Patents Assigned to USV Pharmaceutical
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Patent number: 4496542Abstract: Compounds of the formula ##STR1## wherein R and R.sub.9 are independently hydroxy and lower alkoxy,R.sub.1 and R.sub.2 are independently hydrogen, lower alkyl, aryl-lower alkyl having from 7 to 12 carbon atoms, or heterocyclic-lower alkyl having from 6 to 12 carbon atoms,R.sub.3, R.sub.4, R.sub.5, R.sub.7 and R.sub.8 are hydrogen or lower alkyl,R.sub.6 is heterocyclic and their pharmaceutically acceptable, nontoxic acid addition salts and where R or R.sub.9 or both are hydroxy, their pharmaceutically acceptable, nontoxic basic salts, possess antihypertensive activity.Type: GrantFiled: April 13, 1983Date of Patent: January 29, 1985Assignee: USV Pharmaceutical CorporationInventors: Jerry W. Skiles, Raymond D. Youssefyeh, John T. Suh, Howard Jones
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Patent number: 4491582Abstract: 1,4-Dihydropyridine carboxylic acid esters of the formula: ##STR1## wherein Ar is heteroaryl selected from the group consisting of thiophene, furan, pyridine, thiazole, pyrimidine, pyrrole, benzofuran, quinoline and benzothiophene, cycloalkyl having from 3 to 7 carbon atoms, naphthyl, indanyl, indenyl, tetrahydronaphthyl, or a radical of the formula ##STR2## wherein each of R.sub.5, R.sub.6 and R.sub.7 is independently H, alkyl, phenyl, tolyl, naphthyl, halo, lower alkoxy, nitro, amino, alkylmercapto, cyano, carboxy, carbalkoxy, sulfamyl, trifluoromethyl, hydroxy, methanesulfonyl, or alkylamino and R.sub.5 and R.sub.6 when taken together, form a methylenedioxy; Z is alkylene containing 1 to about 5 carbon atoms in the principal chain; each R.sub.1 is independently hydrogen, alkyl or alkoxyalkyl, with the proviso that only one R.sub.1 may be hydrogen; R.sub.2 is lower alkyl; and wherein N, R.sub.3 and R.sub.Type: GrantFiled: March 3, 1983Date of Patent: January 1, 1985Assignee: USV Pharmaceutical CorporationInventors: Bernard Loev, Howard Jones, John T. Suh
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Patent number: 4490373Abstract: A new method of treating asthma is provided. The method is the administration of an effective dose of a Benzoxazole-2-carboxylic acid amide.Type: GrantFiled: May 20, 1983Date of Patent: December 25, 1984Assignee: USV Pharmaceutical CorporationInventors: Bernard Loev, Richard E. Brown, Fu-chih Huang, Howard Jones
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Patent number: 4482544Abstract: Compounds of the general formula ##STR1## and their pharmaceutically-acceptable salts, wherein the substituents are as defined herein, having antihypertensive activity.Type: GrantFiled: November 29, 1982Date of Patent: November 13, 1984Assignee: USV Pharmaceutical CorporationInventors: Fu-chih Huang, Howard Jones, Wan-Kit Chan
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Patent number: 4479950Abstract: Compounds of the structure ##STR1## wherein: P and Q are independently hydrogen, halo, CF.sub.3, OR.sub.1, SR.sub.1, sulfamoyl, alkyl and NR.sub.1 R.sub.2 ;R.sub.1, and R.sub.2 are independently hydrogen, alkyl, aminoalky, aryl, aralkyl, heteroaryl or cycloalkyl;Y is OH, OR.sub.1, NH.sub.2, or, N(R.sub.1 R.sub.2); andM is alkyl, cycloalkyl, aryl, aminoalkyl, aralkyl, heteroaryl or heterocyclicwherein:the alkyl groups and the alkyl moieties of aminoalkyl, alkoxy and thioalkyl contain from 1 to 6 carbon atoms; the cycloalkyl group contains from 3 to 8 carbon atoms; the aryl group contains from 6 to 10 carbon atoms; the aralkyl group contains from 7 to 16 carbon atoms; and the hetero group is selected from pyrrolidyl, piperidinyl, morpholinyl, pyridyl, quinolinyl, furyl, furfuryl and thienyl; and where Y is a hydroxy, their pharmaceutically acceptable, non-toxic alkali, alkaline earth and amine salts, have angiotensin converting enzyme inhibitory activity.Type: GrantFiled: November 5, 1982Date of Patent: October 30, 1984Assignee: USV Pharmaceutical CorporationInventors: Paul R. Menard, Howard Jones, John T. Suh
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Patent number: 4478834Abstract: New dihydropyridines are described. These compounds are useful in the treatment of asthma.Type: GrantFiled: February 11, 1983Date of Patent: October 23, 1984Assignee: USV Pharmaceutical CorporationInventors: James R. Shroff, Bernard Loev
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Patent number: 4477675Abstract: The process of preparing a compound of the formula: ##STR1## wherein, Y and Z are each H, alkyl, halo, alkoxy, trifluoromethyl, hydroxy, alkanoyloxy, or alkanoylamino;X is F, Cl, Br, or NR.sub.1 R.sub.2 wherein R.sub.1 and R.sub.2 are each hydrogen, alkyl, alkynyl, alkenyl, cycloalkyl, aryl or aralkyl; andR is H, alkyl, cycloalkyl, or aralkyl; which comprises the step of oxidation of the corresponding 3-desoxy compound.Type: GrantFiled: September 7, 1982Date of Patent: October 16, 1984Assignee: USV Pharmaceutical CorporationInventors: Joseph Auerbach, Frederick A. Golec, Jr.
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Patent number: 4477446Abstract: Pharmaceutical compositions comprising 1-benzazepinediones of the formula: ##STR1## wherein: X and Y are independently O, S, NR or CH-R;A and B are independently H, halo, OH, OR, CF.sub.3 or R; andR is H, lower alkyl, aryl, aralkyl or aminoalkyl, are useful as antiallergic agents.Type: GrantFiled: July 1, 1983Date of Patent: October 16, 1984Assignee: USV Pharmaceutical CorporationInventors: Howard Jones, Stephen M. Coutts
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Patent number: 4476125Abstract: New benzobisoxazinetetrones having anti-allergic activity are described. These benzobisoxazinetetrones are represented by the following formula: ##STR1## and pharmaceutically acceptable salts thereof, wherein: X and Y are independently O, S, NH, N-alkyl or N-aryl;R.sub.1 is H, lower alkyl, aryl, aralkyl, heteroalkyl, alkoxyalkyl, aminoalkyl or carboxyalkyl;R.sub.2 and R.sub.3 are independently H, OH, alkoxy, lower alkyl, aryl, aralkyl, halogen, trifluoromethyl, nitro, cyano, carboxy or sulfonamidouseful in the treatment of allergies.Type: GrantFiled: March 24, 1983Date of Patent: October 9, 1984Assignee: USV Pharmaceutical CorporationInventors: Bernard Loev, Fu-Chih Huang
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Patent number: 4472584Abstract: Compounds of the formula: ##STR1## wherein Ar is heteroaryl, cycloalkyl having from 3 to 7 carbon atoms, naphthyl, indanyl, indenyl, tetrahydro naphthyl, or a radical of the formula ##STR2## wherein each of R.sub.5, R.sub.6 and R.sub.7 is independently H, alkyl, aryl, halo, lower alkoxy, nitro, amino, alkylmercapto, cyano, carboxy, carbalkoxy, sulfamyl, trifluoromethyl, hydroxy, acyloxy, methanesulfonyl, alkylamino or acylamino; and R.sub.5 and R.sub.6 when taken together, form a methylenedioxy; Z is alkylene containing 1 to about 5 carbon atoms in the principal chain; each R.sub.1 is independently hydrogen, alkyl or alkoxyalkyl, with the proviso that only one R.sub.1 may be hydrogen; R.sub.2 is lower alkyl; R.sub.3 is hydroxyalkyl containing 2 to 4 carbon atoms and R.sub.4 is H, alkyl, cycloalkyl or hydroxyalkyl containing 2 to 4 carbon atoms; wherein the alkyl, alkoxy, and acyl groups contain up to 10 carbon atoms, and their pharmaceutically-acceptable salts are disclosed.Type: GrantFiled: March 3, 1983Date of Patent: September 18, 1984Assignee: USV Pharmaceutical CorporationInventors: Bernard Loev, Howard Jones, John T. Suh
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Patent number: 4472430Abstract: Polyolefinic compounds, useful in the treatment of psoriasis, are disclosed. The compounds are represented by the general formula ##STR1## in which R and R.sub.1 are each hydrogen or an alkyl group of from 1 to 5 carbon atoms; R.sub.2 is an alkyl group of from 1 to 5 carbon atoms; R.sub.3 is hydroxyl, alkoxy of from 1 to 5 carbon atoms, NH.sub.2,NHR.sub.2 or NR.sub.2 R.sub.2 and Z is a cycloalkyl, cycloalkenyl or cycloalkdienyl group substituted with from 0 to 5 alkyl groups, a keto group or a hydroxyl group or a phenyl group substituted with from 0 to 4 hydroxy, alkoxy, alkyl or trifluoromethyl groups or halogen atoms or combinations thereof and the pharmaceutically-acceptable salts thereof.The foregoing compounds have been found to be effective in the treatment of psoriasis.Type: GrantFiled: June 28, 1982Date of Patent: September 18, 1984Assignee: USV Pharmaceutical CorporationInventors: Bernard Loev, Wan-kit Chan, Howard Jones
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Patent number: 4470965Abstract: An ophthalmic preparation for the treatment of glaucoma by the application to the glaucomatous eye of a celiprolol salt in a pharmaceutically acceptable ophthalmic carrier.Type: GrantFiled: October 27, 1982Date of Patent: September 11, 1984Assignee: USV Pharmaceutical CorporationInventors: Peter Wolf, Morris A. Kesselman
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Patent number: 4465679Abstract: Compounds of the formula ##STR1## and their pharmaceutically-acceptable salts, wherein the substituents are as defined herein, having antihypertensive activity.Type: GrantFiled: January 31, 1983Date of Patent: August 14, 1984Assignee: USV Pharmaceutical CorporationInventors: Fu-chih Huang, Howard Jones, Wan-Kit Chan
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Patent number: 4453007Abstract: Provided is a method of increasing the purity of amphoteric compound compositions. The method is: (a) providing an amount of a crude amphoteric compound composition, (b) using a portion of the crude composition to prepare in solution a cationic salt of the amphoteric compound, (c) using another portion of the crude composition to prepare in solution an anionic salt of the amphoteric compound, (d) mixing together the solutions wherein a precipitate is formed, and (e) collecting the precipitate which is an amphoteric compound composition of higher purity than the crude composition.Type: GrantFiled: November 23, 1981Date of Patent: June 5, 1984Assignee: USV Pharmaceutical CorporationInventor: David Taube
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Patent number: 4443610Abstract: Bicyclothiazoles having the structure: ##STR1## wherein n is 3, 4, or 5R.sub.1 is hydrogen or alkyl,R.sub.2 is hydrogen, alkyl, hydroxyl, alkoxy, cyano, phenyl, carboxyl, tetrazole, or halogen,R.sub.3 is tetrazole, carboxamide or ##STR2## wherein Z is oxygen, sulfur, or NH andR.sub.4 is H, alkali metal, ammonium, alkyl, alkoxyalkyl, aryl, or aralkyl,are novel and useful as antiallergic agents. The compounds are formulated with a pharmaceutical carrier for oral, parental, inhalational, or rectal means of administration.Type: GrantFiled: September 20, 1982Date of Patent: April 17, 1984Assignee: USV Pharmaceutical CorporationInventor: Fu-chih Huang
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Patent number: 4440929Abstract: Provided are imidazoquinoxalines of the structures: ##STR1## wherein R.sub.1, R.sub.5, R.sub.6 and R.sub.7 are independently H, alkyl, aryl, alkenyl, alkynyl, hydroxy, hydroxyalkyl, alkoxy, mercapto, mercaptoalkyl, alkylthio, amino, alkylamino, aminoalkyl, carboxaldehyde, carboxylic acid and salts thereof, carbalkoxy, alkanoyl, cyano, nitro, halo, trifluoromethyl, alkylsulfonyl, sulfonamido, or R.sub.1, R.sub.5, R.sub.6 and R.sub.7 may be taken together with the adjacent group to form a methylenedioxy group.R.sub.4 is H, alkyl, alkenyl, alkynyl, aryl, aralkyl, hydroxy or alkanoyl.R.sub.3 is H, cyano, tetrazolo, carboxaldehyde, hydroxyalkyl, carboxylic acid and salts thereof or derivatives thereof such as esters or amides in which the substituent on the ester oxygen or amide nitrogen is alkyl, aryl, hydroxyalkyl, alkoxyalkyl or amino alkyl.R.sub.2 and R.sub.Type: GrantFiled: March 29, 1982Date of Patent: April 3, 1984Assignee: USV Pharmaceutical CorporationInventors: Thomas D. Lee, Richard E. Brown
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Patent number: 4440941Abstract: Compounds of the structure ##STR1## wherein: Q is oxygen, sulfur or imino.X and Y are hydrogen, halogen, hydroxy, alkoxy, trifluoromethyl, nitro, carboxy, cyano, sulfonamido, sulfhydryl, alkyl, alkenyl, alkynyl, alkanoyl, alkylmercapto, amino, alkylamino, dialkylamino, alkysulfinyl, and alkylsulfonyl and may be the same or different;R.sub.1 is hydrogen, alkanoyl, substituted alkanoyl wherein the substituent is hydroxy, amino or cycloalkyl, aroyl, arylalkanoyl, or cycloalkylcarbonyl,n is an integer from 1 to 4 inclusive,R.sub.2 and R.sub.Type: GrantFiled: December 22, 1980Date of Patent: April 3, 1984Assignee: USV Pharmaceutical CorporationInventors: John T. Suh, Paul R. Menard, Howard Jones
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Patent number: 4440935Abstract: Bicycloimidazoles having the structure: ##STR1## wherein n is 3, 4, or 5R.sub.1 is hydrogen or alkyl,R.sub.2 is hydrogen, alkyl, hydroxyl, alkoxy, cyano, phenyl, carboxyl, tetrazole, or halogen,R.sub.3 is tetrazole, carboxamide or ##STR2## wherein Z is oxygen, sulfur, or NH andR.sub.4 is H, alkali metal, ammonium, alkyl, alkoxyalkyl, aryl, or aralkyl,are novel and useful as antiallergic agents. The compounds are formulated with a pharmaceutical carrier for oral, parental, inhalational, or rectal means of administration.Type: GrantFiled: September 20, 1982Date of Patent: April 3, 1984Assignee: USV Pharmaceutical CorporationInventor: Fu-chih Huang
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Patent number: 4435409Abstract: A new use for nifedipine is provided. The new use is in a method of stimulating production of IgM antibodies in mammals.Type: GrantFiled: December 10, 1981Date of Patent: March 6, 1984Assignee: USV Pharmaceutical CorporationInventors: Mitchell J. Leibowitz, Ah S. Kong, Paula Sonnino-Goldman, Peter Wolf
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Patent number: 4435395Abstract: Compounds of the formula: ##STR1## which are useful as antihypertensive agents are disclosed.Type: GrantFiled: March 3, 1983Date of Patent: March 6, 1984Assignee: USV Pharmaceutical CorporationInventors: Bernard Loev, Howard Jones, James R. Shroff