Patents Assigned to Vertex Pharmaceuticals Inc.
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Patent number: 9038488Abstract: Methods and devices for inline sampling of a bulk material, such as a powder, are provided. The material's bulk density can be determined from samples drawn using methods and devices described herein. One embodiment of a method of sampling a material allows the material to flow through a sampling compartment, closes off the flow of material below the sampling compartment, builds up a column of material through the sampling compartment, shifts the sampling compartment to remove a slice of material in the column, and places the slice of material into a sample container. A device for sampling a material is provided in another embodiment. The device includes an inlet, an outlet aligned with the inlet, and a sample collector. The sample collector can include at least one through hole and be configured to move such that the at least one through hole can be moved into and out of alignment with the inlet and the outlet.Type: GrantFiled: February 25, 2013Date of Patent: May 26, 2015Assignee: Vertex Pharmaceuticals, Inc.Inventors: James E. Sinclair, B. Albert Griffin, Minh Vuong
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Patent number: 8978491Abstract: Methods and devices for inline sampling of a bulk material, such as a powder, are provided. The material's bulk density can be determined from samples drawn using methods and devices described herein. One embodiment of a method of sampling a material allows the material to flow through a sampling compartment, closes off the flow of material below the sampling compartment, builds up a column of material through the sampling compartment, shifts the sampling compartment to remove a slice of material in the column, and places the slice of material into a sample container. A device for sampling a material is provided in another embodiment. The device includes an inlet, an outlet aligned with the inlet, and a sample collector. The sample collector can include at least one through hole and be configured to move such that the at least one through hole can be moved into and out of alignment with the inlet and the outlet.Type: GrantFiled: February 25, 2013Date of Patent: March 17, 2015Assignee: Vertex Pharmaceuticals, Inc.Inventors: James E. Sinclair, B. Albert Griffin, Minh Vuong
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Patent number: 8967024Abstract: Apparatuses and methods for handling a portion of a tissue sample when sectioned by a microtome. The apparatuses include a container, a tissue sample holder in the container, and one or more outlets configured to allow flow of a fluid from the container. The flow through the outlet causes a portion of the tissue sample sectioned by a microtome to move into the outlet. The methods include sectioning one or more portions of a tissue sample, and flowing a fluid past the tissue sample to cause the one or more portions of the tissue sample to move away from the tissue sample and toward at least one fluid outlet.Type: GrantFiled: July 20, 2011Date of Patent: March 3, 2015Assignee: Vertex Pharmaceuticals, Inc.Inventors: Sanjay Shivayogi Magavi, Jack Barger, Michael Paul Emery, James Edward Sinclair, Jorge Arturo Ayala
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Patent number: 8955458Abstract: Disclosed herein are systems and methods for detecting motion of an object, such as the paw of rat. A tag comprising an inductive element and a capacitive element may be attached to the object and the motion detected by monitoring the affect of the tag on a time-varying magnetic field.Type: GrantFiled: November 16, 2005Date of Patent: February 17, 2015Assignee: Vertex Pharmaceuticals, Inc.Inventors: Philip Emanuel Salzmann, Javier Humberto Flores, Matthew Charles Wallace, Di Bian, Trang Nguyen, Ada Silos-Santiago, Minh Vuong
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Patent number: 8895723Abstract: Disclosed herein are methods of preparing a phosphorothioate nucleotide analog, which are useful in treating diseases and/or conditions such as viral infections.Type: GrantFiled: March 18, 2013Date of Patent: November 25, 2014Assignees: Alios BioPharma, Inc., Vertex Pharmaceuticals Inc.Inventors: Vladimir Serebryany, Jyanwei Liu, Leonid Beigelman, Young Chun Jung, Peter Jamison Rose, Shereen Ibrahim, Cavan McKeon Bligh, Luigi Anzalone
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Publication number: 20140303113Abstract: Described herein is a combination that includes compound (A) and compound (B), or a pharmaceutically acceptable salt of the foregoing, for ameliorating and/or treating a hepatitis C viral infection.Type: ApplicationFiled: April 3, 2014Publication date: October 9, 2014Applicants: ALIOS BIOPHARMA, INC., VERTEX PHARMACEUTICALS, INC.Inventors: Julie Krop, Margaret James Koziel, Lawrence M. Blatt, John Fry, Sushmita Mukherjee Chanda
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Patent number: 8852881Abstract: A device for characterizing the biological properties of cells can include a plurality of dual-compartment assay chambers wherein the compartments of each chamber are separated by a cell layer across which ions can flow. The biological properties of the cell layer in the presence or absence of experimental compounds can be determined by measuring an electrical gradient across the layer. A individual dual-compartment chamber of this type may be referred to as an “Ussing chamber.Type: GrantFiled: November 29, 2006Date of Patent: October 7, 2014Assignee: Vertex Pharmaceuticals, Inc.Inventors: Paul A. Negulescu, Alec T. Harootunian, Philip E. Salzmann, Javier H. Flores, James E. Sinclair, Minh Vuong, Ashvani K. Singh, Fred F. VanGoor
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Publication number: 20130253181Abstract: Disclosed herein are methods of preparing a phosphorothioate nucleotide analog, which are useful in treating diseases and/or conditions such as viral infections.Type: ApplicationFiled: March 11, 2013Publication date: September 26, 2013Applicants: VERTEX PHARMACEUTICALS INC., ALIOS BIOPHARMA, INC.Inventors: Vladimir Serebryany, Jyanwei Liu, Leonid Beigelman, Young Chun Jung
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Publication number: 20130252920Abstract: Disclosed herein are pharmaceutical compositions that can include a thionucleotide analog for use in combination therapy with other agents. Also disclosed herein are methods of treating diseases and/or conditions with a pharmaceutical composition that can include a thionucleotide analog in combination therapy with other agents.Type: ApplicationFiled: March 12, 2013Publication date: September 26, 2013Applicants: VERTEX PHARMACEUTICALS INC., ALIOS BIOPHARMA, INC.Inventors: Lawrence M. Blatt, Leonid Beigelman, Hua Tan, Julian Alexander Symons, David Bernard Smith, Min Jiang, Tara Lynn Kieffer, Cornelis Arie Rijnbrand
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Publication number: 20130176035Abstract: Systems and methods for monitoring laboratory animals includes a tag comprising an inductive element and a capacitive element attached to a portion of a laboratory animal. The position of the portion is detected by monitoring the effect of the tag on a time-varying magnetic field having different frequencies, one near tag resonance, and one away from tag resonance.Type: ApplicationFiled: February 26, 2013Publication date: July 11, 2013Applicant: Vertex Pharmaceuticals, Inc.Inventor: Vertex Pharmaceuticals, Inc.
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Publication number: 20130160573Abstract: Methods and devices for inline sampling of a bulk material, such as a powder, are provided. The material's bulk density can be determined from samples drawn using methods and devices described herein. One embodiment of a method of sampling a material allows the material to flow through a sampling compartment, closes off the flow of material below the sampling compartment, builds up a column of material through the sampling compartment, shifts the sampling compartment to remove a slice of material in the column, and places the slice of material into a sample container. A device for sampling a material is provided in another embodiment. The device includes an inlet, an outlet aligned with the inlet, and a sample collector. The sample collector can include at least one through hole and be configured to move such that the at least one through hole can be moved into and out of alignment with the inlet and the outlet.Type: ApplicationFiled: February 25, 2013Publication date: June 27, 2013Applicant: Vertex Pharmaceuticals, Inc.Inventor: Vertex Pharmaceuticals, Inc.
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Publication number: 20130160572Abstract: Methods and devices for inline sampling of a bulk material, such as a powder, are provided. The material's bulk density can be determined from samples drawn using methods and devices described herein. One embodiment of a method of sampling a material allows the material to flow through a sampling compartment, closes off the flow of material below the sampling compartment, builds up a column of material through the sampling compartment, shifts the sampling compartment to remove a slice of material in the column, and places the slice of material into a sample container. A device for sampling a material is provided in another embodiment. The device includes an inlet, an outlet aligned with the inlet, and a sample collector. The sample collector can include at least one through hole and be configured to move such that the at least one through hole can be moved into and out of alignment with the inlet and the outlet.Type: ApplicationFiled: February 25, 2013Publication date: June 27, 2013Applicant: Vertex Pharmaceuticals, Inc.Inventor: Vertex Pharmaceuticals, Inc.
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Patent number: 8468975Abstract: Systems and methods for monitoring laboratory animals includes a tag comprising an inductive element and a capacitive element attached to a portion of a laboratory animal. The position of the portion is detected by monitoring the effect of the tag on a time-varying magnetic field having different frequencies, one near tag resonance, and one away from tag resonance.Type: GrantFiled: October 12, 2009Date of Patent: June 25, 2013Assignee: Vertex Pharmaceuticals, Inc.Inventors: Philip Salzmann, Trang Nguyen, James Sinclair
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Patent number: 8398941Abstract: Disclosed herein is a modular test tube rack. The rack contains multiple sub-racks that can be coupled together to form the test tube rack. The sub-rack can be designed to fit into a variety of scientific instrumentation including a fixed rotor centrifuge. The assembled test tube rack can be of a format and size that allows use of standard array pipetters. Thus, a system is provided allowing use of standard array pipetters and high g centrifugation.Type: GrantFiled: April 18, 2012Date of Patent: March 19, 2013Assignee: Vertex Pharmaceuticals Inc.Inventors: James E. Sinclair, Brian Grot
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Patent number: 8397592Abstract: Methods and devices for inline sampling of a bulk material, such as a powder, are provided. The material's bulk density can be determined from samples drawn using methods and devices described herein. One embodiment of a method of sampling a material allows the material to flow through a sampling compartment, closes off the flow of material below the sampling compartment, builds up a column of material through the sampling compartment, shifts the sampling compartment to remove a slice of material in the column, and places the slice of material into a sample container. A device for sampling a material is provided in another embodiment. The device includes an inlet, an outlet aligned with the inlet, and a sample collector. The sample collector can include at least one through hole and be configured to move such that the at least one through hole can be moved into and out of alignment with the inlet and the outlet.Type: GrantFiled: February 19, 2010Date of Patent: March 19, 2013Assignee: Vertex Pharmaceuticals, Inc.Inventors: James Sinclair, B. Albert Griffin, Minh Vuong
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Patent number: 8367690Abstract: The present invention relates to a compound of Formula (I): wherein: R1 is H, —NHCOOR1a, C5-6 cycloalkyl, or phenyl; where the cycloalkyl and phenyl each independently may be substituted with one to three of the same or different substituents selected from R10; R1a is C1-3 alkyl which may be substituted with one to three of the same or different substituents selected from F and Cl; R2 is H, —COOH, —CH2 COOH, —COOR2a, or —CH2COOR2a; R2a is C1-2 alkyl, where the alkyl may be substituted with one to three of the same or different substituents selected from halogen atoms; R3 is H, C1-6 alkyl, where the alkyl may be substituted with one to three of the same or different substituents selected from R11; R10 is F, Cl, CF3, or C1-2 alkyl; R11 is halogen atom, hydroxy, or cyano; W is selected from: W2a is H, halogen atom, cyano, C1-2 alkyl, or C3-5 cycloalkyl, or a pharmaceutically acceptable salt or ester thereof.Type: GrantFiled: March 15, 2010Date of Patent: February 5, 2013Assignees: Vertex Pharmaceuticals Inc., MSD K.K.Inventors: Hayley Binch, Masaya Hashimoto, Michael Mortimore, Mitsuru Ohkubo, Tomoko Sunami
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Publication number: 20130019725Abstract: Disclosed herein are apparatuses and methods handling a portion of a tissue sample when sectioned by a microtome. The apparatuses include a container, a tissue sample holder in the container, and one or more outlets configured to allow flow of a fluid from the container. the flow through the outlet causes a portion of the tissue sample sectioned by a microtome to move into the outlet. The methods include sectioning one or more portions of a tissue sample, and flowing a fluid past the tissue sample to cause the one or more portions of the tissue sample to move away from the tissue sample and toward at least one fluid outlet.Type: ApplicationFiled: July 20, 2011Publication date: January 24, 2013Applicant: Vertex Pharmaceuticals, Inc.Inventors: Sanjay Shivayogi Magavi, Jack Barger, Michael Paul Emery, James Edward Sinclair, Jorge Arturo Ayala
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Patent number: 8268829Abstract: The present invention provides a facile process for the preparation of tri- and tetra-substituted pyrimidines. The process is useful for preparing inhibitors of protein kinases, especially Aurora kinase. These inhibitors are useful for treating or lessening the severity of Aurora-mediated diseases or conditions.Type: GrantFiled: May 6, 2009Date of Patent: September 18, 2012Assignee: Vertex Pharmaceuticals Inc.Inventors: Jean-Damien Charrier, Francesca Mazzei, David Kay, Andrew Miller
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Patent number: 8268811Abstract: The present invention relates to compounds useful as inhibitors of Aurora protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.Type: GrantFiled: October 30, 2009Date of Patent: September 18, 2012Assignee: Vertex Pharmaceuticals Inc.Inventors: Michael Mortimore, Julian Golec, Christopher Davis, Daniel Robinson, John Studley
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Patent number: 8242272Abstract: The present invention relates to a process for the synthesis of 5-fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine in high yield and purity. The present invention also relates to processes for the synthesis of 5-fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine derivatives. These processes are useful for preparing biologically active compounds, particularly certain GSK-3 inhibitors, or derivatives thereof.Type: GrantFiled: January 28, 2010Date of Patent: August 14, 2012Assignee: Vertex Pharmaceuticals Inc.Inventors: Juan Miguel Jimenez, Philip Collier, Andrew Miller, Jeremy Green, Huai Gao, Sylvain Loïc Jean-Luc Hamon, Albert Cornelis Dros