Patents Assigned to University
  • Compositions and methods for inhibiting Wnt signaling
    Patent number: 12252515
    Abstract: Provided herein are agents that bind to the lipid binding groove of Frizzled (FZD). In some embodiments, the agent is a fragment of TcdB corresponding to amino acids 1285-1804 of SEQ ID NO: 1. In some embodiments, binding of the agent to the lipid binding groove of FZD inhibits TcdB entry into cells, and/or inhibits Wnt signaling. Methods of treating Clostridium difficile infection (CDI) and methods of treating cancer are also provided.
    Type: Grant
    Filed: January 14, 2019
    Date of Patent: March 18, 2025
    Assignees: Children's Medical Center Corporation, The Regents of the University of California
    Inventors: Min Dong, Liang Tao, Rongsheng Jin, Peng Chen, Aina He
  • Methods and kits for labeling cellular molecules
    Patent number: 12252736
    Abstract: Methods of uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are provided. Kits for uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are also provided. The molecules to be labeled may include, but are not limited to, RNAs, cDNAs, DNAs, proteins, peptides, and/or antigens.
    Type: Grant
    Filed: July 25, 2024
    Date of Patent: March 18, 2025
    Assignee: University of Washington
    Inventors: Georg Seelig, Richard Muscat, Alexander B. Rosenberg
  • Blood flow control devices, systems, and methods
    Patent number: 12251111
    Abstract: Systems and methods for blood flow control are described herein. In some variations, a blood flow control system may comprise a blood flow control device. The blood flow control device may be placed within a body of a patient and may comprise an expandable member and a sensor. The sensor may be configured to measure at least one of a physiologic condition of the patient and a pressure associated with the expandable member. The blood flow control system may include at least one controller communicably coupled to the sensor to: receive data indicative of at least one of the physiologic condition of the patient and the pressure associated with the expandable member from the sensor, compare the received data with target data, identify at least one error based on the comparison, and in response to identifying the error, inhibit at least one function of the blood flow control system.
    Type: Grant
    Filed: March 30, 2023
    Date of Patent: March 18, 2025
    Assignees: Certus Critical Care, Inc., Wake Forest University Health Sciences
    Inventors: Michael Austin Johnson, David Poisner, Melanie McWade, Timothy Williams, Lucas Neff
  • Mechano-sensitive microcapsules for drug delivery
    Patent number: 12251476
    Abstract: Embodiments of the present invention relate to mechanically-activated microcapsules (MAMCs) for controlled drug-delivery, wherein the MAMCs release one or more active ingredients in response to mechanical stimuli in a subject's body. The MAMCs provide a platform for stimulating biological regeneration, biological repair, modifying disease, and/or controlling disease in mechanically-loaded musculoskeletal tissues.
    Type: Grant
    Filed: August 3, 2022
    Date of Patent: March 18, 2025
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Daeyeon Lee, Robert Leon Mauck, George R Dodge, Fuquan Tu, Bhavana Mohanraj
  • Method of synthesizing high-efficiency bifunctional electrocatalysts
    Patent number: 12251692
    Abstract: The design of bifunctional catalysts for water splitting by modifying the electronic structure of the catalyst. That bifunctional catalyst that is synthesized is a quaternary FeNi—PSe nanoporous film (FeNi—PSe NF). A self-supported FeNi—PSE NF is synthesized and used as an anode and a cathode in a two-electrode electrolytic cell. The cell is subjected to a water source, and the FeNi—PSe NFs split the water molecules to produce hydrogen fuel. The slightly oxidized FeNi—PSe surface serves as an active site for oxygen evolution reactions, making hydrogen evolution reactions and oxygen evolution reactions well-balanced, thereby improving electrolysis efficiency.
    Type: Grant
    Filed: May 18, 2021
    Date of Patent: March 18, 2025
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventors: Yang Yang, Jinfa Chang
  • Drug detection using cobalt thiocyanate and Eosin Y
    Patent number: 12253460
    Abstract: Materials and methods for testing unknown substances for the presence of an opioid are described.
    Type: Grant
    Filed: March 11, 2021
    Date of Patent: March 18, 2025
    Assignees: Bowling Green State University, Vuronyx Technologies LLC
    Inventors: Jeremy Canfield, Jon Sprague, Sandip Agarwal, Kateland Herault, Mark Benjamin Volkin
  • Methods of preparing nicotinamide riboside and derivatives thereof
    Patent number: 12252506
    Abstract: Methods of preparing nicotinamide riboside and derivatives thereof.
    Type: Grant
    Filed: April 26, 2023
    Date of Patent: March 18, 2025
    Assignee: The Queen's University of Belfast
    Inventors: Marie Migaud, Philip Redpath, Kerri Crossey, Mark Doherty
  • Free fatty acid-based composites
    Patent number: 12252664
    Abstract: An improved material, preferably a biomaterial, is provided which is the reaction product of S8 and a free fatty acid or free fatty acid-containing material, preferably in the presence of metal. The improved material can be made by a method comprising reacting S8 with a free fatty acid to obtain a FFA/S8 composite and shaping the FFA/S8 composite into a solid form. The solid form of said FFA/S8 is melted to form melted FFA/S8 and the melted FFA/S8 is optionally applied as a coating on a surface, used as an adjacent material to a surface or the FFA/S8 composite itself is shaped thereby forming a device and preferably a medical device.
    Type: Grant
    Filed: December 11, 2019
    Date of Patent: March 18, 2025
    Assignee: Clemson University Research Foundation
    Inventors: Andrew G. Tennyson, Rhett C. Smith
  • Reduced oxygen carriers and their use for the treatment of carboxyhemoglobinemia
    Patent number: 12251427
    Abstract: In vitro and in vivo methods of removing carbon monoxide from hemoglobin in blood or animal tissue are described. Methods of treating carboxyhemoglobinemia (carbon monoxide poisoning) in a subject are also described. The methods include administering natural or artificial oxygen carriers that are in their reduced form. Methods of producing a reduced oxygen carrier are further described. Methods of treating cyanide poisoning or hydrogen sulfide poisoning with oxygen carriers are also described.
    Type: Grant
    Filed: March 17, 2021
    Date of Patent: March 18, 2025
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Jason Joseph Rose, Qinzi Xu, Mark T. Gladwin, Jesus Tejero Bravo
  • Method and system for directly and rapidly detecting C of carbon dioxide
    Patent number: 12253638
    Abstract: In the technical field of power generation, a method and system for directly and rapidly detecting 14C of carbon dioxide, which can quickly complete a 14C activity measurement of carbon dioxide, while further improving uniformity and accuracy for directly and rapidly detecting 14C of carbon dioxide. The method includes: pressurizing and liquefying gaseous carbon dioxide to obtain liquid carbon dioxide; mixing the liquid carbon dioxide with a cosolvent and a scintillator in a pressure vessel to obtain a mixed solution; and placing the pressure vessel in a liquid scintillation counter for carrying out radiocarbon activity detection.
    Type: Grant
    Filed: March 31, 2023
    Date of Patent: March 18, 2025
    Assignee: Zhejiang University
    Inventors: Zhongyang Luo, Yinchen Wang, Chunjiang Yu, Qinhui Wang
  • Antifungal composition having excellent antifungal activity even at low temperature
    Patent number: 12250946
    Abstract: The present disclosure relates to an antifungal composition including propylene glycol, caprylic acid, and carvacrol as active ingredients.
    Type: Grant
    Filed: October 20, 2021
    Date of Patent: March 18, 2025
    Assignee: Korea University Research and Business Foundation
    Inventors: Min Suk Rhee, Byung Soo Ko
  • Compositions and methods for modulating kinase activity
    Patent number: 12253514
    Abstract: The present invention features an antibody mimetic, or an antigen binding fragment thereof, that specifically binds to an allosteric site of Aurora A kinase, therapeutic compositions comprising this antibody mimetic, and the use of the monobody to modulate Aurora A kinase for the treatment of cancer.
    Type: Grant
    Filed: July 20, 2021
    Date of Patent: March 18, 2025
    Assignee: Brandeis University
    Inventors: Dorothee Kern, Adelajda Zorba
  • High performance electrodes, materials, and precursors thereof
    Patent number: 12255333
    Abstract: Provided herein are high performance electrodes, electrode materials comprising a plurality of active electrode material-containing particles secured within one or more graphenic web, and precursors thereof. Also provided herein are processes of generating the same by an electrospray process.
    Type: Grant
    Filed: April 1, 2022
    Date of Patent: March 18, 2025
    Assignee: Cornell University
    Inventors: Yong Lak Joo, Ling Fei
  • Methods and kits for labeling cellular molecules
    Patent number: 12252734
    Abstract: Methods of uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are provided. Kits for uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are also provided. The molecules to be labeled may include, but are not limited to, RNAs, cDNAs, DNAs, proteins, peptides, and/or antigens.
    Type: Grant
    Filed: August 24, 2023
    Date of Patent: March 18, 2025
    Assignee: University of Washington
    Inventors: Georg Seelig, Richard Muscat, Alexander B. Rosenberg
  • Adjustable accumulator for selectively modifying spring rate of gas spring system
    Patent number: 12253136
    Abstract: An accumulator defines an accumulator volume that can be placed into communication with a spring chamber of a gas spring. A working volume of the gas spring is the sum of the spring chamber volume and the accumulator volume. The accumulator can be configured so that the accumulator volume can be selectively increased or decreased as desired, thus modifying performance of the associated gas spring.
    Type: Grant
    Filed: August 16, 2021
    Date of Patent: March 18, 2025
    Assignee: Universal Air, Inc.
    Inventor: Daniel Zachary Ratcliff
  • Controlling wind turbine based on wind veer
    Patent number: 12253063
    Abstract: A method includes determining, by a control system, from among a plurality of categories, a current category of an incoming wind approaching a wind turbine, and setting, by the control system, a yaw bias of the wind turbine based on the current category. In some examples, the plurality of categories includes two or more wind conditions, such as a first wind condition in which wind contacting an upper rotor of the wind turbine is veering and wind contacting a lower rotor of the wind turbine is veering, a second wind condition in which the wind contacting the upper rotor of the wind turbine is veering and the wind contacting the lower rotor of the wind turbine is backing, and so on.
    Type: Grant
    Filed: January 26, 2022
    Date of Patent: March 18, 2025
    Assignee: Regents of the University of Minnesota
    Inventors: Jiarong Hong, Linyue Gao
  • Method of stimulating a conditional quantum master equation in a quantum transport process by a recurrent neural network
    Patent number: 12254380
    Abstract: The disclosure claims a method of stimulating a conditional quantum master equation in a quantum transport process by a recurrent neural network, comprising the following steps of: establishing a recurrent neural network which is a long short term memory network (LSTM), wherein the LSTM comprises TLSTM cells arranged in chronological order, and each LSTM cell has an input value xt and an output value ht, and there is a parameter (W, b) in the LSTM cell; replacing the input value xt with a shot noise spectrum S(?) of the current obtained according to the conditional quantum master equation; replacing the output value ht with a trace of density matrices in the conditional quantum master equation; and replacing the parameter (W, b) with a connection between density matrices in the conditional quantum master equation at imminent moments.
    Type: Grant
    Filed: May 26, 2021
    Date of Patent: March 18, 2025
    Assignee: University of Electronic Science and Technology of China
    Inventors: Xiaoyu Li, Qinsheng Zhu, Yong Hu, Qing Yang, Junyi Lu
  • Methods of treating endometrial cancer using hemp extract
    Patent number: 12251411
    Abstract: A method for treating endometrial cancer comprising: administering to a patient a cannabis extract (CE) wherein the cannabis extract comprises cannabidiol (CBD) at between 50% and 99% by weight of the CE.
    Type: Grant
    Filed: September 15, 2023
    Date of Patent: March 18, 2025
    Assignees: Ecofibre USA Inc., The University of Newcastle
    Inventors: Alexandra M. Capano, Pradeep Singh Tanwar, Alex Nance
  • Interactive imagery systems and methods
    Patent number: 12254717
    Abstract: An interactive portrait system includes a camera configured to capture imagery of an environment and a controller. The controller is configured to analyze the imagery to identify a guest in the environment, instruct an output device to provide an initial output to attempt to interact with the guest, and analyze the imagery to identify a behavior of the guest during the initial output, after the initial output, or both. The controller is also configured to evaluate the behavior of the guest using one or more artificial intelligence algorithms to determine whether the guest responded to the initial output. The controller is further configured to, in response to determining that the guest responded to the initial output, instruct the output device to provide an additional output to continue to attempt to interact with the guest.
    Type: Grant
    Filed: June 21, 2023
    Date of Patent: March 18, 2025
    Assignee: Universal City Studios LLC
    Inventors: Robert Michael Jordan, Anthony Melo, Angelo Pagliuca, Brandon David Burnette, John Adams, Jacob David Allinson, Eric To Chan, Mark James Traynor
  • Anti-aging preparation for skin and application thereof
    Patent number: 12251458
    Abstract: The present disclosure relates to the technical field of anti-aging preparations for skin, and especially relates to an anti-aging preparation for skin and an application thereof. Components of the anti-aging preparation for skin includes a 4-[(1E)-2-[[(4-chlorophenyl)methyl]sulfonyl]alkyne]-benzoic acid and/or a salt thereof. In the present disclosure, the anti-aging effect of the 4-[(1E)-2-[[(4-chlorophenyl)methyl]sulfonyl]alkyne]-benzoic acid and the salt thereof (such as sodium 4-[(1E)-2-[[(4-chlorophenyl)methyl]sulfonyl]alkyne]-benzoate) on skin has been discovered, and the 4-[(1E)-2-[[(4-chlorophenyl)methyl]sulfonyl]alkyne]-benzoic acid and the salt thereof can be applied in preparing the anti-aging preparation for skin that has good anti-aging effect on skin.
    Type: Grant
    Filed: October 22, 2024
    Date of Patent: March 18, 2025
    Assignee: South China Normal University
    Inventors: Haocai Chang, Wenwen Ouyang, Yongci Tan, Jing Tong