Patents Assigned to VERO BIOTECH LLC
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Publication number: 20200139071Abstract: Various systems generating nitric oxide are disclosed herein. According to one embodiment, the system includes a first gas source providing nitrogen dioxide mixed in air or oxygen, and a second gas source supplying compressed air and/or compressed oxygen. The system also includes a ventilator coupled to the first and second gas sources, wherein the ventilator is resistant to nitrogen dioxide. The ventilator regulates gas flow and allows for the adjustment of nitrogen dioxide concentration in the gas flow. The system further includes one or more conversion devices operably coupled to the ventilator where the conversion devices convert nitrogen dioxide into nitric oxide. A patient interface delivers nitric oxide to the patient and is operably coupled to the conversion devices. The system allows oxygen and nitric oxide levels to be varied independently.Type: ApplicationFiled: June 18, 2019Publication date: May 7, 2020Applicant: VERO Biotech LLCInventors: David H. FINE, Bryan JOHNSON, Gregory VASQUEZ
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Publication number: 20200139073Abstract: Various systems generating nitric oxide are disclosed herein. According to one embodiment, the system includes a first gas source providing nitrogen dioxide mixed in air or oxygen, and a second gas source supplying compressed air and/or compressed oxygen. The system also includes a ventilator coupled to the first and second gas sources, wherein the ventilator is resistant to nitrogen dioxide. The ventilator regulates gas flow and allows for the adjustment of nitrogen dioxide concentration in the gas flow. The system further includes one or more conversion devices operably coupled to the ventilator where the conversion devices convert nitrogen dioxide into nitric oxide. A patient interface delivers nitric oxide to the patient and is operably coupled to the conversion devices. The system allows oxygen and nitric oxide levels to be varied independently.Type: ApplicationFiled: June 20, 2019Publication date: May 7, 2020Applicant: VERO Biotech LLCInventors: Alfred TECTOR, Priscilla C. PETIT, Kurt A. DASSE, David H. FINE
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Publication number: 20190255277Abstract: A nitric oxide delivery system can include a cassette which is a single use disposable component used to store liquid N2O4, activate upon operator demand, convert N2O4 to NO2 via a heating element(s) controlled by a console to deliver NO2 at a controlled flow rate, direct concentrated NO2 to a contained pair of conversion cartridges and exhaust NO gas to the console for delivery to the patient.Type: ApplicationFiled: February 22, 2019Publication date: August 22, 2019Applicant: VERO BIOTECH LLCInventors: Barry N. Gellman, Eddie Tajudeen, Lucas Gamero, Joshua Hopkins, Edward E.A. Bromberg, Ryan Denton, Bryan J. Johnson, David Fine
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Publication number: 20190217043Abstract: A system for delivering a therapeutic amount of nitric oxide can include a reservoir assembly, a gas supply, and a delivery conduit including a first cartridge, wherein the first cartridge can include a surface-activated material saturated with an aqueous solution of a reducing agent.Type: ApplicationFiled: January 14, 2019Publication date: July 18, 2019Applicant: VERO BIOTECH LLCInventors: David H. FINE, Gregory VASQUEZ, Bryan Johnson, Ryan Denton, Lucas G. Gamero
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Publication number: 20190209993Abstract: A nitric oxide delivery system, which includes a gas bottle having nitrogen dioxide in air, converts nitrogen dioxide to nitric oxide and employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid. A nitric oxide delivery system may be used to generate therapeutic gas including nitric oxide for use in delivering the therapeutic gas to a mammal.Type: ApplicationFiled: October 1, 2018Publication date: July 11, 2019Applicant: VERO BIOTECH LLCInventors: David H. Fine, David R. Rounbehler, Gregory Vasquez, Bryan Johnson
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Publication number: 20190143068Abstract: Inhalation of low levels of nitric oxide can rapidly and safely decrease pulmonary hypertension in mammals. A nitric oxide delivery system that converts nitrogen dioxide to nitric oxide employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid.Type: ApplicationFiled: November 12, 2018Publication date: May 16, 2019Applicant: VERO BIOTECH LLCInventors: David P. Rounbehler, David H. Fine
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Publication number: 20190092639Abstract: Various systems, devices, NO2 absorbents, NO2 scavengers and NO2 recuperator for generating nitric oxide are disclosed herein. According to one embodiment, an apparatus for converting nitrogen dioxide to nitric oxide can include a receptacle including an inlet, an outlet, a surface-active material coated with an aqueous solution of ascorbic acid and an absorbent wherein the inlet is configured to receive a gas flow and fluidly communicate the gas flow to the outlet through the surface-active material and the absorbent such that nitrogen dioxide in the gas flow is converted to nitric oxide.Type: ApplicationFiled: September 24, 2018Publication date: March 28, 2019Applicant: VERO BIOTECH LLCInventors: David H. Fine, Gregory Vasquez, David P. Rounbehler
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Patent number: 10213572Abstract: A nitric oxide delivery system can include a cassette which is a single use disposable component used to store liquid N2O4, activate upon operator demand, convert N2O4 to NO2 via a heating element(s) controlled by a console to deliver NO2 at a controlled flow rate, direct concentrated NO2 to a contained pair of conversion cartridges and exhaust NO gas to the console for delivery to the patient.Type: GrantFiled: October 20, 2015Date of Patent: February 26, 2019Assignee: VERO BIOTECH LLCInventors: Barry N. Gellman, Eddie Tajudeen, Lucas Gamero, Joshua Hopkins, Edward E. A. Bromberg, Ryan Denton, Bryan J. Johnson, David Fine
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Patent number: 10179222Abstract: A system for delivering a therapeutic amount of nitric oxide can include a reservoir assembly, a gas supply, and a delivery conduit including a first cartridge, wherein the first cartridge can include a surface-activated material saturated with an aqueous solution of a reducing agent. In certain embodiments, the reservoir includes a restrictor.Type: GrantFiled: November 18, 2014Date of Patent: January 15, 2019Assignee: VERO BIOTECH LLCInventors: David H. Fine, Gregory Vasquez, Bryan Johnson, Ryan Denton, Lucas G. Gamero
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Patent number: 10124142Abstract: Inhalation of low levels of nitric oxide can rapidly and safely decrease pulmonary hypertension in mammals. A nitric oxide delivery system that converts nitrogen dioxide to nitric oxide employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid.Type: GrantFiled: December 20, 2016Date of Patent: November 13, 2018Assignee: VERO BIOTECH LLCInventors: David P. Rounbehler, David H. Fine
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Patent number: 10086352Abstract: A nitric oxide delivery system, which includes a gas bottle having nitrogen dioxide in air, converts nitrogen dioxide to nitric oxide and employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid. A nitric oxide delivery system may be used to generate therapeutic gas including nitric oxide for use in delivering the therapeutic gas to a mammal.Type: GrantFiled: August 4, 2016Date of Patent: October 2, 2018Assignee: VERO BIOTECH LLCInventors: David H. Fine, David R. Rounbehler, Gregory Vasquez, Brian Johnson
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Patent number: 10081544Abstract: Various systems, devices, NO2 absorbents, NO2 scavengers and NO2 recuperator for generating nitric oxide are disclosed herein. According to one embodiment, an apparatus for converting nitrogen dioxide to nitric oxide can include a receptacle including an inlet, an outlet, a surface-active material coated with an aqueous solution of ascorbic acid and an absorbent wherein the inlet is configured to receive a gas flow and fluidly communicate the gas flow to the outlet through the surface-active material and the absorbent such that nitrogen dioxide in the gas flow is converted to nitric oxide.Type: GrantFiled: July 10, 2017Date of Patent: September 25, 2018Assignee: VERO BIOTECH LLCInventors: David H. Fine, Gregory Vasquez, David P. Rounbehler