Patents Assigned to UPMC
-
Patent number: 12239776Abstract: Disclosed cannula systems can detect the tissue type within which the cannula tip is located in real time using electrodes adjacent the cannula tip. The sensing cannula system can differentiate when the cannula tip is in adipose tissue or muscle based on electrical impedance. The system can be used in fat grafting and liposuction procedures, for example. An operator can detect if the cannula tip enters muscle by watching for an indicator light or audible alarm that is automatically activated by the device based on a change in sensed impedance. The device may also stop the flow of fat through a pump halting injection into the sub-muscular space.Type: GrantFiled: January 3, 2023Date of Patent: March 4, 2025Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education, UPMCInventors: David Turer, William W. Clark, April Lawrence, Ehsan Qaium, Joseph P. Rubin, Cameron Dezfulian
-
Publication number: 20250027954Abstract: The present disclosure provides a whole blood, protein-based diagnostic test for presence of unruptured aneurysms and allow for tracking progression of unruptured, ruptured, and previously treated aneurysms to guide clinical decision making. Further, the present disclosure relates to methods of treating aneurysms.Type: ApplicationFiled: August 2, 2024Publication date: January 23, 2025Applicants: UNIVERSITY PF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCTION, UPMCInventors: Robert Max Friedlander, Ali A. Alattar, Kamil W. Nowicki, Michael M. McDowell, Aditya M. Mittal
-
Publication number: 20250001111Abstract: Disclosed herein are endotracheal tubes that have multiple inflatable cuffs to help form a seal for ventilation, to reduce unwanted migration of the tube relative to the patient, reduce focalized pressure from a single cuff, and to help prevent aspiration of materials between the outside of the tube and the tracheal walls. Some devices include first and second distal cuffs for placement within the trachea and a proximal third cuff for blocking the entrance to the trachea. The cuffs can include ridges or textures to enhance sealing. The device can also include inflation channels, vacuum channels, and pressure sensors.Type: ApplicationFiled: July 14, 2022Publication date: January 2, 2025Applicants: University of Pittsburgh - Of the Commonwealth System of Higher Education, UPMCInventors: Carl H. Snyderman, Nikki Cwalina, Brinden Elton, Maxwell Baxter, Garrett N. Coyan
-
Patent number: 12181858Abstract: A computer-based workflow management method is provided for use in connection with a process for printing an object with a three-dimensional printer. The method includes executing a request queue phase comprising receiving instructions for defining a request for printing the object; executing an anatomic modeling phase comprising generating an anatomic three-dimensional model representing the object; and executing a build phase comprising printing an object in response to the generated anatomic model. The method includes generating and displaying various user interface screens programmed for visualizing different aspects of phases or stages of the three-dimensional printing process.Type: GrantFiled: June 7, 2022Date of Patent: December 31, 2024Assignee: UPMCInventors: Elliott Hammersley, April Krivoniak, Denise Layne, Mark Briercheck, Anish Ghodadra
-
Publication number: 20240325667Abstract: Disclosed herein are endotracheal tubes that have external baffles near the distal end of the tube to reduce unwanted migration of the tube relative to the trachea and to help prevent materials from passing between the outside of the tube and the tracheal walls. The baffles can be made of soft flexible material that conforms to and seals against the trachea. The baffles can be angled proximally or distally, or both. The baffles can be tapered in thickness and can vary in radial length. Some embodiments can include a supraglottic umbrella. Some embodiments can include an axially expandable portion along the tube. Some embodiments can include a loading tube that helps set the deflection orientation of the baffles within the trachea.Type: ApplicationFiled: July 14, 2022Publication date: October 3, 2024Applicants: University of Pittsburgh - Of the Commonwealth System of Higher Education, UPMCInventors: Carl H. Snyderman, Garrett N. Coyan
-
Publication number: 20240252087Abstract: Disclosed are wearable bands, such as rings, for monitoring and diagnosing cardiovascular conditions of a wearer, along with related systems, algorithms, and methods. The disclosed wearable bands can continuously monitor the wearer's cardiovascular status by measuring heart rate and/or other physiological properties of the wearer. Disclosed wearable bands can further comprise at least two EKG electrodes, including a first electrode on the inner surface adapted to detect a signal from the finger and a second electrode on the outer surface adapted to detect a cardiovascular signal from another body part. The wearable bands can be linked wirelessly to a mobile device that the person can interact with. The mobile device can be linked to other distributed system components and healthcare providers, such as to send a message to a predetermined recipient based upon the physiological properties measured by the wearable band.Type: ApplicationFiled: April 12, 2024Publication date: August 1, 2024Applicants: University of Pittsburgh - Of the Commonwealth System of Higher Education, UPMCInventors: George Stuart Mendenhall, Matthew Jones
-
Patent number: 12042343Abstract: Disclosed adjustable retaining arm systems can include a multi-segmented, articulable arm that holds one or more interchangeable tools and can be made relaxed to set a desired position and made rigid to fix the desired position by adjusting tension in a cable running through the arm. The arm can quickly attach and detach from a support structure. The support structure include a cable tensioning system, sensors, control system, power system, etc. A user input device, such as a foot pedal or button on the arm, can be used by a surgeon to change the arm between relaxed and rigid states. The arm and attachable tools can be detachable, disposable and/or sterilizable, while other system components can remain mounted in a fixed location as the arm is removed and replaced. The arm can hold multiple tools in any desired orientation around subject work location.Type: GrantFiled: July 11, 2022Date of Patent: July 23, 2024Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education, UPMCInventors: Jeffrey S. Vipperman, Christopher Michael Dumm, Garth Abraham Elias, Tyler Michael Ferris, Mark Scaife, Peter David Allen
-
Patent number: 12016846Abstract: The present disclosure relates to the use of a platelet inhibitor to prevent and/or treat aneurysms. The methods include prevention and/or treatment of aneurysms with the administration of a platelet inhibitor to a subject. The present disclosure further provides kits for performing such methods.Type: GrantFiled: August 17, 2021Date of Patent: June 25, 2024Assignees: UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, UPMCInventors: Robert Max Friedlander, Wendy Fellows Mayle, Michael P. D'Angelo, Kamil W. Nowicki
-
Patent number: 11980468Abstract: Disclosed are wearable devices, such as rings and bracelets, for monitoring and diagnosing cardiovascular conditions of a wearer, along with related systems, algorithms and methods. The disclosed wearable devices can continuously monitor the wearer's cardiovascular status by measuring heart rate, motion, blood oxygenation, and/or other properties of the wearer. Disclosed wearable devices can further comprise three EKG electrodes, including a first electrode on the inner surface adapted to detect a signal from the finger/wrist, a second electrode on the outer surface adapted to detect a cardiovascular signal from a finger of the opposing hand, and a third electrode on the outer surface of the frame adapted to detect a cardiovascular signal from a EKG lead location on the wearer's chest or leg. The wearable devices can be linked wirelessly to a mobile device that the person can interact with, and can further be linked to other distributed system components and healthcare providers.Type: GrantFiled: October 23, 2020Date of Patent: May 14, 2024Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education, UPMCInventors: George Stuart Mendenhall, Matthew Jones
-
Publication number: 20240090810Abstract: A neurofeedback system includes an EEG apparatus, a presentation apparatus and a controller. The controller is configured to: (i) cause the presentation apparatus to display an overlaid image to the user that comprises a first image flickering at a first frequency and a second image flickering at a second frequency different than the first frequency, the first image being an affective distractor stimulus image and the second image being a task-relevant stimulus image, (ii) receive from the EEG apparatus a number of first steady-state visual evoked potential (SSVEP) signals generated in response the first image of the overlaid image and a number of second SSVEP signals generated in response the second image of the overlaid image, and (iii) calculate feedback indicative of how much attention of the was user allocated to the task-relevant stimulus image versus how much attention of the user was allocated to the affective distractor stimulus image.Type: ApplicationFiled: September 19, 2023Publication date: March 21, 2024Applicants: UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, UPMC, NORTHEASTERN UNIVERSITYInventors: Mary L. Woody, Murat Akcakaya, Sarah Ostadabbas, Rebecca Price, Xiaofei Huang, Richard T. Gall, Anna Wears, Nastasia O. McDonald, Jennifer Mak
-
Patent number: 11836319Abstract: Disclosed herein are systems, methods, and devices for sensing touch at a surface. Sensing touch can be achieved while decreasing the number of sensors at a surface as well as data and computation complexity, but maintaining accuracy. Such sensing touch can be achieved via applying excitation and detecting emission waveforms at a surface that are associated with touch at a surface.Type: GrantFiled: August 6, 2020Date of Patent: December 5, 2023Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education, UPMCInventor: David A. Anderson
-
Patent number: 11793863Abstract: Disclosed herein are embodiments of a functionalized microbubble designed for treating and/or preventing vascular obstructions, including microvascular obstructions. The functionalized microbubble embodiments comprise a microbubble that can be activated upon exposure to ultrasound and further that has a lipid-based shell that is attached to an exteriorly-attached therapeutically active agent, such as a thrombolytic agent. Also disclosed herein are embodiments of a method for making and using the functionalized microbubble embodiments.Type: GrantFiled: April 24, 2020Date of Patent: October 24, 2023Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education, UPMCInventors: John J. Pacella, Xucai Chen, Francois Tchi Ho Yu, Thiruganesh Ramasamy, Stephen D'Auria
-
Patent number: 11793961Abstract: A temporary esophagus occlusion device for providing temporary occlusion of the esophagus during intubation of a in patient includes a frame configured to transition between a contracted state, in which it can be swallowed by the patient, and an expanded state, wherein in the expanded state, the frame has a maximum outer diameter sufficient to span an inner diameter of the esophagus of the patient. The device also includes a flexible cover connected to and extending over at least a portion of the frame when the frame is in the expanded state to at least partially block flow of fluid and/or solid materials through the esophagus and a guidewire attached to the frame, sized to be swallowed by the patient along with the frame and having a proximal end portion configured to remain external to the patient's body and a distal end connected to the frame.Type: GrantFiled: October 18, 2017Date of Patent: October 24, 2023Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education, UPMCInventors: Youngjae Chun, Philip Charles Carullo
-
Publication number: 20230217916Abstract: Disclosed herein are ex-vivo cardiac perfusion systems that can support the metabolic function of an ex-vivo heart and also have the capacity to test the functions of the heart. For example, an ex-vivo heart can be placed within and connected to a cardiac perfusion system, as disclosed herein, resuscitated and supported medically, and also tested to determine cardiac recovery. Further, these systems can also be used for research purposes to study the pressure, work, and mechanical function of many types of hearts (e.g., failed hearts that are explanted at the time of heart transplant). Some embodiments include a detachable sub-system that includes a heart chamber and components for operating in a Langendorff mode while transporting an ex-vivo heart, and the sub-system can be coupled to a differential perfusion system to form a larger, full service system for supporting, recovering, testing the heart.Type: ApplicationFiled: June 10, 2021Publication date: July 13, 2023Applicants: University of Pittsburgh - Of the Commonwealth System of Higher Education, UPMCInventors: Christopher Michael Sciortino, Sarah Burki, Garrett N. Coyan, Brandon D'Aloiso
-
Patent number: 11660442Abstract: A peripheral device for regulating neural correlates of arousal and emotion regulation to be worn or held against the body is disclosed. The device can be triggered by either physiological signs or manual intervention and produces cutaneous signals such as vibration or electricity using novel combinations of physiologically reactive frequencies without effort on the part of the user. One embodiment includes combining sensors that measure changes in physiological signals of stress such as speech rate and pitch, galvanic skin response, or heart rate variability, and, using a machine learning algorithm on personalized data, can determine whether these changes are likely to benefit from regulation. If they are outside an idiosyncratic predetermined range, the device produces stimulation and the person will feel regulated if they are touching/wearing the device, or can choose to use the device if it is not currently being touched or worn.Type: GrantFiled: April 3, 2017Date of Patent: May 30, 2023Assignees: University of Pittburgh-Of the Commonwealth System of Higher Education, UPMCInventors: Greg J. Siegle, David Mayer Lowell Rabin
-
Publication number: 20230149620Abstract: Disclosed cannula systems can detect the tissue type within which the cannula tip is located in real time using electrodes adjacent the cannula tip. The sensing cannula system can differentiate when the cannula tip is in adipose tissue or muscle based on electrical impedance. The system can be used in fat grafting and liposuction procedures, for example. An operator can detect if the cannula tip enters muscle by watching for an indicator light or audible alarm that is automatically activated by the device based on a change in sensed impedance. The device may also stop the flow of fat through a pump halting injection into the sub-muscular space.Type: ApplicationFiled: January 3, 2023Publication date: May 18, 2023Applicants: University of Pittsburgh - Of the Commonwealth System of Higher Education, UPMCInventors: David Turer, William W. Clark, April Lawrence, Ehsan Qaium, Joseph P. Rubin, Cameron Dezfulian
-
Publication number: 20230110584Abstract: Disclosed herein are safety devices that are positioned on the end of a fiberoptic cable, such as those used in surgical procedures, to prevent patients and other objects from the risk of burn from light or heat emitted from the end of the cable when not connected to an optical instrument. The disclosed safety devices can be added to the ends of existing cables and/or can be included at the end of cables during manufacture. In some embodiments, the safety device replaces an existing connector at the end of a cable, and in some embodiments the safety device is added in addition to a connector at the end of the cable. In some embodiments, a slit end cover is included over an open end of an adaptor that is mounted on a distal connector of a fiberoptic cable.Type: ApplicationFiled: December 13, 2022Publication date: April 13, 2023Applicants: University of Pittsburgh - Of the Commonwealth System of Higher Education, UPMCInventors: Steven Gerard Docimo, William W. Clark, Alexandra Marie Delazio, John A. Holmes, Benjamin T. Ristau
-
Patent number: 11547787Abstract: Disclosed cannula systems can detect the tissue type within which the cannula tip is located in real time using electrodes adjacent the cannula tip. The sensing cannula system can differentiate when the cannula tip is in adipose tissue or muscle based on electrical impedance. The system can be used in fat grafting and liposuction procedures, for example. An operator can detect if the cannula tip enters muscle by watching for an indicator light or audible alarm that is automatically activated by the device based on a change in sensed impedance. The device may also stop the flow of fat through a pump halting injection into the sub-muscular space.Type: GrantFiled: May 10, 2019Date of Patent: January 10, 2023Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education, UPMCInventors: David Turer, William W. Clark, April Lawrence, Ehsan Qaium, Joseph P. Rubin, Cameron Dezfulian
-
Patent number: 11534051Abstract: Disclosed herein are safety devices that are positioned on the end of a fiberoptic cable, such as those used in surgical procedures, to prevent patients and other objects from the risk of burn from light or heat emitted from the end of the cable when not connected to an optical instrument. The disclosed safety devices can be added to the ends of existing cables and/or can be included at the end of cables during manufacture. In some embodiments, the safety device replaces an existing connector at the end of a cable, and in some embodiments the safety device is added in addition to a connector at the end of the cable. In some embodiments, a slit end cover is included over an open end of an adaptor that is mounted on a distal connector of a fiberoptic cable.Type: GrantFiled: February 9, 2017Date of Patent: December 27, 2022Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education, UPMCInventors: Steven Gerard Docimo, William W. Clark, Alexandra Marie Delazio, John A. Holmes, Benjamin T. Ristau
-
Patent number: 11508168Abstract: Systems, methods, devices, and other techniques using machine learning for interpreting, or assisting in the interpretation of, biologic specimens based on digital images are provided. Methods for improving image-based cellular identification, diagnostic methods, methods for evaluating effectiveness of a disease intervention, and visual outputs useful in assisting professionals in the interpretation of biologic specimens are also provided.Type: GrantFiled: October 15, 2019Date of Patent: November 22, 2022Assignee: UPMCInventors: Erastus Zachariah Allen, Keith Michael Callenberg, Liron Pantanowitz, Adit Bharat Sanghvi