Abstract: Described herein are improved purification methods for virus vaccines and compositions. Also described are Zika, Chikungunya, dengue and yellow fever vaccines and methods of producing and administering said vaccines to subjects in need thereof.
Type:
Grant
Filed:
December 4, 2019
Date of Patent:
December 28, 2021
Assignee:
Valneva SE
Inventors:
Jana Barbero Calzado, Mario Nebenführ, Robert Schiegl, Michael Weber, Jürgen Heindl-Wruss
Abstract: The present invention relates to methods of rescue and/or propagation of paramyxovirus species, particularly wherein both rescue and propagation are carried out in the same cell type; i.e., without the use of helper cells for viral rescue. The paramyxoviruses produced by the disclosed methods may encompass wild-type viruses, chimeric viruses, recombinant viruses or engineered viral products such as virus like particles (VLP). Viruses and/or viral products produced in the method according to the current invention are suitable for medical or veterinary use in such applications as treating or preventing infectious diseases, particularly avian paramyxovirus and human respiratory virus infections, and cancer treatment.
Type:
Application
Filed:
July 15, 2019
Publication date:
September 9, 2021
Applicant:
Valneva SE
Inventors:
Luc Batard, Caroline Freslon-Evain, Fabien Perugi, Klaus Schwamborn
Abstract: Described herein are improved purification methods for virus vaccines and compositions. Also described are Zika, Chikungunya, dengue and yellow fever vaccines and methods of producing and administering said vaccines to subjects in need thereof.
Type:
Application
Filed:
December 4, 2019
Publication date:
June 25, 2020
Applicant:
Valneva SE
Inventors:
Jana Barbero Calzado, Mario Nebenführ, Robert Schlegl, Michael Weber, Jürgen Heindl-Wruss
Abstract: Described herein are improved purification methods for virus vaccines and compositions. Also described are Zika, Chikungunya, dengue and yellow fever vaccines and methods of producing and administering said vaccines to subjects in need thereof.
Type:
Grant
Filed:
December 23, 2016
Date of Patent:
January 21, 2020
Assignee:
Valneva SE
Inventors:
Jana Barbero Calzado, Mario Nebenführ, Robert Schlegl, Michael Weber, Jürgen Heindl-Wruss
Abstract: Described herein are improved purification methods for virus vaccines and compositions. Also described are Zika, Chikungunya, dengue and yellow fever vaccines and methods of producing and administering said vaccines to subjects in need thereof.
Type:
Application
Filed:
December 23, 2016
Publication date:
December 27, 2018
Applicant:
Valneva SE
Inventors:
Jana Barbero Calzado, Mario Nebenführ, Robert Schlegl, Michael Weber, Jürgen Wruss