Abstract: A gene that encodes an inhibitor of CDK4 has been discovered and its genomic nucleotide sequence has been identified. Susceptibility to certain cancers has been shown to be causatively related to the deletion of, or polymorphisms in, the CDK4I gene. The invention is therefore directed to the gene (CDK4I), the inhibitor protein, as well as therapeutic and diagnostic methods which utilize both the CDK4I gene and the CDK4I protein.

Abstract: Methods for detecting FlaA1 and enzymes with FlaA1-like activity are disclosed. Methods for screening for inhibitors of the enzymes are disclosed which are useful as anti-microbial agents.

Abstract: The invention relates to variant peptides which bind to HLA molecules, leading to lysis of cells via cytolytic T cell lines. The variants are based upon NY-ESO-1 peptides. The peptides can be incorporated into immune tetramers, which are useful as T cell sorters.

Abstract: The present invention includes free-standing, shaped ceramic-bearing bodies useful in fluid sensors, filters, and catalyst devices. The invention also includes methods and processes for using such devices. In a preferred embodiment of the invention, shaped metallic foils are converted into free-standing, porous rutile foils having an open pore structure by oxidation at an elevated temperature. The exposure of such foils to increasing concentrations of reducing gases such as carbon monoxide results in an increase in the steady-state electrical resistance. The resultant ceramic-bearing bodies may be used as effective sensors of reducing gas species in such applications as automobile and industrial emissions.

Abstract: A remote control for use with a configurable target device. The remote control includes a keypad having a plurality of keys including a function key and a transmission circuit for transmitting a signal to the target device in response to activation of one or more of the plurality of keys. Activation of the function key causes the transmitted signal to be comprised of a command to effect a change in the configuration of the target device where the command is selected from a table comprised of a plurality of commands in the event that a single command has not been assigned to the function key.

Abstract: A polymer which comprises one or more units of formula (II) in the backbone: —R2—A—L—A—R3—A—L—A—  (II) wherein R2 and R3 are each independently a group that will yield a biologically active compound upon hydrolysis of the polymer; each A is independently an amide or ester linkage; and each L is independently a linking group. Methods of producing these polymer, intermediates useful for preparing these polymers, and methods of using these polymers to deliver biologically active compounds to a host are also provided.

Abstract: A thermoacoustic refrigeration device employs a gas-vapor mixture as the working fluid. As a result, the refrigeration device operates according to a modified thermoacoustic refrigeration cycle that adds a condensation-vaporization cycle to the thermoacoustic cycle. The resulting modified refrigeration cycle increases the efficiency of heat transport by harnessing the translational motion of the vapor, as well as the usual acoustic oscillations, to transport the heat energy from one end of a thermal stack to the other.

Abstract: Fluoropolymers consisting of alternating perfluorocyclobutane and aryl ether linkages possess suitable properties for optical waveguides and other devices using refractive properties of the polymers. Perfluorocyclobutane (PFCB) polymers having aryl groups alternating on an ether chain have shown useful physical properties for optical waveguide applications. Processes for micromolding such polymeric films by replicating a pattern or image directly from a silicon master, rather than from a polydimethyl siloxane (PDMS) mold) are disclosed.

Abstract: An ink jet printing medium for an embossed interior decorating member includes a base member having a face, a thermoplastic resin layer deposited on the face of the base member, and a non-aqueous and porous ink receiving layer, deposited on the thermoplastic resin layer, for receiving liquid pigment ink. The thermoplastic resin layer is made of a material including a thermoplastic resin and a heating foaming agent dispersed in the thermoplastic resin. In an aspect, the thermoplastic resin layer has not yet been foamed. In another aspect, the thermoplastic resin layer has already been foamed. In still another aspect, the thermoplastic resin layer has already been foamed and embossed.

Abstract: A brake and anti-tipping system for a conventional wheelchair is disclosed. The system engages the ground to prevent rearward movement of a wheelchair and is disengaged when the wheelchair is occupied. The braking and anti-tipping system comprises a pivotable member which is pivotably supported between portions of a wheelchair frame assembly, a pair of arms each of which is fastened to the pivotable member, an abutment member which is supported on upper ends of arms, and a biasing member which is secured between the wheelchair frame assembly and wheelchair brake system.

Abstract: A method of producing a nanocomposite coating without gaseous precursor reactants. A non-nanocrystalline particulate containing a polymorphic material in an atmospheric phase is introduced into a high-velocity gas jet. The projected particulate is allowed to impact a substrate at a velocity effective to cause at a least a portion of the polymorphic material to transform to a nanocrystalline, high pressure phase.

Abstract: Novel substituted pentacenes and electronic devices made with those substituted pentacenes are disclosed.

Abstract: This invention is generally related to a method of making a molecule-surface interface comprising at least one surface comprising at least one material and at least one organic group wherein the organic group is adjoined to the surface and the method comprises contacting at least one organic group precursor with at least one surface wherein the organic group precursor is capable of reacting with the surface in a manner sufficient to adjoin the organic group and the surface.

Abstract: Provided herein are OspA polypeptides from Lyme Disease-causing Borrelia having certain alteration(s). In one embodiment, the alteration(s) increase the conformational stability of the OspA polypeptide containing the alteration(s) while maintaining at least some of the antigenicity of the corresponding unaltered OspA polypeptide. In another embodiment, the altered OspA polypeptide has reduced cross-reactivity to hLFA-1, as compared to the corresponding unaltered OspA polypeptide.

Abstract: Featured are devices, systems and methods for localized heating of a vessel as well as devices, systems and methods for MR/NMR imaging of a vessel while locally heating a portion of the vessel. More particularly featured are such devices, systems and methods for use when administering or delivering therapeutic agents including genes and/or drugs to the tissues of the vessel. Such a method includes positioning a thermal energy delivery device proximal a target site of an internal the vessel of a body and activating the thermal energy delivery device so as to heat the target site thereby locally increasing a temperature of tissue at the target site. In further embodiments, the method includes introducing a therapeutic medium to the target site over a predetermined time period, and wherein said activating occurs at least one of before, during or after said step of introducing.

Abstract: An improved magnetoelectric composite which incorporates LaSrMn or LaCaMn oxides as a magnetostrictive composition are described. The magnetostrictive composition preferably has the formula La0.7Sr0.3MnO3 or La0.7Ca0.3MnO3. The composites preferably have a magnetostrictive layer joined to a piezoelectric layer. The composites are useful for sensors, read-heads, storage media and high frequency transducer devices.

Abstract: In present invention, a photonic integrated circuit includes a number of optical coupling ports that extend from the surface of the device through at least a dedicated fibre guiding layer or a planar structure for coupling the end of an optical fibre mounted within the optical coupling port to an underlying planar optical wave guide or other light emitting device so that, in use, light is coupled between the underlying optical wave guide or light emitting device and the optical fibre. The other and of the optical fibre may be coupled to an optical fibre holder or to another optimal coupling port. An important advantage of the present invention is the flexibility it gives to a designer since it eliminates the need to for waveguides to be routed to the edge of the chip. It also solves the problem of aligning a large number of fibres onto a chip since the optical coupling ports allow fibres to be passively aligned.

Abstract: A method and apparatus are provided for at least partially disinfecting biological fluid of a mammal, which comprises pathogens in addition to normal cellular fractions. The method includes placing the biological fluid in a reaction volume and contacting a non-thermal plasma with the biological fluid to thereby kill at least a portion of the pathogens within the biological fluid.

Abstract: A new and distinct cultivar of red raspberry (i.e., Rubus idaeus L. ) is provided. The cultivar, designated WSU 1090, forms exceptionally large fruit with good flavor. The fruit is conical in shape. The fruit is larger, firmer, and has a greater length / width ratio than the fruit of most raspberry cultivars.

Abstract: A compound of general formula I below useful as an anticonvulsant for disorders of the central nervous system: wherein: R1, R2, R3 and R4 may be the same or different and each represents a hydrogen or halogen atom, or a C1-9 alkyl, C3-9cycloalkyl, cyano, C1-9alkoxy or C6-10aryloxy group; R5 represents a hydrogen atom or a C1-9alkyl, C3-9cycloalkyl or C6-10aryl group; and X is oxygen or sulfur; or a pharmaceutically-acceptable salt thereof. The compound may be adimistered orally for treating convulsions in humans or animals.