Abstract: This application relates to methods for overcoming or preventing resistance of a KRAS mutant cancer cell to a growth inhibition and/or cell death induction by a KRAS inhibitor or a SHP2 inhibitor, as well as to methods for enhancing sensitivity of a KRAS mutant cancer cell to a KRAS inhibitor or a SHP2 inhibitor. The application further relates to methods of treating a KRAS mutant cancer in a subject, the method comprising administering to the subject an effective amount of a KRAS inhibitor or a SHP2 inhibitor and an inhibitor of expression or function or a degrader or a binding partner of one or more of various proteins described herein. Related pharmaceutical compositions and kits are also disclosed.

Abstract: Provided are circular RNAs (circRNAs) encoding an antigenic polypeptide of a SARS-CoV-2 variant. Provided are circRNA vaccines against a SARS-CoV-2 variant, such as a Delta or Omicron variant. The circRNA vaccine comprises a circRNA comprising a nucleic acid sequence encoding an antigenic polypeptide comprising a Spike(S) protein or a fragment thereof of a SRAS-CoV-2 variant. Also provided are methods of treating or preventing a SARS-CoV-2 infection using the circRNAs or compositions thereof.

Abstract: A mandrel-coiled twisted and coiled polymer fishing line (TCPFL) actuator, method, and computer program product for creating the mandrel-coiled TCPFL) actuator. A plurality of mandrel-coiled TCPFL muscles may be fabricated, wherein fabricating the plurality of mandrel-coiled TCPFL muscles may include synthesizing mesoporous C-NiAg-PVA solution and coating the TCPFL with the mesoporous C-NiAg-PVA solution.

Abstract: A system infers continuous potential energy landscapes, including barrier heights and friction coefficients, from smFRET data without the need to discretely approximate a state-space. The system operates within a Bayesian nonparametric paradigm by placing priors on the family of all possible potential curves, and leverages a Structured-Kernel-Interpolation Gaussian Process prior to help curtail computational cost. The system enables decoding information about continuous energy potential landscapes along a continuous coordinate for biological interactions (e.g., protein folding and binding) using a single dataset, including rarely visited barriers between putative potential minima. As such, the system allows resolution enhancement for probing biophysical systems to obtain deeper insight into protein folding, protein binding, and the physics of molecular motors.

Abstract: A safety-critical control system and method with train-time calibration of object detection. A controller calibrates prediction by a deep neural network. The train-time calibration includes a multi-class confidence calibration, and a bounding box localization calibration. The controller outputs a calibrated image with the object bounding box, the corresponding class label, and a respective confidence score. The confidence score is a probability associated with the predicted class label. The multi-class confidence calibration is determined as a difference between a fused mean confidence and a certainty with accuracy. The fused mean confidence is between a mean logits-based class-wise confidence and class wise certainty. The controller determines the localization calibration by determining a deviation between a predicted mean bounding box overlap and a predictive certainty of the bounding box.

Abstract: A system for speech separation includes data processing hardware and memory hardware in communication with the data processing hardware, the memory hardware storing instructions that when executed on the data processing hardware cause the data processing hardware to perform operations including (i) generating a two-dimensional representation of a speech mixture, (ii) separating the speech mixture into an initial separation (iii) supplying the initial separation and speaker representations to a refinement module, (iv) refining the initial separation based on the initial separation and the speaker representations, (v) estimating a mask per speaker, and (vi) applying the masks to the two-dimensional representation to create two-dimensional, per-speaker representations.

Abstract: A novel method for treating hyponatremia or polycystic kidney disease in a mammal is disclosed. The method involves administering to the mammal in need of such treatment a therapeutically effective amount of an adenine analog selected from the group consisting of: 2-chloro-6-aminopurine, its tautomer, racemate, optical isomer and/or pharmaceutically or nutritionally acceptable salt thereof, and a pharmaceutical carrier, 6-(dimethylamino) purine, its tautomer, racemate, optical isomer and/or pharmaceutically or nutritionally acceptable salt thereof, and a pharmaceutical carrier; and combinations thereof.

Abstract: Systems and methods are disclosed for a 3D microfluidic channel manufacturing device comprising: a main build platform and an auxiliary build platform, for printing microfluidic channels in a 3D printed product.

Abstract: The instant document converter transforms any text or text-predominant document, virtually immediately and automatically, to a list containing solely its culled, formatted references, together with one or more coordinated executables that launch the culled formatted references as a search query, when triggered, to a search engine for verification analysis.

Abstract: An engineered pathway for carbon fixation without rubisco incorporates carbon dioxide into fructose-6-phosphate.

Abstract: An immunoassay device for detecting blood type antigen-specific immunoglobulin, an immunoassay method for detecting blood type antigen-specific immunoglobulin, and a method for collecting blood type antigen-specific immunoglobulin are disclosed. The immunoassay device for detecting blood type antigen-specific immunoglobulin includes a substrate having a reaction space defined therein capable of receiving therein a detection target sample solution; a binding antibody positioned in the reaction space and immobilized on the substrate; a switching peptide having a peptide compound reversibly binding to a Fab region of the binding antibody and a fluorescent label binding to the peptide compound; and a fluorescence-quenching substance positioned adjacent to the fluorescent label and quenching fluorescence from the fluorescent label.

Abstract: The present application discloses an image processing method and image processing apparatus for recognizing a target object.

Abstract: Compositions for treating ocular disease are disclosed herein. In some embodiments, the composition comprises a dynamic hydrogel comprising a polymer and a plurality of nanoparticles, wherein the polymer is non-covalently crosslinked with the plurality of nanoparticles. The dynamic hydrogel can also comprise an ocular therapeutic encapsulated by the dynamic hydrogel.

Abstract: An instrumentation amplifier includes an input chopping circuit configured to convert differential input voltages into differential chopping input voltages according to a chopping signal; a compensation voltage input circuit configured to generate differential compensation voltages according to differential compensation signals; a compensation chopping circuit configured to generated signals by performing chopping operation on the differential compensation voltages according to the chopping signal and to provide the signals to the compensation voltage input circuit; an amplifier circuit configured to generate differential output voltages from the differential chopping input voltages and the differential compensation voltages; a modulation circuit configured to modulate the differential output voltages; an output chopping circuit configured to generate a bitstream signal by converting phase of an output of the modulation circuit according to the chopping signal; and a filter circuit configured to filter the bi

Abstract: A method of treating a brain tumor in a subject in need thereof is disclosed. The method comprising administering to the subject a therapeutically effective amount of an agent capable of downregulating activity or expression of a component of the lipid synthesis and/or transportation pathways in an astrocyte in the tumor microenvironment and/or a therapeutically effective amount of a molecule which is associated with lipid uptake by the tumor cells or immune cells in the tumor microenvironment, or a polynucleotide encoding same.

Abstract: Provided are methods for treating subjects with coronavirus infections. The methods include providing a subject infected with a coronavirus resulting in a prothrombotic condition in addition to being infected by a coronavirus, and administering to the subject an angiotensin (1-7) peptide or an analog or derivative thereof, a Mas Receptor (MasR) agonist, or any combination thereof. The subject may be suffering from COVID-19 disease, including but not limited to a thrombotic complication, an adverse pregnancy outcome, and/or a complication resulting from an underlying prothrombotic state. Also provided are compositions that include Ang (1-7) peptides, analogs, and/or derivatives thereof that are associated with degradable and/or non-degradable polymers having electrostatic interactions therewith, hydrophobic interaction therewith, hydrogen bonding interactions therewith, or any combination thereof.

Abstract: Covalently cross-linked copolymers are described herein. More specifically, polysaccharide-polyamine copolymeric matrices or structures and cationic copolymeric matrices are described herein. The polysaccharide-polyamine copolymers, when protonated, can form cationic copolymeric matrices having exceptionally high densities of cationic sites. In one form, the covalently cross-linked copolymers provide a three-dimensional structure, especially when hydrated.

Abstract: Disclosed is a method of preparing biomass-derived adiponitrile including preparing adiponitrile by subjecting biomass-derived adipamide to dehydration using a catalyst in a medium. The catalyst is configured such that a metal oxide is supported on a carrier containing porous silica with a pore diameter in a range of 5 nm to 15 nm, and the metal is molybdenum, chromium, vanadium, or combinations thereof.

Abstract: A method for recovering a protein from a surimi-rinsing liquid based on a low-temperature plasma technology is provided. The method includes: collecting fish flesh, and chopping the fish flesh to obtain surimi; adding the surimi to water, mixing for rinsing, centrifuging to collect a supernatant, which is the surimi-rinsing liquid; adjusting an input power of a plasma device to 300 W to 800 W, placing a spray gun of the plasma device below a liquid level of the surimi-rinsing liquid, turning on a power supply, and exciting plasma with air as a gas source, such that the plasma acts evenly on the surimi-rinsing liquid for 2 min to 6 min; and allowing the low-temperature plasma treated surimi-rinsing liquid to stand in an environment with a temperature of 10° C. or lower, centrifuging to collect a precipitate, such that the recovery of the protein from the surimi-rinsing liquid is completed.

Abstract: Monoclonal antibodies and antigen binding fragments that specifically bind MCT11 are provided. Also disclosed are nucleic acid molecules encoding the antibody, vectors including these nucleic acid molecules, and host cells transfected with these vectors. Methods of using MCT11 specific antibodies to treat cancer, inhibit or treat T cell exhaustion, and/or enhance immunotherapy, are also provided.