Patents Assigned to Virginia Commonwealth University
-
Patent number: 12239696Abstract: Provided herein are chimeric recombinant polypeptides (chimeritopes) for use in vaccines against Anaplasmosis, in assays for diagnosing Anaplasmosis and in assays for measuring antibody titers induced by vaccination. The chimeritopes comprise, for example, antigenic segments of three Anaplasma proteins (OmpA, AipA and Asp14) and a non-antigenic segment of a Borrelia Osp protein (e.g. OspC) that is 10 amino acids in length, proline rich and random coil in conformation. Compositions comprising the chimeritopes, optionally in combination with additional Anaplasma proteins of interest, are also provided, as are methods of using the compositions as vaccines and diagnostic tools.Type: GrantFiled: February 1, 2022Date of Patent: March 4, 2025Assignee: Virginia Commonwealth UniversityInventors: Richard T. Marconi, Jason A. Carlyon
-
Patent number: 12226423Abstract: Compositions comprising 5-cholesten-3, 25-diol, 3-sulfate (25HC3S) or pharmaceutically acceptable salt thereof and at least one cyclic oligosaccharide, e.g., a cyclodextrin (CD), are provided. The compositions may be used to prevent and/or treat a variety of diseases and conditions, including organ failure (e.g. acute liver failure), high cholesterol/high lipids, and various inflammatory diseases and conditions.Type: GrantFiled: June 28, 2022Date of Patent: February 18, 2025Assignees: Virginia Commonwealth University, Durect Corporation, The United States Government as Represented by The Department of Veterans AffairsInventors: Shunlin Ren, Leyuan Xu, Yanxia Ning, Jin Koung Kim, WeiQi Lin, Andrew R. Miksztal, Hongwei Wu, Min L. Lee
-
Patent number: 12221406Abstract: Scaffold compounds are used to design small molecule compounds and structure-activity relationship studies identify inhibitors of inflammation. Methods include pharmaceutical compositions of the small molecule compounds to inhibit, prevent and treat diseases and conditions associated with inflammation, including multiple sclerosis, Alzheimer's disease, acute myocardial infarction, traumatic brain injury and autoinflammatory diseases.Type: GrantFiled: July 15, 2020Date of Patent: February 11, 2025Assignee: Virginia Commonwealth UniversityInventor: Shijun Zhang
-
Patent number: 12217890Abstract: Embodiments generally relate to subwavelength antennas and, more particularly, extreme subwavelength antennas with high radiation efficiency. One embodiment and its derivatives achieve the objective of an extreme subwavelength dual acoustic and electromagnetic antenna by using spin-orbit torque in an array of nanomagnets.Type: GrantFiled: March 20, 2020Date of Patent: February 4, 2025Assignee: Virginia Commonwealth UniversityInventor: Supriyo Bandyopadhyay
-
Patent number: 12179266Abstract: A polymer-assisted 3D printing method and ink compositions are used to manufacture magnetocaloric devices having many applications including in heat pumps, refrigerators, etc. The ink compositions and printing methods can produce compositionally graded, anisotropically aligned magnetocaloric architectures with designed pores and channels, to bring forth significant improvement in heat exchange efficiency.Type: GrantFiled: May 13, 2021Date of Patent: December 31, 2024Assignee: VIRGINIA COMMONWEALTH UNIVERSITYInventors: Hong Zhao, Radhika Barua, Ravi L. Hadimani, Lilly Balderson
-
Patent number: 12171888Abstract: The invention generally relates to dextran fibers which are preferably electrospun and devices formed from such fibers. In particular, such devices may include substances of interest (such as therapeutic substances) associated with the electrospun fibers. Upon exposure to a liquid the electrospun fibers dissolve immediately and the substances of interest are released into the liquid. Exemplary devices include bandages formed from electrospun dextran fibers and associated agents that promote hemostasis, such as thrombin and fibrinogen.Type: GrantFiled: December 1, 2021Date of Patent: December 24, 2024Assignees: Virginia Commonwealth University, The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.Inventors: Gary Bowlin, David Simpson, James Bowman, Stephen Rothwell
-
Patent number: 12161862Abstract: An example device for repairing a tissue is described herein. The device can include a flexible carrier layer, and a support member including a plurality of micro-protrusions extending therefrom. The support member can be at least partially integrated with the flexible carrier layer. Additionally, the flexible carrier layer can be configured to cover at least a portion of the tissue, and the micro-protrusions can be configured to mechanically interface with the tissue.Type: GrantFiled: February 20, 2024Date of Patent: December 10, 2024Assignees: BioCircuit Technologies, Inc., Virginia Commonwealth UniversityInventors: Jonathan Isaacs, Isaac Perry Clements, Andrew Willsie, James David Ross, Alex Weidenbach
-
Patent number: 12077642Abstract: Polymeric aerogels, articles made from the polymeric aerogels and methods of making the polymeric aerogels are provided. The aerogels are made e.g. from crosslinkable monomers such as isocyanate monomers or phenolic monomers and a filler comprising crosslinkable hydroxyl groups. The filler may be natural (e.g. wood flour) or synthetic. The aerogels and products made therefrom exhibit low thermal conductivity and are mechanically strong. Due to their physical properties, these materials are used as e.g. building envelope components, such as walls, roofs and frames, to improve the thermal performance thereof, and may be used in a variety of other applications such as sound and insulation barriers in mechanical equipment, cryogenic containers, etc.Type: GrantFiled: May 31, 2019Date of Patent: September 3, 2024Assignee: VIRGINIA COMMONWEALTH UNIVERSITYInventors: Massimo Bertino, Sylwia Czlonka
-
Patent number: 12071410Abstract: Cost effective, semi-continuous flow methods and systems for synthesizing the antimalarial drug hydroxychloroquine (HCQ) in high yield are provided. The synthesis method that uses simple, inexpensive reagents to obtain the crucial intermediate 5-(ethyl(2-hydroxyethyl)-amino)pentan-2-one, vertical-integration of the starting material 5-iodopentan-2-one and the integration of continuous stirred tank reactors.Type: GrantFiled: February 25, 2019Date of Patent: August 27, 2024Assignee: Virginia Commonwealth UniversityInventors: Frank B. Gupton, Saeed Ahmad, Hari P. R. Gunuru, Nakul S. Telang
-
Patent number: 12006574Abstract: Crystallization of perovskite films was performed in supercritical carbon dioxide with and without organic co-solvents. Post deposition crystallization of the films was performed in a binary, single phase supercritical fluid at constant conditions (45° C., 1200 psi) but with varying organic co-solvent volume fractions up to 2%. The co-solvents can provide selective interactions with one or both of the perovskite precursor compounds resulting in different film morphologies ranging from uniform films containing large grains to films exhibiting large cubic or hexagonal crystals or preferential crystallographic orientations. The use of supercritical fluids to enhance or tune crystallization in solid-state thin films could have broad applications toward the realization of high efficiency photovoltaic devices.Type: GrantFiled: February 27, 2020Date of Patent: June 11, 2024Assignee: VIRGINIA COMMONWEALTH UNIVERSITYInventors: Gary Tepper, Gilbert Annohene
-
Patent number: 11986822Abstract: Microfluidic devices for analyzing cellular components from biological samples which contain more than one cell type are provided. The microdevice separates cells by type, releases cellular components such as DNA (e.g. by cell lysis) and processes the cellular components (for example, by amplification) to generate products of interest for further analysis. Samples that can be analyzed using the microfluidic devices include forensic samples such as samples from sexual assault victims, and the products of interest include short tandem repeat (STR) amplicons for DNA profiling.Type: GrantFiled: February 7, 2018Date of Patent: May 21, 2024Assignees: Virginia Commonwealth University, University of Virginia Patent FoundationInventors: Tracey Dawson Green, James Landers
-
Patent number: 11986361Abstract: An exemplary device is indicated for use in physically debriding thrombus fragments from a stent retriever, using hospital-grade saline, or heparinized saline, for example. This device may be used in the sterile field, during a mechanical thrombectomy procedure. An exemplary cleaning device for cleaning a stent retriever within a sterile surgical field may include a chamber configured to receive and enclose a stent retriever to be cleaned, at least one port configured for connection with a fluid source to enable inflow and/or outflow of a fluid to or from the chamber, and one or more support structures configured to support the stent retriever in a fixed position inside the chamber.Type: GrantFiled: November 17, 2021Date of Patent: May 21, 2024Assignee: Virginia Commonwealth UniversityInventors: Dennis J. Rivet, II, Shane Diller, John F. Reavey-Cantwell
-
Patent number: 11918801Abstract: An example device for repairing a tissue is described herein. The device can include a flexible carrier layer, and a support member including a plurality of micro-protrusions extending therefrom. The support member can be at least partially integrated with the flexible carrier layer. Additionally, the flexible carrier layer can be configured to cover at least a portion of the tissue, and the micro-protrusions can be configured to mechanically interface with the tissue.Type: GrantFiled: November 5, 2021Date of Patent: March 5, 2024Assignees: BioCircuit Technologies, Inc., Virginia Commonwealth UniversityInventors: Jonathan Isaacs, Isaac Perry Clements, Andrew Willsie, James David Ross, Alex Weidenbach
-
Patent number: 11899015Abstract: Chimeric recombinant proteins for the detection of infection by Borreliella and/or diagnosis of Lyme disease are provided. Methods and devices for conducting immunoassays with the chimeric recombinant proteins are also provided.Type: GrantFiled: October 24, 2022Date of Patent: February 13, 2024Assignee: VIRGINIA COMMONWEALTH UNIVERSITYInventor: Richard Marconi
-
Patent number: 11891399Abstract: Provided herein are, inter alia, compositions that bind to a PDZ1 domain of MDA-9/Syntenin (syndecan binding protein: SDCBP), thereby inhibiting MDA-9/Syntenin activity, and methods of use of same. The compositions and methods provided herein are useful for treating cancer and preventing cancer metastasis, particularly in cancers that have increased MDA-9/Syntenin expression.Type: GrantFiled: January 14, 2021Date of Patent: February 6, 2024Assignees: VIRGINIA COMMONWEALTH UNIVERSITY, SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTEInventors: Paul B. Fisher, Maurizio Pellecchia, Swadesh K. Das, Timothy P. Kegelman, Bainan Wu, Surya K. De, Jun Wei, Mitchell E. Menezes, Luni Emdad
-
Patent number: 11845741Abstract: The present disclosure provides pilocarpine ionic liquid analogs useful in the treatment of ophthalmological disorders such as glaucoma.Type: GrantFiled: September 17, 2021Date of Patent: December 19, 2023Assignee: VIRGINIA COMMONWEALTH UNIVERSITY INTELLECTUAL PROPERTY FOUNDATIONInventors: Juan Wang, Hu Yang
-
Publication number: 20230372445Abstract: A method for treating a subject suffering from chronic multisystem illness, specifically gulf war illness, includes administering to the subject a therapeutically effective amount of a selective inhibitor of solTNF, whereby the subject is treated. In some embodiments, the selective inhibitor of solTNF includes a DN-TNF protein variant and/or a nucleic acid encoding the DN-TNF protein variant. In some embodiments, the DN-TNF protein variant includes XPro1595.Type: ApplicationFiled: September 15, 2022Publication date: November 23, 2023Applicant: VIRGINIA COMMONWEALTH UNIVERSITYInventor: Kirsty J. Dixon
-
Patent number: 11814519Abstract: A nitric oxide-releasing 3D printing ink is described for its composition and uses in fabricating a plurality of types of nitric oxide-releasing medical devices. The printing ink composition comprises a mixture of at least one nitric oxide donor and at least one polymer. The nitric oxide-releasing medical device is manufactured by 3D printing technology and provides antimicrobial and/or antithrombus effects by releasing nitric oxide in the presence of moisture.Type: GrantFiled: March 22, 2021Date of Patent: November 14, 2023Assignee: VIRGINIA COMMONWEALTH UNIVERSITYInventors: Xuewei Wang, Hong Zhao, Yuanhang Yang, Wuwei Li
-
Patent number: 11801309Abstract: The present disclosure relates to carbohydrate-functionalized nanoparticles and methods of treating cardiovascular disease (for example, atherosclerosis).Type: GrantFiled: October 27, 2017Date of Patent: October 31, 2023Assignee: Virginia Commonwealth University Intellectual Property FoundationInventors: Hu Yang, Shobha Ghosh, Hongliang He, Michael Lancina
-
Patent number: 11786585Abstract: Insulin-like growth factor-binding protein 3 receptor (IGFBP-3R) agonists and methods of their use to treat diseases involving IGFBP-3 and IGFBP-3R are provided. The agonists may be antibodies or other molecules specific for binding to and activating IGFBP-3R. The agonists are used to treat e.g. cancer, metabolic syndrome and obstructive respiratory disorders. In addition, methods of diagnosing cancer and predicting the chance of recurrence, metastasis and/or survival by measuring the level of IGFBP-3R in tumor tissue are provided.Type: GrantFiled: November 22, 2021Date of Patent: October 17, 2023Assignee: Virginia Commonwealth UniversityInventors: Youngman Oh, Qing Cai