Abstract: The present invention relates to the field of medical treatment of diseases and disorders, as well as the field of biomedical engineering. Embodiments of the invention relate to the delivery of Irreversible Electroporation (IRE) through the vasculature of organs to treat tumors embedded deep within the tissue or organ, or to decellularize organs to produce a scaffold from existing animal tissue with the existing vasculature intact. In particular, methods of administering non-thermal irreversible electroporation (IRE) in vivo are provided for the treatment of tumors located in vascularized tissues and organs. Embodiments of the invention further provide scaffolds and tissues from natural sources created using IRE ex vivo to remove cellular debris, maximize recellularization potential, and minimize foreign body immune response. The engineered tissues can be used in methods of treating subjects, such as those in need of tissue replacement or augmentation.

Abstract: A system and method that comprises an X-ray source configured to emit an X-ray beam; an object positioned to receive the X-ray beam; a detector configured to receive an attenuated beam of the X-rays through the object for measuring projection data from various orientations that can be used to generate spectral images in terms of energy-dependent linear attenuation coefficients, and a detector, as described above, comprising one or more energy-integrating detector elements and one or more photon counting detector elements in one or more detectors array or separate detector arrays. The photon counting detector elements may also use dynamic thresholds to define energy windows.

Abstract: A power circuit includes a power source for providing electrical power and two driving transistors being disposed in parallel and receiving electrical power from the power source. Each of the two driving transistors includes a gate terminal, a source connection, and a kelvin source connection. The power circuit also includes a control voltage source having a first terminal and a second terminal. The control voltage source provides a control signal to the two driving transistors for determining driving currents through the two driving transistors. The first terminal is connected to the gate terminals of the two driving transistors, and the second terminal is connected to the kelvin source connections of the two driving transistors. The kelvin source connections of the two driving transistors are inductively coupled.

Abstract: The present invention provides a novel chimeric porcine circovirus infectious DNA clone and live attenuated chimeric virus with the PCV2, preferably of subtype PCV2b, capsid gene integrated into a non-pathogenic PCV1 virus genome. In a particular embodiment, the PCV2 capids gene is of subtype PCV2b, the predominant subtype circulating in pigs worldwide. The attenuated chimeric virus, designated PCV1-2b, effectively protects pigs from PCV2b challenges, and can be used as a live vaccine, as well as an inactivated (killed) vaccine, that provides protection and cross protection against PCV2b and PCV2a subtypes infection. The live attenuated vaccine of the present invention is also effective protecting pigs from porcine circovirus-associated disease (PCVAD).

Abstract: A two-stage power converter architecture including an isolation transformer and rectification of the isolation transformer output by an LLC resonant circuit and methodology for operating the same feeds an output voltage back to a circuit for generating waveforms for controlling a totem pole circuit to provide output voltage regulation as well as rectification of AC input voltage. The circuit for controlling the totem pole circuit may also be responsive to the AC input power waveform to provide power factor correction (PFC), in which case, the feedback signal provides additional pulse width modulation of the PFC signals. Bus capacitor size may also be reduced by injecting harmonics of the AC input waveform into the feedback signal which also serves to substantially maintain efficiency of the (preferably LLC) resonant second stage.

Abstract: The present invention provides a radio architecture that contains a main radio path and a sensing path. The parameters of the main radio path are controlled by a cognitive engine. The main radio path is tuned to a desired frequency band. The sensing path is used to monitor the spectrum around the desired frequency band. To minimize effects of undesired non-linearity on sensing, sensing path may have a lower gain setting. The cognitive engine determines the optimal setting of the main RF front-end with respect to the current state of the spectrum.

Abstract: A voltage waveform similar to a waveform of a magnetizing current of an isolation transformer and immune to high frequency oscillatory resonant behavior is developed across a capacitor of a series resistor and capacitor connection connected in parallel with a synchronous rectifier. A simple logic circuit produces a waveform for controlling the synchronous rectifier which is not subject to significant turn on delay or early turn off caused by oscillatory resonances among parasitic inductances and capacitances. Improved timing accuracy of a synchronous converter provides improved power converter accuracy, particularly for flyback converters which are commonly used in converters for supplying power to offline electrical devices but are subject to oscillatory resonant behaviors that cannot be adequately damped at switching frequencies sufficiently high to support miniaturization of adapters.

Abstract: Procedures are described for enhancing target system execution integrity determined by power fingerprinting (PFP): by integrating PFP into the detection phase of comprehensive defense-in-depth security; by deploying a network of PFP enabled nodes executing untrusted devices with predefined inputs forcing a specific state sequence and specific software execution; by embedding module identification information into synchronization signaling; by combining signals from different board elements; by using malware signatures to enhance PFP performance; by automatic characterization and signature extraction; by providing secure signature updates; by protecting against side-channel attacks; performing real-time integrity assessment in embedded platform by monitoring their dynamic power consumption and comparing it against signatures from trusted code, including pre-characterizing power consumption of the platform by concentrating on trace sections carrying the most information about the internal execution status; by u

Abstract: The present invention provides a method for testing a helmet that uses a risk function that incorporates both linear and rotational acceleration to predict the helmet's ability to prevent a concussion. In certain embodiments, the testing matrix includes 3 impact energy levels and 4 impact locations, for a total of 12 testing conditions per helmet.

Abstract: Described herein are stem cells and stem cell compositions that can be used to treat soft tissue injuries, including tendon and ligament injuries. Also described herein are cellular scaffolds that can contain a stem cell or stem cell compositions described herein. Also described herein are soft tissue bioreactor devices. Also described herein are methods of using the stem cells, stem cell compositions, and soft tissue bioreactors and methods of treating tendon and ligament injuries.

Abstract: Aspects of the disclosure provide a system having a power circuit. The power circuit includes a first switch circuit having at least a first transistor and a second switch circuit having at least a second transistor. Further, the power circuit includes first interconnections configured to couple the first switch circuit to driving nodes, a source node and a drain node of the power circuit, and second interconnection configured to couple the second switch circuit in parallel to the first switch circuit to the driving nodes, the source node and the drain node of the power circuit. A polarity of unbalance in the first interconnections and the second interconnections dominates a polarity of current unbalance in the first switch circuit and the second switch circuit.

Abstract: A resistive floating electrode device (RFED) provides a logic cell or non-volatile storage or dynamic or static random access memory on an extremely compact matrix with individual cells scalable to the minimum available lithographic feature size regime by providing atomic switches connected in anti-parallel relationship, preferably with a common inert electrode. Programming is facilitated by limiting current to a compliance current level in order to maintain an OB state from which the cell can be written to either the 0 or 1 state. A perfecting feature of the invention provides for selective operation of a cell as a diode or in a volatile or non-volatile storage mode within the same memory array. A series connection of three or more RFEDs in accordance with the invention having different ON state currents, OFF state currents and reset currents can be used as adaptive, neural or chaotic logic cells.

Abstract: Fine coal is cleaned of its mineral matter impurities and dewatered by mixing the aqueous slurry containing both with a hydrophobic liquid, subjecting the mixture to a phase separation. The resulting hydrophobic liquid phase contains coal particles free of surface moisture and droplets of water stabilized by coal particles, while the aqueous phase contains the mineral matter. By separating the entrained water droplets from the coal particles mechanically, a clean coal product of substantially reduced mineral matter and moisture contents is obtained. The spent hydrophobic liquid is separated from the clean coal product and recycled. The process can also be used to separate one type of hydrophilic particles from another by selectively hydrophobizing one.

Abstract: An energy harvester for converting vibration energy into electrical energy and harvesting the electrical energy includes: a base; a clamping structure which is supported by the base and is spaced apart from the base; an elastic member which is disposed between the base and the clamping structure and allows the clamping structure to be elastically moved relative to the base; and a cantilever structure including a cantilever beam having one side fixed to the clamping structure and the other side which is elastically bendable, and a mass body disposed on the cantilever beam.

Abstract: The present invention provides methods and devices to radiate wideband signals. The devices may include a tunable high Q narrowband antenna having a plurality of ports including a feed port and a tuning port as well as a tuning element coupled to the tuning port of the antenna. One or more voltage sources supply energy for radiating a radio frequency signal. A modulating signal generator may also be provided for generating a high data rate signal coupled at the tuning element for modulating the tuning element.

Abstract: Textured ceramic compositions having improved piezoelectric characteristics as compared with their random counterparts are provided. Methods of making the compositions and devices using them are also included. More particularly, compositions comprising textured ceramic Na0.5Bi0.5TiO3—BaTiO3(NBT-BT) materials synthesized from high aspect ratio NBT seeds exhibit improved characteristics, including an increased longitudinal piezoelectric constant (d33) and magnetoelectric coupling coefficient over randomly oriented NBT-BT. Additionally provided are compositions comprising of nanostructured Na0.5B0.5TiO3—BaTiO3 ferroelectric whiskers having a high aspect ratio. Nanostructured whiskers can be used to improve the piezoelectric properties of the bulk ceramics. The inventive materials are useful in microelectronic devices, with some finding particular application as multilayer actuators and transducers.

Abstract: The present invention provides a gel comprising a physical network formed of polymer chain crystallites interconnected by amorphous chain segments. Functionalization of the chain segments between the crystallites forms a blocky distribution of functionality along the chain whereby the functionalities are concentrated in groups consisting of one or more functionalities, separated by non-functionalized runs of crystallizable segments of the polymer. Removal of the solvent from the gels, without reducing the gel volume, forms an aerogel.

Abstract: In a cascode switching device, avalanche breakdown of a control transistor and loss of soft switching or zero voltage switching in a high voltage normally-on depletion mode transistor having a negative switching threshold voltage and the corresponding losses are avoided by providing additional capacitance in parallel with a parallel connection of drain-source parasitic capacitance of the control transistor and gate-source parasitic capacitance of the high voltage, normally-on transistor to form a capacitive voltage divider with the drain-source parasitic capacitance of the high voltage, normally-on transistor such that the avalanche breakdown voltage of the control transistor cannot be reached. The increased capacitance also assures that the drain source parasitic capacitance of the high voltage, normally-on transistor is fully discharged before internal turn-on can occur.

Abstract: An integrated microfluidic chromatin immunoprecipitation assay dramatically improves the collection efficiency of ChIP DNA from cells. Immunoprecipitation of chromatin fragments is conducted in a microfluidic chamber with a large fraction of its volume (e.g., ˜15-40%) occupied by magnetic immunoprecipitation (IP) beads. Oscillating washing of the beads, enabled by, e.g., solenoid valves (controlled by a computer) and high pressure attached to both ends of the microfluidic chamber, effectively removes unbound chromatin and produces high-quality ChIP DNA. ChIP DNA produced by an example device generates excellent results in the subsequent DNA library preparation. The ChIP-seq (i.e., ChIP followed by next-generation sequencing) results match very well with public data generated using much larger cell sample sizes and a conventional approach.

Abstract: In one example, an omnidirectional wireless power transfer system includes high frequency power generator configured to generate a supply of high frequency oscillating power, a number of transmitter-side resonant tank circuits electrically coupled to the high frequency power generator, a receptacle including a number of coils arranged for omnidirectional power transfer to an electronic device placed in the receptacle, and a controller configured to activate individual ones of the transmitter-side resonant tank circuits to wirelessly transmit power to the electronic device through near-field resonant inductive coupling. In one example, the receptacle can be embodied as a bowl, and the controller can activate individual ones of the transmitter-side resonant tank circuits over time to generate an omnidirectional field distribution for wireless power transmission. In other aspects, various transmitter-side and receiver-side tank circuits for coupling independent resonance and ZVS operation are described.