Patents Assigned to Virginia Commonwealth University
  • Patent number: 10343985
    Abstract: Inhibitors that are anti-inflammatory agents are provided, as are methods of using the analogs to inhibit inflammation and prevent or treat diseases and conditions associated with inflammation, such as heart failure and autoimmune diseases.
    Type: Grant
    Filed: October 30, 2015
    Date of Patent: July 9, 2019
    Assignee: VIRGINIA COMMONWEALTH UNIVERSITY
    Inventors: Antonio Abbate, Shijun Zhang, Benjamin Van Tassell
  • Patent number: 10344001
    Abstract: Azolylacryloyl derivatives with hypoxic properties are provided. The compounds have a generic formula: and are suitable for treating sickle cell disease and hypoxia-underlying diseases, e.g. hemorrhagic and traumatic shock, cardiac arrest and cardiogenic shock, traumatic brain injury, cancer, stroke, myocardial infarction, myocardial ischemia, vaso-occlusive crisis, etc.
    Type: Grant
    Filed: September 30, 2016
    Date of Patent: July 9, 2019
    Assignees: VIRGINIA COMMONWEALTH UNIVERSITY, KING ABDULAZIZ UNIVERSITY, THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Martin K. Safo, Yan Zhang, Mohini Ghatge, Osheiza Abdulmalik, Abdelsattar Mansour Ebid Omar, Moustafa El-Sayed El-Araby
  • Patent number: 10316072
    Abstract: A recombinant Flagrp170 protein and pharmaceutical compositions comprising a Flagrp170 protein and related molecules encoding same, and cells presenting such a protein are provided. The Flagrp170 protein comprises an NF-?B-activating domain of Flagellin and an ATP-binding domain truncated Grp170. The pharmaceutical compositions of the invention can be used for the treatment or prevention of cancer or infectious disease.
    Type: Grant
    Filed: October 26, 2017
    Date of Patent: June 11, 2019
    Assignees: VIRGINIA COMMONWEALTH UNIVERSITY, HEALTH RESEARCH, INC.
    Inventors: Xiang-Yang Wang, Xiaofei Yu, John R. Subjeck
  • Patent number: 10314870
    Abstract: A tropism modified cancer terminator virus (Ad.5/3-CTV; Ad.5/3-CTV-M7) has been found to have infectivity that is Coxsackie Adenoviral Receptor (CAR) independent. The Ad.5/3-CTV (Ad.5/3-CTV-M7) may be used alone or in combination with other therapeutic agents such as agents that augment reactive oxygen (ROS) production, HDAC inhibitors, MCL-1 inhibitors and Bcl-2 inhibitors to treat a variety of cancers particularly including malignant glioma (GBM), renal cancer, prostate cancer, and colorectal cancer.
    Type: Grant
    Filed: December 10, 2013
    Date of Patent: June 11, 2019
    Assignee: VIRGINIA COMMONWEALTH UNIVERSITY
    Inventors: Paul Fisher, Devanand Sarkar, Paul Dent
  • Patent number: 10314857
    Abstract: Compositions, methods and kits for treating victims of carbon monoxide and/or cyanide poisoning and/or nitric acid-induced vasoplagia are provided. The compositions comprise reduced forms of Vitamin B12 such as reduced hydroxocobalamin or reduced cobinamide, and typically comprise at least one reducing agent (e.g. ascorbic acid). The compositions are generally produced, stored and delivered under reducing, usually anaerobic, conditions in order to preserve the desired oxidation state when introduced into the blood stream of a recipient.
    Type: Grant
    Filed: July 2, 2015
    Date of Patent: June 11, 2019
    Assignee: VIRGINIA COMMONWEALTH UNIVERSITY
    Inventor: Joseph D. Roderique
  • Patent number: 10300029
    Abstract: An organ protectant solution which is intravenously administered includes at least one oncotic agent and optionally a high concentration of cell-impermeant molecules. Together, they promote transfer of water from cells to interstitium and into the capillaries, thereby preventing or reducing cell swelling, maintaining blood circulation and oxygenation of tissues, and extending the “Golden Hour” for traumatic and/or hemorrhagic shock patients. In addition, compositions comprising PEG-20k and methods of their use for preserving and/or reanimating harvested organs ex vivo for lengthy periods of time (e.g. at least about 8-24 hours) are also provided.
    Type: Grant
    Filed: October 14, 2016
    Date of Patent: May 28, 2019
    Assignee: Virginia Commonwealth University
    Inventor: Martin Mangino
  • Patent number: 10272097
    Abstract: Methods of preventing and/or treating ischemia, organ dysfunction and/or organ failure, including multiple organ dysfunction syndrome (MODS), and necrosis and apoptosis associated with organ dysfunction/failure, are provided. For instance, the methods involve contacting organ(s) with an oxygenated cholesterol sulfate (OCS), e.g. 5-cholesten-3,25-diol, 3-sulfate (25HC3S). The organ(s) may be in vivo (e.g. in a patient that is treated with the OCS) or ex vivo (e.g. an organ that has been harvested from a donor and is to be transplanted).
    Type: Grant
    Filed: December 23, 2014
    Date of Patent: April 30, 2019
    Assignees: Virginia Commonwealth University, Durect Corporation
    Inventors: Shunlin Ren, Felix Theeuwes, James E. Brown, WeiQi Lin
  • Patent number: 10266571
    Abstract: Antigenic polypeptides comprising linear immunodominant epitopes of Borrelia outer surface protein A (OspA) or Borrelia outer surface protein C (OspC) are useful as vaccines against Lyme disease, and as diagnostics for detecting Borrelia infections. The OspA and OspC antigenic polypeptides typically comprise a plurality of peptides representing epitope containing regions from multiple distinct phyletic groups. The antigenic polypeptides may also include epitopes from both Borrelia OspA and Borrelia OspC.
    Type: Grant
    Filed: November 25, 2016
    Date of Patent: April 23, 2019
    Assignee: VIRGINIA COMMONWEALTH UNIVERSITY
    Inventors: Christopher G. Earnhart, Richard T. Marconi
  • Publication number: 20190111007
    Abstract: Provided are inhibitors of sphingosine kinase Type I and their use in the treatment of asthma, among other indications and diseases.
    Type: Application
    Filed: November 26, 2018
    Publication date: April 18, 2019
    Applicants: Enzo Therapeutics, Inc. c/o Enzo Biochem, Inc., Virginia Commonwealth University
    Inventors: Sarah Spiegel, Robert Elliot Zipkin, Jeffrey Kroll Adams
  • Patent number: 10247650
    Abstract: A portable electronic alcohol-testing device is provided that uses vaporization and sensitive pressure guages to approximate the alcohol content of a solution. The device may be used, for example, to determine the relative alcohol content of a mixed beverage.
    Type: Grant
    Filed: March 20, 2017
    Date of Patent: April 2, 2019
    Assignee: Virginia Commonwealth University
    Inventors: Illya Kajan, David Saul, Boris Solomonov, Alex Ucci, Matthew Leccadito
  • Patent number: 10221333
    Abstract: A compound is provided, having the formula (I), wherein Rs is a soft block polymer; wherein each T is independently a urethane or urea linkage; see formulae (A) and (B); wherein each RD is independently —CH3, —CH2CH3, —CH2CH2CH3, or —CH2CH2CH2CH3; wherein each R?D is independently —CH3, —CH2CH3, —CH2CH2CH3, —CH2CH2CH2CH3, or —ORD; and wherein each p is independently 1, 2, or 3. Compositions containing the compound, and methods of making and using the compound are provided.
    Type: Grant
    Filed: September 30, 2014
    Date of Patent: March 5, 2019
    Assignee: VIRGINIA COMMONWEALTH UNIVERSITY
    Inventors: Kenneth J. Wynne, Wei Zhang
  • Patent number: 10183991
    Abstract: Pharmaceutical compositions and methods for the treatment of DENND1A.V2 related disorders, such as PCOS, are provided. In particular, humanized and mouse monoclonal antibodies specific for DENND1A.V2 and methods for using the same are provided.
    Type: Grant
    Filed: May 9, 2017
    Date of Patent: January 22, 2019
    Assignees: Virginia Commonwealth University, The Penn State Research Foundation
    Inventors: Janette M. McAllister, Jerome F. Strauss, Neil D. Christensen
  • Patent number: 10166300
    Abstract: The presently disclosed subject matter generally relates to genetic constructs and methods for their use in cancer imaging, cancer treatment, and combined imaging and treatment protocols. In particular, the presently disclosed subject matter relates to tripartite cancer theranostic nucleic acid constructs that permit simultaneous cancer specific viral replication, expression of a diagnostic gene product, and expression of a therapeutic gene.
    Type: Grant
    Filed: June 4, 2014
    Date of Patent: January 1, 2019
    Assignees: Virginia Commonwealth University, The Johns Hopkins University
    Inventors: Paul B. Fisher, Swadesh K. Das, Mitchell E. Menezes, Devanand Sarkar, Martin G. Pomper
  • Patent number: 10159676
    Abstract: Methods and compositions for enhancing the ability of hypoxia-activated bioreductive agents to kill tumor cells within solid tumors are provided. Local regions of hypoxia are created within a tumor, or within a region containing a tumor, resulting in enhanced activation of hypoxia-activated bioreductive agents (e.g. tirapazamine) within the local region. The activated hypoxia-activated bioreductive agents kill tumor cells in the hypoxic region by catalyzing DNA stand breakage within the tumor cells. Because the activity is localized, side effects that typically occur as a result of systemic administration of bioreductive agents are reduced.
    Type: Grant
    Filed: April 5, 2017
    Date of Patent: December 25, 2018
    Assignee: Virginia Commonwealth University
    Inventors: Ruey-min Lee, Peck-sun Lin
  • Patent number: 10144759
    Abstract: The sulfated oxysterol 5-cholesten-3?, 25-diol 3-sulphate, a nuclear cholesterol metabolite that decreases lipid biosynthesis and increases cholesterol secretion and degradation, is provided as an agent to lower intracellular and serum cholesterol and/or triglycerides, and to prevent or treat lipid accumulation-associated inflammation and conditions associated with such inflammation. Methods which involve the use of this sulfated oxysterol to treat conditions associated with high cholesterol and/or high triglycerides and/or inflammation (e.g. hypercholesterolemia, hypertriglyceridemia, non-alcoholic fatty liver diseases, atherosclerosis, etc.) are also provided.
    Type: Grant
    Filed: February 12, 2016
    Date of Patent: December 4, 2018
    Assignee: VIRGINIA COMMONWEALTH UNIVERSITY
    Inventors: Shunlin Ren, William M. Pandak
  • Patent number: 10117436
    Abstract: A compound having the formula: wherein n, y, R1 and R2 are defined herein, and others, methods of making of and using, and compositions made thereby which have an antimicrobial resistance effect are described.
    Type: Grant
    Filed: March 24, 2016
    Date of Patent: November 6, 2018
    Assignee: VIRGINIA COMMONWEALTH UNIVERSITY
    Inventors: Kenneth J. Wynne, Souvik Chakrabarty, Wei Zhang, Asima Chakravorty, Olufemi O. Oyesanya
  • Patent number: 10119035
    Abstract: A monolithic, self-stratifying polymer coating, comprising: inner and outer-most surfaces on opposite sides of the coating, the inner surface being in contact with and adhered to an article; a surface region, extending from the outermost surface to a depth of about 2 nm from the outermost surface; a middle region, extending from a depth of about 2 nm from the outermost surface to a depth of less than about 2000 nm from the outermost surface; and a bulk region, extending from a depth of less than about 2000 nm from the outermost surface to the inner surface; wherein the surface region comprises a fluorous polyoxetane having the formula: (I) wherein n is an integer of 0-1 1, and m is an integer>0, in a greater concentration relative to the middle and bulk regions; wherein the middle region comprises 3F-SiO1.5 groups in a greater concentration relative to the surface and bulk regions; and wherein the bulk region comprises a polyurethane in a greater concentration relative to the surface and middle regions.
    Type: Grant
    Filed: July 26, 2012
    Date of Patent: November 6, 2018
    Assignee: VIRGINIA COMMONWEALTH UNIVERSITY
    Inventors: Kenneth J. Wynne, Wei Zhang, Chenyu Wang, Souvik Chakrabarty
  • Patent number: 10105554
    Abstract: A method and apparatus are used to compare an intended treatment plan using a radiation source with a delivered plan. This done by arranging markers at known three-dimensional (3D) positions in a detection reference system between a two dimensional radiation detector configured to acquire images generated by radiation emitted by the radiation source and an area where the radiation source is positioned during a treatment. The positions of projections of the markers on an image detected are determined when the radiation source is at a treatment position in an intended treatment plan reference system. A plurality of lines in the detection reference system are calculated, each line being defined by a 3D position of a marker and a 3D position of a corresponding projection of the marker on the detector according to the image. A 3D position of the radiation source in the detection reference system is inferred based on the calculated lines.
    Type: Grant
    Filed: September 12, 2016
    Date of Patent: October 23, 2018
    Assignee: VIRGINIA COMMONWEALTH UNIVERSITY
    Inventors: Dorin A. Todor, Aditya A. Bondal
  • Patent number: 10105500
    Abstract: A dry powder inhaler (DPI) device has a flow passage with a three-dimensional (3D) rod array. The rod array includes multiple rows each having multiple unidirectional rods. The rows are spaced apart along a primary direction of air flow and are staggered. A viewing window to the capsule chamber allows viewing of the capsule's position within the chamber which provides visual feedback of inhalation flow rate to the user during inhalation. The capsule chamber may orient the capsule parallel to a primary direction of air flow or perpendicular to a primary direction of air flow and provide capsule motion in a plane which is perpendicular to the primary direction of air flow.
    Type: Grant
    Filed: April 23, 2013
    Date of Patent: October 23, 2018
    Assignee: Virginia Commonwealth University
    Inventors: Phillip Worth Longest, Michael Hindle, Yoen-Ju Son, Srinivas Ravindra Babu Behara, Dale Farkas
  • Patent number: 10102335
    Abstract: Computer-implemented methods for providing improvements in genome-scale metabolic models are described. The methods identify and optimize metabolic flux states that minimize the cost of enzyme production while maximizing a desired cellular phenotype. The computer-implemented methods may maximize cellular phenotypes such as growth (biomass) or production of a metabolite, such as a commercially valuable chemical compound, through the selection of metabolic pathways that maximize these phenotypes while minimizing metabolic costs associated with production of the proteomic constituents of individual metabolic pathways. The computer implemented methods may be useful for computationally designing microbial strains for the production of chemicals.
    Type: Grant
    Filed: December 19, 2013
    Date of Patent: October 16, 2018
    Assignee: Virginia Commonwealth University
    Inventors: Adam Fisher, J. Paul Brooks, Stephen S. Fong