Abstract: Disclosed are novel polymers derivatized with at least one —SNO group per 1200 atomic mass unit of the polymer. In one embodiment, the S-nitrosylated polymer has stabilized —S-nitrosyl groups. In another embodiment the S-nitrosylated polymer prepared by polymerizing a compound represented by the following structural formula: R is an organic radical. Each X′ is an independently chosen aliphatic group or substituted aliphatic group. Preferably, each X′ is the same and is a C2-C6 alkylene group, more preferably —CH2—, —CH2CH2—, —CH2CH2CH2— or —CH2CH2CH2CH2—. p and m are independently a positive integer such that p+m is greater than two. The polymers of the present invention can be used to coat medical devices to deliver nitric oxide in vivo to treatment sites.

Abstract: The present invention is directed to a workstation having a base including two spaced apart arcuate legs having a common first radius. A worksurface support assembly is supported on the base and includes two spaced apart arcuate supports. Each support has a common second radius that is equal to the common first radius of the legs. Elongate slots extend through each of the supports. Each of the legs has a central segment that is received in a respective one of the elongate slots in the supports. Each of the supports includes an arcuate member that is slidably fitted on a support track. A worksurface is secured to and supported by the arcuate members. A lift assembly is provided and is configured to move the worksurface support assembly in a generally horizontal direction with respect to the base to vertically adjust the worksurface between upper and lower elevational positions.

Abstract: Oliognucleotide primers are provided that are specific for nucleic acid characteristic of certain beta-lactamases. The primers can be employed in methods to identify nucleic acid characteristic of family-specific beta-lactamase enzymes in samples, and particularly, in clinical isolates of Gram-negative bacteria.

Abstract: In the invention, an analog signal is converted to an optical deflection. In preferred embodiments, an N-bit parallel output is obtained. A particularly preferred embodiment patterns the light beam with a spatial filter into an N-bit binary light pattern that is then collected and sensed by optical detectors.

Abstract: The invention provides genetic suppressor elements that confer upon a cell resistance to platinum-based drugs, including cisplatin, methods for identifying and obtaining such elements, and methods of using such elements. The invention also provides cloned genes associated with sensitivity to cisplatin.

Abstract: This invention is based on the discovery that certain genes have expression levels that are substantially increased or decreased in the liver of animals with diabetes. Monitoring the expression levels of such genes allows diagnosis of diabetes. In certain embodiments, the invention also provides methods of modulating the expression levels of such genes to treat diabetes and diabetic complications. In other embodiments, the invention provides a screening assay that identifies compounds which modulate the expression level of polynucleotides or functional properties of polypeptides that are over or under expressed in diabetes. In some cases, these compounds can be used to treat diabetes and diabetic complications. In still other embodiments, the invention provides assays to determine whether compounds intended for treatment of other diseases also induce diabetes.

Abstract: The present invention provides a class of semi-interpenetrating polymeric networks that include a linear polymer molecule functionalized with a bioactive moiety. The linear polymer is physically entangled within a matrix based upon a thermo-responsive polymer. The bioactive moiety is, e.g., a therapeutic moiety or a moiety that enhances the interaction of a cell with the polymer network. The polymer networks of the invention are flowable at room temperature, becoming solid or semi-solid at elevated temperatures (e.g., body temperature). The polymer networks are of use as drug delivery vehicles and as matrices for tissue engineering.

Abstract: The present invention provides nucleic acids and amino acids for novel gustatory receptors as well as methods for identifying gustatory receptors. More specifically, the present invention provides nucleic acids and amino acids for novel gustatory receptors in Drosophila as well as methods of using the provided nucleic acids and amino acids. In addition, this invention provides methods of identifying ligands which bind to the novel gustatory receptors as well as a variety of methods for using the receptors and ligands so identified.

Abstract: The present invention provides methods for creating conditionally-immortal cell lines. These transgenic cell lines can be grown indefinitely in culture while maintaining a relatively undifferentiated stated. Upon appropriate switch signal, the cells cease replicating and differentiate much like adult cells. The switch is facilitated by the inactivation of a transforming gene, such as large T antigen. A convenient methodology for such inactivation is Cre-Lox mediated excision of the gene. Cardiac cells are provided as an example of useful a transgenic cell line.

Abstract: The present invention provides the compound having the formula: 1

Abstract: The present invention pertains to a monoclonal antibody, or fragment thereof, having an antigen-binding specific region for NKX3.1 and to a hybridoma cell line for producing the monoclonal antibody. The present invention also pertains to a method for detecting the presence of NKX3.1 in a sample. The method comprises (a) contacting a biopsy tissue sample with a monoclonal antibody, or a fragment thereof, having an antigen-binding specific region for NKX3.1, under conditions permitting immunospecific binding between the monoclonal antibody, or a fragment thereof, and NKX3.1 in the sample; and (b) detecting whether immunospecific binding has occurred to detect the presence of NKX3.1 in the sample.

Abstract: The subject invention provides polynucleotide sequences, designated BIVM, and transcriptional/translation products obtained from the polynucleotide sequences of the invention. The subject invention also provides polynucleotide and polypeptide sequences provided by SEQ ID NOs:1-28. Also provided are methods of detecting the presence of BIVM nucleic acids or polypeptides in samples suspected of containing BIVM genes, BIVM transcriptional products, or BIVM translational products. These methods are also useful for the detection of BIVM orthologs. Other embodiments provide polypeptide and/or nucleic acid vaccines for the induction of an immune response to in an individual. Kits for detecting the presence of BIVM genes, orthologs thereof, BIVM polypeptides, or BIVM transcriptional products are also provided.

Abstract: Electrochemical fabrication (e.g. EFAB) processes and apparatus are disclosed that provide monitoring of at least one electrical parameter (e.g. voltage) during selective deposition where the monitored parameter is used to help determine the quality of the deposition that was made. If the monitored parameter indicates that a problem occurred with the deposition, various remedial operations may be undertaken to allow successful formation of the structure to be completed.

Abstract: The present invention generally relates to plant nitrogen regulatory PII gene (hereinafter P-PII gene), a gene involved in regulating plant nitrogen metabolism. The invention provides P-PII nucleotide sequences, expression constructs comprising said nucleotide sequences, and host cells and plants having said constructs and, optionally expressing the P-PII gene from said constructs. The invention also provides substantially pure P-PII proteins.

Abstract: A storage device for the storage and retrieval of arbitrary sequences of binary information provides areal densities exceeding terabytes per square centimeter (TB/cm2) and even petabytes per square centimeter (PB/cm2) in a 3D configuration. The information is encoded in long strands of biological or non-biological molecules such as artificial DNA, RNA or other synthetic molecules that form a macromolecule. The strands are written in-situ and, in some cases synthesized in-situ, transported to and from read and write stations and memory locations on the device. The data is read out by detecting individual bases or collection of bases directly from the strand.

Abstract: The nucleic acid sequence of the POMC enhancer is disclosed herein. Sequences from the human, rat, rabbit, hamster, mouse, and cow POMC enhancer are disclosed. Hybrid transgenes, comprising a POMC transcriptional control element operably linked to a nucleic acid sequence encoding a marker are also enclosed. In addition, transgenic mice carrying a hybrid transgene including a POMC control element operably linked to a marker are disclosed herein.

Abstract: An instrument-holding projection imaging vector guide and method of use is provided herein. In one embodiment of the present invention, a instrument-holding projection imaging vector guide is provided comprising a radio-opaque skin entry point member, a frame member and a diaphragm. The radio-opaque skin entry member is used to determine a skin entry point. The diaphragm is used to determine a diaphragm entry point. The radio-opaque skin entry point member and the diaphragm together determine the vector along which an appropriate medical instrument is to follow in order to contact a target inside a patient's body.

Abstract: An apparatus for producing a radionuclide includes a target chamber including a beam strike region for containing a liquid and a condenser region for containing a vapor. A particle beam source is operatively aligned with the beam strike region, and a lower liquid conduit communicates with the beam strike region. The condenser region is disposed above the beam strike region in fluid communication therewith for receiving heat energy from the beam strike region and transferring condensate to the beam strike region. The lower liquid conduit transfers liquid to and from the beam strike region. In operation, the target chamber acts as a thermosyphon that is self-regulating in response to heat energy deposited by the particle beam source. A portion of the liquid expands into the lower liquid conduit prior to boiling. After boiling begins, a vapor void is created above the liquid and an evaporation/condensation cycle is established, with additional liquid being displaced into the lower liquid conduit.

Abstract: We introduce a general designing procedure that allows us, for any given photonic crystal slab, to create an appropriate line defect structure that possesses single-mode bands with large bandwidth and low dispersion within the photonic band gap region below the light line. This procedure involves designing a high index dielectric waveguide that is phase matched with the gap of the photonic crystal slab, and embedding the dielectric waveguide as a line defect into a crystal in a specific configuration that is free of edge states within the guiding bandwidth. As an example, we show a single mode line defect waveguide with a bandwidth approaching 13% of the center-band frequency, and with a linear dispersion relation throughout most of the bandwidth.

Abstract: Melatonin (N-acetyl-5-methoxytryptamine), or its biologically active analogues, are used to induce anesthesia.