Abstract: The present invention feature antisense IAP nucleic acids and other negative regulators of the IAP anti-apoptotic pathway, and methods for using them to enhance apoptosis.

Abstract: A method and apparatus for ex-situ nuclear magnetic resonance spectroscopy for use on samples outside the physical limits of the magnets in inhomogeneous static and radio-frequency fields. Chemical shift spectra can be resolved with the method using sequences of correlated, composite z-rotation pulses in the presence of spatially matched static and radio frequency field gradients producing nutation echoes. The amplitude of the echoes is modulated by the chemical shift interaction and an inhomogeneity free FID may be recovered by stroboscopically sampling the maxima of the echoes. In an alternative embodiment, full-passage adiabatic pulses are consecutively applied. One embodiment of the apparatus generates a static magnetic field that has a variable saddle point.

Abstract: The present invention provides methods and compositions for the treatment of Alzheimer's disease. In particular, the present invention provides methods and compositions suitable to assess, characterize, and identify inhibitors of neuronal transport of Alzheimer's amyloid precursor protein.

Abstract: The present invention provides methods of using a microbe containing a polypeptide that degrades, preferably detoxifies, a compound that is present in the environment. Preferably, the polypeptide is a hydrolase and the compound is at least one s-triazine. The present invention also provides a microbe containing a polypeptide that degrades, preferably detoxifies, a compound that is present in the environment.

Abstract: Methods and devices for preventing a change in the core body temperature of a mammal under cold conditions are provided. In the subject methods, a requirement for thermal energy input in said mammal is first detected. In response to the detection of this requirement for thermal energy input, a surface of a portion of the mammal is contacted with a warm temperature medium under negative pressure conditions for a period of time sufficient to introduce thermal energy into the core body of the mammal. The subject devices include at least a means for detecting a requirement for thermal energy input and a means for contacting a surface of the mammal with a warm temperature medium under negative pressure conditions. The subject methods and devices find use in a variety of applications, and are particularly suited for use in maintaining the core body temperature of a mammal substantially constant under cold conditions for an extended period of time.

Abstract: Imaging apparatus are used in a toroid cavity detector for nuclear magnetic resonance (NMR) analysis to hold samples relative to a principal detector element which is a flat metal conductor, the plane of which is parallel to the longitudinal axis of the toroid cavity. A sample is held adjacent to or in contact with the principal detector element so that the sample can be subjected to NMR analysis when a static main homogeneous magnetic field (B0) produced by a NMR magnetic device is applied to the toroid cavity and an RF excitation signal pulse is supplied from a potentiostat to the principal detector element so that an alternately energized and de-energized magnetic field (B1) is produced in the sample and through the toroid cavity.

Abstract: A fluorescence average excited-state lifetime sensor and sensing method comprising a fluorescence excitation light source, light-directing apparatus directing light from the light source to a sample, light-receiving apparatus receiving fluorescence light generated by the sample, and a narrow-band resonance amplifier providing gain necessary to support self-oscillations in an opto-electronic loop comprising the light source, the sample, the light-directing apparatus, the light-receiving apparatus, and the resonance amplifier.

Abstract: Transgene constructs for generating transgenic animals, wherein the transgene encodes a gene product which modulates transcription of a hypertrophy-sensitive gene, are provided. Further provided are recombinant vectors comprising the transgenes of the invention. Further provided are transgenic animals generated using the transgene constructs. Further provided are enzyme-based, cell-based, and whole-animal-based assays for detecting substances having therapeutic activity toward cardiac hypertrophy. Further provided are compositions comprising substances which modulate levels of active product of a hypertrophy-sensitive gene. Further provided are methods of treating cardiac hypertrophy.

Abstract: Methods for treating diseases or disorders of the skin which are characterized by angiogenesis have been developed using curcumin and curcumin analogs. Based on the results obtained with curcumin, it has been determined that other angiogenesis inhibitors can also be used to treat these skin disorders. It has further been discovered that curcumin acts to inhibit angiogenesis in part by inhibition of basic fibroblast growth factor (bFGF), and thereby provides a means for treating other disorders characterized by elevated levels of bFGF, such as bladder cancer, using curcumin and other analogues which also inhibit bFGF.

Abstract: Disclosed are bioluminescent bioreporter integrated circuit devices that detect selected analytes in fluids when implanted in the body of an animal. The device comprises a bioreporter that has been genetically engineered to contain a nucleic acid segment that comprises a cis-activating response element that is responsive to the selected substance operably linked to a gene encoding a bioluminescent reporter polypeptide. In preferred embodiments, the target analyte is glucose, glucagons, or insulin. Exposure of the bioreporter to the target substance causes the response element to up-regulate the nucleic acid sequence encoding the reporter polypeptide to produce a luminescent response that is detected and quantitated. In illustrative embodiments, the bioreporter device is encapsulated on an integrated circuit that is capable of detecting the emitted light, processing the resultant signal, and then remotely reporting the results.

Abstract: The present invention is directed to a workstation having a base including two spaced apart arcuate legs having a common first radius. A worksurface support assembly is supported on the base and includes two spaced apart arcuate supports. Each support has a common second radius that is equal to the common first radius of the legs. Elongate slots extend through each of the supports. Each of the legs has a central segment that is received in a respective one of the elongate slots in the supports. Each of the supports includes an arcuate member that is slidably fitted on a support track. A worksurface is secured to and supported by the arcuate members. A lift assembly is provided and is configured to move the worksurface support assembly in a generally horizontal direction with respect to the base to vertically adjust the worksurface between upper and lower elevational positions.

Abstract: The inventive bioprocessing system (and technique) relies on non-invasive optical chemical sensing technology wherein an optical excitation source excites an optical chemical sensor. The optical chemical sensor then emits luminescence or absorbs light which is measured by a detector. The luminescence emitted from the chemical sensor or the amount of light absorbed by the chemical sensor is related to the concentration of an analyte, such as oxygen. If the luminescence emitted changes, or if the amount of light absorbed changes, then the concentration of the analyte has changed. Using such a system to measure and adjust multiple parameters at one time allows one to efficiently and cost-effectively determine optimal conditions for a given cell type and/or cell environment, for example.

Abstract: With highly heterogeneous groups or streams of minerals, physical segregation using online quality measurements is an economically important first stage of the mineral beneficiation process. Segregation enables high quality fractions of the stream to bypass processing, such as cleaning operations, thereby reducing the associated costs and avoiding the yield losses inherent in any downstream separation process. The present invention includes various methods for reliably segregating a mineral stream into at least one fraction meeting desired quality specifications while at the same time maximizing yield of that fraction.

Abstract: Methods for detecting allelic variants of the myostatin (growth and differentiation factor-8) gene are provided. Specifically provided are methods of identifying subjects having or having a predisposition for increased muscle mass as compared to subjects having wild-type myostatin. Increased muscle mass is particularly desirable for identification of animals used to produce food products, including bovine, porcine, ovine, avian and piscine species.

Abstract: The invention concerns an alkaloid glycoside for use in medicine. In a preferred aspect, the alkaloid glycoside is used for the stimulation of a class I-restricted immune response and/or a class II-restricted immune response. In a preferred aspect, the alkaloid glycoside is tomatine.

Abstract: The present invention provides formulae for fluorescent compounds that have a number of properties which make them uniquely suited for use in sensors of analytes such as saccharides. The advantageous fluorescent properties include favorable excitation wavelengths, emission wavelengths, fluorescence lifetimes, and photostability. Additional advantageous properties include enhanced aqueous solubility, as well as temperature and pH sensitivity. The compound comprises an aryl or a substituted phenyl botonic acid that acts as a substrate recognition component, a fluorescence switch component, and a fluorophore. Fluorescent compounds are described that are excited at wavelengths greater than 400 nm and emit at wavelengths greater than 450 nm, which is advantageous for optical transmission through skin. The fluorophore is typically selected from transition metal-ligand complexes and thiazine, oxazine, oxazone, or oxazine-one as well as anthracene compounds.

Abstract: A method is described for treating hypercholesterolemic atherosclerosis or for reducing total cholesterol while raising high-density lipoportoein cholesterol. It involves administering to a patient a substantially pure complex derived from flaxseed and containing secoisolariciresinol diglucoside (SDG), cinnamic acid glucosides and hydroxymethyl glutaric acid.

Abstract: Partitioned sigma instructions are provided in which processor capacity is effectively distributed among multiple sigma operations which are executed concurrently. Special registers are included for aligning data on memory word boundaries to reduce packing overhead in providing long data words for multimedia instructions which implement shifting data sequences over multiple iterations. Extended partitioned arithmetic instructions are provided to improve precision and avoid accumulated carry over errors. Partitioned formatting instructions, including partitioned interleave, partitioned compress, and partitioned interleave and compress pack subwords in an effective order for other partitioned operations.

Abstract: The present invention relates to a device and method for measuring force, primarily due to fatigue. In one embodiment, a finger fatigue measuring system is provided which measures the force output from fingers while the fingers are repetitively generating forces as they strike a keyboard. Force profiles of the fingers are generated from the measurements and evaluated for fatigue. The system can be used clinically to evaluate patients, to ascertain the effectiveness of clinical intervention, pre-employment screening, to assist in minimizing the incidence of repetitive stress injuries at the keyboard, mouse, joystick, and to monitor effectiveness of various finger strengthening systems. The system can also be used in a variety of different applications adapted for measuring forces produced during performance of repetitive motions.

Abstract: A method and apparatus for monitoring the progress of the solidification of a solidifying material involves using a transmitter to transmit a relatively low frequency compression wave to the solidifying material. A receiver is provided for detecting the resonant compression wave vibrations induced in the solidifying material, and the detected wave vibrations are analyzed to obtain an indication of the progress of solidification.