Patents Assigned to Virginia Commonwealth University
  • Patent number: 11918801
    Abstract: An example device for repairing a tissue is described herein. The device can include a flexible carrier layer, and a support member including a plurality of micro-protrusions extending therefrom. The support member can be at least partially integrated with the flexible carrier layer. Additionally, the flexible carrier layer can be configured to cover at least a portion of the tissue, and the micro-protrusions can be configured to mechanically interface with the tissue.
    Type: Grant
    Filed: November 5, 2021
    Date of Patent: March 5, 2024
    Assignees: BioCircuit Technologies, Inc., Virginia Commonwealth University
    Inventors: Jonathan Isaacs, Isaac Perry Clements, Andrew Willsie, James David Ross, Alex Weidenbach
  • Patent number: 11899015
    Abstract: Chimeric recombinant proteins for the detection of infection by Borreliella and/or diagnosis of Lyme disease are provided. Methods and devices for conducting immunoassays with the chimeric recombinant proteins are also provided.
    Type: Grant
    Filed: October 24, 2022
    Date of Patent: February 13, 2024
    Inventor: Richard Marconi
  • Patent number: 11891399
    Abstract: Provided herein are, inter alia, compositions that bind to a PDZ1 domain of MDA-9/Syntenin (syndecan binding protein: SDCBP), thereby inhibiting MDA-9/Syntenin activity, and methods of use of same. The compositions and methods provided herein are useful for treating cancer and preventing cancer metastasis, particularly in cancers that have increased MDA-9/Syntenin expression.
    Type: Grant
    Filed: January 14, 2021
    Date of Patent: February 6, 2024
    Inventors: Paul B. Fisher, Maurizio Pellecchia, Swadesh K. Das, Timothy P. Kegelman, Bainan Wu, Surya K. De, Jun Wei, Mitchell E. Menezes, Luni Emdad
  • Patent number: 11845741
    Abstract: The present disclosure provides pilocarpine ionic liquid analogs useful in the treatment of ophthalmological disorders such as glaucoma.
    Type: Grant
    Filed: September 17, 2021
    Date of Patent: December 19, 2023
    Inventors: Juan Wang, Hu Yang
  • Publication number: 20230372445
    Abstract: A method for treating a subject suffering from chronic multisystem illness, specifically gulf war illness, includes administering to the subject a therapeutically effective amount of a selective inhibitor of solTNF, whereby the subject is treated. In some embodiments, the selective inhibitor of solTNF includes a DN-TNF protein variant and/or a nucleic acid encoding the DN-TNF protein variant. In some embodiments, the DN-TNF protein variant includes XPro1595.
    Type: Application
    Filed: September 15, 2022
    Publication date: November 23, 2023
    Inventor: Kirsty J. Dixon
  • Patent number: 11814519
    Abstract: A nitric oxide-releasing 3D printing ink is described for its composition and uses in fabricating a plurality of types of nitric oxide-releasing medical devices. The printing ink composition comprises a mixture of at least one nitric oxide donor and at least one polymer. The nitric oxide-releasing medical device is manufactured by 3D printing technology and provides antimicrobial and/or antithrombus effects by releasing nitric oxide in the presence of moisture.
    Type: Grant
    Filed: March 22, 2021
    Date of Patent: November 14, 2023
    Inventors: Xuewei Wang, Hong Zhao, Yuanhang Yang, Wuwei Li
  • Patent number: 11801309
    Abstract: The present disclosure relates to carbohydrate-functionalized nanoparticles and methods of treating cardiovascular disease (for example, atherosclerosis).
    Type: Grant
    Filed: October 27, 2017
    Date of Patent: October 31, 2023
    Assignee: Virginia Commonwealth University Intellectual Property Foundation
    Inventors: Hu Yang, Shobha Ghosh, Hongliang He, Michael Lancina
  • Patent number: 11786585
    Abstract: Insulin-like growth factor-binding protein 3 receptor (IGFBP-3R) agonists and methods of their use to treat diseases involving IGFBP-3 and IGFBP-3R are provided. The agonists may be antibodies or other molecules specific for binding to and activating IGFBP-3R. The agonists are used to treat e.g. cancer, metabolic syndrome and obstructive respiratory disorders. In addition, methods of diagnosing cancer and predicting the chance of recurrence, metastasis and/or survival by measuring the level of IGFBP-3R in tumor tissue are provided.
    Type: Grant
    Filed: November 22, 2021
    Date of Patent: October 17, 2023
    Assignee: Virginia Commonwealth University
    Inventors: Youngman Oh, Qing Cai
  • Patent number: 11737992
    Abstract: Provided are inhibitors of sphingosine kinase Type I that are useful in the treatment of neuropathic pain.
    Type: Grant
    Filed: February 8, 2021
    Date of Patent: August 29, 2023
    Inventors: Sarah Spiegel, Robert Elliot Zipkin, Jeffrey Kroll Adams
  • Publication number: 20230218639
    Abstract: Aspects of the present disclosure include methods for treating at least one of depression, neurodegenerative disease, multiple sclerosis, Parkinson's disease, spinocerebellar degeneration, Friedreich ataxia, ataxia-telangiectasia, progressive supranuclear palsy, Huntington's disease, striatonigral degeneration, olivopontocerebellar atrophy, Shy-Drager syndrome, schizophrenia, schizoaffective disorder, manic-depression (bipolar) disorder, disturbed or abnormal circadian entrainment, childhood Alice in Wonderland syndrome, childhood acute cerebellar ataxia, and Alzheimer's disease. In some instances, methods include treating an addiction to a drug, such as alcohol addiction, cocaine addiction or amphetamine addiction.
    Type: Application
    Filed: June 25, 2021
    Publication date: July 13, 2023
    Applicant: Virginia Commonwealth University
    Inventors: Shunlin Ren, Yaping Wang, WeiQi Lin, James E. Brown, Felix Theeuwes
  • Patent number: 11690964
    Abstract: Containment units, dry powder inhalers, delivery systems, and methods for the same are disclosed. Exemplary devices are configured to have inlets and outlets which are formed with the containment walls of a containment unit. Air jets formed by the configuration of inlet(s) and outlet(s) inside the containment unit create significant turbulence and deaggregate the powder. Delivery system components downstream of the containment unit may integrate the exiting aerosol plume with a low flow nasal cannula air stream for delivery to a subject.
    Type: Grant
    Filed: May 31, 2018
    Date of Patent: July 4, 2023
    Assignee: Virginia Commonwealth University
    Inventors: Philip Worth Longest, Michael Hindle, Dale Farkas, Susan Boc
  • Patent number: 11673913
    Abstract: Tetrameric N-terminally acetylated ?-synuclein is prepared by transforming an expression system with an expression vector encoding ?-synuclein, wherein the expression system expresses a native NatB acetylase complex or ortholog thereof and/or wherein an exogenous NatB acetylase complex or ortholog thereof is co-expressed in the expression system, inducing protein expression in the transformed expression system, lysing cells in the transformed expression system to produce a cell lysate, performing salt precipitation of the cell lysate, recovering tetrameric N-terminally acetylated ?-synuclein by centrifugation, and purifying the tetrameric N-terminally acetylated ?-synuclein. Compositions comprising the same and methods for identifying compounds that stabilize natively folded tetrameric ?-synuclein are also provided.
    Type: Grant
    Filed: May 10, 2019
    Date of Patent: June 13, 2023
    Assignee: Virginia Commonwealth University
    Inventors: Heather R. Lucas, Ricardo D. Fernandez
  • Patent number: 11670441
    Abstract: In various aspects, methods of making perovskite manganese oxide particles are provided as well as perovskite manganese oxide particles made therefrom. The perovskite manganese oxide particles exhibit a strong magnetocaloric effect, making them well suited for applications in power generation and magnetic refrigeration, especially at or near room temperature. The methods can include forming an aqueous mixture of (i) a low-molecular-weight polymeric polyalcohol gel precursor, (ii) a stoichiometric amount of metal salts or hydrates thereof, wherein the metal salts or hydrates thereof comprise at least a Manganese (Mn), and (iii) a polybasic carboxylic acid; polymerizing the aqueous mixture to form a gel containing perovskite manganese oxide nanoparticles entrapped therein; and calcining the gel to remove at least a portion of organic material in the gel and form the perovskite manganese oxide particles.
    Type: Grant
    Filed: December 1, 2018
    Date of Patent: June 6, 2023
    Inventor: Everett E. Carpenter
  • Patent number: 11661433
    Abstract: Near-infrared activatable fluorescent small molecules for the photodynamic treatment of cancer are provided. Methods of treatment include contacting a plurality of cells of the cancer with a near-infrared activatable fluorescent small molecule and directing a near-IR light to the molecule for an amount of time sufficient to induce release of the active platinum species and a reactive oxygen species.
    Type: Grant
    Filed: May 9, 2019
    Date of Patent: May 30, 2023
    Inventors: Matthew Hartman, Koushambi Mitra
  • Patent number: 11654409
    Abstract: A method of synthesizing aerogels and cross-linked aerogels are described that incorporate freeze-drying in lieu of super-critical solvent drying. Advantages over supercritical drying include a reduction in hazard risks posed by drying at supercritical conditions as well as the ability to up-scale the process to accommodate large pieces of material without introducing risk. In addition, inexpensive and more sophisticated mold technologies, which are not impervious to super-critical conditions, can be used to produce aerogel materials according to the freeze-drying method of the invention. This introduces a level of freedom never before available for the production of aerogel components.
    Type: Grant
    Filed: July 27, 2020
    Date of Patent: May 23, 2023
    Assignee: Virginia Commonwealth University
    Inventors: Massimo Bertino, Lauren White, Dalton Echard, Tyler Selden
  • Patent number: 11612609
    Abstract: Methods of preventing and/or treating ischemia, organ dysfunction and/or organ failure, including multiple organ dysfunction syndrome (MODS), and necrosis and apoptosis associated with organ dysfunction/failure, are provided. For instance, the methods involve contacting organ(s) with an oxygenated cholesterol sulfate (OCS), e.g. 5-cholesten-3,25-diol, 3-sulfate (25H-C3S). The organ(s) may be in vivo (e.g. in a patient that is treated with the OCS) or ex vivo (e.g. an organ that has been harvested from a donor and is to be transplanted).
    Type: Grant
    Filed: August 3, 2020
    Date of Patent: March 28, 2023
    Assignees: Durect Corporation, Virginia Commonwealth University
    Inventors: Shunlin Ren, Felix Theeuwes, James E. Brown, WeiQi Lin
  • Patent number: 11590241
    Abstract: Provided herein are nanoparticle conjugated synthetic opioid prodrugs that target the peripheral mu opioid receptor (MOR). The prodrugs exhibit long-lived bioavailability, do not compromise the analgesic effects of opioids administered for pain relief (and in some cases can be used for pain relief), and do not induce opioid withdrawal symptoms, when their use is discontinued. Certain of the prodrugs are especially useful for the prevention and/or treatment of unwanted opioid-induced side effects such as opioid-induced constipation (OIC).
    Type: Grant
    Filed: February 17, 2017
    Date of Patent: February 28, 2023
    Assignee: Virginia Commonwealth University
    Inventors: Yan Zhang, Hu Yang, Dana Selley, William Dewey, Hamid Akbarali
  • Patent number: 11566173
    Abstract: Colloidal synthesis of narrowly disperse, near IR emitting Group IV alloy quantum dots with wide range of Sn compositions via reduction of precursor halides is provided, allowing for less-toxic, earth abundant, and silicon-compatible Group IV alloy quantum dots for application in a broad range of electronic and photonic technologies.
    Type: Grant
    Filed: March 18, 2019
    Date of Patent: January 31, 2023
    Assignee: Virginia Commonwealth University
    Inventors: Indika U. Arachchige, Umit Ozgur, Denis O. Demchenko, Venkatesham Tallapally, Tanner A. Nakagawara
  • Patent number: 11534569
    Abstract: Devices, systems, and methods are disclosed which permit ventilation therapy concurrent with humidity and aerosol drug delivery. Exemplary mixer-heaters employ alternating actuation of humidity and drug nebulizers and may use a single constant power setting for the heating section while keeping a controlled outlet temperature over the course of treatment.
    Type: Grant
    Filed: May 31, 2018
    Date of Patent: December 27, 2022
    Inventors: Philip Worth Longest, Jr., Michael Hindle, Benjamin Spence, Sneha Dhapare, Wei Xiangyin
  • Patent number: 11531982
    Abstract: An exemplary transaction sharding method comprises splitting a distributed ledger into a plurality of shards; and storing a shard across the subgroup of computer nodes associated with the shard. Such a method further comprises assigning a new transaction to one of the plurality of shards, wherein assigning the new transaction comprises iteratively choosing one of the plurality of shards; in each iteration, determining a transaction-to-shard score measuring a probability that a subgroup of computing nodes associated with the chosen shard for the current iteration would be involved in a same-shard transaction for the new transaction; in each iteration, determining a latency-to-shard score by estimating a confirmation latency of the new transaction under the chosen shard for the current iteration; and selecting the new transaction to be assigned to the shard based on a combination of the transaction-to-shard score and the latency-to-shard score.
    Type: Grant
    Filed: June 24, 2020
    Date of Patent: December 20, 2022
    Assignees: University of Florida Research Foundation, Inc., Virginia Commonwealth University
    Inventors: My T. Thai, Thang N. Dinh, Lan Nguyen, Truc Nguyen