Patents Assigned to University
  • Electroporation and electrophoresis system and method for achieving molecular penetration into cells in vivo
    Patent number: 6714816
    Abstract: The electroporation system and method combine pulses having different characteristics for delivering molecules to cells in vivo. The pulses include a high-intensity pulse for inducing electroporation and a low-intensity pulse to induce electrophoretic molecule movement within an interstitial space, molecule adherence to a cell membrane, and electrophoretic movement of the molecule through the permeabilized membrane. The use of a high-intensity and a low-intensity pulse achieves improved delivery; reduction of intensity and/or duration of pulses for inducing electroporation; and decreased muscle stimulation, tissue damage, and patient discomfort.
    Type: Grant
    Filed: February 22, 2000
    Date of Patent: March 30, 2004
    Assignee: University of South Florida
    Inventors: Richard Heller, Richard Gilbert, Mark J. Jaroszeski, Loree C. Heller, Melinda L. Lucas
  • Magnetorheological fluids and related method of preparation
    Patent number: 6712990
    Abstract: Magnetorheological (MR) fluids, dispersions of magnetically soft particles in fluids (gases, liquids, or semi-solids such as greases), are disclosed. The present invention uses the initial steps of a sol-gel process to assist in preparation of MR fluids that have significantly enhanced stability and redispersibility, without the use of ceramic particles such as silica or bridging polymers such as PVP.
    Type: Grant
    Filed: June 14, 2002
    Date of Patent: March 30, 2004
    Assignee: University of Pittsburgh of the Commonwealth System of Higher Education
    Inventor: Pradeep P. Phule
  • Design of optical superlattice to realize third-harmonic generation and multi-wavelength laser output and its application in the all-solid state laser
    Patent number: 6714569
    Abstract: The design of a special type of optical superlattice and its application in the all-solid state laser is involved in this invention. Nd ions doped laser crystal in common use can radiate three relatively intense spectral lines when excited: the first wavelength is around 900 nm; the second wavelength is around 1064 nm; the third wavelength is around 1300 nm, whose accurate wavelength are depended on their host crystal (for example, to Nd:YAG, they are 946 nm, 1064 nm and 1319 nm, respectively). On the other hand, for LiNbO3 (LN), LiTaO3 (LT), KTP and other ferroelectric crystals, the positive and negative 180° ferroelectric domains in these crystals can be arranged orderly according to certain sequence via crystal growth, electric field poling, and other state-of-the-art domain reversion technique, forming superlattice that is applicable to quasi-phase-matching (QPM) laser frequency conversion.
    Type: Grant
    Filed: January 3, 2002
    Date of Patent: March 30, 2004
    Assignee: Nanjing University
    Inventors: Shining Zhu, Jingliang He, Yongyuan Zhu, Huitian Wang, Guozheng Ruo, Chao Zhang, Yiqiang Qin, Naiben Ming
  • Synthetic immunogenic but non-amyloidogenic peptides homologous to amyloid &bgr; for induction of an immune response to amyloid &bgr; and amyloid deposits
    Patent number: 6713450
    Abstract: The present invention relates to synthetic immunogenic but non-amyloidogenic peptides homologous to amyloid &bgr; which can be used alone or conjugated to an immunostimulatory molecule in an immunizing composition for inducing an immune response to amyloid &bgr; peptides and amyloid deposits.
    Type: Grant
    Filed: May 22, 2001
    Date of Patent: March 30, 2004
    Assignee: New York University
    Inventors: Blas Frangione, Thomas Wisniewski, Einar M. Sigurdsson
  • Methods for the prophylactic and therapeutic treatment of cardiac tissue damage
    Patent number: 6713459
    Abstract: The invention provides a method for treating tissue damage caused by ischemia/reperfusion, microbial infection, or sepsis using (1→3)-&bgr;-D-glucans to modulate immune response mediators and their effects.
    Type: Grant
    Filed: April 28, 2000
    Date of Patent: March 30, 2004
    Assignee: East Tennessee State University
    Inventors: David L. Williams, Chuanfu Li
  • Antibodies raised against immunogenic conjugates of gram-negative bacterial autoinducer molecules
    Patent number: 6713059
    Abstract: The present invention relates to an immunogenic conjugate comprising a carrier molecule coupled to an autoinducer of a Gram negative bacteria. The immunogenic conjugate, when combined with a pharmaceutically acceptable carrier, forms a suitable vaccine for mammals to prevent infection by the Gram negative bacteria. The immunogenic conjugate is also used to raise and subsequently isolate antibodies or binding portions thereof which are capable of recognizing and binding to the autoinducer. The antibodies or binding portions thereof are utilized in a method of treating infections, a method of inhibiting autoinducer activity, and in diagnostic assays which detect the presence of autoinducers or autoinducer antagonists in fluid or tissue samples.
    Type: Grant
    Filed: April 11, 2002
    Date of Patent: March 30, 2004
    Assignee: University of Rochester
    Inventors: Andrew S. Kende, Barbara H. Iglewski, Roger Smith, Richard P. Phipps, James P. Pearson
  • Nucleic acid and amino acid sequences for ATP-binding cassette transporter and methods of screening for agents that modify ATP-binding cassette transporter
    Patent number: 6713300
    Abstract: The present invention provides nucleic acid and amino acid sequences of an ATP binding cassette transporter and mutated sequences thereof associated with macular degeneration. Methods of detecting agents that modify ATP-binding cassette transporter comprising combining purified ATP binding cassette transporter and at least one agent suspected of modifying the ATP binding cassette transporter an observing a change in at least one characteristic associated with ATP binding cassette transporter. Methods of detecting macular degeneration is also embodied by the present invention.
    Type: Grant
    Filed: February 27, 1998
    Date of Patent: March 30, 2004
    Assignees: University of Utah Research Foundation, Baylor College of Medicine, Johns Hopkins University, The United States of America as represented by the Department of Health and Human Services
    Inventors: Rando Allikmets, Kent L. Anderson, Michael Dean, Mark Leppert, Richard A. Lewis, Yixin Li, James R. Lupski, Jeremy Nathans, Amir Rattner, Noah F. Shroyer, Nanda Singh, Philip Smallwood, Hui Sun
  • Adaptive multiplexing/demultiplexing method and multiplexer/demultiplexer therefor
    Patent number: 6714561
    Abstract: An adaptive multiplexing/demultiplexing method, and a multiplexer/demultiplexer (MUX/DEMUX) using the same and a computer readable medium including software for implementing the same in an H.324M system, are provided. The adaptive MUX/DEMUX in the H.324M system includes one or more MUX/DEMUXs having different complexities, between an H.223/Annex C MUX/DEMUX and an H.223 MUX/DEMUX.
    Type: Grant
    Filed: July 18, 2000
    Date of Patent: March 30, 2004
    Assignees: Samsung Electronics Co., Ltd., University of California
    Inventors: Dong-seek Park, John Villasenor
  • Methods for removing a contaminant by a polyoxometalate-modified fabric or a polyoxometalate-modified cellulosic fiber and fabrics thereof
    Patent number: 6713076
    Abstract: The invention relates to a method for removing a contaminant from a gas phase or a liquid phase by contacting an article composed of (1) a fabric or cellulosic fiber and (2) a polyoxometalate, wherein the polyoxometalate is incorporated in the fabric or cellulosic fiber, with the gas phase or liquid phase containing the contaminant. The invention further relates to a polyoxometalate-modified fabric composed of a fabric and a polyoxometalate of the present invention incorporated in the fabric. The invention further relates to an article containing the polyoxometalate-modified fabric. The invention further relates to a method for making the polyoxometalate-modified fabric, by contacting the fabric with a polyoxometalate to produce a polyoxometalate-modified fabric.
    Type: Grant
    Filed: December 4, 2000
    Date of Patent: March 30, 2004
    Assignee: Emory University
    Inventors: Craig L. Hill, Ling Xu
  • Self-aligned vertical combdrive actuator and method of fabrication
    Patent number: 6713367
    Abstract: A method of fabricating a self-aligned vertical combdrive is described. The method includes the steps of etching in a semiconductor wafer a first comb with a coarse set of teeth. A second semiconductor wafer is bonded to the first set of teeth. A set of accurately positioned teeth is etched in the second wafer with teeth overlapping the teeth in the first comb. The lower teeth are etched using the overlapping teeth as a mask to assure proper alignment. One variation in this fabrication method whereby the first coarse comb teeth are etched on semiconductor-on-insulator instead, allows creation of double-sided comb actuators with increased torsional deflection range. Another variation to this fabrication method that keeps the electrically isolated upper masking teeth allows creation of dual-mode vertical comb actuators after an initial assembly step.
    Type: Grant
    Filed: August 27, 2002
    Date of Patent: March 30, 2004
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Olav Solgaard, Uma Krishnamoorthy
  • Apparatus and methods for electrospinning polymeric fibers and membranes
    Patent number: 6713011
    Abstract: An apparatus and method for electrospinning polymer fibers and membranes. The method includes electrospinning a polymer fiber from a conducting fluid in the presence of a first electric field established between a conducting fluid introduction device and a ground source and modifying the first electric field with a second electric field to form a jet stream of the conducting fluid. The method also includes electrically controlling the flow characteristics of the jet stream, forming a plurality of electrospinning jet streams and independently controlling the flow characteristics of at least one of the jet streams.
    Type: Grant
    Filed: May 16, 2001
    Date of Patent: March 30, 2004
    Assignee: The Research Foundation at State University of New York
    Inventors: Benjamin Chu, Benjamin S. Hsiao, Dufei Fang
  • Treatment of breast cancer
    Patent number: 6713503
    Abstract: Compounds of the class of 4-oxo-butenoic acid derivatives are disclosed along with the surprising use property of these compounds as a anti-tumor agents in humans against breast carcinoma, which include: 2-(N′-Fluoren-9-ylidene-hydrazino)-5,5-dimethyl-4-oxo-hex-2-enoic acid methyl ester (OF-06), 1-(2,4-Dimethyl-phenyl)-2,4-dihydroxy-3-4-methyl-benzoyl)-5-oxo-2,5-dihydro-1H-pyrrole-2-carboxylic acid methyl ester (1F-07), 4-(4-Methoxy-phenyl)-2,4-dioxo-3-(phenyl-hydrazono)-butyric acid (3F-10), 4-(4-Chloro-phenyl)-2,4-dioxo-3-(phenyl-hydrazono)-butyric acid ethyl ester (3F-11), 2-Hydroxy-4-oxo-4-(2,3,5,6-tetrafluoro-4-methoxy-phenyl)-but-2-enoic acid (3F-15), and 4,4-Dihydroxy-5-4-methyl-benzoyl)-2-phenyl-2,4-dihydro-pyrazol-3-one (3F-16) as well as some novel derivatives of these compounds claimed (see Table 2).
    Type: Grant
    Filed: December 4, 2002
    Date of Patent: March 30, 2004
    Assignee: University of Central Florida
    Inventors: D. Howard Miles, Solodnikov Sergey Yurjevich, Krasnykh Olga Petrovna, Pimenova Elena Valentinovna, Elena A. Goun
  • Frozen beverage topping
    Patent number: 6713114
    Abstract: The invention relates to a frozen beverage topping composition which provides a frothy or foam layer to a beverage. The beverage topping composition provides creaming and can flavor, sweeten, and slightly cool coffee and other beverages. The frozen beverage topping composition of the invention may be made in non-dairy, dairy (containing non-fat dry milk and non-dairy fat), and real dairy (containing non-fat dry mile and butterfat) forms, as well as caloric and non-caloric sweetened versions. Methods of producing the frozen beverage topping composition are provided as well as methods of using the frozen beverage topping compositions.
    Type: Grant
    Filed: February 14, 2001
    Date of Patent: March 30, 2004
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Barbara Klein, James Faller, Teresa Paeschke, Eleftherios Moros, Jennifer Grady, Maureen Cheng, Glinda Lofton, Lynn Magden, Nicole Romero
  • Growth differentiation factor-6
    Patent number: 6713302
    Abstract: Growth differentiation factor-6 (GDF-6) is disclosed along with its polynucleotide sequence and amino acid sequence. Also disclosed are diagnostic and therapeutic methods of using the GDF-6 polypeptide and polynucleotide sequences.
    Type: Grant
    Filed: July 18, 2000
    Date of Patent: March 30, 2004
    Assignee: The Johns Hopkins University School of Medicine
    Inventors: Se-Jin Lee, Thanh Huynh
  • Chimeric oligonucleotides for modulating gene expression
    Patent number: 6713621
    Abstract: Genes coding for vascular cell adhesion molecules, particularly VCAM-1, are modulated through interaction of oligonucleotides with transcriptional regulatory factors which bind to the genes. Specific and effective oligonucleotides are provided which interact with the transcriptional regulatory factors to diminish their interaction with the genes and downregulate their function. Multi-modal oligonucleotides are also provided which interact both with a transcriptional regulatory factor and with another aspect of gene function.
    Type: Grant
    Filed: March 9, 1995
    Date of Patent: March 30, 2004
    Assignees: ISIS Pharmaceuticals, Inc., Emory University
    Inventors: Russell M. Medford, Clarence Frank Bennett
  • Method for detecting and excising nonpalpable lesions
    Patent number: 6714808
    Abstract: A novel method of hematoma-directed ultrasound guided excisional breast biopsy is disclosed. In one aspect of the inventon, the hematoma is produced by an injection of the patient's own blood into a pre-selected area to target a lesion. Detection of the targeted lesion and hematoma is achieved with MRI. In a second aspect of the invention, the hematoma is produced by stereotactic core needle breast biopsy in a pre-selected area, and the targeted lesion and hematoma are detected using intraoperative ultrasound. The method avoids many of the disadvantages associated with traditional needle localized breast biopsy. The method can also be used to guide the excision of lesions visualized by MRI, ultrasound, mammography, PET scanning, and scintimammography. The method may be used in any organ and, in particular, the breast.
    Type: Grant
    Filed: October 3, 2001
    Date of Patent: March 30, 2004
    Assignee: University of Arkansas
    Inventors: V. Suzanne Klimberg, Steven E. Harms, Sohelia Korourian
  • Antimicrobial compounds
    Patent number: 6713654
    Abstract: This invention provides methods for treating a mycobacterial infection by administering to an animal a pharmaceutical composition containing a compound having the formula R—SOn—Z—CO—Y, where R is an alkyl group having 6-20 carbons; Z is a radical selected from —CH2—, —O—, and —NH—, two of these radicals coupled together, or —CH2═CH2—; Y is —NH2, O—CH2—C6H5, —CO—CO—O—CH3, or O—CH3; and n is 1 or 2. It has been discovered that these compounds inhibit growth of microbial cells which synthesize &agr;-substitued, &bgr;-hydroxy fatty acids, particularly corynemycolic acid, nocardic acid, and mycolic acid. These compounds may be used to inhibit growth of mycobacterial cells, such as Mycobacterium tuberculosis, drug-resistant M. tuberculosis, M. avium intracellulare, and M. leprae.
    Type: Grant
    Filed: August 28, 2000
    Date of Patent: March 30, 2004
    Assignee: The Johns Hopkins University School of Medicine
    Inventors: Craig A. Townsend, James D. Dick, Gary R. Pasternack, Francis P. Kuhajda, Nicole M. Parrish
  • Insulating and functionalizing fine metal-containing particles with conformal ultra-thin films
    Patent number: 6713177
    Abstract: Particles have an ultrathin, conformal coating are made using atomic layer deposition methods. The base particles include ceramic and metallic materials. The coatings can also be ceramic or metal materials that can be deposited in a binary reaction sequence. The coated particles are useful as fillers for electronic packaging applications, for making ceramic or cermet parts, as supported catalysts, as well as other applications.
    Type: Grant
    Filed: July 16, 2002
    Date of Patent: March 30, 2004
    Assignee: Regents of the University of Colorado
    Inventors: Steven M. George, John D. Ferguson, Alan W. Weimer, Jeffrey R. Wank
  • Nucleozymes
    Patent number: 6713456
    Abstract: Nucleozymes containing ribonucleotides and deoxyribonucleotides or nucleic acid analogues are described herein. The nucleozymes have catalytic activity and are significantly more resistant to degradation than their all-RNA ribozyme counterparts. Also described are methods for preparing the nucleozymes along with methods of using nucleozymes, e.g., as therapeutic agents.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: March 30, 2004
    Assignees: Massachusetts Institute of Technology, University of Montreal
    Inventors: Nassim Usman, Robert J. Cedergren, Jean-Pierre Perreault, Jing-Hua Yang, Alexander Rich
  • Vehicle wheel
    Patent number: D487882
    Type: Grant
    Filed: June 13, 2003
    Date of Patent: March 30, 2004
    Assignee: PT Prima Alloy Steel Universal
    Inventor: Sumantri Cahyono