Abstract: The solution of the problem to be solved is the provision of a means for determining timing both accurately and securely at which a treatment is shifted from gripping and coagulation (hemostasis or sealing) to resection by using a multifunctional treatment tool capable of exfoliation, gripping, coagulation (hemostasis or sealing) and resection of the treated region in a bipolar microwave treatment tool. A microwave surgical device control method and a device, in which the completion of coagulation (hemostasis or sealing) of tissue is detected and a microwave oscillation output is controlled by making use of the change in the direct current electric resistance value due to the reduction in the amount of water as the temperature rise of the tissue at the time of heating and coagulation of the tissue in the treated region with microwaves.

Abstract: A problem of the present invention is to provide a switching power supply device and a pulse width modulation circuit capable of operating stably in synchronization with a clock signal. To solve the problem, a pulse width modulation circuit 3A in a switching power supply device 1A includes square-wave voltage output means 8A for, when an integrated voltage Vn rises to an upper threshold voltage or more, shifting a square-wave voltage VPWM to L level, or when the voltage Vn drops to a lower threshold voltage or less, shifting the voltage VPWM to H level, and clock means 6A for outputting a first clock signal VCL1 and a second clock signal VCL2, which are 180° out of phase from each other.

Abstract: Provided are novel sensitive methylation assays referred to herein as Digital MethyLight, comprising stochastically distributing and compartmentalizing bisulfite-treated genomic DNA over multiple PCR reaction wells for detection of individually methylated DNA molecules in a large background of unmethylated DNA. Digital Bisulfite Genomic DNA Sequencing methods are also provided for high-resolution DNA methylation information without subcloning. Background signal and PCR contaminants are diluted, while the ratio of primer to methylated template DNA is kept high. Preferably, biological fluid (e.g., urine, blood-based (e.g., plasma and/or serum)) samples are analyzed for cancer diagnosis, prognosis and surveillance. Multiplexed PCR formats may be implemented to enhance when using small DNA amounts.

Abstract: A sensor for detecting one or more materials includes a substrate, a passivation layer formed on the substrate, a self-resonant structure and a high surface area material disposed on the passivation layer. The self-resonant structure includes a planar spiral inductor and a plurality of planar interdigitated capacitor electrodes disposed within the passivation layer. The planar spiral inductor includes an electrically conductive trace formed on the substrate in a planar spiral pattern having at least two turns and an inter-winding space between parallel segments of the electrically conductive trace. The plurality of planar interdigitated capacitor electrodes are electrically connected to the electrically conductive trace of the planar spiral inductor and formed on the substrate within the inter-winding space of at least one outermost turn of the planar spiral inductor. The high surface area material includes a conformal polymer coating to increase a sensitivity to the one or more materials.

Abstract: The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.

Abstract: A cyclopentadienyl-substituted Salan catalyst, a catalyst system comprising an activator and the cyclopentadienyl-substituted Salan catalyst, a process comprising contacting one or more olefins with the catalyst system, and polymers produced by the process are disclosed herein.

Abstract: An appliance such as a refrigerator receives a demand response signal indicating a peak demand period and operates the refrigerator in an energy savings mode by disabling an anti-sweat heater. A sensor on an external surface of the refrigerator enables the anti-sweat heater during the peak demand period if moisture is detected by the sensor. A preselected location can be defined where incipient moisture would form such as reducing the amount of insulation in this location. By forming a depression in the location and using an impedance-type sensor, moisture can be easily detected. The sensor signal is sent to the controller which then activates the anti-sweat heater to remove the moisture.

Abstract: A method for generating vibration and measuring vibration properties of a structure, such as information equipment, micro-electrco/mechanical systems, and large-equipment, using a non-contact type laser excitation in a non-contact type vibration property measurement system.

Abstract: The present invention relates to a blood-brain barrier recovery curve assessment method which uses a focused ultrasound dynamic contrast-enhanced MRI technique, in order to obtain a permeability constant of drug. Furthermore, the present invention, using a double exponential distribution function mathematical model, can estimate the actual physiological recovery curve of the blood-brain barrier. Meanwhile, the present invention also provides a monitoring system for the blood-brain barrier permeability.

Abstract: Systems and methods are provided for ultrafast optical waveform sampling based on temporal stretching of an input signal waveform. Temporal stretching is performed using a time lens based on four-wave mixing in a nonlinear medium. The signal is passed through an input dispersive element. The dispersed signal is sent into the time lens, which comprises a chirped pump pulse and a nonlinear medium. The chirped pump pulse is combined with the signal. The four-wave mixing process occurs in the nonlinear device or medium, which results in the generation of a signal at a new optical frequency (idler). The idler is spectrally separated from the signal and pump pulse using a bandpass filter and sent into an output dispersive element. The output dispersive element is longer than the input dispersive element and the temporal stretching factor is given by the ratio between the dispersions of these two elements.

Abstract: The present invention provides methods of treating and enhancing efficacy of immunotherapy for a solid tumor in a subject, comprising the step of contacting the subject with a compound or composition that modulates the expression or activity of ETRB, ET-1, ICAM-1, or another protein found herein to play a role in homing of T cells to a solid tumor. The present invention also provides methods of prognosticating a solid tumor in a subject, comprising the step of measuring an expression level of a protein found herein to play a role in homing of T cells to a solid tumor, or a nucleotide molecule encoding same.

Abstract: A spintronic device and a method for making said spintronic device. The spintronic device includes an epitaxial crystalline ferromagnetic oxide formed directly on the semiconductor material thereby allowing spin-polarized current to be efficiently injected from the ferromagnetic oxide into the semiconductor material. A host crystal lattice includes multiple sets of stacked oxide layers of material A and B of a perovskite structure with a formula of ABO3. After an oxide layer of B is grown, magnetic ions are introduced to intermix with the B material, which may replace some of the ions of the B material. The process of growing additional stacked oxide layers of material A and B and introducing further magnetic ions after the deposition of the oxide layer of B continues until enough magnetic ions are sufficiently close to one another that they align in the same direction thereby forming a ferromagnetic oxide on the semiconductor material.

Abstract: The invention relates to the field of covalently attaching proteins to a substrate, particularly to methods of immobilizing proteins by posttranslationally modifying a cysteine residue of said protein through the addition of functional groups. The invention also relates to biological molecules used in such techniques, including proteins, and detection methods and kits that utilize such immobilized proteins, such as a microdevice or “protein chip”, a high-throughput screening device, and for the microscopy of proteins on a surface.

Abstract: A method of modulating the expression of at least one trait in a plant, the method comprising the step of modulating the expression of at least one polypeptide by the plant, wherein the polypeptide is selected from the group consisting of: i) a polypeptide which comprises the amino acid sequence according to SEQ ID NO:1; ii) a polypeptide which comprises an amino acid sequence which is selected from the group consisting of any one or more of from amino acid 1 to amino acid 7, from amino acid 9 to amino acid 230, from amino acid 1 to amino acid 58, from amino acid 77 to amino acid 485, from amino acid 59 to amino acid 76, from amino acid 150 to amino acid 191, from amino acid 231 to amino acid 405, and from amino acid 406 to amino acid 438 of SEQ ID NO: 1, or at equivalent positions in a homologue thereof, and which is capable of modulating cytokinin signaling in the plant; iii) a polypeptide which comprises an amino acid sequence with at least 70% sequence identity to the amino acid sequence according to SEQ

Abstract: The present invention provides a method for producing a composition containing 2-acyl-lysophosphatidylserine, including (a) a step of obtaining a composition containing phosphatidylserine by allowing phospholipase D to act on a raw material containing phosphatidylcholine in the presence of serine and (b) a step of obtaining a composition containing 2-acyl-lysophosphatidylserine by allowing phospholipase A1 to act on the composition containing phosphatidylserine in the presence of one or more additives selected from the group consisting of the following (I), (II), and (III), in which (I) one or more salts selected from the group consisting of sulfate salts, phosphate salts, nitrate salts, citrate salts, and tartarate salts of monovalent cations, (II) a gum, and (III) an emulsifier.

Abstract: The present invention provides an Al2O3 coated Si3N4 cutting tool comprising a Si3N4 based substrate body and a coating layer on the substrate body, wherein the coating layer has at least one Al2O3 coating layer consisting of amorphous Al2O3 or nanocrystalline ?-, ?-, or ?-Al2O3. The hard and wear resistant refractory coating is deposited onto the Si3N4-based substrate body by reactive sputtering using bipolar pulsed DMS technique or dual magnetron sputtering method at substrate temperatures of 300-700° C. During the deposition, preferably, the substrate temperature is controlled to achieve the desired crystal structure of the coating. To form amorphous Al2O3 coating on the surface of the substrates, the deposition temperature can be controlled from 300 to 500° C.; on the other hand, to form nanocrystalline ?-, ?-, or ?-Al2O3, the deposition temperature can be controlled in the range of 500-700° C.

Abstract: Disclosed are various embodiments for a power stage that can drive various types of loads. The power stage includes a first capacitor and a second capacitor that are coupled to the load. The power stage also includes switches that are operable in a first power stage state and a second power stage state. When the switches are in the first power stage state, the first capacitor discharges to the load, and the second capacitor charges. When the switches are in the second power stage state, the second capacitor discharges to the load, and the first capacitor charges.

Abstract: A self-cleaning optical system for the transmission or reflection of light to and/or from a process region comprises a liquid bath and a transparent or reflective optical component continuously rotatable about a non-vertical axis so that a lower part of the component continuously rotates through the bath. When the component emerges from the bath, a coating of the liquid remains thereon which forms a substantially uniform film on at least a part of the component through which the light is transmitted or from which the light is reflected.

Abstract: The water desalination system using geothermal energy includes a plurality of stepped evaporation trays. Salt water flows into the uppermost tray and cascades to each successively lower tray to overflow from the lowermost tray when all trays are full. Two sloped glass panels pass solar energy therethrough to heat the water. Condensation collects on the inner panel and runs down the panel to collect in a trough at the lower edge. The desalinated water then flows to a collection tank. Additional heat energy is provided by a working fluid (e.g., air) that is pumped to subterranean levels where significant geothermal heat is produced. The heated air is then circulated around the evaporation trays to enhance evaporation. The required energy for the operation of the system may be provided by solar cells and wind energy. Mirrors and functionally graded material further increase the efficiency of the desalination system.

Abstract: The invention provides molecular switches which couple external signals to functionality, and combinatorial methods of making and using the same involving circular permutation of nucleic acid and amino acid sequences. The switches according to the invention can be used, for example, to regulate gene transcription, target drug delivery to specific cells, transport drugs intracellularly, control drug release, provide conditionally active proteins, perform metabolic engineering, and modulate cell signaling pathways. Libraries comprising the switches, expression vectors and host cells for expressing the switches are also provided.