Abstract: The present invention provides a method for detecting synthetic indole and indazole cannabinoids in a sample known or suspected to contain a synthetic indole or indazole cannabinoid. A deuterated solvent is added to the solid sample, creating a suspension. The suspension is mixed to release the cannabinoid from the solid sample. The suspension is subject to a NMR spectroscopy process to produce a sample NMR spectrum. The synthetic cannabinoid is detected in the suspension by analysis of the sample NMR spectrum. When one-dimensional proton NMR is used, detection of a first peak between 8.00 and 8.50 ppm and a second peak between 4.00 and 4.40 ppm, indicates the presence of a synthetic indole or indazole cannabinoid. When two-dimensional Correlation Spectroscopy (COSY) NMR is used, detection of a first spot between 6.50 and 9.00 ppm and a second spot between 1.50 and 4.50 ppm indicates the presence of a synthetic indole or indazole cannabinoid.

Abstract: An audio metadata providing apparatus and method and a multichannel audio data playback apparatus and method to support a dynamic format conversion are provided. Dynamic format conversion information may include information about a plurality of format conversion schemes that are used to convert a first format set by an author of multichannel audio data into a second format that is based on a playback environment of the multichannel audio data and that are each set for corresponding playback periods of the multichannel audio data. The audio metadata providing apparatus may provide audio metadata including the dynamic format conversion information. The multichannel audio data playback apparatus may identify the dynamic format conversion information from the audio metadata, may convert the first format of the multichannel audio data into the second format based on the identified dynamic format conversion information, and may play back the multichannel audio data in the second format.

Abstract: The invention described herein relates to colloidal particles useful for photoacoustic imaging. The particles comprise a photoacoustic imaging agent with an absorbance maximum or plateau in the range of wavelengths 700-1100 nm. The imaging agent also displays low optical absorbance at some wavelength in the range 700-1100 nm. This combination of high and low optical absorbance enables background subtraction in photoacoustic imaging applications. The imaging agent is an organic compound having low aqueous solubility so that it is stably encapsulated in the hydrophobic core of the particle. The particle is stabilized by a polymeric surface coating, and the polymeric stabilizing layer on the surface of the particle may contain targeting ligands for targeted diagnostics or therapeutic delivery. The particle core may also contain therapeutic agents or other imaging agents.

Abstract: phEPO/ABP polyplexes and methods for the use thereof are disclosed and described. In one embodiment, a phEPO/ABP polyplex may be administered to a subject in a therapeutically effective amount to treat or prevent a cardiac condition. Administration may 5 be made, in some aspects, by intramyocardial injection of a composition or solution containing the phEPO/ABP polyplex.

Abstract: It has been discovered that the Sal target represents a new and promising target for antibacterial drug discovery. The Sal target is distinct from the rifamycin target and from the CBR703 target. This indicates that antibacterial compounds that function through the Sal target should exhibit no, or minimal, cross-resistance with rifamycins and CBR703. This further implies that it should be possible to co-administer antibacterial compounds that function through the Sal target together with a rifamycin, together with CBR703, or together with both a rifamycin and CBR703, in order to achieve additive or synergistic antibacterial effects and in order to suppress or eliminate the emergence of resistance.

Abstract: The invention relates to eukaryotic organisms such as vascular plants that include recombinant microcompartments.

Abstract: Described herein are methods for promoting microbiome development in honey bees using an effective amount of Fructobacillus as a probiotic. Also described are compositions comprising Fructobacillus strains capable of promoting microbiome development in honey bees, and processes for making such compositions.

Abstract: A system for tracking drugs during a transfer and administering process is configured to reduce labeling errors that can occur during that process. The system includes a storage container reader configured to read a set of one or more storage-container-associated machine-readable indicia positioned on a container containing a drug. The set of one or more storage-container-associated machine-readable indicia identifies the drug. The system further includes, at the point of care of a patient, an indicia-generating device configured to generate machine readable drug-delivery-container-associated indicia identifying the drug based on the storage-container-associated machine-readable indicia. A drug delivery container reader, also located at the point of care, is configured to read both sets of machine readable indicia to verify that the drug delivery container has been correctly labelled. A method implemented by the system results in the reduction in labeling errors.

Abstract: In one embodiment, a selectable-rate spring comprises a flexure bar connected to a rotatable shaft, the flexure bar having at least one arched portion. The selectable-rate spring also includes at least one rotational contactor connectable to a link member, wherein the rotational contactor rotates about an axis while maintaining contact with the arched portion of the flexure bar. As the rotational contactor rotates, it changes the connection stiffness between the rotatable shaft and the link member.

Abstract: According to embodiments of the present invention are a system and method that use projected structured patterns of light and linear optical sensors for motion tracking. Sensors are capable of recovering two-dimensional location within the projection area, while several sensors can be combined for up to six degrees of freedom tracking. The structure patterns are based on m-sequences, in which any consecutive subsequence of m bits is unique. Both digital and static light sources can be used. The system and method of the present invention enables high-speed, high precision, and low-cost motion tracking for a wide range of applications.

Abstract: The presently disclosed subject matter demonstrates that ThnG and ThnQ enzymes encoded by the thienamycin gene cluster in Streptomyces cattleya oxidize the C-2 and C-6 moieties of carbapenems, respectively. ThnQ stereospecifically hydroxylates PS-5 giving N-acetyl thienamycin. ThnG catalyzes sequential desaturation and sulfoxidation of PS-5, giving PS-7 and its sulfoxide. The ThnG and ThnQ enzymes are relatively substrate selective, but give rise to the oxidative diversity of carbapenems produced by S. cattleya, and orthologues likely function similarly in allied streptomyces.

Abstract: A non-reciprocal radio frequency transceiver front end utilizing multiple time-varying transmission lines (TVTLs) implemented using distributed modulated capacitors (DMC) to exploit time-varying properties of transmission line structures to isolate the transmit and receive signals. The TVTLs are coupled at an input side to an antenna and ground through a first 90 degree coupler, and the outputs of the TVTLs are coupled through a second 90 degree coupler for connection to a receiver and transmit circuit, respectively. The apparatus allows simultaneously operating a transmitter and receiver sharing a single antenna (or single antenna array).

Abstract: Systems and methods for inhibiting attacks with a network are provided. In some embodiments, methods for inhibiting attacks by forwarding packets through a plurality of intermediate nodes when being transmitted from a source node to a destination node are provided, the methods comprising: receiving a packet at one of the plurality of intermediate nodes; determining at the selected intermediate node whether the packet has been sent to the correct one of the plurality of intermediate nodes based on a pseudo random function; and forwarding the packet to the destination node, based on the determining. In some embodiments an intermediate node is selected based on a pseudo random function. In some embodiments, systems and methods for establishing access to a multi-path network are provided.

Abstract: An information processing device is provided. The device comprises a 3D sensor configured to acquire depth information of a user's hand image and depth information of a background image on an object plane; a storage device in which a character input application is stored; a processor configured to execute the character input application; and a display configured to display a virtual keyboard by executing the character input application.

Abstract: A time synchronization slave apparatus and a method of determining a time synchronization period are disclosed. In the apparatus, a time synchronization processing unit performs a time synchronization operation and determines an offset and a rate used to correct local time error based on a calculated time error, a timer corrects the local time based on the determined offset and rate, a time error estimation unit estimates a time error in the local time during a present time synchronization period, and generates excess error information regarding an excess point at which the estimated time error exceeds a threshold allowable time error range, a time synchronization period determination unit determines a subsequent time synchronization period based on the excess error information, and a synchronization period information transmission unit transmits synchronization period information regarding the subsequent time synchronization period to a time synchronization master apparatus.

Abstract: The present invention provides surface plasmon resonance (SPR) based sensing systems and methods for rapid, sensitive, and real-time analysis of analyte secretion from living cells. In one embodiment, the SPR based sensing device of the present invention comprises at least one cell culture module for culturing living cells, wherein the cell culture module is configured so that analytes secreted from the living cells can be released onto a SPR sensing surface.

Abstract: A method for forming a graphene-reinforced-polymer matrix composite by distributing graphite microparticles into a molten thermoplastic polymer phase comprising one or more molten thermoplastic polymers; and applying a succession of shear strain events to the molten polymer phase so that the molten polymer phase exfoliates the graphene successively with each event, until tearing of exfoliated multilayer graphene sheets occurs arid produces reactive edges on the multilayer sheets that react with and cross-link the one or more thermoplastic polymers; where the one or more thermoplastic polymers are selected from thermoplastic polymers subject to UV degradation.

Abstract: The invention provides recombinant microorganisms capable of producing isobutyraldehyde using CO2 as a carbon source. The invention further provides methods of preparing and using such microorganisms to produce isobutyraldehyde.

Abstract: At least one example embodiment discloses a method of converting a vector corresponding to an input image. The method includes receiving first-dimensional vector data associated with an input image, the input image including an object and converting the received first-dimensional vector data to second-dimensional vector data based on a projection matrix with an associated rank. A first dimension of the first-dimensional vector data is higher than a second dimension of the second-dimensional vector data.

Abstract: A composition for delivering an agent to a cell, comprising a bispecific affinity reagent and a pH-responsive, membrane destabilizing polymer. The bispecific affinity reagent may include a first affinity reagent covalently linked to a second affinity reagent, wherein the first affinity reagent binds to a molecule on the surface of a cell, and the second affinity reagent binds to an intracellular target.