Patents Assigned to University
  • Patent number: 7666591
    Abstract: The invention provides ssDNA-binding proteins from three species of archaeons, Methanococcus jannaschii, Methanobacter theromoautotrophicum, and Archaeoglobus fulgidus, as well as the ability to identify ssDNA-binding proteins from other archaeons. The proteins help render DNA more accessible to DNA polymerase and are robust reagents for a variety of biotechnical processes, including PCR. The invention further provides nucleic acids encoding such proteins, vectors for transfecting host cells, host cells comprising the vectors, and methods of using the proteins.
    Type: Grant
    Filed: January 14, 2005
    Date of Patent: February 23, 2010
    Assignees: The Regents of the University of California, The United States of America as represented by the Department of Health and Human Services
    Inventors: Stephen C. Kowalczykowski, Frédéric Chédin, Erica M. Seitz
  • Patent number: 7668843
    Abstract: Identifying anomalies or outliers in a set of data records employs a distance or similarity measure between features of record pairs that depends upon the frequencies of the feature values in the set. Feature distances may be combined for a total distance between record pairs. An outlier is indicated for a certain score that may be based upon the pairwise distances. Outliers may be employed to detect intrusions in computer networks.
    Type: Grant
    Filed: December 14, 2005
    Date of Patent: February 23, 2010
    Assignee: Regents of the University of Minnesota
    Inventors: Levent Ertoz, Vipin Kumar
  • Patent number: 7666445
    Abstract: Surgically implantable drug delivery systems for long-term delivery of haloperidol containing a biodegradable polymer and haloperidol fabricated into the surgically implantable drug delivery systems via solvent casting and compression molding are provided. Also provided are methods for producing the surgically implantable drug delivery systems and methods for using these systems in the treatment of psychotic disorders such as schizophrenia.
    Type: Grant
    Filed: October 19, 2001
    Date of Patent: February 23, 2010
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Steven J. Siegel, Karen I. Winey, Raquel E. Gur, Robert H. Lenox
  • Patent number: 7666380
    Abstract: A porous carbon composition comprises carbon particles having substantially uniform mesopores, wherein the mesopores have a diameter greater than 5 nanometers. A carbon composition may also comprise carbon particles having a predetermined surface configuration, wherein the surface configuration inversely corresponds to the configuration of at least a portion of an imprinting material. A method of synthesizing mesoporous carbon particles comprises the steps of providing particles of at least one carbon precursor, mixing the particles of at least one carbon precursor with a medium containing an imprinting material to form pretreated solid carbon precursor particles, heating the pretreated solid carbon precursor particles to a temperature at least as high as 20° C.
    Type: Grant
    Filed: January 4, 2006
    Date of Patent: February 23, 2010
    Assignee: Kent State University
    Inventors: Mietek Jaroniec, Zuojiang Li
  • Patent number: 7667088
    Abstract: Pemphigus vulgaris (PV) is an autoimmune disease with a possible fatality of the skin and mucosae which is induced by an antibody against desmoglein 3 (Dsg3). Persistent production of anti-Dsg3 IgG can be induced by adoptively transferring spleen cells of a DSG3?/? mouse immunized with rDsg3 into an RAG2?/? immunodeficient mouse expressing Dsg3 protein. This IgG in the blood binds to the Dsg3 protein in vivo, induces the breakage of intercellular adhesion of keratinocytes and thus brings about the phenotype of pemphigus vulgaris involving the formation of blisters in the oral mucosa and the disappearance of resting hair. These effects are sustained over 6 months. By using this method, active disease model animals relating to various autoimmune diseases can be constructed.
    Type: Grant
    Filed: April 3, 2006
    Date of Patent: February 23, 2010
    Assignee: Keio University
    Inventors: Masayuki Amagai, Takeji Nishikawa, Harumi Suzuki, Shigeo Koyasu
  • Patent number: 7667096
    Abstract: The present disclosure provides methods, recombinant DNA molecules, recombinant host cells containing the DNA molecules, and transgenic plant cells, plant tissue and plants which contain and express at least one antisense or interference RNA specific for a thiamine biosynthetic coding sequence or a thiamine binding protein or a thiamine-degrading protein, wherein the RNA or thiamine binding protein is expressed under the regulatory control of a transcription regulatory sequence which directs expression in male and/or female reproductive tissue. These transgenic plants are conditionally sterile; i.e., they are fertile only in the presence of exogenous thiamine. Such plants are especially appropriate for use in the seed industry or in the environment, for example, for use in revegetation of contaminated soils or phytoremediation, especially when those transgenic plants also contain and express one or more chimeric genes which confer resistance to contaminants.
    Type: Grant
    Filed: June 3, 2004
    Date of Patent: February 23, 2010
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: Richard B. Meagher, Elizabeth McKinney, Tehryung Kim
  • Patent number: 7667993
    Abstract: A dual-ported AND-type match-line circuit includes at least one dual-ported dynamic AND gate. The dual-ported dynamic AND gate includes a group of CAM cells and a dual-ported dynamic circuit. A group of CAM cells connected to a dual-ported dynamic circuit and to the GND. The dual-ported dynamic circuit is connected to a group of CAM cells. The dual-ported dynamic circuit includes a setting circuit, a first directing circuit, a second directing circuit, a first AND dynamic output circuit and a second AND dynamic output circuit.
    Type: Grant
    Filed: October 12, 2007
    Date of Patent: February 23, 2010
    Assignee: National Chung Cheng University
    Inventors: Chao-Ching Wang, Chieh-Jen Cheng, Jinn-Shyan Wang, Tien-Fu Chen
  • Patent number: 7667089
    Abstract: Hemophilia A is one of the major inherited bleeding disorders caused by a deficiency or abnormality in coagulation factor VIII (FVIII). Hemophiliacs have been treated with whole plasma or purified FVIII concentrates. The risk of transmitting blood-borne viruses and the cost of highly purified FVIII are the major factors that restrict prophylaxis in hemophilia therapy. One of the challenges created by the biotechnology revolution is the development of methods for the economical production of highly purified proteins in large scales. The present invention provides improved mammary expression cassettes useful for the expression of genes at high levels in the milk of transgenic animals. In particular, the present invention provides recombinant signal peptide sequences derived from a-lactalbumin and aS1-casein milk genes suitable for leading protein secretion in the mammary gland.
    Type: Grant
    Filed: April 9, 2004
    Date of Patent: February 23, 2010
    Assignee: National Chung Hsing University
    Inventors: Winston T. K. Cheng, Chuan-Mu Chen, Shwu-Wha Lin, Chih-Hong Wang, Chih-Jen Lin, Shinn-Chih Wu
  • Patent number: 7667995
    Abstract: A method for creating a logic state for teleporting quantum information using a single photon is described. The method includes receiving a photon with an initial polarization and causing a first semiconductor crystal to have a first spin orientation. The photon interacts with the first semiconductor crystal for producing a resulting polarization dependent upon the first spin orientation. Causing the photon to interact with the first semiconductor crystal generates a maximally entangled state.
    Type: Grant
    Filed: February 9, 2006
    Date of Patent: February 23, 2010
    Assignees: University of Iowa Research Foundation, The Regents of the University of California
    Inventors: Michael N. Leuenberger, Michael E. Flatté, David D. Awschalom
  • Patent number: 7666673
    Abstract: The present invention provides a method of growing spermatogonial stem cells of mammals and the like in vitro, which is characterized in that glial cell-derived neurotrophic factor (GDNF) or an equivalent thereto, and leukemia inhibitory factor (LIF) are contained in a medium (culture broth) for culturing spermatogonial stem cells. According to the method of the present invention, spermatogonial stem cells can be grown in vitro to the extent that enables use thereof for developmental engineering.
    Type: Grant
    Filed: March 31, 2004
    Date of Patent: February 23, 2010
    Assignee: Kyoto University
    Inventors: Takashi Shinohara, Mito Shinohara
  • Patent number: 7667276
    Abstract: There is provided a small-type semiconductor integrated circuit whose circuit area is small and whose wiring length is short. The semiconductor integrated circuit is constructed in a multi-layer structure and is provided with a first semiconductor layer, a first semiconductor layer transistor formed in the first semiconductor layer, a wiring layer which is deposited on the first semiconductor layer and in which metal wires are formed, a second semiconductor layer deposited on the wiring layer and a second semiconductor layer transistor formed in the second semiconductor layer. It is noted that insulation of a gate insulating film of the first semiconductor layer transistor is almost equal with that of a gate insulating film of the second semiconductor layer transistor and the gate insulating film of the second semiconductor layer transistor is formed by means of radical oxidation or radical nitridation.
    Type: Grant
    Filed: July 15, 2005
    Date of Patent: February 23, 2010
    Assignees: Advantest Corporation, National University Corporation Tohoku University
    Inventors: Tadahiro Ohmi, Koji Kotani, Kazuyuki Maruo, Takahiro Yamaguchi
  • Patent number: 7667077
    Abstract: A new class of fluorinated or polyhalogenated triazapentadienes are disclosed. The synthesized triazapentadienes are thermally stable, soluble in typical solvents and have several metal binding sites for complexation with metal ions. The compounds are prepared as colorless crystalline solids. Synthesis takes advantage of a reaction with triethylamine. Synthesized triazapentadienes (with and without complexed metals) inhibit bacterial growth of both Gram positive and Gram-negative bacteria.
    Type: Grant
    Filed: September 12, 2007
    Date of Patent: February 23, 2010
    Assignee: Board of Regents, The University of Texas
    Inventors: H. V. Rasika Dias, Lorraine G. Van Waasbergen, Jaime A. Flores
  • Patent number: 7666849
    Abstract: The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.
    Type: Grant
    Filed: February 25, 2005
    Date of Patent: February 23, 2010
    Assignees: Rib-X Pharmaceuticals, Inc., Yale University
    Inventors: Thomas A. Steitz, Peter B. Moore, Joyce A. Sutcliffe, Adegboyega K. Oyelere, Joseph A. Ippolito
  • Patent number: 7666163
    Abstract: An actuator for an interventional surgical procedure is described. The actuator may include an actuator body having a distal end and a proximal end. A central expandable section is located between the distal end and the proximal end. The expandable section is operable between an unactuated condition in which the expandable section is in a furled state and an actuated condition in which the expandable section is in an unfurled state. A needle is located at the expandable section. The needle is moveable in an approximately perpendicular direction relative to a central longitudinal axis of the actuator body from a position within the actuator body to a position outside of the actuator body.
    Type: Grant
    Filed: May 11, 2009
    Date of Patent: February 23, 2010
    Assignee: The Regents of The University Of California
    Inventors: Kirk P. Seward, Albert P. Pisano
  • Patent number: 7666608
    Abstract: The invention provides a diagnostics assay for measuring the responsiveness to a drug by comparing the protein levels of a gene that responds to the drug, such as a steroid, to the protein levels of a gene that does not respond to the drug. Methods according to the invention are useful for predicting the ability of a patient (or a tissue, body fluid or cell sample in vitro) to respond to a drug or steroid at any stage of their treatment (i.e., before, during or after), and to monitor the patient (or a tissue, body fluid or cell) over time to assess continued responsiveness to the drug or steroid.
    Type: Grant
    Filed: May 11, 2009
    Date of Patent: February 23, 2010
    Assignee: The Trustees of the University of Pennsylvania
    Inventor: Alexander Steven Whitehead
  • Patent number: 7667438
    Abstract: An energy storage system for a vehicle includes an ultracapacitor that is electrically coupled in parallel with a battery through a diode connected in series with the battery. The ultracapacitor delivers the energy required for all high current surges that occur during engine start, acceleration, and regeneration. The battery is used only to assist with longer duration, high energy loads, such as accessory loads when an engine of the vehicle is not running. In other words, the battery conducts only during longer and less-frequent pulses and, therefore, does not have to withstand high-power pulses.
    Type: Grant
    Filed: November 10, 2005
    Date of Patent: February 23, 2010
    Assignees: Chrysler Group LLC, University of Toledo
    Inventors: Cyrus N Ashtiani, Thomas A Stuart
  • Patent number: 7666250
    Abstract: A process of producing magnesium metal includes providing magnesium carbonate, and reacting the magnesium carbonate to produce a magnesium-containing compound and carbon dioxide. The magnesium-containing compound is reacted to produce magnesium metal. The carbon dioxide is used as a reactant in a second process. In another embodiment of the process, a magnesium silicate is reacted with a caustic material to produce magnesium hydroxide. The magnesium hydroxide is reacted with a source of carbon dioxide to produce magnesium carbonate. The magnesium carbonate is reacted to produce a magnesium-containing compound and carbon dioxide. The magnesium-containing compound is reacted to produce magnesium metal. The invention further relates to a process for production of magnesium metal or a magnesium compound where an external source of carbon dioxide is not used in any of the reactions of the process. The invention also relates to the magnesium metal produced by the processes described herein.
    Type: Grant
    Filed: April 29, 2005
    Date of Patent: February 23, 2010
    Assignees: UT-Battelle, LLC, University of Tenessee Research Foundation, Virginia Museum of Natural History Foundation
    Inventors: James G. Blencoe, Lawrence M. Anovitz, Donald A. Palmer, James S. Beard
  • Patent number: 7665621
    Abstract: A self movable boom system is provided. The self movable boom system include: a boom disposed on a plane perpendicular to a building clamp structure; and a moving unit apparatus including a circumferential moving unit which is disposed between the boom and the building clamp structure to move the boom on a plane perpendicular to the building clamp structure, a lifting-up unit of which one end is disposed toward the circumferential moving unit and of which other end is disposed toward the building clamp structure to move the boom along a longitudinal direction of the building clamp structure, and a boom moving unit which moves an object along the longitudinal direction of the building clamp structure and along a longitudinal direction of the boom.
    Type: Grant
    Filed: February 19, 2008
    Date of Patent: February 23, 2010
    Assignee: Korea University Industrial & Academic Collaboration Foundation
    Inventors: Nak Ju Doh, Gwi Tae Park, Kyung In Kang, Ung Kyun Lee, Tae Hoon Kim, Sung Hoon An, Tae Koo Kang, Jeong Eom Lee, Seoung Kyou Lee
  • Patent number: 7666817
    Abstract: The present invention provides compositions including peptide display scaffolds that present at least one candidate peptide and at least one detectable moiety in at least one of the N-terminal and C-terminal candidate peptide presenting domains that when expressed in a cell are accessible at a surface of the cell outermembrane. In addition, the present invention also provides kits and methods for screening a library of cells presenting the candidate peptides in peptide display scaffolds to identify a ligand for an enzyme.
    Type: Grant
    Filed: August 30, 2006
    Date of Patent: February 23, 2010
    Assignee: The Regents of the University of California
    Inventors: Patrick Sean Daugherty, Kevin T. Boulware
  • Patent number: 7665374
    Abstract: The present application relates to a surface-coated SPME with an extracting tip that resists breaking during analysis. Rather than utilizing a hollow fiber tip, a resilient surface coated rod is utilized. Specifically, several grooves are machined into the tip of the SPME device, allowing an adsorbent material to be retained thereon. The resulting surface coated SPME device is more rugged in laboratory use and allows for testing of analytes in chemical environments that result in failures when using fiber tipped SPME devices.
    Type: Grant
    Filed: March 12, 2007
    Date of Patent: February 23, 2010
    Assignee: Butler University
    Inventors: Olujide T. Akinbo, Michael J. Samide