includes nucleic acid.
Type:
Application
Filed:
July 31, 2009
Publication date:
July 22, 2010
Applicants:
SAMSUNG ELECTRONICS CO., LTD., Korea University Industrial & Academic Collaboration Foundation
Inventors:
Yoon-chul Son, Yong-chul Kim, Jeong-na Heo, Byeong-kwon Ju
Abstract: The invention provides for a method of producing an isoprenyl alkanoate in a genetically modified host cell. In one embodiment, the method comprises culturing a genetically modified host cell which expresses an enzyme capable of catalyzing the esterification of an isoprenol and a straight-chain fatty acid, such as an alcohol acetyltransferase (AAT), wax ester synthase/diacylglycerol acyltransferase (WS/DGAT) or lipase, under a suitable condition so that the isoprenyl alkanoate is produced.
Type:
Application
Filed:
December 22, 2009
Publication date:
July 22, 2010
Applicant:
The Regents of the University of California
Inventors:
Taek Soon Lee, Jeffrey L. Fortman, Jay D. Keasling
Abstract: Compounds of formula (I) and (II) are provided as modulators of Rb:Raf-1 interactions which are potent, selective disruptors of Rb:Raf-1 binding. Therapeutic methods of using the compounds, for example for treating or ameliorating a cell proliferation disorder such as cancer, are provided.
Type:
Application
Filed:
August 31, 2009
Publication date:
July 22, 2010
Applicant:
University of South Florida
Inventors:
Said M. Sebti, Srikumar Chellappan, Nicholas James Lawrence
Abstract: A GMR material includes a polymer matrix and a plurality of carbon nanotubes. The plurality of carbon nanotubes are dispersed in such a manner that substantially none of the plurality of carbon nanotubes are in contact with each other.
Type:
Application
Filed:
September 3, 2009
Publication date:
July 22, 2010
Applicants:
Tsinghua University, Hon Hai Precision Industry Co., Ltd.
Inventors:
Chun-Hua Hu, Chang-Hong Liu, Shou-Shan Fan
Abstract: The present invention is a composition identified as a region of ralA binding protein 1, wherein the region neighbors a membrane-associated portion of the ralA binding protein 1, reduces transport activity and membrane association of the ralA binding protein 1 and kills cells undergoing uncontrolled cell growth in a subject that has cells undergoing uncontrolled cell growth. The region is used to generate medicines that kill malignant cells and tumorigenic cells. Medicines may be in the form of antibodies, si-RNA and small molecules that recognize the region.
Type:
Application
Filed:
March 25, 2008
Publication date:
July 22, 2010
Applicant:
Board of Regents, The University of Texas System
Inventors:
Sanjay Awasthi, Sharad S. Singhal, Sushma Yadav
Abstract: A pixel output line (14) is independently provided for each of the pixels arranged in a two-dimensionally array within a pixel area so that pixel signals can be sequentially written in a plurality of memory sections (22) through the pixel output lines (14). When a plurality of frames of pixel signals are held in the memory sections (22), the pixel signals corresponding to two arbitrarily selected frames are read and respectively stored in sample-and-hold circuits (61 and 62), and their difference is obtained. Then, the difference signals corresponding to a predetermined range of the image are integrated, and the integrated value is compared with a threshold. If the integrated value exceeds the threshold, it is presumed that a change in an imaging object has occurred, and a pulse generation circuit (66) generates a trigger signal.
Abstract: This invention relates to inhibition of hepatitis gene expression. More specifically, the invention relates to a method of using RNA sequences to inhibit Hepatitis B and C Virus replication. Expression cassettes that include DNA sequences derived from endogenous micro RNAs (miRs) are used in the method and are transcribed by Pol II promoters, and then processed to generate sequences that are specific to target hepatitis virus sequences (RNAi effecter sequences). The RNAi effecter sequences can target the selected hepatitis virus sequences resulting in gene silencing or transcriptional inhibition of the hepatitis virus gene. The expression cassettes may be delivered in vitro or in vivo to host cells. A pharmaceutical composition containing the expression cassettes is also claimed.
Type:
Application
Filed:
November 30, 2009
Publication date:
July 22, 2010
Applicant:
University of the Witwatersrand
Inventors:
Patrick Arbuthnot, Abdullah Ely, Tanusha Naidoo, Marc Saul Weinberg, Victoria Mary Longshaw
Abstract: Systems, methods, and techniques are provided for performing any one or more of edge-preserving image sharpening, edge-preserving image smoothing, edge-preserving image dynamic range compression, and edge-aware data interpolation on digital images, wherein a pixel prediction module is adapted for coupling to a memory storing pixel data representative of a digital image and extracts from the image predicted pixel values using robust smoothing. The predicted pixels are stored in a memory and respective detail values equal to the difference between respective original and predicted values are computed. A pixel update module computes approximation values by averaging the respective detail values with original pixel values using robust smoothing, and stores the approximation values for subsequent rendering.
Type:
Application
Filed:
January 21, 2010
Publication date:
July 22, 2010
Applicant:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Abstract: This invention provides novel carbonic anhydrase (CAIX) nucleic acid and peptide sequences, as well as related methods and compositions, including anti-cancer immunogenic agent(s) (e.g. vaccines and chimeric molecules) that elicit an immune response specifically directed against cancer cells expressing a CAIX antigenic marker. The novel CAIX variant and related compositions are useful in a wide variety of treatment modalities including, but not limited to protein vaccination, DNA vaccination, and adoptive immunotherapy.
Type:
Application
Filed:
December 21, 2007
Publication date:
July 22, 2010
Applicant:
The Regents of teh University of California
Abstract: A unique composition of a 5-amino salicylic acid (5ASA) and a phospholipid is disclosed for treating Inflammatory Bowel Disease (IBD), where the composition can be a mixture, a molecular association complex or a covalent compound of 5ASA and a reactive phospholipid covalently bonded together via a diazo linkage and to methods for administering the compositions to treat symptoms of IBD.
Type:
Application
Filed:
March 22, 2010
Publication date:
July 22, 2010
Applicant:
The Board of Regents of the University of Texas System
Abstract: The present invention relates to a method of time-domain magnetic resonance imaging and device thereof. The method includes transiently exciting a sample; receiving a signal emitted form the sample; and processing the received signal without Fourier transformation to acquire an image. The device includes an excitation device, a detecting coil and an operating circuit to process a received emitting signal and generating an image, wherein the received emitting signal is a time-domain signal free from Fourier transformation. The time of generating an image can be reduced dramatically by the present invention.
Abstract: A system and a method for resource allocation in the semiconductor testing industry are provided. In the system, an industry characteristic conversion module is used to transform the industry characteristic obtained from an input module into a chromosome structure. Next, an artificial intelligence evolution module proceeds to find an optimal solution by handling the chromosome structure until a candidate solution having a maximum final total profit converges to a value.
Type:
Application
Filed:
August 20, 2009
Publication date:
July 22, 2010
Applicant:
National Taiwan University of Science and Technology
Abstract: Disclosed is a dual-rail asynchronous insensitive scan chain circuit designed for test. This scan chain does not require any clock even in scan mode, so it is truly an asynchronous design for testability. The normal function of the asynchronous scan chain can not be affected when removing any clock controls. The handshake protocols between two sequential elements used in the asynchronous scan chain become the scan chain transmission structure, rather than the timing control used in synchronous scan chain in the prior arts. Therefore, both in the function mode and scan mode, the scan chain always operates under the asynchronous condition. It not only can reach a complete test scanning, achieve high fault detection coverage and consume lower power, but also avoid the clock skew problem.
Abstract: The invention is directed compositions and methods related to bacterial cells physically associated with ceramide-like glycolipids. The invention allows for delivery of ceramide-like glycolipid adjuvants directly to the same cells that become infected with a bacterial vaccine. The compositions and methods of the present invention are useful for the prevention and treatment of diseases.
Type:
Application
Filed:
January 8, 2010
Publication date:
July 22, 2010
Applicant:
Albert Einstein College of Medicine of Yeshiva University
Inventors:
Steven A. Porcelli, Manjunatha M. Venkataswamy
Abstract: This invention describes a first report on the synthesis of certain 124I-labelled photosensitizers related to chlorines and bacteriochlorins with long wavelength absorption in the range of 660-800 nm. In preliminary studies, these compounds show a great potential for tumor detection by positron emission tomography (PET) and treatment by photodynamic therapy (PDT). The development of tumor imaging or improved photodynamic therapy agent(s) itself represent an important step, but a dual function agent (PET imaging and PDT) provides the potential for diagnostic body scan followed by targeted therapy.
Type:
Application
Filed:
August 5, 2009
Publication date:
July 22, 2010
Applicants:
Health Research, Inc., The Research Foundation of State University of New York
Inventors:
Ravindra K. Pandey, Munawwar Sajjad, Suresh Pandey, Amy Gryshuk, Allan Oseroff, Hani A. Nabi, Stephanie Pincus
Abstract: A medical resin composition is produced by mixing a powder of a polymer (A) comprising repeating units having an ester group and a liquid of a vinyl ester monomer (B) having 6 or more carbon atoms to increase a viscosity and, according to demand, further performing a polymerization reaction. The thus produced resin composition inhibits leaching of irritative substances, reduces any adverse effects on the human body by endocrine disruptors, etc. and can be prepared with high operational efficiency. The resin composition is suitably used as a dental resin composition such as a tissue conditioner, a functional impression material, a lining material, a denture base material or a mouth piece material.
Type:
Application
Filed:
February 1, 2010
Publication date:
July 22, 2010
Applicant:
National University Corporation Okayama University
Abstract: Identified herein are sperm ligand proteins located in the membrane of sperm, which proteins interact with the membrane of oocytes. Methods of using these proteins, or fragments or derivatives or analogs thereof, are also described. These include methods of increasing (or reducing) successful fertilization, for instance through improved sperm-oocyte binding, fusion or activation (or the blocking thereof); methods of preventing fertilization of an oocyte, for instance by inducing an immune response to at least one sperm ligand that promotes sperm-oocyte binding, sperm-oocyte fusion or oocyte activation; and methods for enhancing assisted reproductive technologies, for instance through stimulation of activation with nuclear transfer, stimulation of inactive or weak sperm, and so forth.
Type:
Application
Filed:
March 17, 2010
Publication date:
July 22, 2010
Applicant:
Utah State University
Inventors:
Kenneth L. White, Bart C. Weimer, Barry Joseph Pate, Dong Chen