Abstract: The invention is directed to methods for the non-radioactive labeling, detection, quantitation and isolation of nascent proteins translated in a cellular or cell-free translation system. tRNA molecules are misaminoacylated with non-radioactive markers which may be non-native amino acids, amino acid analogs or derivatives, or substances recognized by the protein synthesizing machinery. Markers may comprise cleavable moieties, detectable labels, reporter properties wherein markers incorporated into protein can be distinguished from unincorporated markers, or coupling agents which facilitate the detection and isolation of nascent protein from other components of the translation system. The invention also comprises proteins prepared using misaminoacylated tRNAs which can be utflized in pharmaceutical compositions for the treatment of diseases and disorders in humans and other maninials, and kits which may be used for the detection of diseases and disorders.

Abstract: The invention relates to compounds, compositions and methods for inhibiting sphingosine kinase and for treating or preventing hyperproliferative disease, autoimmune disease, inflammatory disease, or allergy.

Abstract: The invention provides a series of lipophilic phosphonium cations (PhCs) labeled with 18F for non-invasive assessment of &Dgr;&PSgr;m, lipophilic ammonium cation analogs of the PhCs, and methods of using same for imaging and detection of mitochondrial-related pathologies in patients using PET or SPECT.

Abstract: A portable, hand-held meter used to measure direct current (DC) attenuation in low impedance electrical signal cables and signal attenuators. A DC voltage is applied to the signal input of the cable and feedback to the control circuit through the signal cable and attenuators. The control circuit adjusts the applied voltage to the cable until the feedback voltage equals the reference voltage. The “units” of applied voltage required at the cable input is the system attenuation value of the cable and attenuators, which makes this meter unique. The meter may be used to calibrate data signal cables, attenuators, and cable-attenuator assemblies.

Abstract: A two-piece wrist-hand-finger orthosis of the present invention includes a rigid forearm section secured to the patient's arm, and a rigid hand section with a proximally projecting extension lever. The hand section is donned on the patient with the patient's hand in flexion. The hand section is then leveraged into a position of predetermined flexion or extension by pivoting the extension lever downwardly into contact with the forearm section. The extension lever is then secured to the forearm section.

Abstract: A DNA comprising a deoxynucleotide sequence coding for bovine growth hormone is described. A transfer vector and an expression vector containing this DNA and microorganisms transformed by these vectors are also described.

Abstract: A method and apparatus for characterizing and sensing the stability of a magnetic memory element. The method comprises setting a reference threshold, reading the state signal of the memory element, and comparing the magnitude of the state signal to the reference threshold, such that a state signal exceeding the reference threshold is considered stable. The apparatus comprises a reference generator having an output that is compared, in a windowed comparator, to the state signal magnitude, such that an output signal of the windowed comparator can be used to characterize the stability of the memory element.

Abstract: This invention includes methods and/or apparatus for limb position sensing and, more particularly, measurement of limb position acuity during an ongoing movement rather than after movement has stopped.

Abstract: Compounds having the formula or a pharmaceutically acceptable salt thereof wherein R1 is (a) hydrogen, (b) loweralkyl, (c) alkenyl, (d) alkoxy, (e) thioalkoxy, (f) halo, (g) haloalkyl, (h) aryl-L2—, and (i) heterocyclic-L2—; R2 is selected from (e) —C(O)NH—CH(R14)-tetrazolyl, (f) —C(O)NH-heterocyclic, and (g) —C(O)NH—CH(R14)—C(O)NR17R18; R3 is heterocyclic, aryl, substituted or unsubstituted cycloalkyl; R4 is hydrogen, lower alkyl, haloalkyl, halogen, aryl, arylakyl, heterocyclic, or (heterocyclic)alkyl; L1 is absent or is selected from (a) —L4—N(R5)—L5—, (b) —L4—O—L5—, (c) —L4—S(O)n—L5— (d) —L4—L6—C(W)—N(R5)—L5—, (e) —L4—L6—S(O)m—N(R5)—L5—, (f) —L4—N(R5)—C(W)—L7—L5—, (g) —L4—N(R5)—S(O)p—L7—L5—, (h) optionally subs

Abstract: A novel composition has been discovered for decontaminating biofilm-contaminated surfaces (the “Biocidal Complex”). The novel composition both kills bacteria and destroys at least a part of the biofilm. The composition comprises an effective amount of a free-radical generating compound (e.g., hydrogen peroxide), a disinfectant from the “GRAS” list of food-safe compounds (e.g., thymol), and an acid sulfate such as sodium bisulfate (NaHSO4) to acidify the solution and help catalyze free radical formation. A preferred method of using this invention employs a multi-component approach that permits long-term storage of the components in a stable, concentrated form. Immediately before use, the components are mixed and then applied to the biofilm-contaminated surface. A separate metal catalyst for the generation of free-radicals may be added to increase the production of free radicals in the Biocidal Complex.

Abstract: The invention provides compounds that inhibit epoxide hydrolase in therapeutic applications for treating hypertension. A preferred class of compounds for practicing the invention have the structure shown by wherein R is alkyl or aryl, the compound is trans-across the epoxide ring, OX is a carbonyl (═O) or hydroxy group (OH) and R′ is a H, alkyl or aryl group. The invention further provides methods of identifying patients at increased risk for hypertension, comprising assaying for epoxide hydrolase activity in a urine sample from the patient. In particular, the assays comprise determining the amount of dihydroxyeicosatrienoic acids (DHETs), determining the amount of epoxyeicosatrienoic acids (EETs) in said sample, or determining the amount of both DHETs and EETs in said sample.

Abstract: The invention provides vitamin k-dependent polypeptides with enhanced membrane binding affinity. These polypeptides can be used to modulate clot formation in mammals. Methods of modulating clot formation in mammals are also described.

Abstract: An associative memory composed of plural chips or a single chip which is preferably used in the fields of bandwidth compression for video images in mobile communication terminals and artificial intelligence systems. The associative memory is a small-area associative memory formed using CMOS technology with a fast parallel minimum-distance-search capability. The transistor number of the provided search circuit is only linear proportional to the number of rows of the associative memory. Therefore, the increase in the number of required circuits is small even if the unit number of the input data or the unit number of the reference data is large. With the associative memory, it is possible to realize the functions of video signal compression and object recognition necessary for artificial intelligence systems, data bank systems and mobile network terminals with a single chip or plural chips.

Abstract: A novel growth factor, persephin, which belongs to the GDNF/neurturin family of growth factors, is disclosed. The mouse and rat amino acid sequences have been identified. Mouse and rat persephin genomic DNA sequences have been cloned and sequenced and the respective cDNA sequences identified. In addition, methods for treating degenerative conditions using persephin, methods for detecting persephin gene alterations and methods for detecting and monitoring patient levels of persephin are provided. Methods for identifying additional members of the persephin-neurturin-GDNF family of growth factors are also provided.

Abstract: In a micro gas turbine engine, a capacitive sensor is used for measuring a tip clearance of a radial compressor section thereof, and an actuator is used for axially displacing a rotor shaft in response to an output from the capacitive sensor. Because the capacitive change gives an accurate measure of the size of the tip clearance, a particularly high sensitivity can be achieved in parts where the tip clearance is small, thereby providing a highly precise tip clearance control.

Abstract: The angular imaging system, and related method utilizes translating apertures to acquire data at a number of angles of interrogation. For omnidirectional scatterers, that is scatterers which emit a uniform sound field in all directions when insonified, the translating apertures should theoretically yield identical speckle patterns at all angles of interrogation. The result is in strong contrast to previously applied convention angular scatter measurement methods which produced rapidly varying speckle patterns with interrogation angle. Thus by using the translating apertures, using the transmit aperture translator (62), and the receive aperture translator (72), it is possible to acquire data for which the only variation in received signal with angle is due to the intrinsic scattering of the target.

Abstract: A gene which encodes a murine leukocyte &agr;(1,3)fucosyltransferase capable of synthesizing the sialyl Lewis x determinant has been cloned.

Abstract: A method and system are provided for effecting interactive, three-dimensional renderings of selected body organs for purposes of medical observation and diagnosis. A series of CT images of the selected body organs are acquired. The series of CT images is stacked to form a three-dimensional volume file. To facilitate interactive three-dimensional rendering, the three-dimensional volume file may be subjected to an optional dataset reduction procedure to reduce pixel resolution and/or to divide the three-dimensional volume file into selected subvolumes. From a selected volume or subvolume, the image of a selected body organ is segmented or isolated. A wireframe model of the segmented organ image is then generated to enable interactive, three-dimensional rendering of the selected organ.

Abstract: The present invention provides methods for treating physical conditions resulting from postmenopausel estrogen decline in a postmenopausel subject, and in particular methods for reducing the risk of osteoporotic bone fractures in a postmenopausal subject. The present invention also provides a kit for carrying out the methods of the present invention.

Abstract: A method of broadband amplification divides an optical signal of wavelength of 1430 nm to 1620 nm at a preselected wavelength into a first beam and a second beam. The first beam is directed to at least one optical amplifier and produces an amplified first beam. The second beam is directed to at least one rare earth doped fiber amplifier to produce an amplified second beam. The first and second amplified beams are combined.