Abstract: Systems and methods for real-time target validation during radiation treatment therapy based on real-time target displacement and radiation dosimetry measurements.

Abstract: A method of generating a template image includes: receiving an input from a user representing identifications of an object in different respective slices of a volumetric image; using the input to determine a volume-of-interest (VOI) that includes voxels in a subset of the volumetric image; and determining the template image using at least some of the voxels in the VOI, wherein the act of determining the template image comprises performing a forward projection of the at least some of the voxels in the VOI using a processor. An image processing method includes: obtaining a volumetric image; performing forward projection of voxels in the volumetric image from different positions onto a first plane using a processor; and summing projections on the first plane resulted from the forward projection from the different positions to create a first image slice in the first plane.

Abstract: A method of monitoring a patient includes obtaining a first image of an object, obtaining a second image of the object, determining a level of similarity between the first and second images, obtaining a third image of the object, determining a level of similarity between the first and third images, analyzing a time series of values that includes the determined level of similarity between the first and second images and the determined level of similarity between the first and third images, and determining a state of the patient based at least on a result of the act of analyzing.

Abstract: Computer-implemented methods and systems can be used to facilitate generation of VMAT treatment plans for providing radiation therapy to patients. Starting from a seed plan, a library of alternative plans, each with an associated outcome for a set of treatment objectives, can be generated via a set of parallel optimization operations performed on the seed plan. A graphical user interface is provided, via which the user can navigate within a treatment space defined by the alternative plans to identify a satisfactory outcome. Based on the satisfactory outcome and a candidate plan selected from the alternative plans, a deliverable VMAT treatment plan can be generated using another optimization operation.

Abstract: A medical device includes: a base; a positioner coupled to the base; an accelerator coupled to the positioner, wherein the positioner is operable to rotate the accelerator relative to the base about at least two axes; and a power source coupled to the accelerator, the power source configured to provide microwave power for the accelerator, wherein a position of the power source relative to the base remains fixed during movement of the accelerator. A medical device includes: a base; a positioner coupled to the base; an accelerator coupled to the positioner; a power source configured to provide microwave power for the accelerator, wherein a position of the source relative to the base remains fixed during movement of the accelerator; and a waveguide for coupling the power source and the accelerator; wherein the waveguide has a first segment with a first cross section, the first cross section being a circular cross-section.

Abstract: Methods for treating tumors by administering ionizing radiation and an immune modulator to a patient with cancer are disclosed. The methods provide the dual benefits of anti-tumor efficacy plus normal tissue protection when combining immune modulators with ionizing radiation to treat cancer patients. The methods described herein also allow for the classification of patients into groups for receiving optimized radiation treatment in combination with an immune modulator based on patient-specific biomarker signatures.

Abstract: Apparatuses and methods for implanting objects, such as a marker, in the lungs of patients. In one embodiment, a bronchoscopic catheter assembly for implanting an object in the lung of a patient includes a handle, a delivery catheter projecting outwardly from the handle, and a push wire contained within the catheter. In one aspect of this embodiment, the catheter can be configured to releasably hold a plurality of markers at a distal end. In another aspect of this embodiment, the push wire can be operably connected to the handle and axially moveable within the delivery catheter to eject the marker out of the catheter within the bronchi of the patient. In a further aspect of this embodiment, the marker can further include an anti-migration device associated with the marker for holding the marker in place once the marker is deployed in the bronchi. The anti-migration device can be integral with the marker or positioned proximate to the marker to prevent migration of the marker.

Abstract: Collision free regions are predetermined for one or more class solutions. Each class solution has defined limits for allowed field geometry variations. Collision free regions in planning can be defined as a set of allowed isocenter positions relative to a fixation device. The collision free regions may be visualized by a user to plan for field geometry and isocenter position tradeoffs. Collision free regions in delivery can be defined as a set of allowed couch support coordinates. The treatment fields in a radiation treatment plan can be checked against the collision free regions in delivery to determine whether they will pose any collision risks.

Abstract: A method for generating one or more images includes collecting data samples representative of a motion of an object, acquiring image data of at least a part of the object over a time interval, synchronizing the data samples and the image data to a common time base, and generating one or more images based on the synchronized image data. A method for generating one or more images includes acquiring image data of at least a part of an object over a time interval, associating the image data with one or more phases of a motion cycle, and constructing one or more images using the image data that are associated with the respective one or more phases.

Abstract: An apparatus for coupling to an input connection of an electron gun, the input connection having a heater terminal and a cathode terminal, includes: a connector having a first end and a second end; wherein the first end of the connector is configured to attach to a cable; wherein the second end of the connector is configured to connect to the input connection of the electron gun; and wherein the connector comprises an opening configured to receive the heater terminal of the input connection of the electron gun.

Abstract: A medical apparatus includes: a beam deflector having an electromagnet configured to provide a first magnetic field for deflecting a particle beam; and a current control configured to adjust a current of the electromagnet in correspondence with an energy level associated with an accelerator. A treatment planning method includes: defining control points in a treatment plan; setting up energy switching in one or more of the control points; and performing treatment optimization on the treatment plan based at least in part on the energy switching that is set up in the one or more of the control points. The medical apparatus also includes an energy adjuster configured to adjust the treatment energy so that the treatment energy has a first energy level when the beam output is at the first gantry angle, and a second energy level when the beam output is at the first gantry angle.

Abstract: A method of determining treatment geometries for a radiotherapy treatment includes providing a patient model having one or more regions of interest (ROIs); defining a delivery coordinate space (DCS); for each beam's eye view (BEV) plane of each vertex in the DCS, and for each ROI, evaluating a dose of the ROI using transport solutions; evaluating a BEV scores of each pixel of the BEV plane using the doses of the one or more ROIs; determining one or more BEV regions in the BEV plane based on the BEV scores; determining a BEV region connectivity manifold based on the BEV regions; determining a set of treatment trajectories based on the BEV region connectivity manifold; and determining one or more IMRT fields. Each treatment trajectory defines a path through a set of vertices in the DCS. Each IMRT field defines a direction of incidence corresponding to a vertex in the DCS.

Abstract: A method of trajectory optimization for radiotherapy treatment includes providing a patient model having one or more regions of interest (ROIs), defining a delivery coordinate space (DCS), for each ROI, solving an adjoint transport to obtain an adjoint solution field from the ROI, for each vertex in the DCS, evaluating an adjoint photon fluence by performing ray tracing of the adjoint solution field, evaluating a dose of the ROI using the adjoint photon fluence, for each vertex in the DCS, evaluating a respective beam's eye view (BEV) score of each pixel of a BEV plane using the doses of the one or more ROIs, determining one or more BEV regions in the BEV plane based on the BEV scores, determining a BEV region connectivity manifold based on the BEV regions, and determining one or more optimal treatment trajectories based on the BEV region connectivity manifold.

Abstract: A method of beam angle optimization for an IMRT radiotherapy treatment includes providing a patient model having one or more regions of interest (ROIs), defining a delivery coordinate space (DCS), for each ROI, solving an adjoint transport to obtain an adjoint solution field from the ROI, for each vertex in the DCS, evaluating an adjoint photon fluence by performing ray tracing of the adjoint solution field, evaluating a dose of the ROI using the adjoint photon fluence, for each vertex in the DCS, evaluating a respective beam's eye view (BEV) score of each pixel of a BEV plane using the doses of the one or more ROIs, determining one or more BEV regions in the BEV plane based on the BEV scores, determining a BEV region connectivity manifold based on the BEV regions, and determining a set of IMRT fields based on the BEV region connectivity manifold.

Abstract: A system generally includes at least one computing device having a user interface and a display interface. The computing device is configured to generate at least one desktop that can be viewed by a user via the display interface and to access a plurality of functionality modules that are each configured to receive at least one radiotherapy parameter. The computing device is configured to enable the user, via the user interface, to place the functionality modules onto the desktop. The computing device is configured to enable the user, via the user interface, to connect one of the placed functionality modules to at least another one to commence the generation of at least one workflow output. The computing device is also configured to enable the user, via the user interface, to connect a plurality of input components to the placed functionality modules to finalize the generation of the workflow output.

Abstract: An apparatus to examine a target in a patient includes an x-ray source configured to deliver a first x-ray beam towards the target, a device having an array of openings, the device located at an angle less than 180 degrees relative to a beam path of the first x-ray beam to receive a second x-ray beam resulted from an interaction between the first x-ray beam and the target, and a detector aligned with the device, the detector located at an angle less than 180 degrees relative to the beam path of the first x-ray beam to receive a part of the second x-ray beam from the device that exits through the openings at the device.

Abstract: A proton beam therapy system with a cantilever gantry. The cantilever gantry has one end portion (the fixed end portion) affixed to an external structure that supports the weight of the gantry. The remainder of the gantry is suspended and the free end portion is coupled to a beam nozzle. A main bearing is coupled to the fixed end portion and enables the gantry to rotate in a full range of 360° around the iso-center. A large counterweight can be disposed in the fixed end portion to keep the system center of mass close to the bearing. The gantry may have a monocoque housing, including a cantilever section enclosing the magnets and other components of the gantry beamline and a drum section on which the bearing is placed.

Abstract: To overcome the difficulties inherent in conventional treatment planning approaches, new techniques are described herein for providing an intuitive user interface for automatic structure derivation in patient modeling. In an embodiment, a graphical user interface is provided that provides a list of structures of a specified region. The interface uses medical terminology instead of mathematical one. In one or more embodiments, the list of structures may be a pre-defined list of structures that correspond to that region for the purposes of treatment planning. A user is able to actuate a toggle to include and/or exclude each of the structures separately. In one or more embodiments, the user is also able to actuate a toggle to define a perimeter around each included structure, and further define a margin around the perimeter. The user is also able to specify whether the desired output should include a union or the intersection of all included structures.

Abstract: A medical device for treating a skin of a patient includes: a radiation source configured to provide radiation; a collimator coupled to the radiation source; and an optical device for viewing a target area on the skin when a distal end of the medical device is covering the skin. A method of treating a skin of a patient includes: providing a treatment device having a distal end, a radiation source, and a collimator, wherein the distal end is configured for placement over the skin of the patient so that the skin of the patient is covered by the distal end of the treatment device; and providing an image of a target on the skin when the distal end of the treatment device is covering the skin of the patient.

Abstract: Radiation treatment planning includes determining a number of beams to be directed into a target, determining directions (e.g., gantry angles) for the beams, and determining an energy level for each of the beams. The number of beams, the directions of the beams, and the energy levels are determined such that the beams do not overlap outside the target and the prescribed dose will be delivered across the entire target.