Abstract: Provided herein are agents that bind to the lipid binding groove of Frizzled (FZD). In some embodiments, the agent is a fragment of TcdB corresponding to amino acids 1285-1804 of SEQ ID NO: 1. In some embodiments, binding of the agent to the lipid binding groove of FZD inhibits TcdB entry into cells, and/or inhibits Wnt signaling. Methods of treating Clostridium difficile infection (CDI) and methods of treating cancer are also provided.
Type:
Grant
Filed:
January 14, 2019
Date of Patent:
March 18, 2025
Assignees:
Children's Medical Center Corporation, The Regents of the University of California
Inventors:
Min Dong, Liang Tao, Rongsheng Jin, Peng Chen, Aina He
Abstract: Methods of uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are provided. Kits for uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are also provided. The molecules to be labeled may include, but are not limited to, RNAs, cDNAs, DNAs, proteins, peptides, and/or antigens.
Type:
Grant
Filed:
July 25, 2024
Date of Patent:
March 18, 2025
Assignee:
University of Washington
Inventors:
Georg Seelig, Richard Muscat, Alexander B. Rosenberg
Abstract: Systems and methods for blood flow control are described herein. In some variations, a blood flow control system may comprise a blood flow control device. The blood flow control device may be placed within a body of a patient and may comprise an expandable member and a sensor. The sensor may be configured to measure at least one of a physiologic condition of the patient and a pressure associated with the expandable member. The blood flow control system may include at least one controller communicably coupled to the sensor to: receive data indicative of at least one of the physiologic condition of the patient and the pressure associated with the expandable member from the sensor, compare the received data with target data, identify at least one error based on the comparison, and in response to identifying the error, inhibit at least one function of the blood flow control system.
Type:
Grant
Filed:
March 30, 2023
Date of Patent:
March 18, 2025
Assignees:
Certus Critical Care, Inc., Wake Forest University Health Sciences
Inventors:
Michael Austin Johnson, David Poisner, Melanie McWade, Timothy Williams, Lucas Neff
Abstract: Embodiments of the present invention relate to mechanically-activated microcapsules (MAMCs) for controlled drug-delivery, wherein the MAMCs release one or more active ingredients in response to mechanical stimuli in a subject's body. The MAMCs provide a platform for stimulating biological regeneration, biological repair, modifying disease, and/or controlling disease in mechanically-loaded musculoskeletal tissues.
Type:
Grant
Filed:
August 3, 2022
Date of Patent:
March 18, 2025
Assignee:
The Trustees of the University of Pennsylvania
Inventors:
Daeyeon Lee, Robert Leon Mauck, George R Dodge, Fuquan Tu, Bhavana Mohanraj
Abstract: The design of bifunctional catalysts for water splitting by modifying the electronic structure of the catalyst. That bifunctional catalyst that is synthesized is a quaternary FeNi—PSe nanoporous film (FeNi—PSe NF). A self-supported FeNi—PSE NF is synthesized and used as an anode and a cathode in a two-electrode electrolytic cell. The cell is subjected to a water source, and the FeNi—PSe NFs split the water molecules to produce hydrogen fuel. The slightly oxidized FeNi—PSe surface serves as an active site for oxygen evolution reactions, making hydrogen evolution reactions and oxygen evolution reactions well-balanced, thereby improving electrolysis efficiency.
Type:
Grant
Filed:
May 18, 2021
Date of Patent:
March 18, 2025
Assignee:
University of Central Florida Research Foundation, Inc.
Abstract: An improved material, preferably a biomaterial, is provided which is the reaction product of S8 and a free fatty acid or free fatty acid-containing material, preferably in the presence of metal. The improved material can be made by a method comprising reacting S8 with a free fatty acid to obtain a FFA/S8 composite and shaping the FFA/S8 composite into a solid form. The solid form of said FFA/S8 is melted to form melted FFA/S8 and the melted FFA/S8 is optionally applied as a coating on a surface, used as an adjacent material to a surface or the FFA/S8 composite itself is shaped thereby forming a device and preferably a medical device.
Abstract: In vitro and in vivo methods of removing carbon monoxide from hemoglobin in blood or animal tissue are described. Methods of treating carboxyhemoglobinemia (carbon monoxide poisoning) in a subject are also described. The methods include administering natural or artificial oxygen carriers that are in their reduced form. Methods of producing a reduced oxygen carrier are further described. Methods of treating cyanide poisoning or hydrogen sulfide poisoning with oxygen carriers are also described.
Type:
Grant
Filed:
March 17, 2021
Date of Patent:
March 18, 2025
Assignee:
University of Pittsburgh—Of the Commonwealth System of Higher Education
Inventors:
Jason Joseph Rose, Qinzi Xu, Mark T. Gladwin, Jesus Tejero Bravo
Abstract: In the technical field of power generation, a method and system for directly and rapidly detecting 14C of carbon dioxide, which can quickly complete a 14C activity measurement of carbon dioxide, while further improving uniformity and accuracy for directly and rapidly detecting 14C of carbon dioxide. The method includes: pressurizing and liquefying gaseous carbon dioxide to obtain liquid carbon dioxide; mixing the liquid carbon dioxide with a cosolvent and a scintillator in a pressure vessel to obtain a mixed solution; and placing the pressure vessel in a liquid scintillation counter for carrying out radiocarbon activity detection.
Type:
Grant
Filed:
March 31, 2023
Date of Patent:
March 18, 2025
Assignee:
Zhejiang University
Inventors:
Zhongyang Luo, Yinchen Wang, Chunjiang Yu, Qinhui Wang
Abstract: The present invention features an antibody mimetic, or an antigen binding fragment thereof, that specifically binds to an allosteric site of Aurora A kinase, therapeutic compositions comprising this antibody mimetic, and the use of the monobody to modulate Aurora A kinase for the treatment of cancer.
Abstract: Provided herein are high performance electrodes, electrode materials comprising a plurality of active electrode material-containing particles secured within one or more graphenic web, and precursors thereof. Also provided herein are processes of generating the same by an electrospray process.
Abstract: Methods of uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are provided. Kits for uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are also provided. The molecules to be labeled may include, but are not limited to, RNAs, cDNAs, DNAs, proteins, peptides, and/or antigens.
Type:
Grant
Filed:
August 24, 2023
Date of Patent:
March 18, 2025
Assignee:
University of Washington
Inventors:
Georg Seelig, Richard Muscat, Alexander B. Rosenberg
Abstract: An accumulator defines an accumulator volume that can be placed into communication with a spring chamber of a gas spring. A working volume of the gas spring is the sum of the spring chamber volume and the accumulator volume. The accumulator can be configured so that the accumulator volume can be selectively increased or decreased as desired, thus modifying performance of the associated gas spring.
Abstract: A method includes determining, by a control system, from among a plurality of categories, a current category of an incoming wind approaching a wind turbine, and setting, by the control system, a yaw bias of the wind turbine based on the current category. In some examples, the plurality of categories includes two or more wind conditions, such as a first wind condition in which wind contacting an upper rotor of the wind turbine is veering and wind contacting a lower rotor of the wind turbine is veering, a second wind condition in which the wind contacting the upper rotor of the wind turbine is veering and the wind contacting the lower rotor of the wind turbine is backing, and so on.
Abstract: The disclosure claims a method of stimulating a conditional quantum master equation in a quantum transport process by a recurrent neural network, comprising the following steps of: establishing a recurrent neural network which is a long short term memory network (LSTM), wherein the LSTM comprises TLSTM cells arranged in chronological order, and each LSTM cell has an input value xt and an output value ht, and there is a parameter (W, b) in the LSTM cell; replacing the input value xt with a shot noise spectrum S(?) of the current obtained according to the conditional quantum master equation; replacing the output value ht with a trace of density matrices in the conditional quantum master equation; and replacing the parameter (W, b) with a connection between density matrices in the conditional quantum master equation at imminent moments.
Type:
Grant
Filed:
May 26, 2021
Date of Patent:
March 18, 2025
Assignee:
University of Electronic Science and Technology of China
Abstract: A method for treating endometrial cancer comprising: administering to a patient a cannabis extract (CE) wherein the cannabis extract comprises cannabidiol (CBD) at between 50% and 99% by weight of the CE.
Type:
Grant
Filed:
September 15, 2023
Date of Patent:
March 18, 2025
Assignees:
Ecofibre USA Inc., The University of Newcastle
Inventors:
Alexandra M. Capano, Pradeep Singh Tanwar, Alex Nance
Abstract: An interactive portrait system includes a camera configured to capture imagery of an environment and a controller. The controller is configured to analyze the imagery to identify a guest in the environment, instruct an output device to provide an initial output to attempt to interact with the guest, and analyze the imagery to identify a behavior of the guest during the initial output, after the initial output, or both. The controller is also configured to evaluate the behavior of the guest using one or more artificial intelligence algorithms to determine whether the guest responded to the initial output. The controller is further configured to, in response to determining that the guest responded to the initial output, instruct the output device to provide an additional output to continue to attempt to interact with the guest.
Type:
Grant
Filed:
June 21, 2023
Date of Patent:
March 18, 2025
Assignee:
Universal City Studios LLC
Inventors:
Robert Michael Jordan, Anthony Melo, Angelo Pagliuca, Brandon David Burnette, John Adams, Jacob David Allinson, Eric To Chan, Mark James Traynor
Abstract: The present disclosure relates to the technical field of anti-aging preparations for skin, and especially relates to an anti-aging preparation for skin and an application thereof. Components of the anti-aging preparation for skin includes a 4-[(1E)-2-[[(4-chlorophenyl)methyl]sulfonyl]alkyne]-benzoic acid and/or a salt thereof. In the present disclosure, the anti-aging effect of the 4-[(1E)-2-[[(4-chlorophenyl)methyl]sulfonyl]alkyne]-benzoic acid and the salt thereof (such as sodium 4-[(1E)-2-[[(4-chlorophenyl)methyl]sulfonyl]alkyne]-benzoate) on skin has been discovered, and the 4-[(1E)-2-[[(4-chlorophenyl)methyl]sulfonyl]alkyne]-benzoic acid and the salt thereof can be applied in preparing the anti-aging preparation for skin that has good anti-aging effect on skin.