Patents Assigned to UPMC
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Publication number: 20240090810Abstract: A neurofeedback system includes an EEG apparatus, a presentation apparatus and a controller. The controller is configured to: (i) cause the presentation apparatus to display an overlaid image to the user that comprises a first image flickering at a first frequency and a second image flickering at a second frequency different than the first frequency, the first image being an affective distractor stimulus image and the second image being a task-relevant stimulus image, (ii) receive from the EEG apparatus a number of first steady-state visual evoked potential (SSVEP) signals generated in response the first image of the overlaid image and a number of second SSVEP signals generated in response the second image of the overlaid image, and (iii) calculate feedback indicative of how much attention of the was user allocated to the task-relevant stimulus image versus how much attention of the user was allocated to the affective distractor stimulus image.Type: ApplicationFiled: September 19, 2023Publication date: March 21, 2024Applicants: UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, UPMC, NORTHEASTERN UNIVERSITYInventors: Mary L. Woody, Murat Akcakaya, Sarah Ostadabbas, Rebecca Price, Xiaofei Huang, Richard T. Gall, Anna Wears, Nastasia O. McDonald, Jennifer Mak
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Patent number: 11836319Abstract: Disclosed herein are systems, methods, and devices for sensing touch at a surface. Sensing touch can be achieved while decreasing the number of sensors at a surface as well as data and computation complexity, but maintaining accuracy. Such sensing touch can be achieved via applying excitation and detecting emission waveforms at a surface that are associated with touch at a surface.Type: GrantFiled: August 6, 2020Date of Patent: December 5, 2023Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education, UPMCInventor: David A. Anderson
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Patent number: 11793961Abstract: A temporary esophagus occlusion device for providing temporary occlusion of the esophagus during intubation of a in patient includes a frame configured to transition between a contracted state, in which it can be swallowed by the patient, and an expanded state, wherein in the expanded state, the frame has a maximum outer diameter sufficient to span an inner diameter of the esophagus of the patient. The device also includes a flexible cover connected to and extending over at least a portion of the frame when the frame is in the expanded state to at least partially block flow of fluid and/or solid materials through the esophagus and a guidewire attached to the frame, sized to be swallowed by the patient along with the frame and having a proximal end portion configured to remain external to the patient's body and a distal end connected to the frame.Type: GrantFiled: October 18, 2017Date of Patent: October 24, 2023Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education, UPMCInventors: Youngjae Chun, Philip Charles Carullo
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Patent number: 11793863Abstract: Disclosed herein are embodiments of a functionalized microbubble designed for treating and/or preventing vascular obstructions, including microvascular obstructions. The functionalized microbubble embodiments comprise a microbubble that can be activated upon exposure to ultrasound and further that has a lipid-based shell that is attached to an exteriorly-attached therapeutically active agent, such as a thrombolytic agent. Also disclosed herein are embodiments of a method for making and using the functionalized microbubble embodiments.Type: GrantFiled: April 24, 2020Date of Patent: October 24, 2023Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education, UPMCInventors: John J. Pacella, Xucai Chen, Francois Tchi Ho Yu, Thiruganesh Ramasamy, Stephen D'Auria
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Publication number: 20230217916Abstract: Disclosed herein are ex-vivo cardiac perfusion systems that can support the metabolic function of an ex-vivo heart and also have the capacity to test the functions of the heart. For example, an ex-vivo heart can be placed within and connected to a cardiac perfusion system, as disclosed herein, resuscitated and supported medically, and also tested to determine cardiac recovery. Further, these systems can also be used for research purposes to study the pressure, work, and mechanical function of many types of hearts (e.g., failed hearts that are explanted at the time of heart transplant). Some embodiments include a detachable sub-system that includes a heart chamber and components for operating in a Langendorff mode while transporting an ex-vivo heart, and the sub-system can be coupled to a differential perfusion system to form a larger, full service system for supporting, recovering, testing the heart.Type: ApplicationFiled: June 10, 2021Publication date: July 13, 2023Applicants: University of Pittsburgh - Of the Commonwealth System of Higher Education, UPMCInventors: Christopher Michael Sciortino, Sarah Burki, Garrett N. Coyan, Brandon D'Aloiso
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Patent number: 11660442Abstract: A peripheral device for regulating neural correlates of arousal and emotion regulation to be worn or held against the body is disclosed. The device can be triggered by either physiological signs or manual intervention and produces cutaneous signals such as vibration or electricity using novel combinations of physiologically reactive frequencies without effort on the part of the user. One embodiment includes combining sensors that measure changes in physiological signals of stress such as speech rate and pitch, galvanic skin response, or heart rate variability, and, using a machine learning algorithm on personalized data, can determine whether these changes are likely to benefit from regulation. If they are outside an idiosyncratic predetermined range, the device produces stimulation and the person will feel regulated if they are touching/wearing the device, or can choose to use the device if it is not currently being touched or worn.Type: GrantFiled: April 3, 2017Date of Patent: May 30, 2023Assignees: University of Pittburgh-Of the Commonwealth System of Higher Education, UPMCInventors: Greg J. Siegle, David Mayer Lowell Rabin
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Publication number: 20230149620Abstract: Disclosed cannula systems can detect the tissue type within which the cannula tip is located in real time using electrodes adjacent the cannula tip. The sensing cannula system can differentiate when the cannula tip is in adipose tissue or muscle based on electrical impedance. The system can be used in fat grafting and liposuction procedures, for example. An operator can detect if the cannula tip enters muscle by watching for an indicator light or audible alarm that is automatically activated by the device based on a change in sensed impedance. The device may also stop the flow of fat through a pump halting injection into the sub-muscular space.Type: ApplicationFiled: January 3, 2023Publication date: May 18, 2023Applicants: University of Pittsburgh - Of the Commonwealth System of Higher Education, UPMCInventors: David Turer, William W. Clark, April Lawrence, Ehsan Qaium, Joseph P. Rubin, Cameron Dezfulian
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Publication number: 20230110584Abstract: Disclosed herein are safety devices that are positioned on the end of a fiberoptic cable, such as those used in surgical procedures, to prevent patients and other objects from the risk of burn from light or heat emitted from the end of the cable when not connected to an optical instrument. The disclosed safety devices can be added to the ends of existing cables and/or can be included at the end of cables during manufacture. In some embodiments, the safety device replaces an existing connector at the end of a cable, and in some embodiments the safety device is added in addition to a connector at the end of the cable. In some embodiments, a slit end cover is included over an open end of an adaptor that is mounted on a distal connector of a fiberoptic cable.Type: ApplicationFiled: December 13, 2022Publication date: April 13, 2023Applicants: University of Pittsburgh - Of the Commonwealth System of Higher Education, UPMCInventors: Steven Gerard Docimo, William W. Clark, Alexandra Marie Delazio, John A. Holmes, Benjamin T. Ristau
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Patent number: 11547787Abstract: Disclosed cannula systems can detect the tissue type within which the cannula tip is located in real time using electrodes adjacent the cannula tip. The sensing cannula system can differentiate when the cannula tip is in adipose tissue or muscle based on electrical impedance. The system can be used in fat grafting and liposuction procedures, for example. An operator can detect if the cannula tip enters muscle by watching for an indicator light or audible alarm that is automatically activated by the device based on a change in sensed impedance. The device may also stop the flow of fat through a pump halting injection into the sub-muscular space.Type: GrantFiled: May 10, 2019Date of Patent: January 10, 2023Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education, UPMCInventors: David Turer, William W. Clark, April Lawrence, Ehsan Qaium, Joseph P. Rubin, Cameron Dezfulian
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Patent number: 11534051Abstract: Disclosed herein are safety devices that are positioned on the end of a fiberoptic cable, such as those used in surgical procedures, to prevent patients and other objects from the risk of burn from light or heat emitted from the end of the cable when not connected to an optical instrument. The disclosed safety devices can be added to the ends of existing cables and/or can be included at the end of cables during manufacture. In some embodiments, the safety device replaces an existing connector at the end of a cable, and in some embodiments the safety device is added in addition to a connector at the end of the cable. In some embodiments, a slit end cover is included over an open end of an adaptor that is mounted on a distal connector of a fiberoptic cable.Type: GrantFiled: February 9, 2017Date of Patent: December 27, 2022Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education, UPMCInventors: Steven Gerard Docimo, William W. Clark, Alexandra Marie Delazio, John A. Holmes, Benjamin T. Ristau
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Patent number: 11508168Abstract: Systems, methods, devices, and other techniques using machine learning for interpreting, or assisting in the interpretation of, biologic specimens based on digital images are provided. Methods for improving image-based cellular identification, diagnostic methods, methods for evaluating effectiveness of a disease intervention, and visual outputs useful in assisting professionals in the interpretation of biologic specimens are also provided.Type: GrantFiled: October 15, 2019Date of Patent: November 22, 2022Assignee: UPMCInventors: Erastus Zachariah Allen, Keith Michael Callenberg, Liron Pantanowitz, Adit Bharat Sanghvi
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Publication number: 20220346908Abstract: Disclosed adjustable retaining arm systems can include a multi-segmented, articulable arm that holds one or more interchangeable tools and can be made relaxed to set a desired position and made rigid to fix the desired position by adjusting tension in a cable running through the arm. The arm can quickly attach and detach from a support structure. The support structure include a cable tensioning system, sensors, control system, power system, etc. A user input device, such as a foot pedal or button on the arm, can be used by a surgeon to change the arm between relaxed and rigid states. The arm and attachable tools can be detachable, disposable and/or sterilizable, while other system components can remain mounted in a fixed location as the arm is removed and replaced. The arm can hold multiple tools in any desired orientation around subject work location.Type: ApplicationFiled: July 11, 2022Publication date: November 3, 2022Applicants: University of Pittsburgh-Of the Commonwealth System of Higher Education, UPMCInventors: Jeffrey S. Vipperman, Christopher Michael Dumm, Garth Abraham Elias, Tyler Michael Ferris, Mark Scaife, Peter David Allen
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Patent number: 11488693Abstract: Among other things, unstructured text items are processed to identify elements of the unstructured text items relevant to classification rules of quality metrics applicable to services provided by a healthcare provider with respect to diseases, conditions, or interventions of patients. The classification rules define classifications of patients based on diseases, conditions, or interventions of patients or on aspects of the services provided. Through a user interface, the unstructured text items, the identified elements, and user interface controls for classifying the patients with respect to the classification rules, based on the identified elements, are presented to the user.Type: GrantFiled: November 1, 2018Date of Patent: November 1, 2022Assignee: UPMCInventors: Melissa Castine, Girish Chavan, Carly Cook, Rebecca Jacobson, Jody Madala, Amy Malanga, Eugene Tseytlin, Adam Yee
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Publication number: 20220273188Abstract: Described herein are sensing cannula systems that include a surgical instrument, a detection unit, and a conductive pad having a reference electrode and configured to be placed on the patient at a location outside the patient's body. The surgical instrument can include a cannula (such as a fat grafting cannula) having an electrically conductive distal tip and electrical insulation covering the cannula proximally from the distal tip, wherein the distal tip comprises a first electrode. The detection unit can include electrical circuitry that is electrically coupled to the surgical instrument and the conductive pad and operable to measure an electrical impedance between the first electrode and the reference electrode to determine what type of tissue the distal tip is in.Type: ApplicationFiled: March 23, 2020Publication date: September 1, 2022Applicants: University of Pittsburgh - Of the Commonwealth System of Higher Education, UPMCInventors: David Turer, William W. Clark, April Lawrence, Ehsan Qaium, Joseph Peter Rubin, Cameron Dezfulian
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Patent number: 11382716Abstract: Disclosed adjustable retaining arm systems can include a multi-segmented, articulable arm that holds one or more interchangeable tools and can be made relaxed to set a desired position and made rigid to fix the desired position by adjusting tension in a cable running through the arm. The arm can quickly attach and detach from a support structure. The support structure include a cable tensioning system, sensors, control system, power system, etc. A user input device, such as a foot pedal or button on the arm, can be used by a surgeon to change the arm between relaxed and rigid states. The arm and attachable tools can be detachable, disposable and/or sterilizable, while other system components can remain mounted in a fixed location as the arm is removed and replaced. The arm can hold multiple tools in any desired orientation around subject work location.Type: GrantFiled: February 2, 2018Date of Patent: July 12, 2022Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education, UPMCInventors: Jeffrey S. Vipperman, Christopher Michael Dumm, Garth Abraham Elias, Tyler Michael Ferris, Mark Scaife, Peter David Allen
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Publication number: 20220125856Abstract: The present disclosure provides methods for restoring reproductive health and/or fertility in a subject by delivering immature follicles to the subject using an ovarian-derived hydrogel. The present disclosure also provides methods for treating ovarian-associated diseases using ovarian-derived hydrogels or their derivatives for delivery of therapeutic agents to the subject in need thereof. The present disclosure further provides kits for restoring reproductive health and/or fertility, and kits for treating ovarian-associated diseases.Type: ApplicationFiled: December 30, 2021Publication date: April 28, 2022Applicants: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, UPMCInventors: Michael Joseph BUCKENMEYER, Kyle E. ORWIG, Bryan Nicklaus BROWN, Meena SUKHWANI
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Publication number: 20220054463Abstract: The present disclosure relates to the use of a platelet inhibitor to prevent and/or treat aneurysms. The methods include prevention and/or treatment of aneurysms with the administration of a platelet inhibitor to a subject. The present disclosure further provides kits for performing such methods.Type: ApplicationFiled: August 17, 2021Publication date: February 24, 2022Applicants: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, UPMCInventors: Robert Max Friedlander, Wendy Fellows Mayle, Michael P. D'Angelo, Kamil W. Nowicki
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Patent number: 11213258Abstract: Methods are disclosed for determining a prognosis of a test patient following or during a surgical procedure. In some embodiments, the disclosed methods comprise forming a test data vector characterizing concurrent measures of mean arterial pressure (MAP), bispectral index (BIS), and standard minimum alveolar concentration (MAC) of the test patient from sequential time intervals during the surgical procedure. A K-means clustering procedure is performed on the test data vector and a plurality of reference data vectors characterizing concurrent MAP, BIS, and MAC measures for sequential time intervals during surgical procedures from reference patients with known clinical outcome. A prognosis of one or more post-surgical outcomes of the test patient is determined based on the known surgical outcome of reference patients in the cluster including the test data vector.Type: GrantFiled: August 7, 2018Date of Patent: January 4, 2022Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education, UPMCInventors: Michael Schnetz, Ata Kaynar
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Patent number: 11134886Abstract: A new and/or novel image analysis technique for quantitative assessment of motion-based testing for injury in a patient using universally available and affordable devices and techniques is provided and disclosed. A video of a test being performed can be processed to track the motion of markers and/or bodily landmarks in two or more dimensions to quantitatively describe motion, thereby removing the subjective aspects typically associated with motion-based testing. In an example, the pivot shift test is a commonly used test for evaluating rotational instability of the anterior cruciate ligament (ACL)-deficient knee. The pivot shift test's subjective grading scale can be quantified and refined using image analysis techniques.Type: GrantFiled: March 23, 2018Date of Patent: October 5, 2021Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education, UPMCInventors: Volker Musahl, Yuichi Hoshino, Paulo Henrique Mendes De Araujo, Mattias Ahlden, James Irrgang, Freddie H. Fu, Richard E. Debski
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Publication number: 20210236700Abstract: The present invention relates to substrates and composites having dynamic, reversible micron-level luminal surface deformation including texture or geometric instabilities, e.g., surface wrinkling and folding. The surface deformation and its reversal to the original surface form or to another, different surface form, is effective to reduce or prevent surface fouling and, more particularly, in certain applications, to reduce or prevent unwanted platelet adhesion and thrombus formation. The substrates and composites include a wide variety of designs and, more particularly, biomedical-related designs, such as, synthetic vascular graft or patch designs.Type: ApplicationFiled: October 18, 2017Publication date: August 5, 2021Applicants: UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, UPMC, UNIVERSIDAD DE SANTIAGO DE CHILEInventors: WILLIAM R. WAGNER, SACHIN SHANKAR VELANKAR, SANG HO YE, EDITH TZENG, LUKA POCIVAVSEK, ENRIQUE CERDA