Patents Assigned to Vanderbilt University
  • HUMAN ORTHOPOXVIRUS ANTIBODIES AND METHODS OF USE THEREFOR
    Publication number: 20200071389
    Abstract: The present disclosure is directed to antibodies binding to and neutralizing Poxvirus and methods for use thereof.
    Type: Application
    Filed: October 18, 2017
    Publication date: March 5, 2020
    Applicant: Vanderbilt University
    Inventors: James E. CROWE, Jr., Iuliia GILCHUK
  • Anti-factor XI monoclonal antibodies and methods of use thereof
    Patent number: 10577428
    Abstract: Compositions and methods for inhibiting thrombosis without compromising hemostasis are described. Compositions include anti-factor XI monoclonal antibodies (aXIMabs) capable of binding to an epitope on the heavy chain of human FXI, particularly the A3 domain of the heavy chain of human FXI. Compositions also include epitope-binding fragments, variants, and derivatives of the monoclonal antibodies, cell lines producing these antibody compositions, and isolated nucleic acid molecules encoding the amino acid sequences of the antibodies. The disclosure further includes pharmaceutical compositions comprising the disclosed anti-factor XI monoclonal antibodies, or epitope-binding fragments, variants, or derivatives thereof, in a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: July 30, 2018
    Date of Patent: March 3, 2020
    Assignees: Oregon Health & Science University, Vanderbilt University
    Inventors: Andras Gruber, Erik I. Tucker, Stephen Raymond Hanson, David Gailani
  • Compositions and methods for targeting nuclear import shuttles and treating inflammatory disorders
    Patent number: 10568928
    Abstract: The present invention relates to compositions and methods for treating autoimmune, microbial, metabolic, neoplastic, and posttraumatic diseases mediated by inflammation in a subject. Compositions and methods including at least one importin beta-selective nuclear transport modifier (NTM) and/or at least one importin alpha-selective NTM, and/or at least one importin alpha-specific NTM, and/or at least one inhibitor of importin alpha and importin beta complex formation may be administered to a subject to modulate the transport of transcription factors, mediated by nuclear import adaptors, into the nucleus of a cell resulting in a decrease or abrogation of inflammation.
    Type: Grant
    Filed: October 19, 2016
    Date of Patent: February 25, 2020
    Assignee: Vanderbilt University
    Inventors: Jack J. Hawiger, Jozef Zienkiewicz
  • Compositions and methods for treatment of bacterial infections
    Patent number: 10538733
    Abstract: A cell, isolated nucleic acid, vector, isolated polypeptide, and method of treating a bacterial infection are provided. The cell includes a modified Acinetobacter baumannii cell having a mutation in an A. baumannii gene selected from a mutation that occurs when generating mutations in A. baumanni using transposon mutagenesis. The isolated nucleic acid includes a sequence expressing a lpsB, mffT, or GctA polypeptide comprising at least one nucleic acid mutation. The vector includes the isolated nucleic acid. The isolated polypeptide includes a lpsB, mffT, or GctA polypeptide comprising at least one nucleic acid mutation. The method of treating a bacterial infection includes administering to a subject an effective amount of an Acinetobacter baumannii composition including modified Acinetobacter baumannii cell.
    Type: Grant
    Filed: June 29, 2018
    Date of Patent: January 21, 2020
    Assignee: Vanderbilt University
    Inventors: Eric P. Skaar, M. Indriati Hood, Michael Noto
  • System for interpretation of image patterns in terms of anatomical or curated patterns
    Patent number: 10540536
    Abstract: Imaging mass spectrometry (IMS) has become a prime tool for studying the distribution of biomolecules in tissue. Although IMS data sets can become very large, computational methods have made it practically feasible to search these experiments for relevant findings. However, these methods lack access to an important source of information that many human interpretations rely upon: anatomical insight. In this work, this need is addressed by (1) integrating a curated anatomical data source with an empirically acquired IMS data source, establishing an algorithm-accessible link between them; and (2) demonstrating the potential of such an IMS-anatomical atlas link by applying it toward automated anatomical interpretation of ion distributions in tissue.
    Type: Grant
    Filed: August 3, 2015
    Date of Patent: January 21, 2020
    Assignees: Katholieke Universiteit Leuven, K.U.Leuven R&D, Vanderbilt University
    Inventors: Richard M. Caprioli, Bart De Moor, Raf Van De Plas, Nico Verbeeck, Etienne Waelkens
  • 4,5-substituted picolinamide and picolinonitrile metabotropic glutamate receptor 2 negative allosteric modulators
    Patent number: 10538491
    Abstract: 4,5-Substituted Picolinamide and picolinonitrile compounds of formula (I), where R4 is CONH2 or CN and R1 is an optionally substituted aryl or heteroaryl, are negative allosteric modulators of the metabotropic glutamate receptor 2 (mGlu2). The compounds and pharmaceutical compositions including the compounds may be useful for treating depression, anxiety, obsessive-compulsive disorder, cognitive disorders, Alzheimer's disease, or autism spectrum disorders in a subject.
    Type: Grant
    Filed: March 16, 2016
    Date of Patent: January 21, 2020
    Assignee: Vanderbilt University
    Inventors: P. Jeffrey Conn, Craig W. Lindsley, Kyle A. Emmitte, Andrew S. Felts, Katrina A. Bollinger
  • Shape memory polymers and methods of use
    Patent number: 10532125
    Abstract: The presently-disclosed subject matter includes a compound comprising a first monomer, which is allyl-functionalized and crosslinkable, and a second monomer, which is not crosslinkable. In some embodiments the compounds are photocrosslinkable, and in certain embodiments are photocrosslinkable by ultraviolet light. Also provided are shape memory vascular grafts comprised the of present compounds that can transition from a temporary shape to an original shape when heated above a melting temperature of the graft. Still further provided are methods for treating vascular conditions that utilize embodiments of the present grafts.
    Type: Grant
    Filed: June 27, 2014
    Date of Patent: January 14, 2020
    Assignee: Vanderbilt University
    Inventors: Hak-Joon Sung, Timothy C. Boire, Mukesh K. Gupta, Angela L. Zachman, Sue Hyun-Lee, Colleen M. Brophy
  • Substituted indole Mcl-1 inhibitors
    Patent number: 10533010
    Abstract: The present invention provides for compounds that inhibit the activity of an anti-apoptotic Bcl-2 family member Myeloid cell leukemia-1 (Mcl-1) protein. The present invention also provides for pharmaceutical compositions as well as methods for using compounds for treatment of diseases and conditions (e.g., cancer) characterized by the over-expression or dysregulation of Mcl-1 protein.
    Type: Grant
    Filed: March 26, 2015
    Date of Patent: January 14, 2020
    Assignee: Vanderbilt University
    Inventors: Taekyu Lee, Zhiguo Bian, Johannes Belmar, Plamen P. Christov, Nicholas F. Pelz, Subrata Shaw, Kwangho Kim, James C. Tarr, Edward T. Olejniczak, Bin Zhao, Stephen W. Fesik
  • HUMAN MONOCLONAL ANTIBODIES TO STAPHYLOCOCCUS AUREUS LUKAB TOXIN
    Publication number: 20200010536
    Abstract: The present disclosure is directed to antibodies binding to prefusion and postfusion forms of both human S. aureus and human metapneumovirus F proteins, including neutralizing antibodies, and methods for use thereof.
    Type: Application
    Filed: March 6, 2018
    Publication date: January 9, 2020
    Applicant: Vanderbilt University
    Inventors: James E. CROWE, Jr., Gopal SAPPARAPU, Isaac THOMSEN, Buddy CREECH
  • PROSTACYCLIN, PROSTACYCLIN ANALOGS, AND METHODS OF TREATING OR PREVENTING REJECTION OF SOLID ORGAN TRANSPLANTS
    Publication number: 20200009105
    Abstract: The present disclosure relates to methods for treating or preventing rejection of solid organ transplants by administering prostacyclin (PGI2) or a prostacyclin analog.
    Type: Application
    Filed: February 28, 2018
    Publication date: January 9, 2020
    Applicants: Vanderbilt University, The United States as Represented by The Departmet of Veterans Affairs
    Inventor: Stokes PEEBLES
  • Intravenous administration of citrulline during surgery
    Patent number: 10525026
    Abstract: A method for administering citrulline to a patient during surgery without filtration of the hemolysis.
    Type: Grant
    Filed: June 29, 2016
    Date of Patent: January 7, 2020
    Assignee: Vanderbilt University
    Inventors: Marshall L. Summar, Frederick E. Barr
  • Surface active ionic liquid with activity in aqueous and non-aqueous media
    Patent number: 10526273
    Abstract: Disclosed herein are surfactant compounds, that are surface active, liquid, chiral, and micelle forming. Also disclose herein are ionic liquids and compsitions comprising the surfactant compounds.
    Type: Grant
    Filed: January 24, 2019
    Date of Patent: January 7, 2020
    Assignee: Vanderbilt University
    Inventors: Prasad L. Polavarapu, Vijay Raghavan
  • Indazole and azaindazole substituted compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
    Patent number: 10526323
    Abstract: Compounds, including those of the following formula: wherein the variables are defined herein, which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.
    Type: Grant
    Filed: February 1, 2016
    Date of Patent: January 7, 2020
    Assignee: Vanderbilt University
    Inventors: P. Jeffrey Conn, Corey R. Hopkins, Craig W. Lindsley, Colleen M. Niswender, Darren W. Engers, Joe Panarese, Joanne Bronson, Yong-Jin Wu, Jason Guernon
  • Systems and method for volitional control of jointed mechanical device based on surface electromyography
    Patent number: 10517745
    Abstract: Systems and methods for controlling a weight bearing member having at least one powered joint are provided. A system includes a velocity reference module for receiving myoelectric control signals from a user during a non-weight bearing mode for the powered joint and generating a velocity reference for the powered joint based on the myoelectric control signals. The system further includes a volitional impedance module for generating a torque control signal for actuating the powered joint based at least on the velocity reference.
    Type: Grant
    Filed: May 8, 2017
    Date of Patent: December 31, 2019
    Assignee: Vanderbilt University
    Inventors: Michael Goldfarb, Huseyin Atakan Varol, Kevin Ha
  • Polymeric particles, method for cytosolic delivery of cargo, methods of making the particles
    Patent number: 10512607
    Abstract: Embodiments of the present disclosure include particles, methods of making particles, methods of delivering an active agent using the particle, and the like.
    Type: Grant
    Filed: October 25, 2016
    Date of Patent: December 24, 2019
    Assignees: Vanderbilt University, University of Florida Research Foundation, Inc.
    Inventors: Benjamin G. Keselowsky, Jamal Lewis, Lawrence Premasiri Fernando, Craig L. Duvall, Brian C. Evans, Lirong Yang
  • Treatment for hereditary neuropathy with liability to pressure palsies (HNPP)
    Patent number: 10507211
    Abstract: A method of treating demyelinating diseases involves administering a PAK1 inhibitor that is PF-3758309 to a subject in need of such treatment.
    Type: Grant
    Filed: July 17, 2017
    Date of Patent: December 17, 2019
    Assignees: Vanderbilt University, The United States as represented by the Department of Veterans Affairs
    Inventors: Jun Li, Bo Hu
  • Indazole compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
    Patent number: 10508105
    Abstract: Indazole compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease states associated with glutamate dysfunction.
    Type: Grant
    Filed: August 16, 2018
    Date of Patent: December 17, 2019
    Assignee: Vanderbilt University
    Inventors: P. Jeffrey Conn, Craig W. Lindsley, Andrew S. Felts, Colleen M. Niswender, Rory A. Capstick, Paul K. Spearing, Sean R. Bollinger
  • Substituted benzimidazoles as modulators of Ras signaling
    Patent number: 10501421
    Abstract: Benzimidazole compounds that increase the rate of SOS-mediated nucleotide exchange on Ras by binding to a functionally relevant, chemically tractable pocket on the SOS protein, as part of the Ras:SOS:Ras complex.
    Type: Grant
    Filed: January 27, 2017
    Date of Patent: December 10, 2019
    Assignee: Vanderbilt University
    Inventors: Steve Fesik, Alex Waterson, Michael Burns, Qi Sun, Jason Phan, James M. Salovich, Jason R. Abbott, Andrew Little
  • Dexterous wrists
    Patent number: 10500002
    Abstract: A rotatable wrist connecting a gripper tool to the distal end of a positioning shaft. The rotatable wrist includes a wrist hub that is non-rotatably connected to the distal end of the shaft. A wrist capstan is rotatably connected to the wrist hub and non-rotatably connected to an actuatable device (e.g., a gripper). A flexible wire loop extends through the wrist hub and partially contacts the wrist capstan. Linear movement of the flexible wire loop through the shaft causes rotation of the wrist capstan due to friction between the flexible wire loop and the wrist capstan. The wrist also supports selective detachability and control of roll, pitch and roll, pitch yaw and roll according to different embodiments.
    Type: Grant
    Filed: June 8, 2017
    Date of Patent: December 10, 2019
    Assignee: Vanderbilt University
    Inventors: Nabil Simaan, Roger E. Goldman, Andrea Bajo
  • WDR5 inhibitors and modulators
    Patent number: 10501466
    Abstract: Described are N-(6-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-2,3-dihydro-1H-inden-1-yl)benzamide and acetamide-containing compounds that inhibit WDR5 and associated protein-protein interactions, pharmaceutical compositions including the compounds, and methods of using the compounds and compositions for treating disorders and conditions in a subject.
    Type: Grant
    Filed: September 19, 2018
    Date of Patent: December 10, 2019
    Assignee: Vanderbilt University
    Inventors: Stephen W. Fesik, Shaun R. Stauffer, James M. Salovich, William P. Tansey, Feng Wang, Jason Phan, Edward T. Olejniczak