Patents Assigned to Vertex Pharmaceuticals Inc.
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Publication number: 20120201727Abstract: Disclosed herein is a modular test tube rack. The rack contains multiple sub-racks that can be coupled together to form the test tube rack. The sub-rack can be designed to fit into a variety of scientific instrumentation including a fixed rotor centrifuge. The assembled test tube rack can be of a format and size that allows use of standard array pipetters. Thus, a system is provided allowing use of standard array pipetters and high g centrifugation.Type: ApplicationFiled: April 18, 2012Publication date: August 9, 2012Applicant: Vertex Pharmaceuticals, Inc.Inventors: James E. Sinclair, Brian Grot
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Patent number: 8236832Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds, to methods of using the compounds and to the compositions in the treatment of various disease, conditions, or disorders. The invention also relates to processes for preparing compounds of the inventions.Type: GrantFiled: August 10, 2009Date of Patent: August 7, 2012Assignee: Vertex Pharmaceuticals Inc.Inventors: Juan-Miguel Jimenez, Ronald Knegtel, Daniel Robinson, Phil Collier
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Patent number: 8178055Abstract: Disclosed herein is a modular test tube rack. The rack contains multiple sub-racks that can be coupled together to form the test tube rack. The sub-rack can be designed to fit into a variety of scientific instrumentation including a fixed rotor centrifuge. The assembled test tube rack can be of a format and size that allows use of standard array pipetters. Thus, a system is provided allowing use of standard array pipetters and high g centrifugation.Type: GrantFiled: May 29, 2009Date of Patent: May 15, 2012Assignee: Vertex Pharmaceuticals, Inc.Inventors: James E. Sinclair, Brian Grot
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Publication number: 20120040935Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.Type: ApplicationFiled: May 18, 2011Publication date: February 16, 2012Applicant: Vertex Pharmaceuticals, Inc.Inventors: Dean M. Wilson, Andreas P. Termin, Timothy D. Neubert, Jian Wang, Yulian Zhang, Jesus E. Gonzalez, III, Esther Martinborough, Nicole Zimmerman
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Publication number: 20110203392Abstract: Methods and devices for inline sampling of a bulk material, such as a powder, are provided. The material's bulk density can be determined from samples drawn using methods and devices described herein. One embodiment of a method of sampling a material allows the material to flow through a sampling compartment, closes off the flow of material below the sampling compartment, builds up a column of material through the sampling compartment, shifts the sampling compartment to remove a slice of material in the column, and places the slice of material into a sample container. A device for sampling a material is provided in another embodiment. The device includes an inlet, an outlet aligned with the inlet, and a sample collector. The sample collector can include at least one through hole and be configured to move such that the at least one through hole can be moved into and out of alignment with the inlet and the outlet.Type: ApplicationFiled: February 19, 2010Publication date: August 25, 2011Applicant: Vertex Pharmaceuticals, Inc.Inventors: James Sinclair, B. Albert Griffin, Minh Vuong
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Patent number: 7968545Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.Type: GrantFiled: August 5, 2004Date of Patent: June 28, 2011Assignee: Vertex Pharmaceuticals Inc.Inventors: Dean M. Wilson, Andreas P. Termin, Timothy D. Neubert, Jian Wang, Yulian Zhang, Jesus E. Gonzalez, III, Esther Martinborough, Nicole Zimmerman
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Publication number: 20110087136Abstract: Systems and methods for monitoring laboratory animals includes a tag comprising an inductive element and a capacitive element attached to a portion of a laboratory animal. The position of the portion is detected by monitoring the effect of the tag on a time-varying magnetic field having different frequencies, one near tag resonance, and one away from tag resonance.Type: ApplicationFiled: October 12, 2009Publication date: April 14, 2011Applicant: Vertex Pharmaceuticals, Inc.Inventors: Philip Salzmann, Trang Nguyen, James Sinclair
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Patent number: 7919523Abstract: The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors characterized by specific structural and physicochemical features. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting HIV-1 and HIV-2 protease activity and consequently, may be advantageously used as anti-viral agents against the HIV-1 and HIV-2 viruses. This invention also relates to methods for inhibiting the activity of HIV aspartyl protease using the compounds of this invention and methods for screening compounds for anti-HIV activity.Type: GrantFiled: July 2, 2008Date of Patent: April 5, 2011Assignee: Vertex Pharmaceuticals, Inc.Inventors: Michael R. Hale, Christopher T. Baker, Timothy A. Stammers, Ronald George Sherrill, Andrew Spaltenstein, Eric Steven Furfine, Francois Maltais, Clarence Webster Andrews, III, John Franklin Miller, Vicente Samano
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Publication number: 20100015090Abstract: The present invention relates to co-administering a Hepatitis C virus NS3/4A protease inhibitor and a cytochrome P450 monooxygenase inhibitor. The combination acts by interfering with the life cycle of the hepatitis C virus and is therefore useful as an antiviral therapy. As such, the combination may be used for treating or preventing Hepatitis C infections in patients. The invention also relates to compositions comprising the combination of inhibitors. The invention also relates to kits and pharmaceutical packs comprising a Hepatitis C virus NS3/4A protease inhibitor and a cytochrome P450 monooxygenase inhibitor. The invention also relates to processes for preparing these compositions, combinations, kits, and packs.Type: ApplicationFiled: June 23, 2009Publication date: January 21, 2010Applicant: Vertex Pharmaceuticals, Inc.Inventors: Roger Tung, Gurudatt Chandorkar, Robert Perni
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Publication number: 20090238727Abstract: Disclosed herein is a modular test tube rack. The rack contains multiple sub-racks that can be coupled together to form the test tube rack. The sub-rack can be designed to fit into a variety of scientific instrumentation including a fixed rotor centrifuge. The assembled test tube rack can be of a format and size that allows use of standard array pipetters. Thus, a system is provided allowing use of standard array pipetters and high g centrifugation.Type: ApplicationFiled: May 29, 2009Publication date: September 24, 2009Applicant: Vertex Pharmaceuticals, Inc.Inventors: James E. Sinclair, Brian Grot
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Patent number: 7553671Abstract: Disclosed herein is a modular test tube rack. The rack contains multiple sub-racks that can be coupled together to form the test tube rack. The sub-rack can be designed to fit into a variety of scientific instrumentation including a fixed rotor centrifuge. The assembled test tube rack can be of a format and size that allows use of standard array pipetters. Thus, a system is provided allowing use of standard array pipetters and high g centrifugation.Type: GrantFiled: May 25, 2004Date of Patent: June 30, 2009Assignee: Vertex Pharmaceuticals, Inc.Inventors: James E. Sinclair, Brian Grot
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Patent number: 7490513Abstract: A liquid level sensor comprises a plurality of electrodes arranged in a defined relationship with respect to a container filling trajectory, a signal generator coupled to one or more of the plurality of electrodes, a signal receiver coupled to one or more of the plurality of electrodes, and a sensing circuit coupled to at least one of the signal generator and signal receiver. The sensing circuit is configured to produce an output indicative of electrical resistance between at least one pair of the plurality of electrodes. The sensing circuit may be associated with the signal receiver and/or with the signal generator.Type: GrantFiled: May 10, 2007Date of Patent: February 17, 2009Assignee: Vertex Pharmaceuticals, Inc.Inventors: Philip E. Salzmann, Alec T. Harootunian, Michael P. Emery, Javier H. Flores, Todd N. Bennett, Minh Vuong
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Patent number: 7323616Abstract: The invention relates to genetically manipulated animals that are deficient in the expression of Caspase-9, a protein involved in programmed cell death. The invention further relates to methods for preventing specific types of cell death associated with Caspase-9 activation.Type: GrantFiled: December 1, 2000Date of Patent: January 29, 2008Assignees: Vertex Pharmaceuticals, Inc., Yale UniversityInventors: Keisuke Kuida, Richard A. Flavell
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Publication number: 20070204690Abstract: A liquid level sensor comprises a plurality of electrodes arranged in a defined relationship with respect to a container filling trajectory, a signal generator coupled to one or more of the plurality of electrodes, a signal receiver coupled to one or more of the plurality of electrodes, and a sensing circuit coupled to at least one of the signal generator and signal receiver. The sensing circuit is configured to produce an output indicative of electrical resistance between at least one pair of the plurality of electrodes. The sensing circuit may be associated with the signal receiver and/or with the signal generator.Type: ApplicationFiled: May 10, 2007Publication date: September 6, 2007Applicant: Vertex Pharmaceuticals, Inc.Inventors: Philip Salzmann, Alec Harootunian, Michael Emery, Javier Flores, Todd Bennett, Minh Vuong
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Patent number: 7244735Abstract: Described herein are compounds that are useful as protein kinase inhibitors of formula I: or a pharmaceutically acceptable salt thereof, wherein Ring B, Z1, Z2, U, p, Q, R1, R2, R3, and R3 are as defined herein. These compounds, and pharmaceutically acceptable compositions thereof, are useful for treating or lessening the severity of a variety of disorders, including stroke, inflammatory disorders, autoimmune diseases such as SLE lupus and psoriasis, proliferative disorders such as cancer, and conditions associated with organ transplantation.Type: GrantFiled: December 2, 2004Date of Patent: July 17, 2007Assignee: Vertex Pharmaceuticals Inc.Inventors: Judith Straub, Michael Hale, Francois Maltais, Gabriel Martinez-Botella, Alex Aronov, Guy Bemis
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Patent number: 7241796Abstract: The present invention relates to peptidomimetic compounds that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3–NS4A protease. As such, they act by interfering with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The invention further relates to compositions comprising these compounds either for ex vivo use or for administration to a patient suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a patient by administering a composition comprising a compound of this invention.Type: GrantFiled: October 24, 2002Date of Patent: July 10, 2007Assignee: Vertex Pharmaceuticals Inc.Inventors: Luc J. Farmer, Robert B. Perni, Janos Pitlik, John H. van Drie, Jr.
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Patent number: 7226920Abstract: The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention, processes for preparing the compounds and methods of using the compositions in the treatment of various disorders.Type: GrantFiled: August 6, 2004Date of Patent: June 5, 2007Assignee: Vertex Pharmaceuticals Inc.Inventors: Michael J. Arnost, Guy W. Bemis, Robert J. Davies, Cornelia J. Forster, Ronald Grey, Jr., Mark W. Ledeboer, Brian Ledford, Craig Marhefka, David Messersmith, Albert C. Pierce, Francesco G. Salituro, Jian Wang
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Patent number: 7226919Abstract: The present invention provides a compound of formula (I): or a pharmaceutically acceptable salt thereof. These compounds are inhibitors of protein kinases, particularly inhibitors of GSK-3, JAK-3, FLT-3, PIM-1, SYK, or PDK-1 mammalian protein kinases. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of utilizing those compounds and compositions in the treatment of various protein kinase mediated disorders.Type: GrantFiled: December 17, 2003Date of Patent: June 5, 2007Assignee: Vertex Pharmaceuticals Inc.Inventors: Mark Ledeboer, Robert Davies, David Messersmith, Young-Choon Moon, Michael Mullican
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Patent number: 7219545Abstract: A liquid level sensor comprises a plurality of electrodes arranged in a defined relationship with respect to a container filling trajectory, a signal generator coupled to one or more of the plurality of electrodes, a signal receiver coupled to one or more of the plurality of electrodes, and a sensing circuit coupled to at least one of the signal generator and signal receiver. The sensing circuit is configured to produce an output indicative of electrical resistance between at least one pair of the plurality of electrodes. The sensing circuit may be associated with the signal receiver and/or with the signal generator.Type: GrantFiled: July 28, 2004Date of Patent: May 22, 2007Assignee: Vertex Pharmaceuticals, Inc.Inventors: Philip E. Salzmann, Alec T. Harootunian, Michael P. Emery, Javier H. Flores, Todd N. Bennett, Minh Vuong
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Patent number: 7077018Abstract: A volume displacement pipette that includes a channel within the piston. The channel allows for cleaning fluids to be continuously run through the pipette tip for cleaning the tip. One end of the channel may be closed during normal operation of the pipette. Multiple pipettes may be combined into an array pipetter.Type: GrantFiled: April 27, 2004Date of Patent: July 18, 2006Assignee: Vertex Pharmaceuticals, Inc.Inventor: James E. Sinclair