Abstract: A probe using integrated confocal reflectance imaging, confocal Raman spectroscopy, and gross spatial imaging for non-invasiveIy evaluating a target of interest of a living subject. In one embodiment, the probe includes a casing with first and second ends, and first, second and third optical pons The firsi and second optical ports are located at the first end of the casing and the third optical port is located at the second end of the casing such that the first and third optical ports define a first optical path therebetween and the second and third optical ports define a second optical path therebetween, respectively. Each optical path has first and second portions, where the second portions of the first and second optical paths arc substantially overlapped and proximal to the third optical port.

Abstract: A high inertance liquid piston engine-compressor that is lightweight, portable and for use with pneumatically actuated devices that may have periods of inactivity between periods of pneumatic use. The engine-compressor provides a power generation system that is for use with mobile or portable devices which need a portable long lasting energy source.

Abstract: The present invention provides methods for the generation of viable reoviruses using only cloned nucleic acid segments representing the RNA segments of the reovirus genome.

Abstract: In one aspect, the invention relates to sulfone compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.

Abstract: Compounds useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4) and use thereof.

Abstract: In one aspect of the present invention, an ultracapacitor has a first plate, a second plate and a separator sandwiched between the first plate and the second plate. Each of the first plate and the second plate includes a substrate, first nanostructures formed on the substrate, and second nanostructures, being different from the first nanostructures, attached to the first nanostructures. The first nanostructures include carbon nanotubes (CNTs) or carbon fibers/nanofibers (CFs). The second nanostructures include nano-particles of an active material including MnO2.

Abstract: In one aspect, the invention relates to compounds and methods useful for activating heme sensor systems; for decreasing virulence of bacteria, for example, Staphylococcus aureus; pharmaceutical compositions comprising the compounds; and methods of treating microbial-related disorders. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: The present invention provides for methods of treating diabetes by providing to a subject brown adipose tissue. The tissue may be transplanted from a culture of the subject's own tissue (autograft) or from a donor. These methods can achieve normoglycemia and suppress hypergluconemia, and alleviate conditions associated with such, even in the absence of or at extremely low levels of adjunct insulin therapy, and without any appreciable increase in insulinogenesis.

Abstract: Systems and methods are provided for controlling a lower limb device having at least one powered joint. The method includes detecting a stumble event based on one or more sensor signals associated with an overall motion lower limb device, classifying the stumble event based on sensor signals following the sensor signals associated with the stumble event, and selecting a stumble recovery strategy for the lower limb device based on the classification of the stumble event.

Abstract: The invention is an accumulator system in which multiple elastomeric accumulators are attached in series or parallel in order to generate total differential pressure in excess of that generated in a non-series system. Also disclosed is a “stacked” accumulator system. The system stores energy when the accumulators deform from their original shape in response to the flow of a pressurized fluid. The stored energy is available for use when the fluid is released from the accumulators and the accumulators return to their original shape.

Abstract: The present invention relates to a protein, ADAM10, ADAM10 nucleic acid sequences and ADAM10 proteins encoded by these sequences that are involved in infection by one or more pathogen such as a virus, a parasite, a bacteria or a fungus or are otherwise associated with the life cycle of a pathogen.

Abstract: The present invention relates to compositions and methods for inhibiting thrombosis without compromising hemostasis. Compositions include anti-factor XI monoclonal antibodies (aXIMabs) capable of binding to an epitope on the heavy chain of human FXI, particularly the A3 domain of the heavy chain of human FXI. Compositions also include epitope-binding fragments, variants, and derivatives of the monoclonal antibodies, cell lines producing these antibody compositions, and isolated nucleic acid molecules encoding the amino acid sequences of the antibodies. The invention further includes pharmaceutical compositions comprising the anti-factor XI monoclonal antibodies of the invention, or epitope-binding fragments, variants, or derivatives thereof, in a pharmaceutically acceptable carrier.

Abstract: The invention is a combination accumulator and reservoir which stores energy when the accumulator deforms from its original shape in response to the flow of a pressurized fluid from the reservoir. The stored energy is returned when the fluid flow is reversed and the accumulator discharges the fluid and returns to its original shape. At least one part of the novelty of the invention is that the accumulator and the fluid reservoir reside in the same housing such that the volume of each varies inversely. Accordingly, the invention is more compact and weighs less than conventional accumulators. Another feature of the invention is that fluid is located around the bladder accumulator to lubricate contact between the bladder and sides of the reservoir.

Abstract: A surgical instrument for securing an anchor in a target area of the skull of a patient, wherein the anchor has a shaped surface, a top and a base. In one embodiment, the surgical instrument includes a driver having a first end, an opposite, second end, and a body portion defined therebetween forming a bore therein along a longitudinal axis, where the bore is configured to allow the anchor to be received therein, a first inner surface formed inside the bore proximate to the first end, wherein the first inner surface is formed with a shape that is complimentary to the shaped surface of the anchor, and a second inner surface formed inside the bore and between the first inner surface and the second end, wherein the second inner surface is formed with a shape that is different from that of the first inner surface.

Abstract: In one aspect of the present invention, an apparatus includes a first light source for generating a broadband light, and a second light source for generating a monochromatic light, a beamsplitter optically coupled to the first light source for receiving the broadband light and splitting the received broadband light into a reference light and a sample light, a reference arm optically coupled to the beamsplitter for receiving the reference light and returning the received reference light into the beamsplitter, and a sample arm optically coupled to the beamsplitter and the second light source for combining the sample light and the monochromatic light, delivering the combined sample and monochromatic light to the target of interest, collecting a backscattering light and a Raman scattering light that are generated from interaction of the sample light and the monochromatic light with the target of interest, respectively, returning the backscattering light into the beamsplitter so as to generate an interference sign

Abstract: Embodiments of the present invention comprise biodegradable composites including a polyurethane component and cells encapsulated in gel beads, as well as methods of making such composite and uses thereof. In certain embodiments the gel beads are alginate beads. The composites may be moldable and/or injectable. After implantation or injection, a composition may be set to form a porous composite that provides mechanical strength, supports the in-growth of cells, and/or delivers cells to particular tissues. Inventive composites have the advantage of being able to fill irregularly shaped implantation sites, deliver cells in a localized and noninvasive manner, and optimize cell proliferation and differentiation of delivered cells.

Abstract: A low-version reader (LVR) includes a frame adapted to be worn by a person as well as first and second light sources supported by the frame and positioned to project light beams focusing on a working surface. The LVR also includes a first battery embedded in the frame and a first power-supply circuit that regulates power provided by the first battery to energize the first light source. The first battery is rechargeable and in electrical communication through a first discharge path with the first light source. The first discharge path allows the first battery to energize the first light source. A first charger receptacle in electrical communication through a first charge path with the first battery. The first charge path allows charging the first battery when a power charger is coupled with the first charger receptacle.

Abstract: This invention provides an interferometric detection device configured to maintain a temperature of a sensing area to within 20 m° C. of a first target temperature and to maintain a temperature of the medium within 500 m° C. of a second target temperature The device can do so under conditions in which ambient temperature changes from 0.1° C. to 5° C. over 5 minutes.

Abstract: An access catheter system, comprising a needle assembly comprising a needle having an elongate lumen configured to be substantially filled with a fluid. The system further comprises a fluid monitor configured to monitor a physical characteristic of fluid within the lumen, and configured to sense a change in the physical characteristic. An indicator provides a indication of the sensed change in the physical characteristic.

Abstract: A side-deployable medical guidewire or guide wire torquer, torque device or wire manipulator.