Abstract: The subject invention provides plants with excellent resistance to powdery mildew. In a specific embodiment, the subject invention provides dogwood (Cornus florida) cultivars that are resistant to infestation with powdery mildew. Specifically exemplified herein are culitvars identified as ‘Jean's Appalachian Snow’, ‘Kay's Appalachian Mist’, and ‘Karen's Appalachian Blush’. The present invention also provides materials and methods for identifying, characterizing, and/or producing powdery mildew resistant plants. In a specific embodiment, the subject invention provides polynucleotide sequences, and patterns of polynucleotide sequences, which are associated with resistance to powdery mildew. These polynucleotides are characteristic of the powdery mildew resistant plants as described herein. Such polynucleotides are particularly useful in identifying and characterizing plant having resistance to powdery mildew.

Abstract: Disclosed is a method for the comprehensive analysis of nucleic acid samples and a detector composition for use in the method. The method, referred to as Fixed Address Analysis of Sequence Tags (FAAST), involves generation of a set of nucleic acid fragments having a variety of sticky end sequences; indexing of the fragments into sets based on the sequence of sticky ends; associating a detector sequence with the fragments; sequence-based capture of the indexed fragments on a detector array; and detection of the fragment labels. Generation of the multiple sticky end sequences is accomplished by incubating the nucleic acid sample with one or more nucleic acid cleaving reagents. The indexed fragments are captured by hybridization and coupling, preferably by ligation, to a probe. The method allows a complex sample of nucleic acid to be quickly and easily cataloged in a reproducible and sequence-specific manner.

Abstract: The present invention relates to patterning methods for organic devices, and more particularly to patterning methods using a die. A first layer of organic materials is deposited over a substrate, followed by a first electrode layer. A first patterned die having a raised portion is then pressed onto the first electrode layer, such that the raised portion of the first patterned die contacts portions of the first electrode layer. The patterned die is removed, such that the portions of the first electrode layer in contact with the raised portions of the first patterned die are removed. In one embodiment of the invention, a second organic layer is then deposited over the first electrode layer, followed by a second electrode layer. A second patterned die having a raised portion is pressed onto the second electrode layer, such that the raised portion of the second patterned die contacts portions of the second electrode layer.

Abstract: Modified starch materials having a number average molecular weight of at least 10,000 for nutritional products provide a relatively slow release of metabolizable carbohydrates, giving a source of carbohydrate energy over a longer period of time than can be obtained from glucose and other carbohydrates such as lactose, fructose, or sucrose. Such modified starch material possess altered processing and pasting profile characteristics.

Abstract: A self-similar log-periodic antenna is described comprising a plurality of substantially triangular conductive elements, 4, symmetrically disposed in either planar or curved configurations about a central conductive boom to form an antenna arm. Two or more antenna arms are assembled into an antenna by symmetrically locating such antenna arms substantially in the shape of a pyramid (for planar arms) or in a conical shape (for curved arms). Some embodiments include a conductive fin, 5, to reduce cross-polarization coupling between antenna arms. Some embodiments include a grounded conductive shield on the interior of the antenna providing electromagnetic shielding for the interior region of the antenna while preserving the self-similar geometry of the antenna and shield combination.

Abstract: This invention provides reagents and methods for specifically delivering antibiotic, antimicrobial and antiviral compounds, drugs and agents to phagocytic mammalian cells. The invention also relates to specific delivery to and uptake of such compounds by phagocytic cells. The invention specifically relates to reagents and methods for facilitating the entry of antibiotic, antimicrobial and antiviral compounds, drugs and agents into phagocytic cells. The invention specifically provides compositions of matter and pharmaceutical embodiments of such compositions comprising such antibiotic, antimicrobial or antiviral compounds, drugs and agents conjugated to, impregnated with or coated onto particulate carriers generally termed microparticles. In particular embodiments, the antibiotic, antimicrobial and antiviral compounds, drugs and agents are covalently linked to a microparticle via a specifically-degradable linker molecule which is the target of a microorganism-specific protein having enzymatic activity.

Abstract: The present invention is directed to methods of using and compositions comprising amelogenin peptides capable of inducing chondrogenesis and osteogenesis when implanted in vivo, a chondrogenesis in cultures in vitro. Compositions and methods of enhancing bone and cartilage growth using these peptides are described.

Abstract: An isolation device is disclosed. The isolation device may have a movable partition and a housing disposed about the movable partition. The isolation device may have a partition biaser joined to the partition, and a CO2 scrubber. A method of delivering inspiratory gas to a patient is also disclosed.

Abstract: A blood-flow decrease preventing agent is used to negate or reduce the decreased oxygen delivery in abdominal organs caused by insufflating gas. Preferably a gas is delivered into the abdominal cavity consisting essentially of the insufflating gas and the blood-flow decrease preventing agent. Very preferably, a gas is used consisting essentially of carbon dioxide as the insufflating gas and ethyl nitrite as the blood-flow to abdominal organ decrease preventing agent.

Abstract: Haemophilus adhesion and penetration proteins, nucleic acids, vaccines and monoclonal antibodies are provided.

Abstract: The present invention relates to compositions comprising analogues of purine nucleosides containing a ring-expanded (“fat”) heterocyclic ring, in place of purine, and an unmodified or modified sugar residue, pharmaceutically acceptable derivatives of such compositions, as well as methods of use thereof. In particular, these compositions may be utilized in the treatment of certain cancers, bacterial, fungal, parasitic, and viral infections, including, but not limited to, Acquired Immunodeficiency Syndrome (AIDS), hepatitis, Epstein-Barr and cytomegalovirus.

Abstract: Compounds and methods for mitigating neurodegeneration, effecting neuroprotection and/or effecting cognition enhancement in a subject are described. Neurological or cognitive conditions are treated by administering to a subject an effective amount of a therapeutic compound comprising a nitrate ester, or a pharmaceutically acceptable salt or ester thereof.

Abstract: Disulfide proteins showed mitigated allergenicity and increased digestibility by pepsin following reduction by thioredoxin. The sulfhydryl groups newly formed on reduction by thioredoxin (at 4° C.) or dithiothreitol (DTT) (at 55° C.) were blocked with a physiological disulfide, such as cystamine or oxidized glutathione (GSSG) to obtain stable forms of the disarmed allergen. When derivatized with cystamine, BLG was separated from its oxidized and reduced forms on non-reducing SDS-PAGE and appeared to lack sulfhydryl groups. Although less effective GSSG, gave similar results. Allergenicity of the two derivatives was compared with that of the oxidized, reduced and reoxidized forms of BLG by skin testing dogs from a colony sensitized to cow's milk. Both the cystamine and GSSG derivatized BLG showed decreased allergenicity and increased sensitivity to pepsin as compared to controls. The reoxidized form resembled the derivatives in having lower allergenicity.

Abstract: A method and an apparatus for predicting and detecting epileptic seizure onsets within a unified multiresolution probabilistic framework, enabling a portion of the device to automatically deliver a progression of multiple therapies, ranging from benign to aggressive as the probabilities of seizure warrant. Based on novel computational intelligence algorithms, a realistic posterior probability function P(St|x) representing the probability of one or more seizures starting within the next T minutes, given observations x derived from IEEG or other signals, is periodically synthesized for a plurality of prediction time horizons. When coupled with optimally determined thresholds for alarm or therapy activation, probabilities defined in this manner provide anticipatory time-localization of events in a synergistic logarithmic-like array of time resolutions, thus effectively circumventing the performance vs. prediction-horizon tradeoff of single-resolution systems.

Abstract: A lithium metal oxide positive electrode for a non-aqueous lithium cell is disclosed. The cell is prepared in its initial discharged state and has a general formula xLiMO2.(1-x)Li2M′O3 in which 0<x<1, and where M is one or more trivalent ion with at least one ion being Mn or Ni, and where M′ is one or more tetravalent ion. Complete cells or batteries are disclosed with anode, cathode and electrolyte as are batteries of several cells connected in parallel or series or both.

Abstract: An oxidation resistant carbon composite material comprises nanocrystalline silicon carbide regions distributed throughout a carbon matrix. The composite is prepared by intermixing in a solvent a silicon carbide precursor and a carbon precursor and forming a solution that is free of solids. After removing the solvent from the mixture, the remaining material is pyrolyzed and forms the characteristic nanocrystalline silicon carbide in a carbon matrix. A composite made by the subject method and a part made from the composite are also provided.

Abstract: A host is immunized against infection by a strain of Chlamydia by initial administration of an attenuated bacteria harbouring a nucleic acid encoding a Chlamydia protein followed by administration of a Chlamydia protein in ISCOMs. This procedure enables a high level of protection to be achieved.

Abstract: A method is provided for selective binding and detecting target molecules, and a method for detecting biological molecules, the method comprising supplying a semi-conductor capable of charge pair separation, and juxtaposing affinity moieties to the semi-conductor so as to effect changes in the charge pair separation characteristics when the affinity molecules are bound to the target molecules.

Abstract: A folded Sagnac fiber optic sensor array uses a common delay path to reduce distributed pickup in downlead fibers. The sensor array is used to detect perturbations (e.g., acoustic waves in water). By basing the folded Sagnac sensor array on operating principles similar to the Sagnac interferometer the sensor array has a stable bias point, has reduced phase noise, and allows a broadband signal source to be used rather than requiring a more expensive narrowline laser. A large number of sensors can be multiplexed into the architecture of the sensor array. In one particularly preferred embodiment, the sensor array is configured with couplers and amplifiers selected to direct substantially equal portions of an input light signal to each sensor in the array. In another particularly preferred embodiment, first and second delay paths are provided for light at first and second wavelengths to increase the dynamic range of the sensors.

Abstract: A new and distinct Chrysanthemum plant named MN98-E90-15 is provided. This new cultivar was the result of a cross between Dendranthema weyrichii and Dendranthema×grandiflora.