Abstract: Pharmaceutical compounds, pharmaceutical compositions and methods of treatment are disclosed, wherein a compound comprises a targeting moiety which, in free form, binds a cell receptor with a dissociation constant Kd of less than about 10?7 M, and a pharmaceutically active moiety, wherein the targeting moiety is other than an oligopeptide, a polypeptide, a peptidomimetic, a protein or a protein domain, and wherein the targeting moiety and the pharmaceutically active moiety are covalently attached. In some aspects, the targeting moiety binds a sigma-2 receptor with high affinity and high specificity, and the pharmaceutically active moiety is a pro-apoptotic peptide moiety. Methods of cancer treatment are disclosed comprising administering a disclosed pharmaceutical compound to a subject in need of thereof. The treatments selectively induce apoptosis in cancer cells. These methods can further comprise co-administration of radiation therapy and/or an additional chemotherapeutic agent.

Abstract: A method is provided for reducing the extent of or occurrence of long-term adverse health effects in human infants, comprising feeding to said infants when newborn a nutrient-containing-formula providing not more than 1 gram of protein per 100 ml of formula and/or not more than 50 kcal per 100 ml of formula. Also disclosed are methods of administering the infant formulas to reduce the occurrence or extent of insulin resistance in an individual later in life, to reduce the occurrence or extent of obesity or atherosclerosis in an individual later in life, or combinations thereof, by feeding newborn infants the newborn infant formula described herein.

Abstract: Compounds, pharmaceutical compositions including the compounds, and methods of preparation and use thereof are disclosed. The compounds are triphenyl methane analogs. The compounds and compositions can be used to treat and/or prevent a wide variety of cancers, including drug resistant cancers, inflammatory, degenerative and vascular diseases, including various ocular diseases, and parasitic infections. Representative triphenyl methane analogs include triphenyl methane analogues of various dyes, hormones, sugars, peptides, oligonucleotides, amino acids, nucleotides, nucleosides, and polyols. The compounds are believed to function by inhibiting tNOX expression, the effects of ROS, and/or the production of HIF2. Thus, the compounds are novel therapeutic agents for a variety of cancers and other diseases.

Abstract: The method of the present invention involves performing the deodorization step before the hydrogenation step and carrying out the hydrogen addition reaction under mild conditions effective to prevent the hardening of edible oil and trans fatty acid production, resulting in the production of processed edible oil having an enriched buttery flavor that is 100-fold stronger than the conventional hydrogenated oil with no unpleasant smell and a very low trans-fatty acid content. Further, the processed edible oil prepared according to the method of the present invention, even with the addition of only a small amount to conventional edible oil, food and feed products, is capable of providing an enriched buttery flavor without increasing the trans-fatty acid content or unpleasant smell and is, thus, useful as a substitute oil for hydrogenated vegetable oil.

Abstract: Disclosed is a composite material comprising a support member that has a plurality of pores extending therethrough, which pores are durably filled or coated with a non crosslinked gel polymer. Also disclosed is a process for the preparation of the composite material, use of the composite material as a separation medium, and a filtering apparatus comprising the composite material.

Abstract: An antenna that has a number of co-located elements, with no (or very small) coupling between the various elements. The antenna may comprise one or more electric dipole elements, such as an electric tripole, co-located with one or more magnetic dipole elements, such as a magnetic tripole. The antenna has the property that although all of the electric and magnetic dipole elements are co-located, there is substantially no coupling between the elements. Some of the antenna elements may operate as transmitters and the others may act as receivers. The antenna elements may be tuned to different frequencies. The antenna may comprise less than six antenna elements. Also disclosed are example devices and systems that may utilize the antenna structure, such as a handheld wireless communication device and an access point of a HVAC wireless communication system.

Abstract: The invention discloses new and advantageous uses for carbon/graphene nanoribbons (GNRs), which includes, but is not limited to, electronic components for integrated circuits such as NOT gates, OR gates, AND gates, nano-capacitors, and other transistors. More specifically, the manipulation of the shapes, sizes, patterns, and edges, including doping profiles, of GNRs to optimize their use in various electronic devices is disclosed.

Abstract: The invention relates to a device for internal pressure relief of a pig movable through a pipeline and/or some other pressure-tight sealed working implement introduced into an external pressure medium and having a pressure relief valve. To increase the classification for operational reliability, it is proposed that at least one rupture disk be placed downstream of the pressure relief valve in the pressure relief direction.

Abstract: The invention relates to a generator, to a magnetic flux conducting unit for a generator, and to a power generation machine comprising such a generator. In an embodiment of the invention, a generator is disclosed which comprises at least one coil assembly and at least one magnetic flux conducting unit. The magnetic flux conducting unit comprises at least one magnet, a pair of opposed magnetic flux conducting elements defining a space therebetween for receiving the coil assembly, and at least one connection portion extending between the opposed magnetic flux conducting elements. The at least is arranged relative to the opposed magnetic flux conducting elements such that the magnetic attraction forces between the elements are redacted through and balances with the connection portion.

Abstract: The present invention relates in general to human genetic polymorphisms and their association with human health and to methods and materials for analyzing allelic variations, and to the use of genetic polymorphisms in the diagnosis and treatment of smoking behavior and nicotine dependence. Provided herein are methods for determining risk in a subject of developing regular smoking behavior. Also provided are primers, probes, microarrays, and kits related thereto.

Abstract: Disclosed are an even-irrigation apparatus for an underground root zone and an even-irrigation method using the same for evenly supplying water into the root zone of a variety of crops. The even-irrigation apparatus includes a plurality of irrigators buried in the entire underground root zone, to directly and evenly supply water into the root zone. Once water is introduced into a pressure-reduction valve after passing through a main pipe, limb pipe and capillary pipe connected in sequence, the water is supplied to the irrigators by way of a plurality of diverged-capillary pipes. With this even-irrigation of water, unnecessary consumption of water due to adsorption of the water into the surrounding soil except for the root zone is minimized, enabling effective irrigation of water and even growth of roots of crops. Further, even nutrition throughout the roots enables balanced growth of crops.

Abstract: Disclosed is a method fox allocating upstream transmission bandwidth so as to prevent Inter-Scheduling Cycle Gaps (ISCGs) from occurring in an N number of Optical Network Units (ONUs) by using an m number of wavelength channels for upstream transmission in a Wavelength-Division Multiplexing (WDM)-Ethernet Passive Optical Network (EPON). The method includes: grouping the ONUs to be allocated each of the m number of wavelength channels; and performing a Dynamic Bandwidth Allocation (DBA) algorithm in order for the grouped ONUs to efficiently use allocated wavelengths and time slots, thereby allocating each wavelength channel. Accordingly, by using a scheme of managing ONUs by each group, it is possible to more efficiently allocate bandwidth than the online scheduling scheme. As compared with the offline scheduling scheme, ISCGs caused by bandwidth allocation do not occur.

Abstract: A frequency-hopping pulse-width modulator is disclosed, which facilitates a switching regulator to use smaller-size inductive and capacitive elements, to have an improved power efficiency at light load, as well as predictable spectrum at different load levels. The improved modulator automatically determines the switching frequency of a switching regulator according to the load current delivered by the switching regulator from a number of pre-defined frequencies, which are all multiples of a fundamental frequency. By designing the maximum switching frequency of frequency-hopping pulse-width modulator in the MHz range, a switching regulator is able to use smaller-size inductive and capacitive elements. Light-load efficiency of the switching regulator with the frequency-hopping pulse-width modulator is also greatly improved as switching frequency of such switching regulator is reduced with decreased load current.

Abstract: Methods for identifying a candidate compound with an ability to modulate cation transport through a transient receptor potential (TRP) channel in a cell are disclosed. The methods can include (a) providing a cell expressing a recombinant nucleic acid sequence encoding an transient receptor potential (TRP) channel gene product or a functional fragment or derivative thereof; (b) contacting the cell with the candidate compound; (c) comparing cation transport in the cell in the absence of the candidate compound with cation transport in the cell in the presence of the candidate compound; and (d) identifying a candidate compound through the comparing step that modulates cation transport in the cell through the transient receptor potential (TRP) channel. Also disclosed are nucleic acid and amino acid sequences for insect TRP channel gene products, antibodies that bind to the disclosed TRP channels, and recombinant host cells the include the disclosed biosequences.

Abstract: The invention encompasses micelle assemblies, compositions having micelle assemblies, and methods for preparing micelle assemblies and compositions thereof. Also, the invention encompasses compounds of the formula: A-X-Y-Z-R1 wherein A is a carboxy group or is absent; X is a polyol, Y is —C(?O)—, —C(?S)—, or is absent; Z is O, S, or NH; and R1 is a polyether, wherein one or more hydroxy groups of the polyol are acylated with a fatty acid residue, wherein the compounds form micelle assemblies. The invention encompasses methods of encapsulating molecules using the compounds of the invention.

Abstract: A third-order transconductance (gm3) cancellation is utilized to obtain a highly linear mixer. Transistors obtain good linearity with complementary gm3 values. The transistor thus obtained can be operated in a wide bandwidth and is applicable to various frequency specifications of systems, like Bluetooth, wireless LAN, Ultra-Wide Band (UWB), etc. Then the transistors are applied to design a transconductance-stage input of the mixer. Hence, the present invention can be widely applied to receiver modules and be realized with a low-cost CMOS transistor.

Abstract: An image processor includes an inter-superimposed-image deformation acquisition unit configured to acquire deformation information between superimposed images included in a multiple image in which images of a subject are superimposed, an image deformation unit configured to generate at least two deformed images by performing deformation processing with respect to the multiple image at least twice to be geometrically deformed based on the acquired deformation information between superimposed images, and a signal intensity relationship acquisition unit configured to acquire signal intensity relationship information indicative of a relationship between signal intensities of the superimposed images included in the multiple image. The image processor further includes a signal processing unit configured to perform addition processing of the at least two deformed images generated from the deformation processing by using the acquired signal intensity relationship information.

Abstract: A novel fluorescent compound having a high light fastness, high fluorescence quantum yield and sharp absorption spectrum, which emits fluorescence having a wavelength in long wavelength region, as well as its use as a labeling agent, is disclosed. In Formula [I] below, by forming a specific hetero ring(s) with R1 and R2, and/or R6 and R7, shift of the wavelength of the fluorescence to longer wavelength and increase in molar extinction coefficient are attained maintaining the high light fastness, high fluorescence quantum yield and sharp absorption spectrum which the fluorescent dyes having the boron dipyrromethene skeleton have.

Abstract: The invented ink-jet printing method for the construction of thin film transistors using all SWNTs on flexible plastic films is a new process. This method is more practical than all of exiting printing methods in the construction TFT and RFID tags because SWNTs have superior properties of both electrical and mechanical over organic conducting oligomers and polymers which often used for TFT. Furthermore, this method can be applied on thin films such as paper and plastic films while silicon based techniques can not used on such flexible films. These are superior to the traditional conducting polymers used in printable devices since they need no dopant and they are more stable. They could be used in conjunction with conducting polymers, or as stand-alone inks.

Abstract: A translation scheme translates DICOM content into a format compatible for storage in an NDMA relational database. The translation scheme employs a schema for indexing the DICOM content, and employs a mechanism for translating queries embedded in XML into SQL. The translation scheme translates DICOM compatible data into a tab delimited flat representation of the DICOM content. The flat representation is then translated into data compatible with a relational database format, such as SQL, and then into database insert commands. The schema enables capture of the DICOM information into relational tables. Methods are also provided to service XML formatted research and clinical queries, to translate XML queries to optimized SQL and to return query results to XML specified destinations with record de-identification where required. Methods are also provided to interface to NDMA WallPlugs, secured query devices, or GRID devices.