Patents Assigned to Virginia Commonwealth University
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Patent number: 11918801Abstract: An example device for repairing a tissue is described herein. The device can include a flexible carrier layer, and a support member including a plurality of micro-protrusions extending therefrom. The support member can be at least partially integrated with the flexible carrier layer. Additionally, the flexible carrier layer can be configured to cover at least a portion of the tissue, and the micro-protrusions can be configured to mechanically interface with the tissue.Type: GrantFiled: November 5, 2021Date of Patent: March 5, 2024Assignees: BioCircuit Technologies, Inc., Virginia Commonwealth UniversityInventors: Jonathan Isaacs, Isaac Perry Clements, Andrew Willsie, James David Ross, Alex Weidenbach
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Patent number: 11899015Abstract: Chimeric recombinant proteins for the detection of infection by Borreliella and/or diagnosis of Lyme disease are provided. Methods and devices for conducting immunoassays with the chimeric recombinant proteins are also provided.Type: GrantFiled: October 24, 2022Date of Patent: February 13, 2024Assignee: VIRGINIA COMMONWEALTH UNIVERSITYInventor: Richard Marconi
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Patent number: 11891399Abstract: Provided herein are, inter alia, compositions that bind to a PDZ1 domain of MDA-9/Syntenin (syndecan binding protein: SDCBP), thereby inhibiting MDA-9/Syntenin activity, and methods of use of same. The compositions and methods provided herein are useful for treating cancer and preventing cancer metastasis, particularly in cancers that have increased MDA-9/Syntenin expression.Type: GrantFiled: January 14, 2021Date of Patent: February 6, 2024Assignees: VIRGINIA COMMONWEALTH UNIVERSITY, SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTEInventors: Paul B. Fisher, Maurizio Pellecchia, Swadesh K. Das, Timothy P. Kegelman, Bainan Wu, Surya K. De, Jun Wei, Mitchell E. Menezes, Luni Emdad
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Patent number: 11845741Abstract: The present disclosure provides pilocarpine ionic liquid analogs useful in the treatment of ophthalmological disorders such as glaucoma.Type: GrantFiled: September 17, 2021Date of Patent: December 19, 2023Assignee: VIRGINIA COMMONWEALTH UNIVERSITY INTELLECTUAL PROPERTY FOUNDATIONInventors: Juan Wang, Hu Yang
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Publication number: 20230372445Abstract: A method for treating a subject suffering from chronic multisystem illness, specifically gulf war illness, includes administering to the subject a therapeutically effective amount of a selective inhibitor of solTNF, whereby the subject is treated. In some embodiments, the selective inhibitor of solTNF includes a DN-TNF protein variant and/or a nucleic acid encoding the DN-TNF protein variant. In some embodiments, the DN-TNF protein variant includes XPro1595.Type: ApplicationFiled: September 15, 2022Publication date: November 23, 2023Applicant: VIRGINIA COMMONWEALTH UNIVERSITYInventor: Kirsty J. Dixon
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Patent number: 11814519Abstract: A nitric oxide-releasing 3D printing ink is described for its composition and uses in fabricating a plurality of types of nitric oxide-releasing medical devices. The printing ink composition comprises a mixture of at least one nitric oxide donor and at least one polymer. The nitric oxide-releasing medical device is manufactured by 3D printing technology and provides antimicrobial and/or antithrombus effects by releasing nitric oxide in the presence of moisture.Type: GrantFiled: March 22, 2021Date of Patent: November 14, 2023Assignee: VIRGINIA COMMONWEALTH UNIVERSITYInventors: Xuewei Wang, Hong Zhao, Yuanhang Yang, Wuwei Li
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Patent number: 11801309Abstract: The present disclosure relates to carbohydrate-functionalized nanoparticles and methods of treating cardiovascular disease (for example, atherosclerosis).Type: GrantFiled: October 27, 2017Date of Patent: October 31, 2023Assignee: Virginia Commonwealth University Intellectual Property FoundationInventors: Hu Yang, Shobha Ghosh, Hongliang He, Michael Lancina
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Patent number: 11786585Abstract: Insulin-like growth factor-binding protein 3 receptor (IGFBP-3R) agonists and methods of their use to treat diseases involving IGFBP-3 and IGFBP-3R are provided. The agonists may be antibodies or other molecules specific for binding to and activating IGFBP-3R. The agonists are used to treat e.g. cancer, metabolic syndrome and obstructive respiratory disorders. In addition, methods of diagnosing cancer and predicting the chance of recurrence, metastasis and/or survival by measuring the level of IGFBP-3R in tumor tissue are provided.Type: GrantFiled: November 22, 2021Date of Patent: October 17, 2023Assignee: Virginia Commonwealth UniversityInventors: Youngman Oh, Qing Cai
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Patent number: 11737992Abstract: Provided are inhibitors of sphingosine kinase Type I that are useful in the treatment of neuropathic pain.Type: GrantFiled: February 8, 2021Date of Patent: August 29, 2023Assignees: ENZO THERAPEUTICS, INC., VIRGINIA COMMONWEALTH UNIVERSITYInventors: Sarah Spiegel, Robert Elliot Zipkin, Jeffrey Kroll Adams
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Publication number: 20230218639Abstract: Aspects of the present disclosure include methods for treating at least one of depression, neurodegenerative disease, multiple sclerosis, Parkinson's disease, spinocerebellar degeneration, Friedreich ataxia, ataxia-telangiectasia, progressive supranuclear palsy, Huntington's disease, striatonigral degeneration, olivopontocerebellar atrophy, Shy-Drager syndrome, schizophrenia, schizoaffective disorder, manic-depression (bipolar) disorder, disturbed or abnormal circadian entrainment, childhood Alice in Wonderland syndrome, childhood acute cerebellar ataxia, and Alzheimer's disease. In some instances, methods include treating an addiction to a drug, such as alcohol addiction, cocaine addiction or amphetamine addiction.Type: ApplicationFiled: June 25, 2021Publication date: July 13, 2023Applicant: Virginia Commonwealth UniversityInventors: Shunlin Ren, Yaping Wang, WeiQi Lin, James E. Brown, Felix Theeuwes
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Patent number: 11690964Abstract: Containment units, dry powder inhalers, delivery systems, and methods for the same are disclosed. Exemplary devices are configured to have inlets and outlets which are formed with the containment walls of a containment unit. Air jets formed by the configuration of inlet(s) and outlet(s) inside the containment unit create significant turbulence and deaggregate the powder. Delivery system components downstream of the containment unit may integrate the exiting aerosol plume with a low flow nasal cannula air stream for delivery to a subject.Type: GrantFiled: May 31, 2018Date of Patent: July 4, 2023Assignee: Virginia Commonwealth UniversityInventors: Philip Worth Longest, Michael Hindle, Dale Farkas, Susan Boc
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Patent number: 11673913Abstract: Tetrameric N-terminally acetylated ?-synuclein is prepared by transforming an expression system with an expression vector encoding ?-synuclein, wherein the expression system expresses a native NatB acetylase complex or ortholog thereof and/or wherein an exogenous NatB acetylase complex or ortholog thereof is co-expressed in the expression system, inducing protein expression in the transformed expression system, lysing cells in the transformed expression system to produce a cell lysate, performing salt precipitation of the cell lysate, recovering tetrameric N-terminally acetylated ?-synuclein by centrifugation, and purifying the tetrameric N-terminally acetylated ?-synuclein. Compositions comprising the same and methods for identifying compounds that stabilize natively folded tetrameric ?-synuclein are also provided.Type: GrantFiled: May 10, 2019Date of Patent: June 13, 2023Assignee: Virginia Commonwealth UniversityInventors: Heather R. Lucas, Ricardo D. Fernandez
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Patent number: 11670441Abstract: In various aspects, methods of making perovskite manganese oxide particles are provided as well as perovskite manganese oxide particles made therefrom. The perovskite manganese oxide particles exhibit a strong magnetocaloric effect, making them well suited for applications in power generation and magnetic refrigeration, especially at or near room temperature. The methods can include forming an aqueous mixture of (i) a low-molecular-weight polymeric polyalcohol gel precursor, (ii) a stoichiometric amount of metal salts or hydrates thereof, wherein the metal salts or hydrates thereof comprise at least a Manganese (Mn), and (iii) a polybasic carboxylic acid; polymerizing the aqueous mixture to form a gel containing perovskite manganese oxide nanoparticles entrapped therein; and calcining the gel to remove at least a portion of organic material in the gel and form the perovskite manganese oxide particles.Type: GrantFiled: December 1, 2018Date of Patent: June 6, 2023Assignee: VIRGINIA COMMONWEALTH UNIVERSITYInventor: Everett E. Carpenter
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Patent number: 11661433Abstract: Near-infrared activatable fluorescent small molecules for the photodynamic treatment of cancer are provided. Methods of treatment include contacting a plurality of cells of the cancer with a near-infrared activatable fluorescent small molecule and directing a near-IR light to the molecule for an amount of time sufficient to induce release of the active platinum species and a reactive oxygen species.Type: GrantFiled: May 9, 2019Date of Patent: May 30, 2023Assignee: VIRGINIA COMMONWEALTH UNIVERSITYInventors: Matthew Hartman, Koushambi Mitra
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Patent number: 11654409Abstract: A method of synthesizing aerogels and cross-linked aerogels are described that incorporate freeze-drying in lieu of super-critical solvent drying. Advantages over supercritical drying include a reduction in hazard risks posed by drying at supercritical conditions as well as the ability to up-scale the process to accommodate large pieces of material without introducing risk. In addition, inexpensive and more sophisticated mold technologies, which are not impervious to super-critical conditions, can be used to produce aerogel materials according to the freeze-drying method of the invention. This introduces a level of freedom never before available for the production of aerogel components.Type: GrantFiled: July 27, 2020Date of Patent: May 23, 2023Assignee: Virginia Commonwealth UniversityInventors: Massimo Bertino, Lauren White, Dalton Echard, Tyler Selden
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Patent number: 11612609Abstract: Methods of preventing and/or treating ischemia, organ dysfunction and/or organ failure, including multiple organ dysfunction syndrome (MODS), and necrosis and apoptosis associated with organ dysfunction/failure, are provided. For instance, the methods involve contacting organ(s) with an oxygenated cholesterol sulfate (OCS), e.g. 5-cholesten-3,25-diol, 3-sulfate (25H-C3S). The organ(s) may be in vivo (e.g. in a patient that is treated with the OCS) or ex vivo (e.g. an organ that has been harvested from a donor and is to be transplanted).Type: GrantFiled: August 3, 2020Date of Patent: March 28, 2023Assignees: Durect Corporation, Virginia Commonwealth UniversityInventors: Shunlin Ren, Felix Theeuwes, James E. Brown, WeiQi Lin
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Patent number: 11590241Abstract: Provided herein are nanoparticle conjugated synthetic opioid prodrugs that target the peripheral mu opioid receptor (MOR). The prodrugs exhibit long-lived bioavailability, do not compromise the analgesic effects of opioids administered for pain relief (and in some cases can be used for pain relief), and do not induce opioid withdrawal symptoms, when their use is discontinued. Certain of the prodrugs are especially useful for the prevention and/or treatment of unwanted opioid-induced side effects such as opioid-induced constipation (OIC).Type: GrantFiled: February 17, 2017Date of Patent: February 28, 2023Assignee: Virginia Commonwealth UniversityInventors: Yan Zhang, Hu Yang, Dana Selley, William Dewey, Hamid Akbarali
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Patent number: 11566173Abstract: Colloidal synthesis of narrowly disperse, near IR emitting Group IV alloy quantum dots with wide range of Sn compositions via reduction of precursor halides is provided, allowing for less-toxic, earth abundant, and silicon-compatible Group IV alloy quantum dots for application in a broad range of electronic and photonic technologies.Type: GrantFiled: March 18, 2019Date of Patent: January 31, 2023Assignee: Virginia Commonwealth UniversityInventors: Indika U. Arachchige, Umit Ozgur, Denis O. Demchenko, Venkatesham Tallapally, Tanner A. Nakagawara
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Patent number: 11534569Abstract: Devices, systems, and methods are disclosed which permit ventilation therapy concurrent with humidity and aerosol drug delivery. Exemplary mixer-heaters employ alternating actuation of humidity and drug nebulizers and may use a single constant power setting for the heating section while keeping a controlled outlet temperature over the course of treatment.Type: GrantFiled: May 31, 2018Date of Patent: December 27, 2022Assignee: VIRGINIA COMMONWEALTH UNIVERSITYInventors: Philip Worth Longest, Jr., Michael Hindle, Benjamin Spence, Sneha Dhapare, Wei Xiangyin
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Patent number: 11531982Abstract: An exemplary transaction sharding method comprises splitting a distributed ledger into a plurality of shards; and storing a shard across the subgroup of computer nodes associated with the shard. Such a method further comprises assigning a new transaction to one of the plurality of shards, wherein assigning the new transaction comprises iteratively choosing one of the plurality of shards; in each iteration, determining a transaction-to-shard score measuring a probability that a subgroup of computing nodes associated with the chosen shard for the current iteration would be involved in a same-shard transaction for the new transaction; in each iteration, determining a latency-to-shard score by estimating a confirmation latency of the new transaction under the chosen shard for the current iteration; and selecting the new transaction to be assigned to the shard based on a combination of the transaction-to-shard score and the latency-to-shard score.Type: GrantFiled: June 24, 2020Date of Patent: December 20, 2022Assignees: University of Florida Research Foundation, Inc., Virginia Commonwealth UniversityInventors: My T. Thai, Thang N. Dinh, Lan Nguyen, Truc Nguyen