Patents Assigned to Vertex Pharmaceuticals Inc.
  • Patent number: 9038488
    Abstract: Methods and devices for inline sampling of a bulk material, such as a powder, are provided. The material's bulk density can be determined from samples drawn using methods and devices described herein. One embodiment of a method of sampling a material allows the material to flow through a sampling compartment, closes off the flow of material below the sampling compartment, builds up a column of material through the sampling compartment, shifts the sampling compartment to remove a slice of material in the column, and places the slice of material into a sample container. A device for sampling a material is provided in another embodiment. The device includes an inlet, an outlet aligned with the inlet, and a sample collector. The sample collector can include at least one through hole and be configured to move such that the at least one through hole can be moved into and out of alignment with the inlet and the outlet.
    Type: Grant
    Filed: February 25, 2013
    Date of Patent: May 26, 2015
    Assignee: Vertex Pharmaceuticals, Inc.
    Inventors: James E. Sinclair, B. Albert Griffin, Minh Vuong
  • Patent number: 8978491
    Abstract: Methods and devices for inline sampling of a bulk material, such as a powder, are provided. The material's bulk density can be determined from samples drawn using methods and devices described herein. One embodiment of a method of sampling a material allows the material to flow through a sampling compartment, closes off the flow of material below the sampling compartment, builds up a column of material through the sampling compartment, shifts the sampling compartment to remove a slice of material in the column, and places the slice of material into a sample container. A device for sampling a material is provided in another embodiment. The device includes an inlet, an outlet aligned with the inlet, and a sample collector. The sample collector can include at least one through hole and be configured to move such that the at least one through hole can be moved into and out of alignment with the inlet and the outlet.
    Type: Grant
    Filed: February 25, 2013
    Date of Patent: March 17, 2015
    Assignee: Vertex Pharmaceuticals, Inc.
    Inventors: James E. Sinclair, B. Albert Griffin, Minh Vuong
  • Patent number: 8967024
    Abstract: Apparatuses and methods for handling a portion of a tissue sample when sectioned by a microtome. The apparatuses include a container, a tissue sample holder in the container, and one or more outlets configured to allow flow of a fluid from the container. The flow through the outlet causes a portion of the tissue sample sectioned by a microtome to move into the outlet. The methods include sectioning one or more portions of a tissue sample, and flowing a fluid past the tissue sample to cause the one or more portions of the tissue sample to move away from the tissue sample and toward at least one fluid outlet.
    Type: Grant
    Filed: July 20, 2011
    Date of Patent: March 3, 2015
    Assignee: Vertex Pharmaceuticals, Inc.
    Inventors: Sanjay Shivayogi Magavi, Jack Barger, Michael Paul Emery, James Edward Sinclair, Jorge Arturo Ayala
  • Patent number: 8955458
    Abstract: Disclosed herein are systems and methods for detecting motion of an object, such as the paw of rat. A tag comprising an inductive element and a capacitive element may be attached to the object and the motion detected by monitoring the affect of the tag on a time-varying magnetic field.
    Type: Grant
    Filed: November 16, 2005
    Date of Patent: February 17, 2015
    Assignee: Vertex Pharmaceuticals, Inc.
    Inventors: Philip Emanuel Salzmann, Javier Humberto Flores, Matthew Charles Wallace, Di Bian, Trang Nguyen, Ada Silos-Santiago, Minh Vuong
  • Patent number: 8895723
    Abstract: Disclosed herein are methods of preparing a phosphorothioate nucleotide analog, which are useful in treating diseases and/or conditions such as viral infections.
    Type: Grant
    Filed: March 18, 2013
    Date of Patent: November 25, 2014
    Assignees: Alios BioPharma, Inc., Vertex Pharmaceuticals Inc.
    Inventors: Vladimir Serebryany, Jyanwei Liu, Leonid Beigelman, Young Chun Jung, Peter Jamison Rose, Shereen Ibrahim, Cavan McKeon Bligh, Luigi Anzalone
  • Publication number: 20140303113
    Abstract: Described herein is a combination that includes compound (A) and compound (B), or a pharmaceutically acceptable salt of the foregoing, for ameliorating and/or treating a hepatitis C viral infection.
    Type: Application
    Filed: April 3, 2014
    Publication date: October 9, 2014
    Applicants: ALIOS BIOPHARMA, INC., VERTEX PHARMACEUTICALS, INC.
    Inventors: Julie Krop, Margaret James Koziel, Lawrence M. Blatt, John Fry, Sushmita Mukherjee Chanda
  • Patent number: 8852881
    Abstract: A device for characterizing the biological properties of cells can include a plurality of dual-compartment assay chambers wherein the compartments of each chamber are separated by a cell layer across which ions can flow. The biological properties of the cell layer in the presence or absence of experimental compounds can be determined by measuring an electrical gradient across the layer. A individual dual-compartment chamber of this type may be referred to as an “Ussing chamber.
    Type: Grant
    Filed: November 29, 2006
    Date of Patent: October 7, 2014
    Assignee: Vertex Pharmaceuticals, Inc.
    Inventors: Paul A. Negulescu, Alec T. Harootunian, Philip E. Salzmann, Javier H. Flores, James E. Sinclair, Minh Vuong, Ashvani K. Singh, Fred F. VanGoor
  • Publication number: 20130253181
    Abstract: Disclosed herein are methods of preparing a phosphorothioate nucleotide analog, which are useful in treating diseases and/or conditions such as viral infections.
    Type: Application
    Filed: March 11, 2013
    Publication date: September 26, 2013
    Applicants: VERTEX PHARMACEUTICALS INC., ALIOS BIOPHARMA, INC.
    Inventors: Vladimir Serebryany, Jyanwei Liu, Leonid Beigelman, Young Chun Jung
  • Publication number: 20130252920
    Abstract: Disclosed herein are pharmaceutical compositions that can include a thionucleotide analog for use in combination therapy with other agents. Also disclosed herein are methods of treating diseases and/or conditions with a pharmaceutical composition that can include a thionucleotide analog in combination therapy with other agents.
    Type: Application
    Filed: March 12, 2013
    Publication date: September 26, 2013
    Applicants: VERTEX PHARMACEUTICALS INC., ALIOS BIOPHARMA, INC.
    Inventors: Lawrence M. Blatt, Leonid Beigelman, Hua Tan, Julian Alexander Symons, David Bernard Smith, Min Jiang, Tara Lynn Kieffer, Cornelis Arie Rijnbrand
  • Publication number: 20130176035
    Abstract: Systems and methods for monitoring laboratory animals includes a tag comprising an inductive element and a capacitive element attached to a portion of a laboratory animal. The position of the portion is detected by monitoring the effect of the tag on a time-varying magnetic field having different frequencies, one near tag resonance, and one away from tag resonance.
    Type: Application
    Filed: February 26, 2013
    Publication date: July 11, 2013
    Applicant: Vertex Pharmaceuticals, Inc.
    Inventor: Vertex Pharmaceuticals, Inc.
  • Publication number: 20130160572
    Abstract: Methods and devices for inline sampling of a bulk material, such as a powder, are provided. The material's bulk density can be determined from samples drawn using methods and devices described herein. One embodiment of a method of sampling a material allows the material to flow through a sampling compartment, closes off the flow of material below the sampling compartment, builds up a column of material through the sampling compartment, shifts the sampling compartment to remove a slice of material in the column, and places the slice of material into a sample container. A device for sampling a material is provided in another embodiment. The device includes an inlet, an outlet aligned with the inlet, and a sample collector. The sample collector can include at least one through hole and be configured to move such that the at least one through hole can be moved into and out of alignment with the inlet and the outlet.
    Type: Application
    Filed: February 25, 2013
    Publication date: June 27, 2013
    Applicant: Vertex Pharmaceuticals, Inc.
    Inventor: Vertex Pharmaceuticals, Inc.
  • Publication number: 20130160573
    Abstract: Methods and devices for inline sampling of a bulk material, such as a powder, are provided. The material's bulk density can be determined from samples drawn using methods and devices described herein. One embodiment of a method of sampling a material allows the material to flow through a sampling compartment, closes off the flow of material below the sampling compartment, builds up a column of material through the sampling compartment, shifts the sampling compartment to remove a slice of material in the column, and places the slice of material into a sample container. A device for sampling a material is provided in another embodiment. The device includes an inlet, an outlet aligned with the inlet, and a sample collector. The sample collector can include at least one through hole and be configured to move such that the at least one through hole can be moved into and out of alignment with the inlet and the outlet.
    Type: Application
    Filed: February 25, 2013
    Publication date: June 27, 2013
    Applicant: Vertex Pharmaceuticals, Inc.
    Inventor: Vertex Pharmaceuticals, Inc.
  • Patent number: 8468975
    Abstract: Systems and methods for monitoring laboratory animals includes a tag comprising an inductive element and a capacitive element attached to a portion of a laboratory animal. The position of the portion is detected by monitoring the effect of the tag on a time-varying magnetic field having different frequencies, one near tag resonance, and one away from tag resonance.
    Type: Grant
    Filed: October 12, 2009
    Date of Patent: June 25, 2013
    Assignee: Vertex Pharmaceuticals, Inc.
    Inventors: Philip Salzmann, Trang Nguyen, James Sinclair
  • Patent number: 8397592
    Abstract: Methods and devices for inline sampling of a bulk material, such as a powder, are provided. The material's bulk density can be determined from samples drawn using methods and devices described herein. One embodiment of a method of sampling a material allows the material to flow through a sampling compartment, closes off the flow of material below the sampling compartment, builds up a column of material through the sampling compartment, shifts the sampling compartment to remove a slice of material in the column, and places the slice of material into a sample container. A device for sampling a material is provided in another embodiment. The device includes an inlet, an outlet aligned with the inlet, and a sample collector. The sample collector can include at least one through hole and be configured to move such that the at least one through hole can be moved into and out of alignment with the inlet and the outlet.
    Type: Grant
    Filed: February 19, 2010
    Date of Patent: March 19, 2013
    Assignee: Vertex Pharmaceuticals, Inc.
    Inventors: James Sinclair, B. Albert Griffin, Minh Vuong
  • Patent number: 8398941
    Abstract: Disclosed herein is a modular test tube rack. The rack contains multiple sub-racks that can be coupled together to form the test tube rack. The sub-rack can be designed to fit into a variety of scientific instrumentation including a fixed rotor centrifuge. The assembled test tube rack can be of a format and size that allows use of standard array pipetters. Thus, a system is provided allowing use of standard array pipetters and high g centrifugation.
    Type: Grant
    Filed: April 18, 2012
    Date of Patent: March 19, 2013
    Assignee: Vertex Pharmaceuticals Inc.
    Inventors: James E. Sinclair, Brian Grot
  • Patent number: 8367690
    Abstract: The present invention relates to a compound of Formula (I): wherein: R1 is H, —NHCOOR1a, C5-6 cycloalkyl, or phenyl; where the cycloalkyl and phenyl each independently may be substituted with one to three of the same or different substituents selected from R10; R1a is C1-3 alkyl which may be substituted with one to three of the same or different substituents selected from F and Cl; R2 is H, —COOH, —CH2 COOH, —COOR2a, or —CH2COOR2a; R2a is C1-2 alkyl, where the alkyl may be substituted with one to three of the same or different substituents selected from halogen atoms; R3 is H, C1-6 alkyl, where the alkyl may be substituted with one to three of the same or different substituents selected from R11; R10 is F, Cl, CF3, or C1-2 alkyl; R11 is halogen atom, hydroxy, or cyano; W is selected from: W2a is H, halogen atom, cyano, C1-2 alkyl, or C3-5 cycloalkyl, or a pharmaceutically acceptable salt or ester thereof.
    Type: Grant
    Filed: March 15, 2010
    Date of Patent: February 5, 2013
    Assignees: Vertex Pharmaceuticals Inc., MSD K.K.
    Inventors: Hayley Binch, Masaya Hashimoto, Michael Mortimore, Mitsuru Ohkubo, Tomoko Sunami
  • Publication number: 20130019725
    Abstract: Disclosed herein are apparatuses and methods handling a portion of a tissue sample when sectioned by a microtome. The apparatuses include a container, a tissue sample holder in the container, and one or more outlets configured to allow flow of a fluid from the container. the flow through the outlet causes a portion of the tissue sample sectioned by a microtome to move into the outlet. The methods include sectioning one or more portions of a tissue sample, and flowing a fluid past the tissue sample to cause the one or more portions of the tissue sample to move away from the tissue sample and toward at least one fluid outlet.
    Type: Application
    Filed: July 20, 2011
    Publication date: January 24, 2013
    Applicant: Vertex Pharmaceuticals, Inc.
    Inventors: Sanjay Shivayogi Magavi, Jack Barger, Michael Paul Emery, James Edward Sinclair, Jorge Arturo Ayala
  • Patent number: 8268811
    Abstract: The present invention relates to compounds useful as inhibitors of Aurora protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.
    Type: Grant
    Filed: October 30, 2009
    Date of Patent: September 18, 2012
    Assignee: Vertex Pharmaceuticals Inc.
    Inventors: Michael Mortimore, Julian Golec, Christopher Davis, Daniel Robinson, John Studley
  • Patent number: 8268829
    Abstract: The present invention provides a facile process for the preparation of tri- and tetra-substituted pyrimidines. The process is useful for preparing inhibitors of protein kinases, especially Aurora kinase. These inhibitors are useful for treating or lessening the severity of Aurora-mediated diseases or conditions.
    Type: Grant
    Filed: May 6, 2009
    Date of Patent: September 18, 2012
    Assignee: Vertex Pharmaceuticals Inc.
    Inventors: Jean-Damien Charrier, Francesca Mazzei, David Kay, Andrew Miller
  • Patent number: 8242272
    Abstract: The present invention relates to a process for the synthesis of 5-fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine in high yield and purity. The present invention also relates to processes for the synthesis of 5-fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine derivatives. These processes are useful for preparing biologically active compounds, particularly certain GSK-3 inhibitors, or derivatives thereof.
    Type: Grant
    Filed: January 28, 2010
    Date of Patent: August 14, 2012
    Assignee: Vertex Pharmaceuticals Inc.
    Inventors: Juan Miguel Jimenez, Philip Collier, Andrew Miller, Jeremy Green, Huai Gao, Sylvain Loïc Jean-Luc Hamon, Albert Cornelis Dros