Abstract: Described herein are compounds, pharmaceutical compositions and methods for inhibiting the expression of a vitamin D receptor target gene, inhibiting interactions between the vitamin D receptor and at least one vitamin D receptor coactivator, for treating cancer in a subject, and for inhibiting angiogenesis in a subject.

Abstract: An infant sleep pod providing passive and/or active safety features. The infant sleep pod provides a safe sleeping environment for infants sharing sleep areas with adults. The infant sleep pod provides a firm, flat, separate, portable, and dedicated sleep space for an infant. The infant sleep pod includes a base with a bed and sidewall, and a bridge extending across the bed. The bridge covers a head portion of the bed, while a foot portion of the bed is left open for inserting and removing the infant. The bridge prevents pillows and blankets from covering the bed and infant. The infant sleep pod also includes electronics for monitoring the sleep pod. The electronics include a sensor unit in the bridge and a control unit in communication with the sensor unit. The control unit and sensor unit are operable to detect unsafe conditions and, in response, generate alerts.

Abstract: The present invention provides cysteine and cystine bioisosteres for the treatment of schizophrenia and drug addiction. The invention further encompasses pharmaceutical compositions containing such bioisosteres and methods of using the bioisosteres for treatment of schizophrenia and drug addiction.

Abstract: An infant sleep pod providing passive and/or active safety features. The infant sleep pod provides a safe sleeping environment for infants sharing sleep areas with adults. The infant sleep pod provides a firm, flat, separate, portable, and dedicated sleep space for an infant. The infant sleep pod includes a base with a bed and sidewall, and a bridge extending across the bed. The bridge covers a head portion of the bed, while a foot portion of the bed is left open for inserting and removing the infant. The bridge prevents pillows and blankets from covering the bed and infant. The infant sleep pod also includes electronics for monitoring the sleep pod. The electronics include a sensor unit in the bridge and a control unit in communication with the sensor unit. The control unit and sensor unit are operable to detect unsafe conditions and, in response, generate alerts.

Abstract: The present disclosure describes compositions containing cyclodextrin and methods of using cyclodextrins to stimulate or enhance the immune system and response in fish. Methods of enhancing the efficacy of a fish vaccine by administering cyclodextrin to the fish are also described.

Abstract: This invention relates to a system that adaptively compensates for subject motion in real-time in an imaging system. An object orientation marker (30), preferably a retro-grate reflector (RGR), is placed on the head or other body organ of interest of a patient (P) during a scan, such as an MRI scan. The marker (30) makes it possible to measure the six degrees of freedom (x, y, and z-translations, and pitch, yaw, and roll), or “pose”, required to track motion of the organ of interest. A detector, preferably a camera (40), observes the marker (30) and continuously extracts its pose. The pose from the camera (40) is sent to the scanner (120) via an RGR processing computer (50) and a scanner control and processing computer (100), allowing for continuous correction of scan planes and position (in real-time) for motion of the patient (P).

Abstract: Described herein are compounds that may be selectively activated to produce active anti-cancer agents in tumor cells. Also disclosed are pharmaceutical compositions comprising the compounds, and methods of treating cancer using the compounds.

Abstract: A target for use in a motion tracking system includes an optically transparent substrate with front and rear artwork. A robust landmark is comprised of portions of the front and rear artwork, and includes alternating spokes and interstitial spaces. The front and rear artwork also define orientation dependent radiation regions that occupy a portion of the interstitial spaces. The artwork also provides target identification markings and markings for providing in-plane rotation information. The surface area of the robust landmark maximized with respect to the total surface area of the target size.

Abstract: A method and system of accelerating the acquisition and reconstruction of magnetic resonance images. Magnetic resonance imaging (“MRI”) data is acquired from a plurality of coils using parallel MRI (“pMRI”). The MRI data represents a reduced field-of-view (“FOV”) image for each of a plurality of coils. The MRI data is further undersampled by sequentially applying a compressed sensing (“CS”) technique, such as SparseMRI. The undersampled, reduced FOV images are then reconstructed into a final magnetic resonance image using a pMRI reconstruction technique, such as SENSitivity encoding (“SENSE”). This combination of MR image acquisition, sampling, and reconstruction is referred to as CS-SENSE.

Abstract: This invention relates to a system that adaptively compensates for subject motion in real-time in an imaging system. An object orientation marker (30), preferably a retro-grate reflector (RGR), is placed on the head or other body organ of interest of a patient (P) during a scan, such as an MRI scan. The marker (30) makes it possible to measure the six degrees of freedom (x, y, and z-translations, and pitch, yaw, and roll), or “pose”, required to track motion of the organ of interest. A detector, preferably a camera (40), observes the marker (30) and continuously extracts its pose. The pose from the camera (40) is sent to the scanner (120) via an RGR processing computer (50) and a scanner control and processing computer (100), allowing for continuous correction of scan planes and position (in real-time) for motion of the patient (P).

Abstract: This invention relates to a system that adaptively compensates for subject motion in real-time in an imaging system. An object orientation marker (30), preferably a retro-grate reflector (RGR), is placed on the head or other body organ of interest of a patient (P) during a scan, such as an MRI scan. The marker (30) makes it possible to measure the six degrees of freedom (x, y, and z-translations, and pitch, yaw, and roll), or “pose”, required to track motion of the organ of interest. A detector, preferably a camera (40), observes the marker (30) and continuously extracts its pose. The pose from the camera (40) is sent to the scanner (120) via an RGR processing computer (50) and a scanner control and processing computer (100), allowing for continuous correction of scan planes and position (in real-time) for motion of the patient (P).

Abstract: Disclosed herein are methods and systems for expressing a polypeptide in a Rhodospirillum species. The methods include introducing an expression vector having a nucleic acid sequence encoding the polypeptide operably linked to a puc promoter into the Rhodospirillum bacterium and growing the Rhodospirillum bacterium under conditions that allow expression of the polypeptide. Vectors for expressing a membrane polypeptide in a Rhodospirillum species are disclosed. The vectors include a puc promoter and a nucleic acid encoding a membrane polypeptide.

Abstract: A method of trapping a charged particle. The method includes providing a planar substrate having a conductive surface thereon, the conductive surface having at least one non-conductive region. The method also includes applying a solution to the conductive surface, the solution comprising at least one charged particle. The method further includes applying a voltage of a threshold level to the conductive surface. The method also includes, in response to the voltage, generating an electrostatic field in the solution adjacent to a boundary between the conductive surface and the non-conductive region. The method also includes setting the threshold level of voltage to result in a strength of the electrostatic field sufficient to prevent the particle from crossing the electrostatic field.

Abstract: The present invention provides cysteine prodrugs for the treatment of schizophrenia and drug addiction. The invention further encompasses pharmaceutical compositions containing prodrugs and methods of using the prodrugs and compositions for treatment of schizophrenia and drug addiction.

Abstract: A membrane for use in an air diffuser. The membrane includes a nub with a perforation. The nub and perforation and arranged and sized to create smaller bubbles of gas in a liquid column above the membrane.

Abstract: Described herein are apparatuses for detecting an analyte in a liquid sample using optical time of flight spectroscopy. A handheld apparatus for remote real-time detection of Zn2+ in aqueous environments and methods for making and using the apparatus are also described herein.

Abstract: Described herein are compounds that may be selectively activated to produce active anti-cancer agents in tumor cells. Also disclosed are pharmaceutical compositions comprising the compounds, and methods of treating cancer using the compounds.

Abstract: This invention relates to a system that adaptively compensates for subject motion in real-time in an imaging system. An object orientation marker, preferably a retro-grate reflector (RGR), is placed on an organ of interest of a patient during a scan, such as an MRI scan. The marker allows measuring the six degrees of freedom or “pose” required to track motion of the organ of interest. A detector, preferably a camera, observes the marker and continuously extracts its pose. The pose from the camera is sent to the scanner via an RGR processing computer and a scanner control and processing computer, allowing for continuous correction of scan planes and position (in real-time) for motion of the patient. This invention also provides for internal calibration and for co-registration over time of the scanner's and tracking system's reference frames to compensate for drift and other inaccuracies that may arise over time.

Abstract: A bioelectrochemical system includes an anode, a saline solution chamber, and a cathode. The anode is at least partially positioned within an anode chamber containing an aqueous reaction mixture including one or more organic compounds and one or more bacteria for oxidizing the organic compounds. The saline solution chamber contains a draw solution and is separated from the anode chamber by a forward osmosis membrane. Water diffuses across the forward osmosis membrane from the aqueous reaction mixture to the draw solution.

Abstract: A bioelectricalchemical system includes an anode, an algal bioreactor, and a cathode. The anode is at least partially positioned within an anode chamber containing a first aqueous reaction mixture including one or more organic compounds and one or more bacteria for oxidizing the organic compounds. The algal bioreactor contains a second aqueous reaction mixture including one or more nutrients and one or more algae for substantially removing the nutrients from the second aqueous reaction mixture. The cathode is at least partially positioned within the algal bioreactor.