Abstract: Disclosed is a functional derivative of a Photoactive Yellow Protein (PYP), or a functional fragment thereof, for fluorescently labelling particles, e.g. proteins, or surfaces, which is capable of binding reversibly a fluorogenic chromophore of formula (I), and which is capable of enhancing the brightness of the fluorogenic chromophore upon complexation thereto; and of inducing the spectral shift of the fluorogenic chromophore through the ionization of an auxochromic group thereof.

Abstract: A new and/or novel image analysis technique for quantitative assessment of motion-based testing for injury in a patient using universally available and affordable devices and techniques is provided and disclosed. A video of a test being performed can be processed to track the motion of markers and/or bodily landmarks in two or more dimensions to quantitatively describe motion, thereby removing the subjective aspects typically associated with motion-based testing. In an example, the pivot shift test is a commonly used test for evaluating rotational instability of the anterior cruciate ligament (ACL)-deficient knee. The pivot shift test's subjective grading scale can be quantified and refined using image analysis techniques.

Abstract: Disclosed are wearable devices, such as rings and bracelets, for monitoring and diagnosing cardiovascular conditions of a wearer, along with related systems, algorithms and methods. The disclosed wearable devices can continuously monitor the wearer's cardiovascular status by measuring heart rate, motion, blood oxygenation, and/or other properties of the wearer. Disclosed wearable devices can further comprise three EKG electrodes, including a first electrode on the inner surface adapted to detect a signal from the finger/wrist, a second electrode on the outer surface adapted to detect a cardiovascular signal from a finger of the opposing hand, and a third electrode on the outer surface of the frame adapted to detect a cardiovascular signal from a EKG lead location on the wearer's chest or leg. The wearable devices can be linked wirelessly to a mobile device that the person can interact with, and can further be linked to other distributed system components and healthcare providers.

Abstract: The present invention relates to a method for predicting the survival time of a patient suffering from myocardial infarction or the recurrence of a myocardial infarction. The method comprises the steps of i) determining the expression level of BAFF in a sample from the patient, ii) comparing the expression level with a predetermined reference value and iii) providing a good prognosis of the survival time or a low risk of the recurrence of a myocardial infarction when the expression level is lower than the predetermined reference value and a poor prognosis of the survival time or a high risk of the recurrence of a myocardial infarction when the expression level is higher than the predetermined reference value.

Abstract: The present invention relates to novel fluoroquinolones, pharmaceutical compositions or medicament containing them and use thereof to treat bacterial infection.

Abstract: An apparatus includes a computer system programmed to retrieve information from a plurality of data sources; the computer system including a plurality of vault query services; an adapter for each of the data sources, each adapter translating an interface for one of the data sources to a vault query service interface; and a cross-vault query service providing an interface for data communication between an application program and the plurality of vault query services; and a user display for displaying the information retrieved from the data sources in response to a query from the application program.

Abstract: A robotic strong arm (RSA) for assisting in the transfer of a person from a first surface to a second surface, comprising: first and second members, wherein in each member comprises a prismatic joint having first and second ends and comprising inner and outer shells and a motor for powered linear movement of the outer shell with respect to the inner shell; a first powered joint interconnecting the second end of the first member with the first end of the second member, wherein the first powered joint provides movement of the second member with respect to the first member; wherein the first end of the first member is attached to a rotatable base and wherein the rotatable base is movably attached for powered movement along a component associated with, and extending around at least a portion of a periphery about, the first surface; and a computer controller for controlling movements of the outer shells, first powered joint, rotation of the rotatable base and movement of the rotatable base and RSA along the compon

Abstract: A method for processing healthcare information includes: receiving information related to a patient and a plurality of providers involved with caring for the patient; using the information to generate patient centered provider graphs that describe relationships among the patient and the plurality of providers and include an indication of provider availability within a clinical situation; and presenting the graphs to a plurality of uses. An apparatus that is used to practice the method is also provided.

Abstract: The present invention relates to a soluble peptide comprising the amino acids sequence: KRFYVVMWKK (SEQ ID NO: 1) or a function-conservative variant thereof for use in the treatment of cancer. The invention also relates to a pharmaceutical composition for use in the treatment of cancer comprising at least one soluble peptide according to the invention or at least one acid nucleic according to the invention or at least one expression vector according to the invention, or at least one host cell according to the invention and a pharmaceutically acceptable carrier.

Abstract: The present invention presents new insights in the mechanism of action of the estrogen receptor alpha in breast cancer cells and provides means and tools for modulating said mechanisms of action, thereby influencing the proliferation of estrogen-positive cells such as cancer cells.

Abstract: An apparatus includes a computer system programmed to retrieve information from a plurality of data sources; the computer system including a plurality of vault query services; an adapter for each of the data sources, each adapter translating an interface for one of the data sources to a vault query service interface; and a cross-vault query service providing an interface for data communication between an application program and the plurality of vault query services; and a user display for displaying the information retrieved from the data sources in response to a query from the application program.

Abstract: A system and method for improved viewing and navigation of large digital images, such as whole slide images used in microscopy. The system and method displays the digital image along with movable navigation and field of view boxes that enable a viewer to pan the digital image in an accurate manner, and also performs automatic absolute reorientation of the digital image and automatic relative reorientation of subsequent digital images in relation to the first digital image.

Abstract: Methods for stimulating an immune response in a mammal by administering a toxin-antigen conjugate are provided. Pharmaceutical compositions and methods for treating an antigen-related state are also described.

Abstract: A system and method for improved viewing and navigation of large digital images, such as whole slide images used in microscopy. The system and method displays the digital image along with movable navigation and field of view boxes that enable a viewer to pan the digital image in an accurate manner, and also performs automatic absolute reorientation of the digital image and automatic relative reorientation of subsequent digital images in relation to the first digital image.

Abstract: An emergency management system includes a plurality of command centers, each having real time updated information about an area of interest, a plurality of uniquely identifiable portable monitors, each of the monitors including a sensor portion for determining one or more exposure parameters, and each of the monitors including a communications portion for providing two-way communications over redundant communications channels with at least two of the command centers. A method of managing emergency responders is also provided.

Abstract: An emergency management system comprises a plurality of command centers, each having real time updated information about an area of interest, a plurality of uniquely identifiable portable monitors, each of the monitors including a sensor portion for determining one or more exposure parameters, and each of the monitors including a communications portion for providing two-way communications over redundant communications channels with at least two of the command centers. A method of managing emergency responders is also provided.

Abstract: A system and method for improved viewing and navigation of large digital images, such as whole slide images used in microscopy. The system and method displays the digital image along with movable navigation and field of view boxes that enable a viewer to pan the digital image in an accurate manner, and also performs automatic absolute reorientation of the digital image and automatic relative reorientation of subsequent digital images in relation to the first digital image.

Abstract: An apparatus includes a container and a content identification device providing an audible identification of the contents of the container. The container can be included in an automatic dispensing system. A method is also provided. The method includes providing a container, and producing an audible identification of contents of the container in response to one of: opening the container, a request to access the contents of the container, or actual access of the contents of the container by a user.

Abstract: A method includes: receiving patient specific data; comparing the patient specific data with reference data; producing alerts when the comparison determines that an event requiring action has occurred; and sending the alerts to care providers. An apparatus that implements the method and a computer readable medium including instructions for performing the method are also provided.

Abstract: The present invention concerns a system for the focusing and/or a collimation of an ion beam, in particular a beam of accelerated protons, wherein the system has a lens with a lens body that is permeable to the ion beam, wherein means for the generation of an in particular electrostatic field, propagating within the lens body and focusing the ion beam, are provided, wherein the lens body has a wall of low thickness, wherein the means for the field generation comprise a source of electromagnetic radiation, whose emitted beam is directed onto the outer side of the wall of the lens body, wherein the thickness of the wall and the quality of the electromagnetic radiation is chosen such that the radiation generates free electrons that emerge from the wall and accumulate on the exit side of the wall in an electron cloud.