Patents Assigned to VERO BIOTECH LLC
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Patent number: 11672938Abstract: Start-up protocols for a device and method for administering NO is described.Type: GrantFiled: July 16, 2019Date of Patent: June 13, 2023Assignee: VERO Biotech LLCInventors: David H. Fine, Edward Bromberg, Ryan Denton, Jason White, Lucas G. Gamero, Bryan Johnson, Gregory Vasquez, Doug Sonosky
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Publication number: 20220088342Abstract: A method for delivering nitric oxide therapy to a subject can include administering a composition including a nitric-oxide releasing agent and silica to the subject and releasing a therapeutic amount of nitric oxide from the composition.Type: ApplicationFiled: August 30, 2021Publication date: March 24, 2022Applicant: VERO Biotech LLCInventor: David H. FINE
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Patent number: 11243197Abstract: A device and method for calibrating a NO delivery device using NO and NO2 measurements, without using a known standard.Type: GrantFiled: July 16, 2019Date of Patent: February 8, 2022Assignee: VERO Biotech LLCInventors: David H. Fine, Edward Bromberg, Thorsten Schmidt, Ryan Denton
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Publication number: 20220016379Abstract: A method and device can alternately deliver high concentration of nitric oxide and oxygen-enriched air.Type: ApplicationFiled: March 29, 2021Publication date: January 20, 2022Applicant: VERO Biotech LLCInventors: David H. FINE, Lee LEICHTER
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Publication number: 20220008679Abstract: Various systems and devices for generating nitric oxide are disclosed herein. According to one embodiment, the device includes a body having an inlet, an outlet, and a porous solid matrix positioned with the body. The porous solid matrix is coated with an aqueous solution of an antioxidant, wherein the inlet is configured to receive a gas flow and fluidly communicate the gas flow to the outlet through the solid matrix to convert nitrogen dioxide in the gas flow into nitric oxide. The porous solid matrix allows the device to be used in any orientation. Additionally, the porous solid matrix provides a rigid structure suitable to withstand vibrations and abuse without compromising device functionality.Type: ApplicationFiled: February 22, 2021Publication date: January 13, 2022Applicant: VERO Biotech LLCInventors: David H. FINE, Bryan JOHNSON, Gregory VASQUEZ
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Patent number: 11208326Abstract: Dinitrogen tetroxide (N2O4) is synthesized in an apparatus by the reaction of concentrated nitric acid with copper. Oxygen is applied as a carrier gas to convert NO to NO2, and water vapor is removed with a tube dryer. A molecular sieve is applied to reduce and remove impurities.Type: GrantFiled: July 18, 2019Date of Patent: December 28, 2021Assignee: VERO Biotech LLCInventors: David H. Fine, Thorsten Schmidt, Bryan Johnson, Alessandra Miranda, Edward Bromberg, Marjorie Nelson
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Publication number: 20210393915Abstract: Inhalation of low levels of nitric oxide can rapidly and safely decrease pulmonary hypertension in mammals. A nitric oxide delivery system that converts nitrogen dioxide to nitric oxide employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid.Type: ApplicationFiled: August 27, 2021Publication date: December 23, 2021Applicant: VERO Biotech LLCInventors: David P. ROUNBEHLER, David H. FINE
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Patent number: 11202880Abstract: Inhalation of low levels of nitric oxide can rapidly and safely decrease pulmonary hypertension in mammals. A nitric oxide delivery system that converts nitrogen dioxide to nitric oxide employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid.Type: GrantFiled: October 26, 2020Date of Patent: December 21, 2021Assignee: VERO Biotech LLCInventors: David P. Rounbehler, David H. Fine
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Publication number: 20210386958Abstract: Inhalation of low levels of nitric oxide can rapidly and safely decrease pulmonary hypertension in mammals. A nitric oxide delivery system that converts nitrogen dioxide to nitric oxide employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid.Type: ApplicationFiled: August 27, 2021Publication date: December 16, 2021Applicant: VERO Biotech LLCInventors: David P. ROUNBEHLER, David H. FINE
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Patent number: 11154210Abstract: A method for treating pulmonary arterial hypertension in a patient can include determining whether a patient with pulmonary arterial hypertension has an enlarged right ventricle or right ventricular dysfunction, where the patient has previously been administered a prostanoid and weaning the patient off of the prostanoid if the patient does not have an enlarged right ventricle or right ventricular dysfunction.Type: GrantFiled: January 7, 2013Date of Patent: October 26, 2021Assignee: VERO Biotech LLCInventors: Tammy Watts, Robert F. Roscigno, David H. Fine, Lewis J. Rubin
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Publication number: 20210316107Abstract: Inhalation of low levels of nitric oxide can rapidly and safely decrease pulmonary hypertension in mammals. A nitric oxide delivery system that converts nitrogen dioxide to nitric oxide employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid.Type: ApplicationFiled: October 26, 2020Publication date: October 14, 2021Applicant: VERO Biotech LLCInventors: David P. ROUNBEHLER, David H. FINE
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Patent number: 11103669Abstract: A method for delivering nitric oxide therapy to a subject can include administering a composition including a nitric-oxide releasing agent and silica to the subject and releasing a therapeutic amount of nitric oxide from the composition.Type: GrantFiled: November 23, 2015Date of Patent: August 31, 2021Assignee: Vero Biotech LLCInventor: David H. Fine
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Patent number: 11000484Abstract: Various methods for diagnosing and treating heart conditions are disclosed herein. According to one method, nitric oxide is delivered to a patient's lungs when the patient has one or more symptoms of a heart condition. The patient is diagnosed as suffering from a heart condition when a symptom of a heart condition subsides after nitric oxide delivery.Type: GrantFiled: July 24, 2009Date of Patent: May 11, 2021Assignee: Vero Biotech LLCInventor: David H. Fine
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Publication number: 20210121655Abstract: A nitric oxide delivery system can include a cassette which is a single use disposable component used to store liquid N2O4 activate upon operator demand, convert N2O4 to NO2 via a heating element(s) controlled by a console to deliver NO2 at a controlled flow rate, direct concentrated NO2 to a contained pair of conversion cartridges and exhaust NO gas to the console for delivery to the patient.Type: ApplicationFiled: August 7, 2020Publication date: April 29, 2021Applicant: VERO Biotech LLCInventors: Barry N. GELLMAN, Eddie TAJUDEEN, Lucas GAMERO, Joshua HOPKINS, Edward E.A. BROMBERG, Ryan DENTON, Bryan J. JOHNSON, David FINE
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Publication number: 20210100972Abstract: A device and method for treating high-altitude sickness can include a handheld device, and can deliver a therapeutic amount of nitric oxide to an individual's lungs in order to minimize or treat high-altitude sickness. The device is self-contained and portable, which allows an individual to carry and use the device in high-altitude or other low-oxygen environments.Type: ApplicationFiled: September 18, 2020Publication date: April 8, 2021Applicant: VERO Biotech LLCInventors: David H. FINE, Gregory VASQUEZ, Bryan JOHNSON
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Patent number: 10960168Abstract: A method and device can alternately deliver high concentration of nitric oxide and oxygen-enriched air. A method of providing a therapeutic amount of nitric oxide to a mammal can include delivering one or more breaths of a therapeutic amount of nitric oxide to the mammal and delivering one or more breaths of an amount of oxygen-enriched air to the mammal immediately after the one or more breaths of the therapeutic amount of nitric oxide.Type: GrantFiled: August 13, 2009Date of Patent: March 30, 2021Assignee: VERO Biotech LLCInventors: David H. Fine, Lee Leichter
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Patent number: 10926054Abstract: Various systems and devices for generating nitric oxide are disclosed herein. According to one embodiment, the device includes a body having an inlet, an outlet, and a porous solid matrix positioned with the body. The porous solid matrix is coated with an aqueous solution of an antioxidant, wherein the inlet is configured to receive a gas flow and fluidly communicate the gas flow to the outlet through the solid matrix to convert nitrogen dioxide in the gas flow into nitric oxide. The porous solid matrix allows the device to be used in any orientation. Additionally, the porous solid matrix provides a rigid structure suitable to withstand vibrations and abuse without compromising device functionality.Type: GrantFiled: March 24, 2017Date of Patent: February 23, 2021Assignee: Vero Biotech LLCInventors: David H. Fine, Bryan Johnson, Gregory Vasquez
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Patent number: 10814092Abstract: Inhalation of low levels of nitric oxide can rapidly and safely decrease pulmonary hypertension in mammals. A nitric oxide delivery system that converts nitrogen dioxide to nitric oxide employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid.Type: GrantFiled: November 12, 2018Date of Patent: October 27, 2020Assignee: VERO Biotech LLCInventors: David P. Rounbehler, David H. Fine
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Patent number: 10780241Abstract: A device and method for treating high-altitude sickness can include a handheld device, and can deliver a therapeutic amount of nitric oxide to an individual's lungs in order to minimize or treat high-altitude sickness. The device is self-contained and portable, which allows an individual to carry and use the device in high-altitude or other low-oxygen environments.Type: GrantFiled: August 13, 2009Date of Patent: September 22, 2020Assignee: VERO Biotech LLCInventors: David Fine, Gregory Vasquez, Bryan Johnson
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Publication number: 20200180958Abstract: Various systems, devices, NO2 absorbents, NO2 scavengers and NO2 recuperator for generating nitric oxide are disclosed herein. According to one embodiment, an apparatus for converting nitrogen dioxide to nitric oxide can include a receptacle including an inlet, an outlet, a surface-active material coated with an aqueous solution of ascorbic acid and an absorbent wherein the inlet is configured to receive a gas flow and fluidly communicate the gas flow to the outlet through the surface-active material and the absorbent such that nitrogen dioxide in the gas flow is converted to nitric oxide.Type: ApplicationFiled: July 15, 2019Publication date: June 11, 2020Applicant: VERO Biotech LLCInventors: David H. FINE, Gregory VASQUEZ, David P. ROUNBEHLER