Abstract: A cross-contamination free and multiple laboratory sample grinder includes: a controller unit having a motor and a controller unit; a tube receptacle unit, removably laid on top of the controller unit, comprises a plurality of compartments designed to contain a plurality of laboratory tubes; and a top housing unit, removably laid on top of the tube receptacle unit, comprises an array of pestles coupled to a gear system that is operated by that motor. The top housing unit comprises a handle and a roller connector having a pair of wheels when rotated operable to eject the array of pestles into the plurality of laboratory tubes.

Abstract: A device for non-invasive monitoring and measuring of intraocular pressure (IOP) of a subject includes a flexible lens that fits on the eye and changes curvature in response to a change in curvature of the eye. A microchannel disposed in or on the lens has one or more ends that are open to the atmosphere and an indicator solution is disposed in a portion of the 5 microchannel. The microchannel exhibits a change in volume in response to a change in curvature of the lens, which results in a change in position of the indicator solution in the microchannel. The change in position of the indicator solution in the microchannel is indicative of a change in IOP. The change in position of the indicator solution may be detected in digital images of the lens taken with a camera of a mobile electronic device such 0 as a smartphone or a camera worn by the subject.

Abstract: A three-phase diagnosis methodology capable of effectively diagnosing and classifying multiple defects in integrated circuits comprises a first phase identifying a defect that resembles traditional fault models, and second and third phases that utilize the X-fault model and machine learning to identify correct candidates.

Abstract: Provided are a hydrogen recycle system and a hydrogen recycle method, whereby hydrogen can be purified to high purity at high yield from a gas, said gas being exhausted from a nitride compound production device, and recycled. The hydrogen recycle system 1 comprises an exhaust gas supply path 11 supplying a gas exhausted from a nitride compound production device 2, a hydrogen recycle means 10 and a hydrogen supply path 12.

Abstract: Methods of uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are provided. Kits for uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are also provided. The molecules to be labeled may include, but are not limited to, RNAs, cDNAs, DNAs, proteins, peptides, and/or antigens.

Abstract: Self-assembled organic ligand functionalized microcapsules encapsulating one or more substrates, which release the substrates upon activation with a power source, are provided. Compositions that include these microcapsules, as well as methods of making the microcapsules and releasing the encapsulated substrates are also provided. The structures, compositions and methods find use in a variety of applications, such as drug and cell encapsulation technologies, for direct delivery, control, and activation of medicines and therapies to specific tissues in a living host.

Abstract: The present invention provides compounds useful as inhibitors of TIR NADase activity, compositions thereof, and methods of using the same. The present invention is useful for inhibition of TIR-domain NADase activity and/or treating microbial infection and/or modulating microbial physiology.

Abstract: Provided is an identification method of plastic microparticles, including: performing an infrared analysis on plastic microparticles to identify whether the plastic microparticles include polyethylene terephthalate, polyethylene, polypropylene, or nylon 66, wherein the identification is to determine whether the plastic microparticles have a characteristic peak of each plastic, and the characteristic peak is selected from signals that do not overlap and interfere with each other in the infrared spectrum signals of each plastic.

Abstract: A sensor can include a redox-active complex. The sensor can be voltage sensitive.

Abstract: The invention relates to a glycopeptide that includes one or more modified amino acid residues having a sidechain comprising a monosaccharide or an oligosaccharide, wherein the glycopeptide binds specifically to a carbohydrate-binding monoclonal antibody from PGT128 family, preferably with an affinity of less than 100 nM. Immunogenic conjugates that include the glycopeptide, and pharmaceutical compositions that include the glycopeptide or the immunogenic conjugate are also disclosed. Various method of using the glycopeptides, immunogenic conjugates, and pharmaceutical compositions are disclosed, including inducing an immune response, inhibiting viral infection, treating a cancerous condition, and detecting a neutralizing antibody.

Abstract: A method for determining if a tissue is ganglionic is provided. The method comprises a) generating at least one hyperspectral Raman image of a tissue from a region of interest in a tissue suspected to contain ganglion cells that was optionally identified by a method comprising autofluorescence (AF) and Second Harmonic generation (SHG) imaging of the tissue; and b) analyzing any of the images for one or more of the following: i) optical excitation; ii) chemical information or emission spectra; or iii) AF, SHG, and/or Raman signatures, wherein the analysis provides indicators that the region of interest is either ganglionic or non-ganglionic. A system for analysis of in vivo tissue or ex vivo tissue samples including a multiphoton autofluorescence microscope, a Second Harmonic Generation microscope, and a hyperspectral Raman microscope in operative communication is also provided.

Abstract: Size-band analysis is used to determine whether a chromosomal region exhibits a copy number aberration or an epigenetic alteration. Multiple size ranges may be analyzed instead of focusing on specific sizes. By using multiple size ranges instead of specific sizes, methods may analyze more sequence reads and may be able to determine whether a chromosomal region exhibits a copy number aberration even when clinically-relevant DNA may be a low fraction of the biological sample. Using multiple ranges may allow for the use of all sequence reads from a genomic region, rather than a selected subset of reads in the genomic region. The accuracy of analysis may be increased with higher sensitivity at similar or higher specificity. Analysis may include fewer sequencing reads to achieve the same accuracy, resulting in a more efficient process.

Abstract: A method for performing Building Information Modelling design collaboration via Confidentiality-Minded Framework using Interplanetary-File-System-Blockchain integrated network by a server is provided. The method includes: segregating one or more sensitive and non-sensitive BIM portions of a BIM object; uploading a target BIM component into an IPFS network to receive a target content identifier (CID) of the target BIM component from the IPFS network; if the target BIM component has one or more of the sensitive portions, encrypting the target CID to obtain a target encrypted CID (ECID), and adding the target ECID into a target blockchain ledger as a target transaction via a target smart contract; accessing the target transaction to download the target BIM component from the IPFS network; and performing a design coordination operation on the target BIM component, so as to distributing revised target BIM component to a receiver terminal.

Abstract: Provided herein is a method for identifying and correcting optical aberrations within a sample under optical microscopy. The method includes providing a plurality of optical beams including at least a first optical beam and a second optical beam; modulating at least one of the optical beams at one or more frequencies; providing a combined optical beam at least partially superimposed in time by the first optical beam and the second optical beam; focusing the combined optical beam into the sample; detecting a first signal excited by the combined optical beam in the sample; demodulating the first signal by at least one lock-in amplifier to obtain a second signal including performing a plurality of measurements of spatial positions of the first optical beam with respect to the second optical beam; identifying and correcting the optical aberrations by the second signal through obtaining the electric-field point spread function of the optical beams.

Abstract: A method and apparatus are disclosed for calibrating a first sensor in a changing operating environment by a calibration process. Sensor data are received from the first sensor and sensor values are received from a known calibrating sensor. A sensor specific model is maintained for the first sensor. Calibration needs are detected by estimating a drift and an error, taking into account a difference of sensor values to the known calibrating sensor and further taking into account a sensor profile of the first sensor. A correction factor or a correction model is estimated to the sensor data using said difference and used for calibrating the sensor. The correction factor or the correction model is derived from the sensor specific model.

Abstract: The present disclosure discloses an asymmetric wavelength multiplexing and demultiplexing chip based on inverse design, which belongs to the technical field of optical components, systems or instrument. The chip includes the first-level asymmetric wavelength multiplexing and demultiplexing unit and the second-level symmetric wavelength multiplexing and demultiplexing unit, which is constructed by silicon based photonics integration technology, includes a substrate, a bottom cladding layer, a core layer and a top cladding layer sequentially stacked from bottom to top. The functional regions inside the first-level unit and the second-level unit are designed based on the inverse design algorithms, and are composed of subunits on the submicron or nanometer scale.

Abstract: The present disclosure provides novel cell compositions engineered to express at least a chimeric antigen receptor and a survival factor. Methods of using such cell compositions are also described.

Abstract: A brain measurement apparatus includes: a magnetoencephalograph module having a cell, a pump laser configured to emit pump light, a probe laser configured to emit probe light to a sensitivity region intersecting the pump light in the cell, an optical sensor group configured to detect a polarization plane angle of the probe light having passed through the sensitivity region, and a bias magnetic field coil configured to apply a bias magnetic field; and an MRI module having a transmission coil for transmitting an RF pulse of a predetermined frequency, and a receiver coil configured to detect a nuclear magnetic resonance signal generated by transmission of the RF pulse. The magnetoencephalograph module and the MRI module are surrounded by a magnetic shield including a soft magnetic material.

Abstract: Disclosed are embodiments of a method for producing a rare earth metal from a metallothermic reaction of a reductant metal and a double salt of the rare earth metal. The double salt of rare earth metal can be prepared from an alkali halide and a salt of the rare earth metal at room temperature over a time period of 2 hours of less without the requirement to use hydrofluoric acid.

Abstract: An optically pumped magnetometer includes a cell, a pump light incidence unit causing pump light to be incident on a sensitivity region inside the cell in a first direction, a probe light incidence unit causing probe light for detecting change in electron spins to be incident on the sensitivity region in a direction intersecting the first direction, a bias magnetic field coil applying a bias magnetic field in the first direction to the inside of the cell and determining a resonance frequency of the electron spins, a gradient correction coil correcting a gradient of the bias magnetic field, an electron spin tilting unit tilting a rotation axis direction of the electron spins, an optical sensor detecting the probe light having passed through the sensitivity region, and a magnetic field measuring unit measuring a magnetic field strength related to the sensitivity region based on an output of the optical sensor.