Patents Assigned to UWM Research Foundation, Inc.
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Patent number: 9417294Abstract: A current sensor device. The current sensor device includes a strain distribution converter; an optical fiber coupled with the strain distribution converter; and a magnetostrictive material associated with the strain distribution converter such that a change in shape of the magnetostrictive material causes a change in length of the optical fiber.Type: GrantFiled: November 14, 2013Date of Patent: August 16, 2016Assignee: UWM Research Foundation, Inc.Inventors: Chiu Tai Law, Rani El-Hajjar
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Patent number: 9236633Abstract: A composition of graphene-based nanomaterials and a method of preparing the composition are provided. A carbon-based precursor is dissolved in water to form a precursor suspension. The precursor suspension is placed onto a substrate, thereby forming a precursor assembly. The precursor assembly is annealed, thereby forming the graphene-based nanomaterials. The graphene-based nanomaterials are crystallographically ordered at least in part and configured to form a plurality of diffraction rings when probed by an incident electron beam. In one aspect, the graphene-based nanomaterials are semiconducting. In one aspect, a method of engineering an energy bandgap of graphene monoxide generally includes providing at least one atomic layer of graphene monoxide having a first energy bandgap, and applying a substantially planar strain is applied to the graphene monoxide, thereby tuning the first energy band gap to a second energy bandgap.Type: GrantFiled: June 12, 2013Date of Patent: January 12, 2016Assignee: UWM Research Foundation, Inc.Inventors: Junhong Chen, Marija Gajdardziska-Josifovska, Carol Hirschmugl, Eric Mattson, Haihui Pu, Michael Weinert
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Patent number: 9138175Abstract: This invention relates to a system that adaptively compensates for subject motion in real-time in an imaging system. An object orientation marker (30), preferably a retro-grate reflector (RGR), is placed on the head or other body organ of interest of a patient (P) during a scan, such as an MRI scan. The marker (30) makes it possible to measure the six degrees of freedom (x, y, and z-translations, and pitch, yaw, and roll), or “pose”, required to track motion of the organ of interest. A detector, preferably a camera (40), observes the marker (30) and continuously extracts its pose. The pose from the camera (40) is sent to the scanner (120) via an RGR processing computer (50) and a scanner control and processing computer (100), allowing for continuous correction of scan planes and position (in real-time) for motion of the patient (P).Type: GrantFiled: April 28, 2015Date of Patent: September 22, 2015Assignees: The Queen's Medical Center, The University of Hawaii, The Medical College of Wisconsin, Inc., UWM Research Foundation, Inc.Inventors: Thomas Michael Ernst, Thomas Edmund Prieto, Brian Stewart Randall Armstrong
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Patent number: 9133141Abstract: The present invention provides cysteine and cystine bioisosteres for the treatment of schizophrenia and drug addiction. The invention further encompasses pharmaceutical compositions containing such bioisosteres and methods of using the bioisosteres for treatment of schizophrenia and drug addiction.Type: GrantFiled: January 7, 2014Date of Patent: September 15, 2015Assignees: Marquette University, UWM Research Foundation, Inc.Inventors: James M. Cook, David A. Baker, Edward Merle Johnson, II, Wenyuan Yin, Ranjit Singh Verma
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Patent number: 9130216Abstract: A bioelectricalchemical system includes an anode, an algal bioreactor, and a cathode. The anode is at least partially positioned within an anode chamber containing a first aqueous reaction mixture including one or more organic compounds and one or more bacteria for oxidizing the organic compounds. The algal bioreactor contains a second aqueous reaction mixture including one or more nutrients and one or more algae for substantially removing the nutrients from the second aqueous reaction mixture. The cathode is at least partially positioned within the algal bioreactor.Type: GrantFiled: July 11, 2012Date of Patent: September 8, 2015Assignee: UWM Research Foundation, Inc.Inventor: Zhen He
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Patent number: 9103721Abstract: A system and method of high-speed microscopy using a two-photon microscope with spectral resolution. The microscope is operable to provide two- to five-dimensional fluorescence images of samples, including two or three spatial dimensions, a spectral dimension (for fluorescence emission), and a temporal dimension (on a scale of less than approximately one second). Two-dimensional (spatial) images with a complete wavelength spectrum are generated from a single scan of a sample. The microscope may include one of a multi-beam point scanning microscope, a single beam line scanning microscope, and a multi-beam line scanning microscope. The line scans may be formed using one or more of curved mirrors and lenses. The multiple beams may be formed using one of a grating, an array of lenses, and a beam splitter.Type: GrantFiled: April 5, 2012Date of Patent: August 11, 2015Assignee: UWM Research Foundation, Inc.Inventors: Valerica Raicu, Gabriel Biener
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Patent number: 9076212Abstract: This invention relates to a system that adaptively compensates for subject motion in real-time in an imaging system. An object orientation marker (30), preferably a retro-grate reflector (RGR), is placed on the head or other body organ of interest of a patient (P) during a scan, such as an MRI scan. The marker (30) makes it possible to measure the six degrees of freedom (x, y, and z-translations, and pitch, yaw, and roll), or “pose”, required to track motion of the organ of interest. A detector, preferably a camera (40), observes the marker (30) and continuously extracts its pose. The pose from the camera (40) is sent to the scanner (120) via an RGR processing computer (50) and a scanner control and processing computer (100), allowing for continuous correction of scan planes and position (in real-time) for motion of the patient (P).Type: GrantFiled: September 23, 2013Date of Patent: July 7, 2015Assignees: The Queen's Medical Center, The University of Hawaii, The Medical College of Wisconsin, Inc., UWM Research Foundation, Inc.Inventors: Thomas Michael Ernst, Thomas Edmund Prieto, Brian Stewart Randall Armstrong
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Publication number: 20150175559Abstract: The present invention discloses cysteine prodrugs having the general formula: cystine dimmers of the cysteine prodrugs having the general formula: protected cysteine analogs having the general formula: and dimmers of the protected cysteine analogs having the general formula: The invention further encompasses pharmaceutical compositions containing the disclosed prodrugs, dimmers, analogs, and methods of using such compounds for treatment of schizophrenia and drug addiction.Type: ApplicationFiled: February 20, 2015Publication date: June 25, 2015Applicants: Marquette University, UWM Research Foundation, Inc.Inventors: James M. Cook, David A. Baker, Wenyuan Yin, Edward M. Johnson, II
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Patent number: 9013700Abstract: A system and method of photon trapping spectroscopy to vary the path length of light for use in spectroscopy. The systems and method include a rotating reflector with slits for selectively permitting light to enter and exit into a reflection cavity containing a sample to be analyzed. After entering the cavity, but before exiting, the light is trapped and repeatedly reflects back and forth through a sample, effectively increasing the path length of light through a sample. The effective path length is quickly adjustable by altering the rotation speed of the rotating reflector to alter the time in which the light is trapped within the cavity. The systems and methods provide a spectroscope with a wide dynamic range, low detection limits, and usable with broadband and monochromatic light sources throughout the optical region (ultraviolet to infrared).Type: GrantFiled: February 21, 2012Date of Patent: April 21, 2015Assignee: UWM Research Foundation, Inc.Inventors: Joseph Aldstadt, III, Peter Geissinger, Beth A. Ruddy, Jörg C. Woehl, John A. Frost
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Patent number: 9006233Abstract: Described herein are ?3 or ?2 or ?2/?3 GABAergic receptor subtype selective ligands, pharmaceutical compositions, and methods of use of such ligands and compositions in treatment of anxiety disorders, epilepsy and schizophrenia with reduced sedative and ataxic side effects. In embodiments, such as ?3 or ?2 or ?2/?3 GABAergic receptor subtype selective ligands lack ester linkages and may be thus relatively insensitive to hydrolysis by esterases.Type: GrantFiled: April 27, 2012Date of Patent: April 14, 2015Assignee: UWM Research Foundation, Inc.Inventors: James M. Cook, Terry S. Clayton, Hiteshkumar D. Jain, Sundari K. Rallipalli, Yun Teng Johnson, Jie Yang, Michael Ming-jin Poe, Ojas A. Namjoshi, Zhi-jian Wang
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Patent number: 8982206Abstract: A system and method of high-speed microscopy using a two-photon microscope with spectral resolution. The microscope is operable to provide spectrally resolved, multi-dimensional images from a single scan of a sample. The microscope may include one of a multi-beam point scanning microscope, a single beam line scanning microscope, and a multi-beam line scanning microscope. The microscope includes a descanning arrangement such that emitted fluorescence is static on a receiving detector. The detector is a narrow detector with a width at least half the size of the length, to reduce the amount of pixel data being transmitted and improve scan speeds. The microscope may also incorporate one or more binning techniques whereby pixels are binned together to improve resolution or scan speeds.Type: GrantFiled: April 5, 2012Date of Patent: March 17, 2015Assignee: UWM Research Foundation, Inc.Inventors: Valerica Raicu, Michael Stoneman
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Patent number: 8962670Abstract: Described herein are compounds that may be selectively activated to produce active anti-cancer agents in tumor cells. Also disclosed are pharmaceutical compositions comprising the compounds, and methods of treating cancer using the compounds.Type: GrantFiled: December 20, 2013Date of Patent: February 24, 2015Assignee: UWM Research Foundation, Inc.Inventors: Xiaohua Peng, Yunyan Kuang, Sheng Cao, Wenbing Chen, Yibin Wang
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Patent number: 8962692Abstract: The present invention discloses cysteine prodrugs having the general formula: cystine dimers of the cysteine prodrugs having the general formula: protected cysteine analogs having the general formula: and dimers of the protected cysteine analogs having the general formula: The invention further encompasses pharmaceutical compositions containing the disclosed prodrugs, dimers, and analogs, and methods of using such compounds for treatment of schizophrenia and drug addiction.Type: GrantFiled: May 7, 2012Date of Patent: February 24, 2015Assignees: Marquette University, UWM Research Foundation, Inc.Inventors: James M. Cook, David A. Baker, Wenyuan Yin, Edward Merle Johnson, II
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Patent number: 8888074Abstract: A membrane for use in an air diffuser. The membrane includes a nub with a perforation. The nub and perforation and arranged and sized to create smaller bubbles of gas in a liquid column above the membrane.Type: GrantFiled: October 18, 2012Date of Patent: November 18, 2014Assignee: UWM Research Foundation, Inc.Inventors: Ryoichi Samuel Amano, Ammar Alkhalidi
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Patent number: 8860236Abstract: A wind energy power conversion system includes a gearbox, a generator, an AC to DC power converter, a DC link, and a DC to AC power converter, and at least one ultracapacitor module connected in parallel on the DC link. A method of reducing stress on a wind turbine gearbox can be performed by obtaining an unwanted frequency of the wind energy power conversion system gearbox; determining an input torque value on the input shaft of the gearbox as a function of time; determining a frequency of the input torque value; and adjusting a torque on the output shaft of the gearbox based on the unwanted frequency.Type: GrantFiled: October 19, 2010Date of Patent: October 14, 2014Assignee: UWM Research Foundation, Inc.Inventor: Adel Nasiri
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Publication number: 20140227225Abstract: The present invention discloses thioflavine S and primuline derivatives which inhibit hepatitis C virus helicase and protease activity. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are useful as antiviral agents. The present invention further relates to pharmaceutical compositions containing the aforementioned compounds and methods of treating an HCV infection.Type: ApplicationFiled: September 7, 2012Publication date: August 14, 2014Applicants: UWM RESEARCH FOUNDATION, INC., UNIVERSITY OF KANSASInventors: Jeffrey Aube, Brian Scott Jonathan Blagg, Kevin John Frankowski, David Norman Frick, Kelin Li, Frank John Schoenen
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Publication number: 20140200250Abstract: Described herein are compounds that may be selectively activated to produce active anti-cancer agents in tumor cells. Also disclosed are pharmaceutical compositions comprising the compounds, and methods of treating cancer using the compounds.Type: ApplicationFiled: December 20, 2013Publication date: July 17, 2014Applicant: UWM Research Foundation, Inc.Inventors: Xiaohua Peng, Yunyan Kuang, Sheng Cao, Wenbing Chen, Yibin Wang
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Publication number: 20140194472Abstract: Described herein are compounds, pharmaceutical compositions and methods for inhibiting the expression of a vitamin D receptor target gene, inhibiting interactions between the vitamin D receptor and at least one vitamin D receptor coactivator, for treating cancer in a subject, and for inhibiting angiogenesis in a subject.Type: ApplicationFiled: August 26, 2012Publication date: July 10, 2014Applicants: WOMEN AND INFANTS' HOSPITAL OF RHODE ISLAND, UWM RESEARCH FOUNDATION, INC.Inventors: Alexander E. Arnold, Preetpal Singh Sidhu, Premchendar Nandhikonda, Rakesh K. Singh
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Publication number: 20140173822Abstract: An infant sleep pod providing passive and/or active safety features. The infant sleep pod provides a safe sleeping environment for infants sharing sleep areas with adults. The infant sleep pod provides a firm, flat, separate, portable, and dedicated sleep space for an infant. The infant sleep pod includes a base with a bed and sidewall, and a bridge extending across the bed. The bridge covers a head portion of the bed, while a foot portion of the bed is left open for inserting and removing the infant. The bridge prevents pillows and blankets from covering the bed and infant. The infant sleep pod also includes electronics for monitoring the sleep pod. The electronics include a sensor unit in the bridge and a control unit in communication with the sensor unit. The control unit and sensor unit are operable to detect unsafe conditions and, in response, generate alerts.Type: ApplicationFiled: February 27, 2014Publication date: June 26, 2014Applicant: UWM Research Foundation, Inc.Inventors: Jennifer J. Doering, Greg Krzecki
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Publication number: 20140155440Abstract: The present invention provides cysteine and cystine bioisosteres for the treatment of schizophrenia and drug addiction. The invention further encompasses pharmaceutical compositions containing such bioisosteres and methods of using the bioisosteres for treatment of schizophrenia and drug addiction.Type: ApplicationFiled: January 7, 2014Publication date: June 5, 2014Applicants: MARQUETTE UNIVERSITY, UWM RESEARCH FOUNDATION, INC.Inventors: James M. Cook, David A. Baker, Edward Merle Johnson, II, Wenyuan Yin, Ranjit Singh Verma