Abstract: The present invention relates to a soluble peptide comprising the amino acids sequence: KRFYVVMWKK (SEQ ID NO: 1) or a function-conservative variant thereof for use in the treatment of cancer. The invention also relates to a pharmaceutical composition for use in the treatment of cancer comprising at least one soluble peptide according to the invention or at least one acid nucleic according to the invention or at least one expression vector according to the invention, or at least one host cell according to the invention and a pharmaceutically acceptable carrier.

Abstract: The present invention presents new insights in the mechanism of action of the estrogen receptor alpha in breast cancer cells and provides means and tools for modulating said mechanisms of action, thereby influencing the proliferation of estrogen-positive cells such as cancer cells.

Abstract: An apparatus includes a computer system programmed to retrieve information from a plurality of data sources; the computer system including a plurality of vault query services; an adapter for each of the data sources, each adapter translating an interface for one of the data sources to a vault query service interface; and a cross-vault query service providing an interface for data communication between an application program and the plurality of vault query services; and a user display for displaying the information retrieved from the data sources in response to a query from the application program.

Abstract: A system and method for improved viewing and navigation of large digital images, such as whole slide images used in microscopy. The system and method displays the digital image along with movable navigation and field of view boxes that enable a viewer to pan the digital image in an accurate manner, and also performs automatic absolute reorientation of the digital image and automatic relative reorientation of subsequent digital images in relation to the first digital image.

Abstract: Methods for stimulating an immune response in a mammal by administering a toxin-antigen conjugate are provided. Pharmaceutical compositions and methods for treating an antigen-related state are also described.

Abstract: A system and method for improved viewing and navigation of large digital images, such as whole slide images used in microscopy. The system and method displays the digital image along with movable navigation and field of view boxes that enable a viewer to pan the digital image in an accurate manner, and also performs automatic absolute reorientation of the digital image and automatic relative reorientation of subsequent digital images in relation to the first digital image.

Abstract: An emergency management system includes a plurality of command centers, each having real time updated information about an area of interest, a plurality of uniquely identifiable portable monitors, each of the monitors including a sensor portion for determining one or more exposure parameters, and each of the monitors including a communications portion for providing two-way communications over redundant communications channels with at least two of the command centers. A method of managing emergency responders is also provided.

Abstract: An emergency management system comprises a plurality of command centers, each having real time updated information about an area of interest, a plurality of uniquely identifiable portable monitors, each of the monitors including a sensor portion for determining one or more exposure parameters, and each of the monitors including a communications portion for providing two-way communications over redundant communications channels with at least two of the command centers. A method of managing emergency responders is also provided.

Abstract: A system and method for improved viewing and navigation of large digital images, such as whole slide images used in microscopy. The system and method displays the digital image along with movable navigation and field of view boxes that enable a viewer to pan the digital image in an accurate manner, and also performs automatic absolute reorientation of the digital image and automatic relative reorientation of subsequent digital images in relation to the first digital image.

Abstract: An apparatus includes a container and a content identification device providing an audible identification of the contents of the container. The container can be included in an automatic dispensing system. A method is also provided. The method includes providing a container, and producing an audible identification of contents of the container in response to one of: opening the container, a request to access the contents of the container, or actual access of the contents of the container by a user.

Abstract: A method includes: receiving patient specific data; comparing the patient specific data with reference data; producing alerts when the comparison determines that an event requiring action has occurred; and sending the alerts to care providers. An apparatus that implements the method and a computer readable medium including instructions for performing the method are also provided.

Abstract: The present invention concerns a system for the focusing and/or a collimation of an ion beam, in particular a beam of accelerated protons, wherein the system has a lens with a lens body that is permeable to the ion beam, wherein means for the generation of an in particular electrostatic field, propagating within the lens body and focusing the ion beam, are provided, wherein the lens body has a wall of low thickness, wherein the means for the field generation comprise a source of electromagnetic radiation, whose emitted beam is directed onto the outer side of the wall of the lens body, wherein the thickness of the wall and the quality of the electromagnetic radiation is chosen such that the radiation generates free electrons that emerge from the wall and accumulate on the exit side of the wall in an electron cloud.

Abstract: A computer-implemented process includes: collecting a plurality of data; implementing a model that uses the data to estimate or predict lost work time at an individual level; and computing absenteeism risk at the individual level. The model can include, for example an artificial neural network or a model that uses regression analysis.

Abstract: An apparatus includes a monitor, a camera for sensing an image on the monitor, a translucent material positioned between the monitor and the camera, and a processor for receiving the sensed image from the camera, determining a location of a laser spot with respect to the sensed image, and controlling an aspect of the display in response to the location of the spot. A method performed by the apparatus is also provided.

Abstract: The invention pertains to methods for using chimeric polypeptides of the formula: B—X wherein B represents the B fragment of Shiga toxin or a functional equivalent thereof, and X represents one or more polypeptides of therapeutic significance. Compositions for therapeutic use comprising the polypeptide B—X are also included.

Abstract: A method for endothelial keratoplasty donor tissue transport and delivery to a recipient's eye, such as in DLEK, DSEK and DSAEK procedures, comprises the steps of: attaching endothelial keratoplasty donor tissue to a tissue holder, wherein the attachment between the tissue holder and the donor tissue is not on the endothelial layer of the endothelial keratoplasty donor tissue; placing the tissue holder and the attached donor tissue within a surrounding insertion tip; transporting the insertion tip to a position adjacent an access opening in the recipient's eye; inserting the tissue holder with the attached donor tissue through the opening and extending the tissue holder from within the insertion tip to position the donor tissue within the recipient's eye; and separating the attached donor tissue from the tissue holder with the tissue holder within the recipient's eye. An associated apparatus is disclosed.

Abstract: A computer-assisted method of assisting a health care provider in diagnosing and treating a patient. The method includes preparing an event-based sequence relating to a disease for which the patient is diagnosed and treated and accepting answers from the health care provider during at least one clinical contact with the patient to a plurality of questions relating to the disease, a stage of the disease, an intervention of the disease, and a response to the intervention. The method also includes segmenting the event-based sequence into a plurality of milestone events for use by the health care provider in diagnosing and treating the patient.

Abstract: A system and method for improved viewing and navigation of large digital images, such as whole slide images used in microscopy. The system and method displays the digital image along with movable navigation and field of view boxes that enable a viewer to pan the digital image in an accurate manner, and also performs automatic absolute reorientation of the digital image and automatic relative reorientation of subsequent digital images in relation to the first digital image.

Abstract: A point of care apparatus includes an identification system for automatically identifying the role of one or more persons in a room, a processor for determining information relevant to the role of the identified person, and a display for displaying the information. A method performed by the apparatus is also provided.

Abstract: The invention provides a method using matrix transformations of the three coordinate systems used in radiotherapy to correct for any deviation between a planned dosimetric treatment target and the actual location of the treatment target.