Abstract: An intramolecular bioluminescence resonance energy transfer (BRET), biosensor for monitoring receptor activity and signalling cascades is disclosed. The “double-brilliance” biosensor sandwiches ?-arrestin (?-arr) between Renilla luciferase (Luc) and the yellow fluorescent protein (YFP). ?-arr associates with G-protein coupled receptors GPCR following receptor activation, bringing Luc and YPF into close proximity that favours energy transfer. In addition to providing new insights into the agonist-induced conformational rearrangements of ?-arr in living cells, the double-brilliance ?-arr offers a universal biosensor for GPCR activation, allowing the study of native receptors in large-scale screening analysis. The activity of other signalling molecules known to interact with ? arrestin could also be monitored by double brilliance ? arr.

Abstract: There are provided compounds of formulas (VA), (VIA), (VIIA) (IXA), (XIA), (XIIA), (XIIIA), and (XIVA): wherein A, Z, R2, X?, and L2 represent various different possibilities. Methods for using such compounds are also provided.

Abstract: The present invention generally relates to intravascular ultrasound (IVUS) image segmentation methods, and is more specifically concerned with an intravascular ultrasound image segmentation method for characterizing blood vessel vascular layers. The proposed image segmentation method for estimating boundaries of layers in a multi-layered vessel provides image data which represent a plurality of image elements of the multi-layered vessel. The method also determines a plurality of initial interfaces corresponding to regions of the image data to segment and further concurrently propagates the initial interfaces corresponding to the regions to segment. The method thereby allows to estimate the boundaries of the layers of the multi-layered vessel by propagating the initial interfaces using a fast marching model based on a probability function which describes at least one characteristic of the image elements.

Abstract: There are provided compounds of formulas (VA), (VIA), (VIIA) (IXA), (XIA), (XIIA), (XIIIA), and (XIVA): wherein A, Z, R2, X?, and L2 represent various different possibilities.

Abstract: A garment assembly for a human body comprising a first garment element and a second garment element. The first garment element comprising a top end having a first neck opening, left and right lateral sides having left and right first arm openings respectively, a front side, a back side having an opening, and a bottom end. The second garment element comprising a top end having a second neck opening, left and right lateral sides having respective left and right second arm openings respectively, a front side having an opening, a back side, and a bottom end. When assembling the first and second garment elements on a human body, the first and second neck openings provide for the neck of the human body to be placed therethrough, the first garment element front side covers the front of the human body, the second garment element back side covers the back of the human body.

Abstract: A garment assembly for a human body comprising a first garment element and a second garment element. The first garment element comprising a top end having a first neck opening, left and right lateral sides having left and right first arm openings respectively, a front side, a back side having an opening, and a bottom end. The second garment element comprising a top end having a second neck opening, left and right lateral sides having respective left and right second arm openings respectively, a front side having an opening, a back side, and a bottom end. When assembling the first and second garment elements on a human body, the first and second neck openings provide for the neck of the human body to be placed therethrough, the first garment element front side covers the front of the human body, the second garment element back side covers the back of the human body.

Abstract: The invention relates to novel aldolase-inhibiting compounds that can be advantageously used as medicaments (in therapeutic doses), especially for treating certain cancers, due to the inhibition efficacy thereof. An inventive compound corresponds to general formula (I) wherein the aldehyde group (—CHO) and the phenol group (—OH) are linked to two carbon atoms adjacent to the same aromatic chain, i.e., the first aromatic chain, and R is a phosphate group or a phosphate group mimetic linked to a carbon atom of the second aromatic chain.

Abstract: The invention relates to novel aldolase-inhibiting compounds that can be advantageously used as medicaments (in therapeutic doses), especially for treating certain cancers, due to the inhibition efficacy thereof. An inventive compound corresponds to general formula (I) wherein the aldehyde group (—CHO) and the phenol group (—OH) are linked to two carbon atoms adjacent to the same aromatic chain, i.e., the first aromatic chain, and R is a phosphate group or a phosphate group mimetic linked to a carbon atom of the second aromatic chain.

Abstract: The present invention describes a method for producing membrane receptors based on a baculovirus/insect cell system. The invention further includes the receptors produced by the method described herein, a model for studying the properties of these membrane receptors and an assay to screen molecules that are active on these membrane receptors.

Abstract: A generator device with both driving units is provided, in which there are a support bracket (10), a frame (a) mounted thereon, on which a generator (1), a control system, a direction-adjustable system, a direction-adjustable motor (6) and a protective system (5) are provided; transmission mechanism (c, c?, 4, 4?), hydraulic pressure controlling brake mechanisms (2,2?), speed change mechanisms (3,3?) and rotating mechanisms (7.7) are separately provided at both ends of the generator (1); they are sequentially assembled with parts and electrical elements by connecting fittings according to demands.

Abstract: Method of producing a recombinant membrane receptor protein by introducing a baculovirus expression vector encoding the membrane receptor protein into a host cell, culturing the resultant host cell for a sufficient time to permit expression of the membrane receptor protein and baculovirus viral particles and separating the cells from the viral particles. The baculovirus viral particles are then recovered.

Abstract: The present invention relates to a method for producing membrane receptors based on a baculovirus/insect cell system. The invention further includes the receptors produced by the method described herein, a model for studying the properties of these membrane receptors and an assay to screen molecules that are active on these membrane receptors.

Abstract: Method for producing membrane receptors based on a baculovirus/insect cell system. The invention further includes the receptors produced by the method described herein, a model for studying the properties of these membrane receptors and an assay to screen molecules that are active on these membrane receptors.