Abstract: Interference of dose application in scanned ion beam therapy and organ motion, also called interplay effect, may lead to dose deviations at target volumes. Current repainting methods are susceptible to artifacts due to a predominant scanning direction, ranging from fringed field edges to under and overdosed regions (hot and cold spots). To overcome the difficulties inherent in the repainting techniques of conventional proton therapy systems, new random repainting techniques are described herein for mitigating the under-dose and/or over-dose pattern inherent in existing repainting techniques using a random repainting approach that randomly selects spot locations within the target area.

Abstract: Systems and methods are provided for efficiently performing daily maintenance or quality assurance on proton therapy systems. Specifically, a system is provided which includes a solid-state phantom, a plurality of ionization chambers disposed within the solid-state phantom, and a measuring device coupled to the plurality of ionization chambers and operable to perform radiation measurements of proton beams received within the plurality of ionization chambers. Measurements of proton beams received in the ionization chambers may be used to derive the dose at the ionization chambers and be subsequently compared to pre-generated target data (e.g., data corresponding to proper treatment according to a radiation therapy treatment plan). If the data obtained through the maintenance procedure does not conform to the target data, the proton beam generator may be further calibrated.

Abstract: In one embodiment of the invention, a method for irradiating a target is disclosed. A proton beam is generated using a cyclotron. A first information is provided to an energy selection system. An energy level for the protons is selected using an energy selection system based on the first information. The first information comprises a depth of said target. The proton beam is routed from the cyclotron through a beam transfer line to a scanning system. A second information is provided to the scanning system. The second information comprises a pair of transversal coordinates. The proton beam is guided to a location on the target determined by the second information using a magnet structure. The target is irradiated with the protons.

Abstract: To overcome the difficulties inherent in conventional proton therapy systems, new techniques are described herein for synchronizing the application of proton radiation with the periodic movement of a target area. In an embodiment, a method is provided that combines multiple rescans of a spot scanning proton beam while monitoring the periodic motion of the target area, and aligning the applications of the proton beam with parameters of the periodic motion.

Abstract: A control system is described which provides a user interface that displays a clear graphical representation of relevant data for a particle radiation therapy system (such as a pencil-beam proton therapy system) for treating multiple beam fields as efficiently as possible. The user interface allows a user to visualize a treatment session, select one or multiple beam fields to include in one or more beam applications, and dissociate beam fields previously grouped if necessary. Further embodiments extend the ability to initiate the application of the generated proton therapy beam and the grouping of beam fields to be performed remotely from the treatment room itself, and even automatically, reducing the need for manual interventions to setup between fields.

Abstract: Beam current variation system for a cyclotron, arranged in the inner center of the cyclotron, downstream from the ion source generating the charged particle beam, the system comprising a deflector system powered by a voltage and a collimator. The beam is dumped in the collimator, if the deflector system (10; 20, 21) is not powered, and the beam is switched on by powering the deflector system with a voltage.

Abstract: Systems and apparatuses for providing particle beams for radiation therapy with a compact design and suitable to a single treatment room. The radiation system comprises a stationary cyclotron coupled to a rotating gantry assembly through a beam line assembly. The system is equipped with a single set of dipole magnets that are installed on the rotating gantry assembly and undertakes the dual functions of beam energy selection and beam deflection. The energy degrader may be exposed to the air pressure. The beam line assembly comprises a rotating segment and a stationary segment that are separated from each other through an intermediate segment that is exposed to an ambient pressure.

Abstract: Systems and methods are provided for efficiently performing daily maintenance or quality assurance on proton therapy systems. Specifically, a system is provided which includes a solid-state phantom, a plurality of ionization chambers disposed within the solid-state phantom, and a measuring device coupled to the plurality of ionization chambers and operable to perform radiation measurements of proton beams received within the plurality of ionization chambers. Measurements of proton beams received in the ionization chambers may be used to derive the dose at the ionization chambers and be subsequently compared to pre-generated target data (e.g., data corresponding to proper treatment according to a radiation therapy treatment plan). If the data obtained through the maintenance procedure does not conform to the target data, the proton beam generator may be further calibrated.

Abstract: In one embodiment of the invention, a method for irradiating a target is disclosed. A proton beam is generated using a cyclotron. A first information is provided to an energy selection system. An energy level for the protons is selected using an energy selection system based on the first information. The first information comprises a depth of said target. The proton beam is routed from the cyclotron through a beam transfer line to a scanning system. A second information is provided to the scanning system. The second information comprises a pair of transversal coordinates. The proton beam is guided to a location on the target determined by the second information using a magnet structure. The target is irradiated with the protons.

Abstract: Irradiation device for irradiating an irradiation object with heavy charged particles, comprising a support for the irradiation object, and an irradiation nozzle irradiating a charged particle beam towards the irradiation object, wherein the beam is deflected within the irradiation nozzle. The support for the irradiation object is moveable at least horizontally, and the irradiation nozzle is moveable at least vertically and rotatable around a nozzle swivel axis along which the particle beam enters into the irradiation nozzle.

Abstract: A method for determining parameters of a beam. As a part of the disclosed method, a beam is received at an image detection array where charges are generated and collected, at a plurality of pixels. Values associated with at least one of a plurality of parameters of the beam are determined by integrating information supplied from each of the pixels. Feedback is generated that presents the values.

Abstract: Beam current variation system for a cyclotron, arranged in the inner centre of the cyclotron, downstream from the ion source generating the charged particle beam, the system comprising a deflector system powered by a voltage and a collimator. The beam is dumped in the collimator, if the deflector system (10; 20, 21) is not powered, and the beam is switched on by powering the deflector system with a voltage.

Abstract: Systems and apparatuses for providing particle beams for radiation therapy with a compact design and suitable to a single treatment room. The radiation system comprises a stationary cyclotron coupled to a rotating gantry assembly through a beam line assembly. The system is equipped with a single set of dipole magnets that are installed on the rotating gantry assembly and undertakes the dual functions of beam energy selection and beam deflection. The energy degrader may be exposed to the air pressure. The beam line assembly comprises a rotating segment and a stationary segment that are separated from each other through an intermediate segment that is exposed to an ambient pressure.

Abstract: Systems and methods are provided to perform efficient, automatic cyclotron initialization, calibration, and beam adjustment. A process is provided that allows the automation of the initialization of a cyclotron after overnight or maintenance imposed shutdown. In one embodiment, five independent cyclotron system states are defined and the transition between one state to another may be automated, e.g., by the control system of the cyclotron. According to these embodiments, it is thereby possible to achieve beam operation after shutdown with minimal manual input. By applying an automatic procedure, all active devices of the cyclotron (e.g., RF system, extraction deflectors, ion source) are respectively ramped to predefined parameters.

Abstract: A particle beam therapy system including an accelerator for making a beam of charged particles available, a beam guiding unit supplying the beam to a treatment location starting from the accelerator, and at least one beam property monitor arranged along the beam path. A control unit communicates with the beam property monitor and guiding unit and determines deviations of actual properties from desired properties of the beam and transmits control signals for adapting the beam properties to the guiding unit, using said deviations. Precise beam guidance is achieved by arranging the beam property monitor on the periphery of the beam perpendicular to the beam path such that the beam properties are detected due to their direct interaction with particles of the beam in the halo region and/or indirectly by electromagnetic interaction. A method for a beam of charged particles in a particle beam therapy system is also disclosed.

Abstract: Systems and methods are provided to perform efficient, automatic adjustment of cyclotron beam currents within a wide range for multiple treatment layers within the same patient and treatment session. In one embodiment, efficient adjustment is achieved by using beam current attenuation by an electrostatic vertical deflector installed in the inner center of the cyclotron. The beam current may, for example, be adjusted by the high voltage applied to the electrostatic vertical deflector. In front of each treatment the attenuation curve of the vertical deflector is recorded. Based on this attenuation curve, the vertical deflector voltage for the needed beam current of each irradiation layer is interpolated. With this procedure the beam current could be automatically adjusted in minimal time over a wide range while maintaining a high level of precision.

Abstract: Systems and methods are provided to perform efficient, automatic cyclotron initialization, calibration, and beam adjustment. A process is provided that allows the automation of the initialization of a cyclotron after overnight or maintenance imposed shutdown. In one embodiment, five independent cyclotron system states are defined and the transition between one state to another may be automated, e.g., by the control system of the cyclotron. According to these embodiments, it is thereby possible to achieve beam operation after shutdown with minimal manual input. By applying an automatic procedure, all active devices of the cyclotron (e.g., RF system, extraction deflectors, ion source) are respectively ramped to predefined parameters.

Abstract: The present invention relates to an irradiation device for irradiating an irradiation object with heavy charged particles at an irradiation station, comprising a particle accelerator for providing a particle beam and a swivelling device for swivelling the particle beam impinging on the irradiation object, wherein the swivelling device comprises a carrier pivotable about an axis. In accordance with the invention, the irradiation device is characterized in that the particle accelerator is mounted on the pivotable carrier.

Abstract: Method and apparatus are disclosed for treating a non-continuous particle beam produced by an accelerator in order to irradiate a target volume, wherein an irradiation spot located in the target volume is formed from this beam, and wherein the location of the irradiation spot is controlled by location controlling elements. The setting of the location controlling elements may take place in between subsequent particle bunches of the beam, for example.

Abstract: The present invention relates to an irradiation device for irradiating an irradiation object with heavy charged particles at an irradiation station, comprising a particle accelerator for providing a particle beam and a swivelling device for swivelling the particle beam impinging on the irradiation object, wherein the swivelling device comprises a carrier pivotable about an axis. In accordance with the invention, the irradiation device is characterized in that the particle accelerator is mounted on the pivotable carrier.