Patents Assigned to Vifor (International) AG
  • Publication number: 20240100074
    Abstract: The invention relates to a dosing schedule for an inositol polyphosphate oligo(ethylene glycol) compound, or its pharmaceutically acceptable salt used in the treatment or prevention of a disease associated with formation of, and/or tissue exposure to, calcium salt crystals. The drug compound is administered at an interval of one week.
    Type: Application
    Filed: January 26, 2022
    Publication date: March 28, 2024
    Applicant: VIFOR (INTERNATIONAL) AG
    Inventor: Mattias Emanuel IVARSSON
  • Publication number: 20240000811
    Abstract: The invention is related to an inositol polyphosphate oligo alkyl ether compound, or its pharmaceutically acceptable salt, for use in treatment or prevention of a disease associated with formation of calcium salt crystals.
    Type: Application
    Filed: November 19, 2021
    Publication date: January 4, 2024
    Applicants: VIFOR (INTERNATIONAL) AG, ETH ZÜRICH
    Inventors: Mattias Emanuel IVARSSON, Jean-Christophe LEROUX, Anna KLETZMAYR, Makoto KURO-O, Hirosaka HAYASHI
  • Patent number: 11590097
    Abstract: A water soluble iron carbohydrate complex obtainable from an aqueous solution of iron (III) salt and an aqueous solution of the oxidation product of one or more maltodextrins using an aqueous hypochlorite solution at a pH-value within the alkaline range, where, when one maltodextrin is applied, its dextrose equivalent lies between 5 and 20, and when a mixture of several maltodextrins is applied, the dextrose equivalent of the mixture lies between 5 and 20 and the dextrose equivalent of each individual maltodextrin contained in the mixture lies between 2 and 40, process for its production and a medicament for the treatment and prophylaxis of iron deficiency conditions.
    Type: Grant
    Filed: April 19, 2019
    Date of Patent: February 28, 2023
    Assignee: Vifor (International) AG
    Inventors: Peter Geisser, Erik Philipp, Walter Richie
  • Publication number: 20220387371
    Abstract: A water soluble iron carbohydrate complex obtainable from an aqueous solution of iron(III) salt and an aqueous solution of the oxidation product of one or more maltrodextrins using an aqueous hypochlorite solution at a pH-value within the alkaline range, where, when one maltodextrin is applied, its dextrose equivalent lies between 5 and 20, and when a mixture of several maltodextrins is applied, the dextrose equivalent of the mixture lies between 5 and 20 and the dextrose equivalent of each individual maltodextrin contained in the mixture lies between 2 and 40, process for its production and a medicament for the treatment and prophylaxis of iron deficiency conditions.
    Type: Application
    Filed: August 15, 2022
    Publication date: December 8, 2022
    Applicant: Vifor (International) AG
    Inventors: Peter Geisser, Erik Philipp, Walter Richle
  • Patent number: 11291645
    Abstract: A water soluble iron carbohydrate complex obtainable from an aqueous solution of iron(III) salt and an aqueous solution of the oxidation product of one or more maltrodextrins using an aqueous hypochlorite solution at a pH-value within the alkaline range, where, when one maltodextrin is applied, its dextrose equivalent lies between 5 and 20, and when a mixture of several maltodextrins is applied, the dextrose equivalent of the mixture lies between 5 and 20 and the dextrose equivalent of each individual maltodextrin contained in the mixture lies between 2 and 40, a process for its production and a medicament for the treatment and prophylaxis of iron deficiency conditions.
    Type: Grant
    Filed: November 2, 2020
    Date of Patent: April 5, 2022
    Assignee: Vifor (International) AG
    Inventors: Peter Geisser, Erik Philipp, Walter Richle
  • Patent number: 11129820
    Abstract: The invention relates to novel salts of compounds of the general formula (I), pharmaceutical compositions comprising them and the use thereof as medicaments, in particular for the use as ferroportin inhibitors, more particularly for the use in the prophylaxis and/or treatment of diseases caused by a lack of hepcidin or iron metabolism disorders, such as particularly iron overload states such as in particular thalassemia, sickle cell disease and hemochromatosis.
    Type: Grant
    Filed: April 18, 2018
    Date of Patent: September 28, 2021
    Assignee: Vifor (International) AG
    Inventors: Collin D. Morris, Fritz Blatter, Giuseppe Lapadula, Stefan Reim, Michael Burgert, Erik Philipp
  • Patent number: 11123321
    Abstract: A water soluble iron carbohydrate complex obtainable from an aqueous solution of iron(III) salt and an aqueous solution of the oxidation product of one or more maltrodextrins using an aqueous hypochlorite solution at a pH-value within the alkaline range, where, when one maltodextrin is applied, its dextrose equivalent lies between 5 and 20, and when a mixture of several maltodextrins is applied, the dextrose equivalent of the mixture lies between 5 and 20 and the dextrose equivalent of each individual maltodextrin contained in the mixture lies between 2 and 40, a process for its production and a medicament for the treatment and prophylaxis of iron deficiency conditions.
    Type: Grant
    Filed: December 23, 2020
    Date of Patent: September 21, 2021
    Assignee: VIFOR (INTERNATIONAL) AG
    Inventors: Peter Geisser, Erik Philipp, Walter Richie
  • Patent number: 11066399
    Abstract: The invention relates to novel compounds of the general formula (I), with Het-2 being an optionally substituted bicyclic heteroaryl of the formula pharmaceutical compositions comprising them and the use thereof as medicaments, in particular for the use as ferroportin inhibitors, more particularly for the use in the prophylaxis and/or treatment of diseases caused by a lack of hepcidin or iron metabolism disorders, such as particularly iron overload states such as in particular thalassemia and hemochromatosis.
    Type: Grant
    Filed: December 3, 2020
    Date of Patent: July 20, 2021
    Assignee: Vifor (International) AG
    Inventors: Franz Dürrenberger, Michael Burgert, Susanna Burckhardt, Wilm Buhr, Aris Kalogerakis, Stefan Reim, Vania Manolova, Susan Boyce, Christopher John Yarnold, Paula Pena, Jon Shepherd, Cristina Lecci, Richard Jarjes-Pike, John Scott
  • Publication number: 20210139472
    Abstract: The invention relates to novel compounds of the general formula (I), with Het-2 being an optionally substituted bicyclic heteroaryl of the formula pharmaceutical compositions comprising them and the use thereof as medicaments, in particular for the use as ferroportin inhibitors, more particularly for the use in the prophylaxis and/or treatment of diseases caused by a lack of hepcidin or iron metabolism disorders, such as particularly iron overload states such as in particular thalassemia and hemochromatosis.
    Type: Application
    Filed: December 3, 2020
    Publication date: May 13, 2021
    Applicant: Vifor (International) AG
    Inventors: Franz Dürrenberger, Michael Burgert, Susanna Burckhardt, Wilm Buhr, Aris Kalogerakis, Stefan Reim, Vania Manolova, Susan Boyce, Christopher John Yarnold, Paula Pena, Jon Shepard, Cristina Lecci, Richard Jarjes-Pike, John Scott
  • Patent number: 11001579
    Abstract: The invention relates to novel compounds of the general formula (I), with Het-2 being an optionally substituted bicyclic heteroaryl of the formula pharmaceutical compositions comprising them and the use thereof as medicaments, in particular for the use as ferroportin inhibitors, more particularly for the use in the prophylaxis and/or treatment of diseases caused by a lack of hepcidin or iron metabolism disorders, such as particularly iron overload states such as in particular thalassemia and hemochromatosis.
    Type: Grant
    Filed: June 12, 2019
    Date of Patent: May 11, 2021
    Assignee: Vifor (International) AG
    Inventors: Franz Dürrenberger, Michael Burgert, Susanna Burckhardt, Wilm Buhr, Aris Kalogerakis, Stefan Reim, Vania Manolova, Susan Boyce, Christopher John Yarnold, Paula Pena, Jon Shepherd, Cristina Lecci, Richard Jarjes-Pike, John Scott
  • Patent number: 10738041
    Abstract: The invention relates to novel ferroportin inhibitors of the general formula (I) pharmaceutical compositions comprising them and the use thereof as medicaments, in particular for the prophylaxis and/or treatment of diseases caused by a lack of hepcidin or iron metabolism disorders, such as particularly iron overload states such as in particular thalassemia and hemochromatosis.
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: August 11, 2020
    Assignee: Vifor (International) AG
    Inventors: Franz Dürrenberger, Wilm Buhr, Susanna Burckhardt, Michael Burgert, Aris Kalogerakis, Stefan Reim, Vania Manolova, Susan Boyce, Christopher John Yarnold, Paula Pena, Jon Shepherd, Cristina Lecci, Richard Jarjes-Pike, John Scott
  • Patent number: 10519252
    Abstract: Water soluble Iron carbohydrate complex obtainable from an aqueous solution of iron(III) salt and an aqueous solution of the oxidation product of one or more maltrodextrins using an aqueous hypochlorite solution at a pH-value within the alkaline range, where, when one maltodextrin is applied, its dextrose equivalent lies between 5 and 20, and when a mixture of several maltodextrins is applied, the dextrose equivalent of the mixture lies between 5 and 20 and the dextrose equivalent of each individual maltodextrin contained in the mixture lies between 2 and 40, process for its production and medicament for the treatment and prophylaxis of iron deficiency conditions.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: December 31, 2019
    Assignee: VIFOR (INTERNATIONAL) AG.
    Inventors: Peter Geisser, Erik Philipp, Walter Richle
  • Patent number: 10364239
    Abstract: The invention relates to novel compounds of the general formula (A-I), with Het-2 being an optionally substituted bicyclic heteroaryl of the formula (AA) pharmaceutical compositions comprising them and the use thereof as medicaments, in particular for the use as ferroportin inhibitors, more particularly for the use in the prophylaxis and/or treatment of diseases caused by a lack of hepcidin or iron metabolism disorders, such as particularly iron overload states such as in particular thalassemia and hemochromatosis.
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: July 30, 2019
    Assignee: Vifor (International) AG
    Inventors: Franz Dürrenberger, Michael Burgert, Susanna Burckhardt, Wilm Buhr, Aris Kalogerakis, Stefan Reim, Vania Manolova, Susan Boyce, Christopher John Yarnold, Paula Pena, Jon Shepherd, Cristina Lecci, Richard Jarjes-Pike, John Scott
  • Patent number: 9943498
    Abstract: The invention relates to iron(III) complex compounds and pharmaceutical compositions comprising them for the use as medicaments, in particular for the treatment and/or prophylaxis of iron deficiency symptoms and iron deficiency anemias.
    Type: Grant
    Filed: June 17, 2016
    Date of Patent: April 17, 2018
    Assignee: Vifor (International) AG
    Inventors: Thomas Bark, Wilm Buhr, Susanna Burckhardt, Michael Burgert, Camillo Canclini, Franz Dürrenberger, Felix Funk, Peter Geisser, Aris Kalogerakis, Simona Mayer, Erik Philipp, Stefan Reim, Diana Sieber, Jörg Schmitt, Katrin Schwarz
  • Patent number: 9821947
    Abstract: A method and a receptacle for storing and supplying a liquid, especially a liquid medical preparation. It is an object of the invention to provide a suitable receptacle and method for storing and supplying a desired liquid quantity. It is solved by a liquid tight and preferably gas-tight receptacle, comprising a compressible tube (7) or foil bag. A rigid opening portion (6) is sealingly mounted to one end of the tube (7). The diameter of the opening portion (6) is the same as the diameter of the tube (7). The tube (7) diameter is not more than 10 mm The liquid has a volume of not more than 1.5 ml, preferably of not more than 1.3 ml. The tube (7) contains additionally a gas having a volume of 10 to 15% of the liquid volume. The tube (7) or foil bag comprises a flat portion having an inscription.
    Type: Grant
    Filed: August 5, 2013
    Date of Patent: November 21, 2017
    Assignee: Vifor (International) AG
    Inventor: Ludwig Daniel Weibel
  • Publication number: 20160310459
    Abstract: The invention relates to iron(III) complex compounds and pharmaceutical compositions comprising them for the use as medicaments, in particular for the treatment and/or prophylaxis of iron deficiency symptoms and iron deficiency anemias.
    Type: Application
    Filed: June 17, 2016
    Publication date: October 27, 2016
    Applicant: Vifor (International) AG
    Inventors: Thomas Bark, Wilm Buhr, Susanna Burckhardt, Michael Burgert, Camillo Canclini, Franz Dürrenberger, Felix Funk, Peter Geisser, Aris Kalogerakis, Simona Mayer, Erik Philipp, Stefan Reim, Diana Sieber, Jörg Schmitt, Katrin Schwarz
  • Patent number: 9452152
    Abstract: The invention relates to iron(III) complex compounds and pharmaceutical compositions comprising them for the use as medicaments, in particular for the treatment and/or prophylaxis of iron deficiency symptoms and iron deficiency anemias.
    Type: Grant
    Filed: December 19, 2013
    Date of Patent: September 27, 2016
    Assignee: Vifor (International) AG
    Inventors: Thomas Bark, Wilm Buhr, Susanna Burckhardt, Michael Burgert, Camillo Canclini, Franz Dürrenberger, Felix Funk, Peter O. Geisser, Aris Kalogerakis, Simona Mayer, Erik Philipp, Stefan Reim, Diana Sieber, Jörg Schmitt, Katrin Schwarz
  • Patent number: 9439910
    Abstract: The invention relates to iron(III) complex compounds and pharmaceutical compositions comprising them for the use as medicaments, in particular for the treatment and/or prophylaxis of iron deficiency symptoms and iron deficiency anemias.
    Type: Grant
    Filed: April 4, 2013
    Date of Patent: September 13, 2016
    Assignee: VIFOR (INTERNATIONAL) AG
    Inventors: Thomas Bark, Wilm Buhr, Susanna Burckhardt, Michael Burgert, Camillo Canclini, Franz Dürrenberger, Felix Funk, Peter Otto Geisser, Aris Kalogerakis, Simona Mayer, Erik Philipp, Stefan Reim, Diana Sieber, Jörg Schmitt, Katrin Schwarz
  • Patent number: 9422247
    Abstract: The invention relates to iron(III) complex compounds and pharmaceutical compositions comprising them for the use as medicaments, in particular for the treatment and/or prophylaxis of iron deficiency symptoms and iron deficiency anemias.
    Type: Grant
    Filed: March 28, 2012
    Date of Patent: August 23, 2016
    Assignee: Vifor (International) AG
    Inventors: Thomas Bark, Wilm Buhr, Susanna Burckhardt, Michael Burgert, Camillo Canclini, Franz Dürrenberger, Felix Funk, Peter Otto Geisser, Aris Kalogerakis, Simona Mayer, Erik Philipp, Stefan Reim, Diana Sieber, Jörg Schmitt, Katrin Schwarz
  • Patent number: 9394324
    Abstract: The invention relates to iron(III) complex compounds and pharmaceutical compositions comprising them for the use as medicaments, in particular for the treatment and/or prophylaxis of iron deficiency symptoms and iron deficiency anemias.
    Type: Grant
    Filed: March 22, 2011
    Date of Patent: July 19, 2016
    Assignee: Vifor (International) AG
    Inventors: Thomas Bark, Wilm Buhr, Susanna Burckhardt, Michael Burgert, Camillo Canclini, Franz Dürrenberger, Felix Funk, Peter Geisser, Aris Kalogerakis, Simona Mayer, Erik Philipp, Stefan Reim, Diana Sieber, Jörg Schmitt, Katrin Schwarz