Abstract: A method of measuring a rotational position of an assembly with circumferential ferromagnetic teeth includes applying an excitation signal for a cycle to an actuator, the cycle causing a first rotational displacement of a first ferromagnetic tooth from a first rotational position to a second rotational position and a second rotational displacement of a second ferromagnetic tooth from the second rotational position to a third rotational position. The method further includes measuring a plurality of first signal outputs from a magnetoresistive sensor during the cycle; determining one or more signal offset values based on the plurality of first signal outputs; applying the signal excitation for a portion of a second cycle to the actuator; measuring second signal outputs from the magnetoresistive sensor; generating corrected signals by modifying the second signal outputs with the signal offset values; and, based on the corrected signals, determining a rotational position of the assembly.

Abstract: The invention provides a non-invasive method for treatment of arrhythmia. In a first aspect, a method for treatment of atrial fibrillation in a heart of a patient comprises directing radiation from outside the patient toward one or more target treatment regions of the heart so as to inhibit the atrial fibrillation. The radiation may induce isolation of a pulmonary vein.

Abstract: Information that describes a target inside a patient to be treated with radiation is accessed from computer system memory. An arrangement of spots inside the target is determined. Each the spots corresponds to a location inside the target where a respective beam of radiation is to be directed during radiation treatment of the patient. A dose rate for each of the beams is determined. The dose rate for each beam is a dose delivered in less than one second to a spot corresponding to that beam. For example, each beam can deliver at least four grays (GY) in less than one second, and may deliver as much as 20 Gy to 50 Gy or 100 Gy or more in less than one second. A radiation treatment plan, that includes the arrangement of the spots and the dose rate for each of the beams, is stored in computer system memory.

Abstract: Disclosed herein are methods and system for training artificial intelligence models configured to execute image segmentation techniques. The methods and system describe a server that receives a first image including a set of pixels depicting multiple objects. The server also receives a second image having a second set of pixels depicting the same set of objects. The server then analyzes the pixels from the first and second images. When a difference between at least one visual attribute of a pixel within the second image and a corresponding pixel within the first image satisfies a predetermined threshold, it will be encoded as spikes to send to the model, the model will be trained using supervised STDP rule by revising weights associated with the nodes within the AI model where the node corresponds to the pixels within the first and/or the second image.

Abstract: A motion-enable device includes a mechanical switch and a capacitive sensor with a sensing region that is located adjacent to the mechanical switch. The mechanical switch enables a first signal when closed or actuated that indicates that the mechanical switch is in an active state. The capacitive sensor enables a second signal when a conductive object is disposed in the sensing region, where the second signal indicates that the capacitive sensor is in an active state. Enablement of operation of an apparatus depends on receipt of both the first signal and the second signal. The mechanical switch and the capacitive sensor act as the two separate switches required by functional safety requirements for a motion enable device. Because the sensing region of the capacitive sensor is adjacent to the mechanical switch, the first and second signals are generated when an operator actuates the mechanical switch with a single digit.

Abstract: A radiation therapy system includes a treatment couch positioning assembly that is directly coupled to a fixed structure supporting the linear accelerator of the radiation therapy system. The radiation therapy system can be installed in a radiation therapy facility without the floor of the facility being excavated and a sub-floor structure, such as a base frame, being installed. To laterally position a patient relative to the linear accelerator, the treatment couch positioning assembly of the radiation therapy system is laterally translated via a linear motor, and laterally translates with the treatment couch, rather than cantilevering the treatment couch to either side of the couch positioning assembly.

Abstract: A microwave applicator for insertion into living body tissue for use in microwave coagulation and ablation treatments includes a microwave transmission line extending between an attachment end of the applicator and an antenna toward an insertion end of the applicator with an outer conductive sleeve forming an enclosed cooling fluid space around the transmission line. Circulation of cooling fluid is guided in the cooling fluid space by a guide sleeve. A fluid circulation system provides a plurality of fluid supply connectors and fluid return connectors which can be connected and used with any number of applicators between one and the number of the fluid supply connectors provided by the system. A portion of the applicator inserted into the tissue can stick to the tissue to stabilize the applicator during treatment. A warning marking on the applicator can be used during track ablation to prevent ablation of the patient skin tissue.

Abstract: An apparatus for use with a medical system, the medical system comprising a medical device configured to treat and/or image a patient, includes: an input configured to receive an image from a camera, the camera configured to view at least a part of the patient and/or at least a part of the medical system; a processing unit configured to replace a damaged-pixel value in the image corresponding with a damaged pixel in the camera that is damaged due to radiation resulted from an operation of the medical device; and an output for outputting an improved image having less noise compared to the image received from the camera.

Abstract: Methods and systems are disclosed for radiating a moving object. The method may comprise acquiring a plurality of indicators of the phase of a physiological cycle of a patient and a plurality of images of the patient that include a target. Each image may be taken at a different phase of the physiological cycle and may be registered to the phase at which the image was taken. The method may also include identifying the target in each of the plurality of images, calculating a dose of radiation required to treat the target, calculating the number, orientation, and dwell time of one or more radiation beams required to deliver the calculated required dose of radiation to the target, and calculating a position of each of the one or more radiation beams required to achieve the calculated orientation. Each position may be a function of the phase of the physiological cycle to which each of the plurality of images is registered.

Abstract: In some aspects, the disclosure pertains to injectable particles that contain at least one pH-altering agent that is configured to be released from the injectable particles in vivo, upon embolization of an intratumoral artery of a tumor with the injectable particles. In certain instances, the pH-altering agent may be a basic agent having a pH value of 7.5, a buffering agent having a pKa value of 7.6 or more, or both. Other aspects of the disclosure pertain to preloaded containers containing such injectable particles and methods of using such injectable particles.

Abstract: A control circuit carries out various actions to facilitate speedy user interaction involving adjustments to radiation dosing that corresponds to a particular mixed radiation treatment plan. These actions can include remixing particular multi-criteria optimization radiation treatment plans.

Abstract: Methods for treating tumors by administering FLASH radiation and a therapeutic agent to a patient with cancer are disclosed. The methods provide the dual benefits of anti-tumor efficacy plus normal tissue protection when combining therapeutic agents with FLASH radiation to treat cancer patients. The methods described herein also allow for the classification of patients into groups for receiving optimized radiation treatment in combination with a therapeutic agent based on patient-specific biomarker signatures. Also provided are radiation treatment planning methods and systems incorporating FLASH radiation and therapeutic agents.

Abstract: A system can have an x-ray source that generates a series of individual x-ray pulses for multi-energy imaging. A first x-ray pulse can have a first energy level and a subsequent second x-ray pulse in the series can have a second energy level different from the first energy level. An x-ray imager can receive the x-rays from the x-ray source and can detect the received x-rays for image generation. A generator interface box (GIB) controls the x-ray source to provide the series of individual x-ray pulses and synchronizes detection by the x-ray imager with generation of the individual x-ray pulses. The GIB can control x-ray pulse generation and synchronization to optimize image generation while minimizing unnecessary x-ray irradiation.

Abstract: A method of radiation therapy comprises, while a gantry of a radiation therapy system rotates continuously in a first direction through a treatment arc from a first treatment delivery position to a second treatment delivery position, causing an imaging X-ray source mounted on the gantry to direct X-rays through a target volume and receiving a set of X-ray projection images from an X-ray imager mounted on the gantry; determining a current location of the target volume based on the set of X-ray projection images; and while the gantry to continues to rotate to the second treatment delivery position, initiating delivery of a treatment beam of a treatment-delivering X-ray source mounted on the gantry to the target volume, and continuing to cause the gantry to rotate in the first direction from the second treatment delivery position to a third treatment delivery position.

Abstract: A control circuit operably couples to a memory having a plurality of different radiation treatment applications stored therein, a data store having patient data stored therein, and at least a first user interface comprising a first display and a first user input interface. The control circuit can be configured to present simultaneously, via the first display and for a given patient, at least two workspaces that each correspond to a different one of the radiation treatment applications wherein the workspaces are using patient data from the data store for the given patient. The control circuit can also be configured to present, via the user input interface, a bookmark capture opportunity, such that a user of the apparatus can selectively create a bookmark that captures a present state for both of the at least two workspaces and hence for the radiation treatment applications that correspond to the at least two workspaces.

Abstract: An apparatus for creating a radiation treatment plan for execution by a radiation treatment machine, includes: a waypoint module configured to obtain imaging waypoint data representing imaging waypoints, the imaging waypoints at least partially defining one or more positions for obtaining images of a patient during a treatment session; a treatment trajectory module configured to obtain treatment data at least partially defining a beam-on direction; a treatment plan generator configured to create the radiation treatment plan based at least in part on the imaging waypoint data and the treatment data.

Abstract: Time-domain interleaving of treatment X-rays and imaging X-rays during an image guided radiation therapy (IGRT) process in a radiation therapy system prevents scatter of the treatment X-rays from degrading the quality of X-ray images used to generate volumetric image data of a target volume. Imaging X-rays are delivered to the target volume during one or more imaging intervals, and one or more pulses of treatment X-rays are delivered to the target volume between the imaging intervals. In instances in which a pulse of treatment X-rays is timed to occur during an imaging interval, the pulse of treatment X-rays is inhibited from occurring during the imaging interval and is rescheduled to occur at a later time that does not coincide with that imaging interval or subsequent imaging intervals.

Abstract: Reconstruction of projection images of a CBCT scan is performed by generating simulated projection data, comparing the simulated projection data to the projection images of the CBCT scan, determining a residual volume based on the comparison, and using the residual volume to determine an accurate reconstructed volume. The reconstructed volume can be used to segment a tumor (and potentially one or more organs) and align the tumor to a planning volume (e.g., from a CT scan) to identify changes, such as shape of the tumor and proximity of the tumor to an organ. These changes can be used to update a radiation therapy procedure, such as by altering a radiation treatment plan and fine-tuning a patient position.

Abstract: Methods for treating tumors by administering FLASH radiation and a therapeutic agent to a patient with cancer are disclosed. The methods provide the dual benefits of anti-tumor efficacy plus normal tissue protection when combining therapeutic agents with FLASH radiation to treat cancer patients. The methods described herein also allow for the classification of patients into groups for receiving optimized radiation treatment in combination with a therapeutic agent based on patient-specific biomarker signatures. Also provided are radiation treatment planning methods and systems incorporating FLASH radiation and therapeutic agents.