Abstract: Zeolites having surface modification with graphene oxide, reduced graphene oxide, or a sulfide have utility in removing pollutants from a water supply. Pollutants include Persistent Organic Pollutants (POPs) and heavy metals, such as lead. POPs are adsorbed onto zeolites having surface modification with graphene oxide and/or reduced graphene oxide. Heavy metals are adsorbed onto zeolites having surface modification with a sulfide.
Type:
Grant
Filed:
January 20, 2021
Date of Patent:
March 4, 2025
Assignee:
UWM Research Foundation, Inc.
Inventors:
Marcia Renata Quadros da Silva, David Garman, Mohsen Manjili, Yan Zhang
Abstract: Disclosed herein are methods of making an electrode. The method includes contacting an electrode material with a mixture that includes an alkali metal, an organic solvent, and an aromatic compound. Also disclosed herein are methods of making a battery that includes an electrode provided by the disclosed methods.
Type:
Grant
Filed:
September 24, 2019
Date of Patent:
January 21, 2025
Assignee:
UWM Research Foundation, Inc.
Inventors:
Deyang Qu, Gong Wei Wang, Xiaoxiao Zhang, Huainan Qu
Abstract: Provided herein are alpha5-containing GABAA receptor agonists and pharmaceutical compositions and methods of treatment of cognitive and mood symptoms in neurodegenerative and neuropsychiatric disorders using them.
Type:
Grant
Filed:
August 2, 2023
Date of Patent:
December 31, 2024
Assignee:
UWM Research Foundation, Inc.
Inventors:
James M. Cook, Guanguan Li, Michael Ming-Jin Poe, Miroslav M. Savic, Etienne Sibille
Abstract: Provided herein are methods of potentiating an effect of an anti-cancer drug in a subject diagnosed with cancer, the method including administering to the subject a combination therapy including: an effective amount of 7-ethynyl-5-(2-fluorophenyl)-1-methyl-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one (BZD-1); and an anti-cancer drug.
Type:
Application
Filed:
June 3, 2022
Publication date:
September 5, 2024
Applicants:
University of Cincinnati, UWM Research Foundation, Inc.
Inventors:
Daniel Pomeranz Krummel, Soma Sengupta, James M. Cook, Taukir Ahmed, Aniruddha Karve, Laura Kallay, Pankaj Desai, Debanjan Bhattacharya, Donatien Kamdem Toukam, Riccardo Barrile
Abstract: Disclosed herein are nuclear male sterile sorghum mutants, three-component genetic constructs, and methods of using said mutants and genetic constructs, such as in a two-line male sterility system for hybrid breeding.
Type:
Grant
Filed:
January 3, 2019
Date of Patent:
August 20, 2024
Assignees:
UWM Research Foundation, Inc., United States of America, As Represented by the Secretary of Agriculture
Abstract: The present invention describes substituted benzo[f]imidazo[1,5-a][1,4]diazepines of the formula (I): wherein R1, R2, R2?, R3, and X are as disclosed herein. These compounds target alpha-4 and alpha-5 GABAa receptors and are useful for the treatment of airway hyperresponsiveness and inflammation in asthma.
Type:
Grant
Filed:
August 11, 2022
Date of Patent:
August 6, 2024
Assignees:
UWM Research Foundation, Inc., The Trustees of Columbia University in the City of New York
Inventors:
Alexander E. Arnold, Douglas C. Stafford, James M. Cook, Charles W. Emala, Gloria Forkuo, Rajwana Jahan, Revathi Kodali, Guanguan Li, Michael Rajesh Stephen
Abstract: Composition and electrode for phosphate sensing. In one embodiment, the composition includes a first component, a second component, and a third component. The first component is selected from a group consisting of cobalt oxide nanoparticles, tin (IV) chloride, diphenyl tin dichloride, and ammonium molybdate. The second component includes graphene oxide or reduced graphene oxide. The third component includes pyrrole or polypyrrole.
Type:
Grant
Filed:
August 10, 2018
Date of Patent:
April 16, 2024
Assignee:
UWM Research Foundation, Inc.
Inventors:
Woo-Jin Chang, Misong Ryu, Mohammad Rizwen Ur Rahman
Abstract: A cured concrete and stone bore working tool and method of forming radially oriented discontinuities in a bore or perforation formed in a cured concrete or stone material such that, after use or application of the tool, the perforation formed in the cured concrete or stone material is configured to provide a non-planar adhesive interface and isolate a properly sized anchor or fastener from direct contact with the wall of the bore. Fasteners or anchors adhesively secured in bores previously treated with the bore treating tool exhibit improved creep failure performance as compared to fasteners adhesively secured to untreated bores.
Abstract: Provided herein are alpha5-containing GABAA receptor agonists and pharmaceutical compositions and methods of treatment of cognitive and mood symptoms in neurodegenerative and neuropsychiatric disorders using them.
Type:
Grant
Filed:
December 15, 2020
Date of Patent:
September 12, 2023
Assignees:
UWM Research Foundation, Inc., Centre for Addiction and Mental Health, University of Belgrade—Faculty of Pharmacy
Inventors:
James M. Cook, Guanguan Li, Michael Ming-Jin Poe, Miroslav M. Savic, Etienne Sibille
Abstract: Disclosed herein are extraction chromatographic supports comprising a porous support, an inert filler, and metal ion binding extractant that may be used for chromatographic separation of metal ions. Also disclosed herein are methods for preparing and using the extraction chromatographic supports.
Abstract: A dust collection assembly for a computer numerical control (CNC) cutting machine includes an adapter configured to couple to an arm of the CNC cutting machine and a head telescopically coupled to the adapter by a plurality of nested members. The CNC cutting machine includes the arm supporting a spindle and a tool holder coupled for co-rotation with the spindle. Each of the plurality of nested members are collapsible relative to each other. The head is movable between an extended position in which the nested members are configured to surround the tool holder and a tool bit, and a retracted position in which at least some of the nested members are telescopically received in the adapter. The head defines an inlet fluidly connected to the plurality of nested members when the head is at least in the extended position. The inlet is configured to fluidly connect to a vacuum.
Type:
Grant
Filed:
March 28, 2019
Date of Patent:
January 31, 2023
Assignee:
UWM Research Foundation, Inc.
Inventors:
Kyle Steven Jansson, J. Dennis Lang, Madeline Charlotte Frank
Abstract: Substituted benzo[f]imidazo[1,5-?][1,4]diazepines of formula (I?) target alpha-4 and alpha-5 GABAA receptors for use in the treatment of airway hyperresponsiveness and inflammation in asthma. Compounds selectively partition to the peripheral compartment and have reduced CNS effects.
Type:
Grant
Filed:
August 16, 2017
Date of Patent:
September 20, 2022
Assignees:
UWM Research Foundation, Inc., The Trustees of Columbia University in the City of New York
Inventors:
Alexander E. Arnold, Douglas C. Stafford, James M. Cook, Charles W. Emala, Gloria Forkuo, Rajwana Jahan, Revathi Kodali, Guanguan Li, Michael Rajesh Stephen
Abstract: A coating composition comprises a functionalized epoxy resin and a fluoroalkyl-modified particle, such as activated carbon or silica. The functionalized epoxy resin is a ternary polymer composition comprising one or more epoxy resin moieties linked to a polyethylene backbone through an oxygen atom, fluoroalkyl(poly)propionyl groups being grafted to the polyethylene backbone. The coating compositions have superhydrophobic properties useful for self-cleaning surfaces and bubble release from sensors.
Abstract: Provided herein are novel pyrazoloquinolinone compounds and method of using such compounds to treat disorders such as neuropsychiatric disorders with sensorimotor gating deficits, such as schizophrenia, tic disorders, attention deficit hyperactivity disorder, obsessive compulsive disorder, panic disorder, Huntington's disease and nocturnal enuresis; depression; temporomandibular myofascial pain; disorders of trigeminal nerve, such as trigeminal neuralgia and trigeminal neuropathy; migraine; and tinnitus.
Abstract: Sensors for detecting and distinguishing metals in a sample comprise phenol group-containing azo dyes, the phenol group having one hydroxy involved in reversible metal ion binding and a second hydroxy alkylated to an optically transparent substrate. The sensors have utility for detecting chromium, calcium, magnesium, copper, mercury, nickel, zinc, cobalt, manganese, cadmium, lead, tin, aluminum, potassium, sodium, or arsenic ions in a sample.
Type:
Grant
Filed:
October 14, 2016
Date of Patent:
March 15, 2022
Assignee:
UWM Research Foundation, Inc.
Inventors:
Alan Schwabacher, Peter Geissinger, Trevor Hagemann, Sarah Oehm, Tyler G. Fenske
Abstract: Disclosed herein are novel HDAC inhibitors. The HDAC inhibitors may be used in methods of treating cancer. The HDAC inhibitors may be used in methods of treating a neurological disorder.
Type:
Grant
Filed:
October 29, 2015
Date of Patent:
October 19, 2021
Assignee:
UWM Research Foundation, Inc.
Inventors:
Yi-Qiang Cheng, M. Mahmun Hossain, Douglas Steeber, Karyn Frick, Steven Clark, Joseph Ulicki
Abstract: A panel assembly for a building includes a panel configured to extend between a first surface and a second surface. The panel is movable along a predetermined path relative to the first surface and the second surface. A first pin and a second pin are coupled to the panel. A first bottom face plate is positioned on a first side and defines a first slot. A second bottom face plate is positioned on a second side and defines a second slot. A first top face plate is positioned on the first side and defines a third slot. A second top face plate is positioned on the second side and defines a fourth slot. The first pin is movable in the first slot and the second slot, and the second pin is movable in the third slot and the fourth slot for guiding movement of the panel along the predetermined path.
Abstract: The present invention relates to methods of using cell-free DNA analysis for guiding treatment of advanced prostate cancer. In particular, liquid biopsies are collected from urine and/or plasma of patients for measuring copy number variation in cell-free DNA associated with metastatic prostate cancer. In particular, urine genomic abnormality (UGA) and plasma genomic abnormality (PGA) values are contemplated for use in predicting treatment responses in advanced prostate cancer patients and for use in making decisions related to androgen deprivation therapy (ADT) treatment outcomes in hormone sensitive stage and for starting or changing chemotherapy treatments in castrate resistant advanced cancer stage.
Type:
Grant
Filed:
January 20, 2017
Date of Patent:
April 20, 2021
Assignees:
Mayo Foundation for Medical Education and Research, The Medical College of Wisconsin, Inc., UWM Research Foundation, Inc.
Abstract: Provided herein are alpha5-containing GABAA receptor agonists and pharmaceutical compositions and methods of treatment of cognitive and mood symptoms in neurodegenerative and neuropsychiatric disorders using them.
Type:
Grant
Filed:
March 20, 2017
Date of Patent:
February 2, 2021
Assignees:
UWM Research Foundation, Inc., Centre for Addiction and Mental Health, University of Belgrade—Faculty of Pharmacy
Inventors:
James M. Cook, Guanguan Li, Michael Ming-Jin Poe, Miroslav M. Savic, Etienne Sibille
Abstract: This invention relates to a system that adaptively compensates for subject motion in real-time in an imaging system. An object orientation marker (30), preferably a retro-grate reflector (RGR), is placed on the head or other body organ of interest of a patient (P) during a scan, such as an MRI scan. The marker (30) makes it possible to measure the six degrees of freedom (x, y, and z-translations, and pitch, yaw, and roll), or “pose”, required to track motion of the organ of interest. A detector, preferably a camera (40), observes the marker (30) and continuously extracts its pose. The pose from the camera (40) is sent to the scanner (120) via an RGR processing computer (50) and a scanner control and processing computer (100), allowing for continuous correction of scan planes and position (in real-time) for motion of the patient (P).
Type:
Grant
Filed:
December 11, 2017
Date of Patent:
December 22, 2020
Assignees:
The Queen's Medical Center, The University of Hawaii, The Medical Collene of Wisconsin, Inc., UWM Research Foundation, Inc.
Inventors:
Thomas Michael Ernst, Thomas Edmund Prieto, Brian Stewart Randall Armstrong