Abstract: The present invention relates to novel hepcidin antagonists of the general formula (I), pharmaceutical compositions comprising them and the use thereof as medicaments, in particular for treatment of disorders in iron metabolism, such as, in particular, iron deficiency diseases and anaemias, in particular anaemias in connection with chronic inflammatory diseases (ACD: anaemia of chronic disease and AI: anaemia of inflammation).

Abstract: Subject of the present invention are compositions comprising a mixture of calcium, magnesium and iron salts for use as a pharmaceutical preparation for adsorbing phosphate, especially for use as pharmaceutical preparations for the treatment of hyperphosphataemia, chronic kidney deficiency as well as for the treatment of haemodialysis patients.

Abstract: The invention relates to a tip cap assembly for closing a distal opening of a receptacle like a syringe body or a tube in a sealed manner, and to a method for producing the tip cap. A cap assembly according to the invention comprises a frangible tip of a receptacle, preferably a pre-filled receptacle. An upper portion of the tip closes the receptacle respectively a lower tip portion comprising a passage as known from the state of the art. Hence, the receptacle is reliably sealed to prevent contamination or loss of the medication. Compared with the state of the art, a receptacle has a more effectively sealed tip. It is necessary to break the upper tip portion away in order to open the receptacle. A cap element protects the tip on one side. On the other side, unscrewing the cap breaks the upper portion away without hurting a person.

Abstract: The invention relates to a method for storing and supplying a liquid, especially a liquid medical preparation. The invention further relates to a receptacle for storing and supplying a liquid, especially a liquid medical preparation. It is an object of the invention to provide a suitable receptacle and method for storing and supplying a desired liquid quantity. The object of the invention is solved by a receptacle for storing and supplying a liquid which receptacle is liquid tight and preferably gas-tight comprising a tube or a foil bag which can be compressed. The tube or foil bag preferably comprises a rigid opening portion sealingly mounted to one end of the tube. The diameter of the opening portion preferably is the same as the diameter of the tube. The rigid opening portion is stable in respect of shape. The tube diameter preferably is not more than 10 mm and, in an embodiment of the invention, the tube contains a liquid, preferably a liquid medical preparation.

Abstract: Water-soluble iron-carbohydrate derivative complex obtainable from an aqueous iron(III) salt solution and an aqueous solution of the product of the oxidation and subsequent derivatisation of one or more maltodextrins with an aqueous hypochlorite solution at an alkaline pH value, wherein when one maltodextrin is used its dextrose equivalent is from 5 to 20 and when a mixture of a plurality of maltodextrins is used the dextrose equivalent of the mixture is from 5 to 20 and the dextrose equivalent of each individual maltodextrin in the mixture is from 2 to 40, and the subsequent derivatisation is carried out with a suitable reagent, process for the preparation thereof, and medicament for the treatment and prophylaxis of iron deficiency states.

Abstract: What is proposed is a dispensing device for dispensing tablets belonging to a stack of tablets separately. There is arranged, in a casing (100), a conveying element (200) which can be moved to and fro, in relation to said casing, between a dispensing position and a conveying position. The dispensing device also comprises holding means, in particular a lift element (300), which cause the stack of tablets to be kept stationary when a movement of the conveying element, relative to the casing, from the dispensing position into the conveying position occurs, and which cause said stack of tablets to be entrained towards the removing aperture by the conveying element when said conveying element returns to the dispensing position. In this way, the stack of tablets is conveyed in the direction of conveyance by a predetermined amount, particularly by the thickness of a single tablet, when a forward-and-backward movement of the conveying element occurs, and said single tablet can be easily removed.

Abstract: Water soluble iron carbohydrate complex obtainable from an aqueous solution of iron(III) salt and an aqueous solution of the oxidation product of one or more maltodextrins using an aqueous hypochlorite solution at a pH-value within the alkaline range, where, when one maltodextrin is applied, its dextrose equivalent lies between 5 and 20, and when a mixture of several maltodextrins is applied, the dextrose equivalent of the mixture lies between 5 and 20 and the dextrose equivalent of each individual maltodextrin contained in the mixture lies between 2 and 40, process for its production and medicament for the treatment and prophylaxis of iron deficiency conditions.

Abstract: The invention provides an iron-carbohydrate complex compound which is characterized by a content of iron(II). The invention also provides processes for the preparation of the iron-carbohydrate complex compound and the use thereof for treatment of iron deficiency anaemias.

Abstract: Water soluble iron carbohydrate complex obtainable from an aqueous solution of iron (III) salt and an aqueous solution of the oxidation product of one or more maltrodextrins using an aqueous hypochlorite solution at a pH-value within the alkaline range, where, when one maltodextrin is applied, its dextrose equivalent lies between 5 and 20, and when a mixture of several maltodextrins is applied, the dextrose equivalent of the mixture lies between 5 and 20 and the dextrose equivalent of each individual maltodextrin contained in the mixture lies between 2 and 40, process for its production and medicament for the treatment and prophylaxis of iron deficiency conditions.

Abstract: The present invention relates to a process for the preparation of a novel composition, and to the use of the composition as a phosphate adsorbent, in particular for administration in humans or animals.

Abstract: The invention is related to a new process for the preparation of ferri-succinylcasein.

Abstract: A preparation is disclosed that comprises one or more iron(III) complex compounds which have a redox potential at pH 7 of from ?324 mV to ?750 mV relative to a normal hydrogen electrode (NHE), and one or more redox-active substances, wherein the carbohydrates are selected from the group consisting of dextrans and hydrogenated dextrans, dextrins, oxidised or hydrogenated dextrins, as well as pullulan, oligomers thereof and/or hydrogenated pullulans, and wherein the redox-active substance(s) is/are selected from the group consisting of ascorbic acid; vitamin E; cysteine; physiologically acceptable phenols/polyphenols selected from the group consisting of quercetin, rutin, flavones, flavonoids, hydroquinones; and glutathione, and in particular is ascorbic acid.

Abstract: The use of iron(III) complex compounds with carbohydrates or derivatives thereof for the preparation of a medicament for oral treatment of iron deficiency states in patients with chronic inflammatory bowel disease, in particular Crohn's disease and colitis ulcerosa, is disclosed.

Abstract: The present invention relates to novel therapeutic uses of iron(III) complex compounds with carbohydrates or derivatives thereof, in the preparation of a medicament for improving immune defence and/or brain performance.

Abstract: The present invention relates to a container (1, 1?, 1?) for the intake and release of a medicament, in particular a parenteral medicament, the container (1, 1?, 1?) exhibiting a casing (6, 6?) which is sealed, except for an opening (7) for the purpose of releasing the medicament, the container (1, 1?, 1?) being designed in such a way that a release of the medicament is effected by alteration of at least one region of the casing (6, 6?). The casing (6, 6?) is furthermore formed in one piece. The container exhibits a hollow needle (9, 10).

Abstract: An adsorbent for phosphate from aqueous medium, particularly for inorganic phosphate or phosphate bound to foodstuffs from body fluids or foodstuffs, which contains beta-iron hydroxide stabilized by carbohydrates and/or by humic acid.