Abstract: Integrated, stand-alone, multiple-purpose pump stands are provided for controlled pumping of different liquids from a stand-mounted tank to a downstream use location, e.g., a seed treating device. The pump stands are equipped with an operating assembly including a liquid tank, a powered pump, a liquid flow line equipped with a flow meter from the tank and pump to the use location, and a programmable digital control device. During operation, the control device serves to approach and maintain the flow rate from the pump stand at or about a desired setpoint flow rate.

Abstract: A bulk seed handling system (20) is provided to facilitate seed transfer from a distributor to a farm and then to a planter or the like. The handling system (20) includes one or more upright bin assemblies (22) adapted to be moved in a filled condition, and a trailer (24) designed to move the bin assembly (22) and unload seed therefrom. The bin assembly (22) includes a seed bin (26) having a lower unload opening (34) and supported by a frame assembly (38) including telescopic legs (50) shiftable between a retractable travel position and an extended bin support position. The trailer (24) includes a lift frame (60) operable to engage and elevate the bin assembly (22) for travel with the legs (50) thereof in a retracted position, and a seed-conveying arrangement including an intermediate conveyor (62) and a delivery conveyor (64).

Abstract: The present invention is directed to methods and compositions for expanding and stabilizing the phenotype of natural regulatory T cells. In particular, the present invention provides methods and compositions for treating natural regulatory T cells that renders the cells resistant to factors present in the inflammatory milieu and stabilizes the suppressive properties of the cells.

Abstract: A seed metering gate assembly (12) is provided for use with an upright seed bin (10) having a shiftable primary gate (24), wherein the gate assembly (12) provides an additional seed flow control function allowing more accurate dispensing of seed from the bin (10). The gate assembly (12) includes a seed hopper (13) equipped with a fore and aft-shiftable metering gate (42) movable between a closed position and an open position presenting a seed output passageway (40). Apparatus (62) is operably coupled with the gate member (42) in order to determine the travel of metering gate member between the fully closed position and a plurality of open positions presenting respective, differently sized passageways (40). The apparatus (62) preferably includes a rod (64) having a series of through openings (70) and coupled with the gate member (42), with a shiftable, motion-limiting collar (72) mounted on the rod (64) and securable at any of the openings (70) by a clip (76).

Abstract: A low-profile particulate handling assembly is provided for use in conjunction with a downstream treating device, such as a seed treater unit. The assembly includes a plurality of juxtaposed particulate bins and a surmounting turret assembly designed to successively deliver particulates to the bins. The particulates within the bins are delivered to the downstream treating device through respective lower outlets each equipped with an adjustable slide gate assembly and a lower, multiple-chute assembly. Preferably, each bin has a top wall which in plan configuration approximates a sector of a circle, planar sidewalls, and downwardly tapered, arcuate sidewall structure leading to the lower outlet; in this fashion, the bins can be grouped with the sidewalls in close adjacency, and with the outlets located to feed into a single inlet of the downstream treating device.

Abstract: A low-profile particulate handling assembly is provided for use in conjunction with a downstream treating device, such as a seed treater unit. The assembly includes a plurality of juxtaposed particulate bins and a surmounting turret assembly designed to successively deliver particulates to the bins. The particulates within the bins are delivered to the downstream treating device through respective lower outlets each equipped with an adjustable slide gate assembly and a lower, multiple-chute assembly. Preferably, each bin has a top wall which in plan configuration approximates a sector of a circle, planar sidewalls, and downwardly tapered, arcuate sidewall structure leading to the lower outlet; in this fashion, the bins can be grouped with the sidewalls in close adjacency, and with the outlets located to feed into a single inlet of the downstream treating device.

Abstract: A low-profile particulate handling assembly is provided for use in conjunction with a downstream treating device, such as a seed treater unit. The assembly includes a plurality of juxtaposed particulate bins and a surmounting turret assembly designed to successively deliver particulates to the bins. The particulates within the bins are delivered to the downstream treating device through respective lower outlets each equipped with an adjustable slide gate assembly and a lower, multiple-chute assembly. Preferably, each bin has a top wall which in plan configuration approximates a sector of a circle, planar sidewalls, and downwardly tapered, arcuate sidewall structure leading to the lower outlet; in this fashion, the bins can be grouped with the sidewalls in close adjacency, and with the outlets located to feed into a single inlet of the downstream treating device.

Abstract: The invention provides a method and system for electrolytically coating an article. The method includes providing an article to be coated and disposing the article in an electrolytic cell. The cell includes an anode, a cathode in operable communication with the article, and an electrolyte bath. During electrolysis, the electrolyte bath comprises cobalt ions, phosphorous acid, and tribological particles selected from the group consisting of refractory materials, solid lubricants and mixtures thereof dispersed therein. The method further includes applying steady direct electric current through the anode, the electrolyte bath and the cathode to coat the article with cobalt, phosphorous and the tribological particles. An improved composition of matter is also provided that may be used as a coating, or the composition may be electroformed on a mandrel to form an article made from the composition of matter.

Abstract: A low-profile particulate handling assembly is provided for use in conjunction with a downstream treating device, such as a seed treater unit. The assembly includes a plurality of juxtaposed particulate bins and a surmounting turret assembly designed to successively deliver particulates to the bins. The particulates within the bins are delivered to the downstream treating device through respective lower outlets each equipped with an adjustable slide gate assembly and a lower, multiple-chute assembly. Preferably, each bin has a top wall which in plan configuration approximates a sector of a circle, planar sidewalls, and downwardly tapered, arcuate sidewall structure leading to the lower outlet; in this fashion, the bins can be grouped with the sidewalls in close adjacency, and with the outlets located to feed into a single inlet of the downstream treating device.

Abstract: A low-profile particulate handling assembly is provided for use in conjunction with a downstream treating device, such as a seed treater unit. The assembly includes a plurality of juxtaposed particulate bins and a surmounting turret assembly designed to successively deliver particulates to the bins. The particulates within the bins are delivered to the downstream treating device through respective lower outlets each equipped with an adjustable slide gate assembly and a lower, multiple-chute assembly. Preferably, each bin has a top wall which in plan configuration approximates a sector of a circle, planar sidewalls, and downwardly tapered, arcuate sidewall structure leading to the lower outlet; in this fashion, the bins can be grouped with the sidewalls in close adjacency, and with the outlets located to feed into a single inlet of the downstream treating device.

Abstract: A low-profile particulate handling assembly (24) is provided for use in conjunction with a downstream treating device, such as a seed treater unit (22). The assembly (24) includes a plurality of juxtaposed particulate bins (34) and a surmounting turret assembly (36) designed to successively deliver particulates to the bins (34). The particulates within the bins (34) are delivered to the downstream treating device through respective lower outlets (110) each equipped with an adjustable slide gate assembly (112) and a lower, multiple-chute assembly (114). Preferably, each bin (34) has a top wall (50) which in plan configuration approximates a sector of a circle, planar sidewalls (64), and downwardly tapered, arcuate sidewall structure (58) leading to the lower outlet (110); in this fashion, the bins (34) can be grouped with the sidewalls (64) in close adjacency, and with the outlets (110) located to feed into a single inlet (26) of the downstream treating device.

Abstract: The invention provides a method and system for electrolytically coating an article. The method includes providing an article to be coated and disposing the article in an electrolytic cell. The cell includes an anode, a cathode in operable communication with the article, and an electrolyte bath. During electrolysis, the electrolyte bath comprises cobalt ions, phosphorous acid, and tribological particles selected from the group consisting of refractory materials, solid lubricants and mixtures thereof dispersed therein. The method further includes applying steady direct electric current through the anode, the electrolyte bath and the cathode to coat the article with cobalt, phosphorous and the tribological particles. An improved composition of matter is also provided that may be used as a coating, or the composition may be electroformed on a mandrel to form an article made from the composition of matter.

Abstract: Compounds that act as capture agents to sequester unsaturated metal complexes are provided. In particular, the compounds may be host materials, dopant materials, or co-dopant materials containing functional groups, such as an isocyanide or a phosphine group, which are suitable for trapping an unsaturated coordination complex. These compounds may be used in organic light emitting devices, particularly blue devices, to provide improved device lifetime.

Abstract: A low-profile particulate handling assembly (24) is provided for use in conjunction with a downstream treating device, such as a seed treater unit (22). The assembly (24) includes a plurality of juxtaposed particulate bins (34) and a surmounting turret assembly (36) designed to successively deliver particulates to the bins (34). The particulates within the bins (34) are delivered to the downstream treating device through respective lower outlets (110) each equipped with an adjustable slide gate assembly (112) and a lower, multiple-chute assembly (114). Preferably, each bin (34) has a top wall (50) which in plan configuration approximates a sector of a circle, planar sidewalls (64), and downwardly tapered, arcuate sidewall structure (58) leading to the lower outlet (110); in this fashion, the bins (34) can be grouped with the sidewalls (64) in close adjacency, and with the outlets (110) located to feed into a single inlet (26) of the downstream treating device.

Abstract: The invention provides a method and system for electrolytically coating an article. The method includes providing an article to be coated and disposing the article in an electrolytic cell. The cell includes an anode, a cathode in operable communication with the article, and an electrolyte bath. During electrolysis, the electrolyte bath comprises cobalt ions, phosphorous acid, and tribological particles selected from the group consisting of refractory materials, solid lubricants and mixtures thereof dispersed therein. The method further includes applying steady direct electric current through the anode, the electrolyte bath and the cathode to coat the article with cobalt, phosphorous and the tribological particles. An improved composition of matter is also provided that may be used as a coating, or the composition may be electroformed on a mandrel to form an article made from the composition of matter.

Abstract: Particular aspects confirm the existence of a CpG island methylator phenotype (CIMP) in colorectal cancer, and provide novel validated DNA methylation markers associated with CIMP. Additional aspects provide novel methods and compositions for: determining CIMP status in colorectal cancers, determining the relationship between CIMP status and other molecular features of the cancers (e.g., BRAF mutation, KRAS mutation and MSI status); determining the relationship between CIMP status and other variables (e.g., age, sex, tumor location, family history, race, country of origin, tumor characteristics (including, tumor type, tumor grade, invasive margin characteristics, lymphocyte infiltration characteristics, direct spread, lymph node spread, venous spread and type of residual adjacent polyp, if present)); and determining, between subgroups defined by CIMP status and BRAF mutations, effects of selected risk factors (e.g.

Abstract: A seed metering gate assembly (12) is provided for use with an upright seed bin (10) having a shiftable primary gate (24), wherein the gate assembly (12) provides an additional seed flow control function allowing more accurate dispensing of seed from the bin (10). The gate assembly (12) includes a seed hopper (13) equipped with a fore and aft-shiftable metering gate (42) movable between a closed position and an open position presenting a seed output passageway (40). Apparatus (62) is operably coupled with the gate member (42) in order to determine the travel of metering gate member between the fully closed position and a plurality of open positions presenting respective, differently sized passageways (40). The apparatus (62) preferably includes a rod (64) having a series of through openings (70) and coupled with the gate member (42), with a shiftable, motion-limiting collar (72) mounted on the rod (64) and securable at any of the openings (70) by means of clip (76).

Abstract: A method and system are disclosed for computerized training, monitoring, certification or re-certification of human raters in clinical trials. The invention provides an interactive computerized interview that can be compared scores obtained by human raters to monitor and train clinical raters on a continuing basis in order to reduce rater drift and variance during clinical trials. Remediation can be automatically flagged or provided to improve a deviating rater's performance. Computerized assessment of symptom severity is provided without the need for human clinical raters. The system and method enable screening of prospective patients for inclusion or exclusion from a clinical trial by automatically obtaining computerized ratings of symptom severity.

Abstract: A bulk seed handling system (20) is provided to facilitate seed transfer from a distributor to a farm and then to a planter or the like. The handling system (20) includes one or more upright bin assemblies (22) adapted to be moved in a filled condition, and a trailer (24) designed to move the bin assembly (22) and unload seed therefrom. The bin assembly (22) includes a seed bin (26) having a lower unload opening (34) and supported by a frame assembly (38) including telescopic legs (50) shiftable between a retractable travel position and an extended bin support position. The trailer (24) includes a lift frame (60) operable to engage and elevate the bin assembly (22) for travel with the legs (50) thereof in a retracted position, and a seed-conveying arrangement including an intermediate conveyor (62) and a delivery conveyor (64).

Abstract: The present invention relates to methods for efficient adaptive measurement and classification of contrast sensitivity functions and spatiotemporal contrast sensitivity surface by selecting the most informative stimulus before each trial. Also disclosed are devices for implementing such methods.