Patents Assigned to Vanderbilt University
  • HUMAN MONOCLONAL ANTIBODIES TO SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 (SARS-CoV-2)
    Publication number: 20210277092
    Abstract: The present disclosure is directed to antibodies binding to and neutralizing the coronavirus designated SARS-CoV-2 and methods for use thereof.
    Type: Application
    Filed: February 11, 2021
    Publication date: September 9, 2021
    Applicant: Vanderbilt University
    Inventors: James E. Crowe, JR., Seth Zost, Robert Carnahan, Pavlo Gilchuk
  • Positive allosteric modulators of the muscarinic acetylcholine receptor M
    Patent number: 11111251
    Abstract: Described are positive allosteric modulators of muscarinic acetylcholine receptor M1 (mAChR M1), pharmaceutical compositions including the compounds, and methods of using the compounds and compositions for treating neurological disorders, psychiatric disorders, or a combination thereof.
    Type: Grant
    Filed: February 16, 2017
    Date of Patent: September 7, 2021
    Assignee: Vanderbilt University
    Inventors: Craig W. Lindsley, P. Jeffrey Conn, Darren W. Engers, Katrina A. Bollinger, Julie L. Engers
  • Pro-fluorophore compounds and use thereof
    Patent number: 11104926
    Abstract: Provided are N,N?-diacyl rhodamine compounds, which may be converted to rhodamine by porcine liver esterase (PLE) to produce a fluorescence signal. These compounds may be used, for example, as substrates in enzymatic assays or as labels in cellular imaging.
    Type: Grant
    Filed: March 26, 2019
    Date of Patent: August 31, 2021
    Assignees: Vanderbilt University, Meharry Medical College
    Inventors: Gary A. Sulikowski, Kristopher K. Abney, Susan J. Ramos-Hunter, Ian M. Romaine, Charles David Weaver
  • INDOMETHACIN ANALOGS FOR THE TREATMENT OF CASTRATE-RESISTANT PROSTATE CANCER
    Publication number: 20210251960
    Abstract: Provided are compositions for inhibiting a biological activity of an aldo-keto reductase family 1, member C3 (AKR1C3) polypeptide. In some embodiments, the compositions are indomethacin derivatives that are AKR1C3-specific inhibitors. Also provided are methods for producing disclosed indomethacin derivatives that substantially lack cyclooxygenase inhibitory activity but that have AKR1C3 inhibitory activity, methods for inhibiting AKR1C3 polypeptide biological activities, and methods for treating prostate tumors in subjects.
    Type: Application
    Filed: April 21, 2021
    Publication date: August 19, 2021
    Applicants: Vanderbilt University, The Trustees of the University of Pennsylvania
    Inventors: Lawrence J. Marnett, Andy J. Liedtke, Trevor M. Penning, Adegoke O. Adeniji, Michael C. Byrns
  • REMOVAL OF HOMOGENEOUS CATALYSTS FROM NMR/MRI AGENTS HYPERPOLARIZED VIA SABRE OR PHIP
    Publication number: 20210252493
    Abstract: The present disclosure provides a method that embodies a simple and effective route to remove homogeneous catalysts from solutions wherein NMR/MRI signal amplification by reversible exchange (SABRE) or parahydrogen-induced polarization (PHIP) is performed. A method for recovering a homogeneous SABRE/PHIP catalyst for reuse is also described.
    Type: Application
    Filed: February 17, 2020
    Publication date: August 19, 2021
    Applicants: Board of Trustees of Southern Illinois University, Vanderbilt University, The Regents of the University of California
    Inventors: Boyd M. Goodson, Eduard Y. Chekmenev, Igor V. Koptyug, Kirill V. Kovtunov, Roman V. Shchepin, Bryce E. Kidd, Jonathan Gesiorski, Max E. Gemeinhardt, Danila A. Barskiy
  • Detection of angiopoietin-2 and thrombospondin-2 in connection with diagnosing acute heart failure
    Patent number: 11079394
    Abstract: Methods for detecting angiopoietin-2 (Angpt-2) and/or thrombospondin-2 (Tsp-2) in a sample involve obtaining or having obtained a blood or plasma sample from a subject; and detecting Angpt-2 and Tsp-2 in the sample. Detecting can involve performing an assay to determine whether the sample includes Angpt-2 and/or Tsp-2 or elevated levels of Angpt-2 and/or Tsp-2. Elevated levels are indicative of acute heart failure.
    Type: Grant
    Filed: July 25, 2018
    Date of Patent: August 3, 2021
    Assignees: Vanderbilt University, Beth Israel Deaconess Medical Center, Inc.
    Inventors: Thomas J. Wang, Deepak K. Gupta, Quinn S. Wells, Robert E. Gerszten
  • System, method and computer program product for determining a decodability index for one or more words
    Patent number: 11068659
    Abstract: Described herein are methods, systems and computer program products for determining a decodability index for one or more words. One of the methods of determining a decodability index for one or more words comprises receiving one or more words for analysis; analyzing the received one or more words using a plurality of effects; and assigning a decodability index to the received one or more words based on the analysis of the received one or more words using the plurality of effects, wherein the assigned decodability index indicates an ability of a person to pronounce or sound out the one or more words.
    Type: Grant
    Filed: May 23, 2018
    Date of Patent: July 20, 2021
    Assignee: Vanderbilt University
    Inventors: Laura Elizabeth Cutting, Neena Marie Saha, Ted Stephen Hasselbring
  • Spine-mounted stereotactic systems and related methods
    Patent number: 11058510
    Abstract: A stereotactic system for positioning a device relative to a spine includes a first frame with an attached first pedicle screw, a second frame with an attached second pedicle screw, and a platform for mounting the device. The lower parts of the frames are horizontally spaced apart, and attachable to the spine by the pedicle screws. The platform is attached to the upper parts of the frames and supported by the frames above the spine. The platform is slidably attached to the upper parts of the frames to adjust a longitudinal position of the platform relative to the frames. The platform is pivotally attached to the upper parts of the frame to adjust a horizontal distance between the lower parts of the frames, while maintaining a constant orientation of the platform.
    Type: Grant
    Filed: September 24, 2018
    Date of Patent: July 13, 2021
    Assignees: The Governors of the University of Alberta, Vanderbilt University
    Inventors: Amirali Toossi, Dirk Everaert, Vivian Mushahwar, Peter Konrad, Changqing Kao
  • Protein quantitation in multicellular tissue specimens
    Patent number: 11047860
    Abstract: Provided are methods for measuring the amount of a target protein in a heterogeneous multicellular biospecimen having two or more cell types.
    Type: Grant
    Filed: April 20, 2016
    Date of Patent: June 29, 2021
    Assignee: Vanderbilt University
    Inventors: Daniel C. Liebler, Lisa J. Zimmerman, Robbert J. C. Slebos
  • System and method for tomography-based radiomic mass analysis
    Patent number: 11026641
    Abstract: Systems and methods are provided for classifying a tissue mass as malignant or benign. The method includes identifying a region of interest in the tissue mass in computed tomography (CT) imaging data, segmenting the CT imaging data to delimit at least a portion of the tissue mass into image segments, extracting a set of radiomic parameters indicative of the tissue mass. The set of radiomic parameters may include tissue mass location, tissue mass shape, tissue mass surface characteristic, or tissue mass texture distribution indicative of the amount of image segments identified. The method also includes generating a report classifying the indeterminate lung nodule as being malignant or benign based on the set of radiomic parameters of the indeterminate lung nodule.
    Type: Grant
    Filed: October 16, 2018
    Date of Patent: June 8, 2021
    Assignees: Mayo Foundation for Medical Education and Research, Vanderbilt University
    Inventors: Tobias Peikert, Ronald A. Karwoski, Fabien Maldonado, Srinivasan Rajagopalan, Brian J. Bartholmai
  • Noise-robust neural networks and methods thereof
    Patent number: 11030487
    Abstract: The exemplified methods and systems facilitate the training of a noise-robust deep learning network that is sufficiently robust in the recognition of objects in images having extremely noisy elements such that the noise-robust network can match, or exceed, the performance of human counterparts. The extremely noisy elements may correspond to extremely noisy viewing conditions, e.g., that often manifests themselves in the real-world as poor weather or environment conditions, sub-optimal lighting conditions, sub-optimal image acquisition or capture, etc. The noise-robust deep learning network is trained both (i) with noisy training images with low signal-to-combined-signal-and-noise ratio (SSNR) and (ii) either with noiseless, or generally noiseless, training images or a second set of noisy training images having a SSNR value greater than that of the low-SSNR noisy training images.
    Type: Grant
    Filed: September 5, 2019
    Date of Patent: June 8, 2021
    Assignee: Vanderbilt University
    Inventors: Frank Tong, Hojin Jang
  • Pyridazinoindole compounds and methods for PET imaging
    Patent number: 11027027
    Abstract: Embodiments of the invention include a novel synthesis of the translocator protein (TSPO) ligands, and methods of imaging a molecular events. Also disclosed are compounds for treatment of diseases, including cancer.
    Type: Grant
    Filed: February 1, 2016
    Date of Patent: June 8, 2021
    Assignee: Vanderbilt University
    Inventors: H. Charles Manning, Yiu-Yin Cheung, Jason R. Buck, Jun Li
  • Compositions and methods for preventing and reducing inflammation and treating disorders associated with inflammation
    Patent number: 11026992
    Abstract: The present invention relates to compositions and methods for preventing and reducing inflammation and preventing and treating diseases and disorders associated with inflammation. It has been shown that CRADD plays a pivotal role in maintaining the integrity of endothelial monolayers. The recombinant cell-penetrating CRADD protein (CP-CRADD)-based compositions and methods described herein provide for the development of a novel treatment for inflammatory vascular disorders including cardiovascular, cerebrovascular, respiratory, gastrointestinal, and renal systems.
    Type: Grant
    Filed: June 21, 2019
    Date of Patent: June 8, 2021
    Assignee: Vanderbilt University
    Inventors: Jack J. Hawiger, Ruth Ann Veach, Yan Liu, Huan Qiao, Lukasz S. Wylezinski
  • Method for creating hyperpolarization at microtesla magnetic fields
    Patent number: 11016152
    Abstract: Provided are methods for nuclear spin polarization enhancement via signal amplification by reversible exchange at very low magnetic fields. The spin polarization is hyperpolarization of isotopically enriched heteronuclei by using a catalyst and parahydrogen to create a complex using iridium and applying magnetic fields in the microtesia range to transfer the spin order from parahydrogen to the complex.
    Type: Grant
    Filed: May 12, 2018
    Date of Patent: May 25, 2021
    Assignees: Vanderbilt University, Duke University, The Board of Trustees of Southern Illinois University
    Inventors: Eduard Y. Chekmenev, Danila A. Barskiy, Roman V. Shchepin, Warren S. Warren, Thomas Theis, Boyd Goodson
  • Positive allosteric modulators of the muscarinic acetylcholine receptor M4
    Patent number: 11008335
    Abstract: Disclosed herein are pyrido[3?,2?:4,5]thieno[2,3-d]pyridazin-8-amine and thieno[2,3-c:4,5-d?]dipyridazin-8-amine compounds, which may be useful as positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.
    Type: Grant
    Filed: November 7, 2017
    Date of Patent: May 18, 2021
    Assignee: Vanderbilt University
    Inventors: Craig W. Lindsley, Darren W. Engers, P. Jeffrey Conn, Sean R. Bollinger, Julie L. Engers
  • Nanostructured carbon materials and methods of making and use thereof
    Patent number: 10995000
    Abstract: Disclosed herein are methods of making a plurality of carbon nanotubes, the methods comprising applying a current across a catalytically passive anode and a catalytic cathode; wherein the catalytic cathode comprises a catalyst and the catalyst comprises Fe, Co, Mo, Cr, Cu, or a combination thereof; wherein the catalytically passive anode and the catalytic cathode are in electrochemical contact with a molten carbonate electrolyte and a source of CO2; thereby forming a plurality of carbon nanotubes on the catalytic cathode.
    Type: Grant
    Filed: August 1, 2017
    Date of Patent: May 4, 2021
    Assignee: Vanderbilt University
    Inventors: Anna Douglas, Cary Pint
  • HUMAN WEST NILE VIRUS ANTIBODIES AND METHODS OF USE THEREFOR
    Publication number: 20210115115
    Abstract: The present disclosure is directed to antibodies binding to and neutralizing West Nile virus and methods for use thereof.
    Type: Application
    Filed: March 26, 2019
    Publication date: April 22, 2021
    Applicant: Vanderbilt University
    Inventor: James E. Crowe, Jr.
  • Methods for treating inflammation and hypertension with ?-ketoaldehyde skavengers
    Patent number: 10975033
    Abstract: A method of treating at least one of inflammation, psoriasis, and/or hypertension comprising administering to a patient in need there of an effective gamma-ketoaldehyde scavenging amount of a gamma-ketoaldehyde scavenging compound.
    Type: Grant
    Filed: July 12, 2012
    Date of Patent: April 13, 2021
    Assignee: Vanderbilt University
    Inventors: L. Jackson Roberts, II, Venkataraman Amarnath, David G. Harrison, Annet Kirabo
  • Continuum robots with multi-scale motion through equilibrium modulation
    Patent number: 10967504
    Abstract: A robotic system, such as a continuum robot, that includes at least one hollow tube backbone and an equilibrium modulation wire at least partially positioned within the backbone. The robotic system is configured to adjust a position of an end effector by bending the hollow tube and to further adjust the position of the robotic device by adjusting a linear insertion position of the equilibrium modulation wire inside the hollow tube, wherein adjusting the linear insertion position of the equilibrium modulation wire changes a flexural rigidity of the hollow tube resulting in a change in the resulting bending angle of the robotic device.
    Type: Grant
    Filed: September 13, 2018
    Date of Patent: April 6, 2021
    Assignee: Vanderbilt University
    Inventors: Nabil Simaan, Giuseppe Del Giudice, Long Wang, Karen M. Joos, Jin-Hui Shen
  • Isoquinoline ether compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
    Patent number: 10968227
    Abstract: Isoquinoline ether compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.
    Type: Grant
    Filed: November 8, 2017
    Date of Patent: April 6, 2021
    Assignee: Vanderbilt University
    Inventors: P. Jeffrey Conn, Craig W. Lindsley, Andrew Felts, Anna L. Blobaum