Abstract: An isolated and purified GnRH protein receptor protein including an amino acid sequence selected from the group and an isolated and purified DNA which comprises a nucleotide sequence coding for the GnRH protein receptor protein. Also, a vector comprising the DNA of the GnRH protein receptor protein, a transformant carrying the vector comprising the DNA of the GnRH protein receptor protein, a process for producing a GnRH protein receptor protein or a salt thereof including culturing the transformant carrying the vector comprising the DNA of the GnRH protein receptor protein under sufficient conditions and for appropriate time to express the GnRH protein receptor protein, and a method of screening for a ligand to the GnRH protein receptor protein including contacting the GnRH protein receptor protein or a salt thereof with a sample to be tested. A screening method for a compound capable of inhibiting binding of the GnRH protein receptor protein with a ligand.
Type:
Grant
Filed:
December 1, 2008
Date of Patent:
February 23, 2010
Assignee:
University of New Hampshire
Inventors:
Stacia Sower, Nathaniel V. Nucci, Matthew R. Silver
Abstract: A frequency shift keying modulator having sigma-delta modulated phase rotator is disclosed, which includes a phase-locked loop for generating a voltage-controlled signal; a multi-phase generator for receiving the voltage-controlled signal and generating N phase-shift signals having same frequency according to the voltage-controlled signal, the N phase-shift signals having a same phase shift between the phase-shift signals adjacent to each other; a sigma-delta modulator for receiving transmission data and randomly outputting a modulation bit at a modulation clock according to the transmission data; and a phase rotator for receiving the N phase-shift signals and selectively outputting one of the N phase-shift signals and a frequency-divided signal according to the modulation bit, wherein the frequency of the frequency-divided signal is 1 / ( 1 + n N ) of the frequency of any one of the N phase-shift signals.
Abstract: Systems, methods, apparatus and devices for head mounted stereoscopic 3-D display devices using the tunable focus liquid crystal micro-lens array eye to produce eye accommodation information. A liquid crystal display panel displays stereoscopic images and uses tunable liquid crystal micro-lens array to change the diopter of the display pixels to provide eye accommodation information. The head mounted display device includes a planar display screen, planar tunable liquid crystal micro-lens array and planar black mask. The display device may optionally include a bias lens. In an embodiment, the display device also includes a backlight and a prism sheet for displaying the images on the display screen. The display screen, tunable liquid crystal micro-lens array, black mask and optional backlight and prism may be flat or curved.
Type:
Grant
Filed:
June 1, 2007
Date of Patent:
February 23, 2010
Assignees:
University of Central Florida Research Foundation, Inc., Toppoly Optoelectronics Corp.
Inventors:
Qi Hong, Ruibo Lu, Thomas Xinzhang Wu, Shin-Tson Wu
Abstract: The present invention relates to genes encoding proteins involved in prokaryotic type or plastid division and/or morphology and the encoded proteins, and in particular to isolated Ftn2 (ARC6), ARC5, and Fzo-like genes and polypeptides. The present invention also provides methods for using Ftn2 (ARC6), ARC5, and Fzo-like genes, and polypeptides.
Type:
Grant
Filed:
June 20, 2003
Date of Patent:
February 23, 2010
Assignee:
Board of Trustees of Michigan State University
Inventors:
Katherine W. Osteryoung, Stanislav Vitha, Olga A. Koksharova, Hongbo Gao
Abstract: The present invention relates generally to reagents useful in the immunotherapeutic or immunoprophylactic treatment of allergic diseases. More particularly, the present invention provides modified allergens exhibiting reduced IgE interactivity including reduced IgE production-stimulatory activity, while retaining T-cell antigenicity, which are useful in the immunomodulation of type I allergic disease conditions. The present invention further contemplates a method of immunomodulation of allergic diseases such as type I allergic disease conditions by the administration of modified allergens exhibiting reduced IgE interactivity while retaining T-cell antigenicity.
Type:
Grant
Filed:
September 13, 2002
Date of Patent:
February 23, 2010
Assignee:
The University of Melbourne
Inventors:
Nicole Deweerd, Mohan Bir Singh, Prem L. Bhalla, Ines Swoboda
Abstract: Non-volatile resistance-switching oxide films, and devices therewith, are disclosed. One embodiment of a suitable device is composed of a SRO-CZO thin film having a thickness of from about 6 to about 30 nm, and composed of from about 3 to about 10 molar % of a SrRuO3 conducting oxide dopant and from about 90 to about 97 molar % of a CaZrO3 insulating oxide material.
Type:
Grant
Filed:
April 26, 2007
Date of Patent:
February 23, 2010
Assignee:
The Trustees of the University of Pennsylvania
Abstract: The claimed invention describes methods to diagnose or aid in the diagnosis of cancer. The claimed methods are based on the identification of biomarkers which are particularly well suited to discriminate between cancer subjects and healthy subjects. These biomarkers were identified using a unique and novel screening method described herein. The biomarkers identified herein can also be used in the prognosis and monitoring of cancer. The invention comprises the use of leptin, prolactin, OPN and IGF-II for diagnosing, prognosis and monitoring of ovarian cancer.
Type:
Grant
Filed:
January 18, 2005
Date of Patent:
February 23, 2010
Assignee:
Yale University
Inventors:
Gil G. Mor, David C. Ward, Patricia Bray-Ward
Abstract: The present invention provides methods of screening chickens to determine those more likely to have a lean or fat phenotype. The invention also provides methods of screening chickens to identify a polymorphism associated with a fat or lean phenotype.
Type:
Grant
Filed:
December 16, 2004
Date of Patent:
February 23, 2010
Assignee:
University of Delaware
Inventors:
Larry A. Cogburn, Wilfrid G. Carre, Xiaofei Wang
Abstract: A novel photovoltaic solar cell and method of making the same are disclosed. The solar cell includes: at least one absorber layer which could either be a lightly doped layer or an undoped layer, and at least a doped window-layers which comprise at least two sub-window-layers. The first sub-window-layer, which is next to the absorber-layer, is deposited to form desirable junction with the absorber-layer. The second sub-window-layer, which is next to the first sub-window-layer, but not in direct contact with the absorber-layer, is deposited in order to have transmission higher than the first-sub-window-layer.
Abstract: Synthesis and herbicidal activity of novel 1-(2-substituted benzo[d]thiazol-5-yl)-1H-1,2,4-triazol-5(4H)-one derivatives. Using a dose of 300 gai./h, the compounds of the invention possess significant herbicidal activity for Echinochloa crusgalli, Digiatria sanguinalis, Setaria viridis, Brassica juncea, Amaranthus retroflexus and Chenopodium album.
Abstract: An electric variable inertia apparatus uses a servo drive device to drive a planetary gear mechanism to which a load assembly is attached to provide variable and wide-ranging rotational inertia. A planetary frame and a ring gear of the planetary gear mechanism act as two input ends of the electric variable inertia apparatus, and a rotated shaft of a sun gear assembly of the planetary gear mechanism acts as a load terminal. The load assembly is rotated at a controlled rotational velocity with the ring gear to generate a widely ranging rotational inertia to change a dissipating degree of an input energy from the planetary frame. The electric variable inertia apparatus can be used in different fields such as shock absorbers, stabilizers, dampers or vibrators in the automotive field, etc.
Type:
Grant
Filed:
January 8, 2007
Date of Patent:
February 23, 2010
Assignee:
National Formosa University
Inventors:
Bor-Jeng Lin, Mi-Ching Tsai, Cheng-Chi Huang, Li-Jung Tu
Abstract: Chronic obstructive airway diseases are treated by administering an osmotically active compound such as a salt, sugar, sugar alcohol, or organic osmolyte to the afflicted airway surface. The compound may be administered as a liquid or dry powder aerosol formulation. Diseases that can be treated by the method include cystic fibrosis, chronic bronchitis, and ciliary dyskinesia. The formulations of the invention can also be used in conjunction with other active agents such as bronchodilators, sodium channel blockers, antibiotics, enzymes, or purinoceptor agonists on airway surfaces.
Type:
Grant
Filed:
November 18, 2004
Date of Patent:
February 23, 2010
Assignee:
The University of North Carolina at Chapel Hill
Abstract: The present invention relates to methods and compositions for the prevention and treatment of infectious diseases, and cancers. The methods of the invention comprises complexing a population of antigenic proteins or antigenic peptides derived from antigenic cells or viral particles to one or more different heat shock proteins in vitro. The population or the protein preparation used to produce the antigenic peptides comprises at least 50% of the different proteins or at least 50 different proteins of the antigenic cells or viral particles. Methods for making antigenic peptides comprise digesting a protein preparation of antigenic cells, a cellular fraction thereof, or of viral particles with one or more proteases, or exposing the protein preparation to ATP, guanidium hydrochloride, and/or acidic conditions.
Abstract: The invention provides autoinducer-2 analogs that regulate the activity of autoinducer-2 and methods of using such analogs for regulating bacterial growth and pathogenesis.
Type:
Grant
Filed:
March 17, 2004
Date of Patent:
February 23, 2010
Assignees:
Princeton University, Quorex Pharmaceuticals, Inc., University Technologies International, Inc.
Inventors:
Bonnie L. Bassler, Stephan Schauder, Kevan Shokat, Michael G. Surette
Abstract: There is disclosed a multi-metal-nitrogen compound for use in hydrogen storage materials. The compound comprising two dissimilar metal atoms and a nitrogen atom. The multi-metal-nitrogen compound being capable of absorbing hydrogen at an absorption temperature and pressure, and of desorbing 60% or more by weight of said absorbed hydrogen at a desorption temperature and pressure.
Abstract: The present invention relates to compositions and methods for cancer diagnostics, including but not limited to, cancer markers. In particular, the present invention provides methods of identifying methylation patterns in genes associated with specific cancers.
Type:
Grant
Filed:
October 2, 2003
Date of Patent:
February 23, 2010
Assignee:
Northwestern University
Inventors:
Victor V. Levenson, Ronald B. Gartenhaus
Abstract: The invention is in general directed to compounds and methods for diagnosing, preventing or alleviating the symptoms of amyloid-associated diseases, for example, neuronal diseases, such as, for example, Alzheimer's disease, methods of screening for compounds useful in preventing or alleviating the symptoms of amyloid-associated diseases, methods of diagnostic imaging of A-beta fibrils, and compounds and methods useful for studying normal or disease-associated cellular mechanisms relating to amyloid proteins.
Type:
Grant
Filed:
July 14, 2006
Date of Patent:
February 23, 2010
Assignee:
The Regents of the University of California
Abstract: Methods for synthesizing isopentenyl pyrophosphate are provided. A first method comprises introducing into a host microorganism a plurality of heterologous nucleic acid sequences, each coding for a different enzyme in the mevalonate pathway for producing isopentenyl pyrophosphate. A related method comprises introducing into a host microorganism an intermediate in the mevalonate pathway and at least one heterologous nucleic acid sequence, each sequence coding for an enzyme in the mevalonate pathway necessary for converting the intermediate into isopentenyl pyrophosphate. The invention also provides nucleic acid sequences, enzymes, expression vectors, and transformed host cells for carrying out the methods.
Type:
Grant
Filed:
September 1, 2006
Date of Patent:
February 23, 2010
Assignee:
The Regents of the University of California
Inventors:
Jay D. Keasling, Vincent J. J. Martin, Douglas J. Pitera, Seon-Won Kim, Sydnor T. Withers, III, Yasuo Yoshikuni, Jack D. Newman, Artem Valentinovich Khlebnikov
Abstract: This invention relates to an aggregation sensor useful for the detection and analysis of aggregants in a sample, and methods, articles and compositions relating to such a sensor. The sensor comprises first and second optically active units, where energy may be transferred from an excited state of the first optically active unit to the second optically active unit. The second optically active unit is present in a lesser amount, but its relative concentration is increased upon aggregation, increasing its absorption of energy from the first optically active units. This increase in energy transfer can be detected in variety of formats to produce an aggregation sensing system for various aggregants, including for quantitation. Other variations of the inventions are described further herein.
Type:
Grant
Filed:
January 31, 2006
Date of Patent:
February 23, 2010
Assignee:
The Regents of the University of California