Abstract: The invention disclosed herein relates generally to the fields of microbiology, ecology and microfluidics. Particularly, the invention disclosed herein provides compositions and methods for isolating bacteria from complex microbial communities and measuring growth rates of the isolated bacteria in a given environmental condition.
Abstract: A direct structured illumination microscopy (dSIM) reconstruction method is provided. First, a time domain modulation signal is extracted through a wavelet. Then, an incoherent signal is converted into a coherent signal. Next, an accumulation amount at each pixel is calculated. Finally, a super-resolution image is generated by using a correlation between signals at different spatial positions. An autocorrelation algorithm of dSIM is insensitive to an error of a reconstruction parameter. dSIM bypasses a complex frequency domain operation in structured illumination microscopy (SIM) image reconstruction, and prevents an artifact caused by the parameter error in the frequency domain operation. The dSIM algorithm has high adaptability and can be used in laboratory SIM, nonlinear SIM imaging systems, or commercial systems.
Type:
Grant
Filed:
August 20, 2020
Date of Patent:
March 18, 2025
Assignee:
Peking University
Inventors:
Peng Xi, Shan Jiang, Hui Qiao, Qionghai Dai
Abstract: Methods of uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are provided. Kits for uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are also provided. The molecules to be labeled may include, but are not limited to, RNAs, cDNAs, DNAs, proteins, peptides, and/or antigens.
Type:
Grant
Filed:
July 25, 2024
Date of Patent:
March 18, 2025
Assignee:
University of Washington
Inventors:
Georg Seelig, Richard Muscat, Alexander B. Rosenberg
Abstract: Tissue culture platforms that may be configured for tissue culture or biological cell culture, and methods for use thereof, are described. In general, the tissue culture platforms include multiple well chambers that are fluidically coupled by one or more channels Flow between the different well chambers is controlled via one or more selector valves, enabling a single tissue culture platform that can provide multiple integrated culture subsystems, multiple non-interacting culture subsystems, or combinations thereof.
Type:
Grant
Filed:
October 16, 2019
Date of Patent:
March 18, 2025
Assignee:
Northwestern University
Inventors:
Hunter B. Rogers, Teresa K. Woodruff, Ji-Yong Julie Kim, Hannes Marcus Campo
Abstract: A method for in situ measurement of temperature at microwave-induced microscopic hot spots, temperature measuring particles and the device used are provided. For the temperature measurement demand of the microscopic hot spot of microwave field, loading fluorescent temperature measuring particles on the surface of solid particles, and the actual temperature of particles in micro scale can be measured by using its temperature sensitive fluorescence characteristics. The present disclosure builds a microwave field in-situ fluorescence test device to disperse the test particles loaded with fluorescent temperature measuring materials in the liquid solvent and place in the quartz sample tank in the microwave cavity, which can measure the actual temperature of the particles to be measured under microwave radiation.
Abstract: Featured is a vertebral body manipulation instrument or vertebral body manipulation device being configured and arranged to allow correction of vertebral translation. Such a vertebral body manipulation device embodies one or more identical modules that are configured as needed for correcting the deformity. Such a vertebral body manipulation device also is usable in combination with a plurality of vertebral anchors, such vertebral anchors being any such vertebral anchors as are known to those skilled in the art (e.g., conventional spinal pedicle screw instrumentation) or hereinafter developed so as to form a spinal implant system. Also featured are treatment methods utilizing such a vertebral body manipulation device.
Abstract: The design of bifunctional catalysts for water splitting by modifying the electronic structure of the catalyst. That bifunctional catalyst that is synthesized is a quaternary FeNi—PSe nanoporous film (FeNi—PSe NF). A self-supported FeNi—PSE NF is synthesized and used as an anode and a cathode in a two-electrode electrolytic cell. The cell is subjected to a water source, and the FeNi—PSe NFs split the water molecules to produce hydrogen fuel. The slightly oxidized FeNi—PSe surface serves as an active site for oxygen evolution reactions, making hydrogen evolution reactions and oxygen evolution reactions well-balanced, thereby improving electrolysis efficiency.
Type:
Grant
Filed:
May 18, 2021
Date of Patent:
March 18, 2025
Assignee:
University of Central Florida Research Foundation, Inc.
Abstract: Provided herein is a method for treating a cancer in a subject by quantitating the concentration of a soluble form of Semaphorin 4D (sSema4D) in a blood sample obtained from the subject and administering an immunotherapy when the blood concentration of sSema4D is below a threshold value of 155 ng/ml. Also provided is a method for determining the continued susceptibility of a tumor tissue to immunotherapy in a subject by identifying the inflammatory subtype of the tumor tissue from a blood sample from the subject and administering immunotherapy over at least one interval as long as the tumor tissue exhibits an inflamed subtype.
Abstract: Methods for treating neurological and other disorders, including autoimmune disorders are described. Also described is a method of treating a disorder in which Toll-like Receptor 2 (TLR2) activation by binding to myeloid differentiation primary response 88 (MyD88) plays a role in disease pathogenesis. Further a method is described that includes the administration of a composition, including a peptide sequence, that inhibits the activation of TLR2 by MyD88.
Abstract: A syringe device and methods for device for separating liquids of different densities are provided where the syringe device includes a hollow syringe barrel, a perforated plunger seal with a seal hole, and a hollow plunging tube with a closed bottom with at least one tube hole.
Type:
Grant
Filed:
August 4, 2020
Date of Patent:
March 18, 2025
Assignee:
Board of Trustees of Southern Illinois University
Inventors:
Ashim Gupta, Michael W. Neumeister, Sohyung Cho, Scott Moore, Robert B. Zajeski, Jr.
Abstract: The present application relates to processes for the preparation of quinolone compounds and intermediates thereof, particularly to processes for the preparation of quinolones and pharmaceutical intermediates of the quinolones. In particular, the present application provides a process for the preparation of a compound of Formula I, and a process for the synthesis of quinolone compounds using the compound of Formula I as an intermediate.
Type:
Grant
Filed:
May 5, 2022
Date of Patent:
March 18, 2025
Assignee:
Chongqing University of Arts and Sciences
Inventors:
Jie Lei, Zhongzhu Chen, Zhigang Xu, Dianyong Tang, Jiayu Xu, Haoyi Zhou, Dandan Xia, Yao Liu, Yihua Cao, Jie Luo
Abstract: Provided herein are agents that bind to the lipid binding groove of Frizzled (FZD). In some embodiments, the agent is a fragment of TcdB corresponding to amino acids 1285-1804 of SEQ ID NO: 1. In some embodiments, binding of the agent to the lipid binding groove of FZD inhibits TcdB entry into cells, and/or inhibits Wnt signaling. Methods of treating Clostridium difficile infection (CDI) and methods of treating cancer are also provided.
Type:
Grant
Filed:
January 14, 2019
Date of Patent:
March 18, 2025
Assignees:
Children's Medical Center Corporation, The Regents of the University of California
Inventors:
Min Dong, Liang Tao, Rongsheng Jin, Peng Chen, Aina He
Abstract: A method for treating endometrial cancer comprising: administering to a patient a cannabis extract (CE) wherein the cannabis extract comprises cannabidiol (CBD) at between 50% and 99% by weight of the CE.
Type:
Grant
Filed:
September 15, 2023
Date of Patent:
March 18, 2025
Assignees:
Ecofibre USA Inc., The University of Newcastle
Inventors:
Alexandra M. Capano, Pradeep Singh Tanwar, Alex Nance
Abstract: An interactive portrait system includes a camera configured to capture imagery of an environment and a controller. The controller is configured to analyze the imagery to identify a guest in the environment, instruct an output device to provide an initial output to attempt to interact with the guest, and analyze the imagery to identify a behavior of the guest during the initial output, after the initial output, or both. The controller is also configured to evaluate the behavior of the guest using one or more artificial intelligence algorithms to determine whether the guest responded to the initial output. The controller is further configured to, in response to determining that the guest responded to the initial output, instruct the output device to provide an additional output to continue to attempt to interact with the guest.
Type:
Grant
Filed:
June 21, 2023
Date of Patent:
March 18, 2025
Assignee:
Universal City Studios LLC
Inventors:
Robert Michael Jordan, Anthony Melo, Angelo Pagliuca, Brandon David Burnette, John Adams, Jacob David Allinson, Eric To Chan, Mark James Traynor
Abstract: The present disclosure relates to the technical field of anti-aging preparations for skin, and especially relates to an anti-aging preparation for skin and an application thereof. Components of the anti-aging preparation for skin includes a 4-[(1E)-2-[[(4-chlorophenyl)methyl]sulfonyl]alkyne]-benzoic acid and/or a salt thereof. In the present disclosure, the anti-aging effect of the 4-[(1E)-2-[[(4-chlorophenyl)methyl]sulfonyl]alkyne]-benzoic acid and the salt thereof (such as sodium 4-[(1E)-2-[[(4-chlorophenyl)methyl]sulfonyl]alkyne]-benzoate) on skin has been discovered, and the 4-[(1E)-2-[[(4-chlorophenyl)methyl]sulfonyl]alkyne]-benzoic acid and the salt thereof can be applied in preparing the anti-aging preparation for skin that has good anti-aging effect on skin.
Abstract: The disclosure discloses a point-of-interest recommendation method based on a temporal knowledge graph. Based on the historical behavior trajectory of the user and multimodal information, the disclosure constructs a dynamic temporal knowledge graph and a static group knowledge graph, which are used to learn interest preferences of the user that change over time and stable features that do not change over time, respectively. At the same time, the disclosure uses deep learning methods to build a point-of-interest recommendation model, which can extract a point-of-interest fusion feature representation and a user fusion feature representation from the two knowledge graphs in combination with a user review sentiment embedding sequence to accurately predict a point of interest most likely to be visited by the target user at a next moment. The disclosure has the characteristics of high precision and strong scalability, and can provide support for personalized user behavior trajectory prediction.
Type:
Grant
Filed:
November 12, 2024
Date of Patent:
March 18, 2025
Assignees:
Hangzhou Dianzi University Binjiang Institute Co., Ltd., Hangzhou Dianzi University
Inventors:
Xiao Xiao Sun, Dong Jin Yu, Bo Yi Huang, Si Xuan Wang, Dong Jing Wang, Yao Wang Chen
Abstract: A multiple scenario-oriented item retrieval method and system. The method includes the steps of extracting, by Hashing learning, image features from an image training set to train a pre-built item retrieval model; when an image is in a scenario of hard samples, introducing an adaptive similarity matrix, optimizing the similarity matrix by an image transfer matrix, constructing an adaptive similarity matrix objective function in combination with an image category label; constructing a loss quantization objective function between the image and a Hash code according to the image transfer matrix; when the image is in a scenario of zero samples, introducing an asymmetric similarity matrix, constructing an objective function by taking the image category label as supervisory information in combination with equilibrium and decorrelation constraints of the Hash code; and training the item retrieval model based on the above objective function to obtain a retrieved result of a target item image.
Type:
Grant
Filed:
August 5, 2022
Date of Patent:
March 18, 2025
Assignee:
Shandong Jianzhu University
Inventors:
Xiushan Nie, Yang Shi, Jie Guo, Xingbo Liu, Yilong Yin
Abstract: A method of additively manufacturing a structure for use in a reactionary process includes forming a material from metal or metal oxide particles, a dispersion solvent, and a binder. The method also includes depositing the material onto a build platform and curing the material to form a structure for use in a reactionary process. The structure includes the metal or metal oxide particles and is configured to provide a reaction when exposed to a reactant.
Type:
Grant
Filed:
January 31, 2022
Date of Patent:
March 18, 2025
Assignee:
The Curators of the University of Missouri
Inventors:
Fateme Rezaei, Ali Rownaghi, Shane Lawson