Patents Assigned to Vysis, Inc.
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Patent number: 8594944Abstract: A method and/or system for making determinations regarding samples from biologic sources. A computer implemented method and/or system can be used to automate parts of the analysis.Type: GrantFiled: February 6, 2008Date of Patent: November 26, 2013Assignees: Vysis, Inc., Metasystems GmbHInventors: James R. Piper, Ian Poole, Thomas Richard Lörch
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Publication number: 20120164626Abstract: Methods of using probes and probe sets for the detection of high grade dysplasia and carcinoma in cervical cells are described. Methods of the invention include hybridizing one or more chromosomal probes to a biological sample obtained from a subject and detecting the hybridization pattern of the chromosomal probes to the sample to determine whether the subject has high grade dysplasia or carcinoma. Methods of the invention also include preliminary screening the cells for a marker associated with a risk for cancer, and preferably involves screening for HPV infected cells by in situ hybridization using an HPV probe mixture.Type: ApplicationFiled: October 24, 2011Publication date: June 28, 2012Applicant: VYSIS, INC.Inventors: Irina A. Sokolova, Steven A. Seelig, Larry E. Morrison, Walter King, Alicia Algeciras-Schimnich
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Patent number: 8043805Abstract: Methods of using probes and probe sets for the detection of high grade dysplasia and carcinoma in cervical cells are described. Methods of the invention include hybridizing one or more chromosomal probes to a biological sample obtained from a subject and detecting the hybridization pattern of the chromosomal probes to the sample to determine whether the subject has high grade dysplasia or carcinoma. Methods of the invention also include preliminary screening the cells for a marker associated with a risk for cancer, and preferably involves screening for HPV infected cells by in situ hybridization using an HPV probe mixture.Type: GrantFiled: April 13, 2009Date of Patent: October 25, 2011Assignee: Vysis, Inc.Inventors: Irina A. Sokolova, Steven A. Seelig, Larry E. Morrison, Walter King, Alicia Algeciras-Schimnich
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Patent number: 7998670Abstract: Methods for detecting cancer that include hybridizing a set of chromosomal probes to a biological sample obtained from a patient, and identifying if aneusomic cells are present in a selected subset of cells obtained from the biological sample are described. A set of chromosomal probes and kits for detecting cancer that include sets of chromosomal probes, are also described.Type: GrantFiled: May 21, 2007Date of Patent: August 16, 2011Assignees: Mayo Foundation for Medical Education and Research, Vysis, Inc.Inventors: Kevin C. Halling, Robert B. Jenkins, Walter King, Irina A. Sokolova, Steven A. Seelig
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Patent number: 7998678Abstract: Probe sets and methods of using probes and probe sets for the detection of cancer are described. Methods for detecting cancer that include hybridizing a set of chromosomal probes to a biological sample obtained from a patient, and identifying if cancer cells are present the sample. Also included are methods of selecting a combination of probes for the detection of cancer.Type: GrantFiled: August 6, 2009Date of Patent: August 16, 2011Assignees: VYSIS, Inc., Mayo Foundation for Medical Education and ResearchInventors: Larry E. Morrison, Irina A. Sokolova, Steven A. Seelig, Kevin C. Halling
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Publication number: 20090269768Abstract: Methods of using probes and probe sets for the detection of high grade dysplasia and carcinoma in cervical cells are described. Methods of the invention include hybridizing one or more chromosomal probes to a biological sample obtained from a subject and detecting the hybridization pattern of the chromosomal probes to the sample to determine whether the subject has high grade dysplasia or carcinoma. Methods of the invention also include preliminary screening the cells for a marker associated with a risk for cancer, and preferably involves screening for HPV infected cells by in situ hybridization using an HPV probe mixture.Type: ApplicationFiled: April 13, 2009Publication date: October 29, 2009Applicant: Vysis, Inc.Inventors: IRINA A. SOKOLOVA, STEVEN A. SEELIG, LARRY E. MORRISON, WALTER KING, ALICIA ALGECIRAS-SCHIMNICH
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Patent number: 7517645Abstract: Methods of using probes and probe sets for the detection of high grade dysplasia and carcinoma in cervical cells are described. Methods of the invention include hybridizing one or more chromosomal probes to a biological sample obtained from a subject and detecting the hybridization pattern of the chromosomal probes to the sample to determine whether the subject has high grade dysplasia or carcinoma. Methods of the invention also include preliminary screening the cells for a marker associated with a risk for cancer, and preferably involves screening for HPV infected cells by in situ hybridization using an HPV probe mixture.Type: GrantFiled: June 2, 2004Date of Patent: April 14, 2009Assignee: VYSIS, Inc.Inventors: Irina A. Sokolova, Steven A. Seelig, Larry E. Morrison, Walter King, Alicia Algeciras-Schimnich
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Publication number: 20080032302Abstract: Methods for detecting cancer that include hybridizing a set of chromosomal probes to a biological sample obtained from a patient, and identifying if aneusomic cells are present in a selected subset of cells obtained from the biological sample are described. A set of chromosomal probes and kits for detecting cancer that include sets of chromosomal probes, are also described.Type: ApplicationFiled: May 21, 2007Publication date: February 7, 2008Applicants: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH, VYSIS, INC.Inventors: Kevin Halling, Robert Jenkins, Walter King, Irina Sokolova, Steven Seelig
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Patent number: 7232655Abstract: Methods for detecting cancer that include hybridizing a set of chromosomal probes to a biological sample obtained from a patient, and identifying if aneusomic cells are present in a selected subset of cells obtained from the biological sample are described. A set of chromosomal probes and kits for detecting cancer that include sets of chromosomal probes, are also described.Type: GrantFiled: April 12, 2002Date of Patent: June 19, 2007Assignees: Mayo Foundation for Medical Education and Research, Vysis, Inc.Inventors: Kevin C. Halling, Robert B. Jenkins, Walter King, Irina A. Sokolova, Steven A. Seelig
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Patent number: 6841388Abstract: A method and system for diagnosing pathology, such as carcinoma, in a biological sample identifies presence of pathology based on the existence of an infrared markers in the extracellular material, rather than cells, in the biological sample. In the case of breast cancer diagnosis, an effective marker is a baseline slope of a 1280 cm?1 band in the infrared spectra of connective tissue, with normal biopsy samples exhibiting a positive slope and cancerous samples showing a relatively flat baseline. Infrared spectroscopy, both microscopic and macroscopic, may be used to identify a sample region containing extracellular material and to collect infrared absorbance data, from which the existence of the pathology marker is determined.Type: GrantFiled: November 28, 2001Date of Patent: January 11, 2005Assignees: Vysis, Inc., Procter & GambleInventors: Rina K. Dukor, Curtis A. Marcott
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Publication number: 20030170703Abstract: A method and/or system for making determinations regarding samples from biologic sources. A computer implemented method and/or system can be used to automate parts of the analysis.Type: ApplicationFiled: January 14, 2003Publication date: September 11, 2003Applicant: Vysis, Inc., a Corporation of the State of DelawareInventors: James R. Piper, Ian Poole, Thomas Richard Lorch
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Publication number: 20030124589Abstract: A method of obtaining a corrected image of a microarray includes acquiring an image of a microarray including a target spot, and processing the image to correct for background noise and chip misalignment. The method also includes analyzing the image to identify a target patch, edit debris, and correct for ratio bias; and detecting single copy number variation in the target spot using an objective statistical analysis that includes a t-value statistical analysis. The method provides statistically robust computational processes for accurately detecting genomic variation at the single copy level.Type: ApplicationFiled: October 11, 2002Publication date: July 3, 2003Applicant: Vysis, Inc.Inventor: James R. Piper
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Patent number: 6569626Abstract: Direct label probe compositions which stain DNA of a preselected single chromosome or region of a chromosome of a multi-chromosomal genome are provided that comprise mixed DNA segments which are covalently bound to fluorophore groups through linking groups. The mixed DNA segments are derived from the DNA present in the preselected chromosome or chromosome region. These probe compositions can be used concurrently or sequentially with other probe compositions.Type: GrantFiled: June 21, 2001Date of Patent: May 27, 2003Assignee: Vysis, Inc.Inventors: Michael L. Bittner, Larry E. Morrison, Mona S. Legator
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Patent number: 6482589Abstract: Nucleic acids having approximately 10 to 250 nucleotides which are capable of hybridizing to rRNA and RDNA of mycoplasma etiological agents of nongonococcal urethritis, pelvic inflammatory disease, salpingiuis, and other infections due to mycoplasmas from the genital areas, Mycoplasma hominis, Mycoplasma genitalium, and Ureaplasma urealyticum.Type: GrantFiled: May 26, 1995Date of Patent: November 19, 2002Assignee: Vysis, Inc.Inventors: William G. Weisburg, Dale A. Pelletier
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Patent number: 6455260Abstract: Fluorescence-based assay methods for detecting biological analytes in a sample. The fluorescence background in these methods is significantly lower than in conventional assay methods. Also provided are methods of attaching nucleic acids to a metallic or metalloid surface.Type: GrantFiled: October 16, 2001Date of Patent: September 24, 2002Assignee: Vysis, Inc.Inventors: Uwe Richard Müller, Diping Che, Yijia Bao
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Patent number: 6376188Abstract: Methods for detecting cancer that include hybridizing a set of chromosomal probes to a biological sample obtained from a patient, and identifying if aneusomic cells are present in a selected subset of cells obtained from the biological sample are described. A set of chromosomal probes and kits for detecting cancer that include sets of chromosomal probes, are also described.Type: GrantFiled: July 21, 2000Date of Patent: April 23, 2002Assignees: Mayo Foundation for Medical Education and Research, Vysis, Inc.Inventors: Kevin C. Halling, Robert B. Jenkins, Walter King, Irina A. Sokolova, Steven A. Seelig
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Publication number: 20020034762Abstract: Fluorescence-based assay methods for detecting biological analytes in a sample. The fluorescence background in these methods is significantly lower than in conventional assay methods. Also provided are methods of attaching nucleic acids to a metallic or metalloid surface.Type: ApplicationFiled: October 16, 2001Publication date: March 21, 2002Applicant: Vysis, Inc., a Delaware corporationInventors: Uwe Richard Muller, Diping Che, Yijia Bao
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Patent number: 6306587Abstract: Methods, apparatus and compositions are presented for ligating ligands together which bind to a common receptor. One embodiment includes polynucleotide probes having photoreactive functional groups. The probes are capable of assuming substantially contiguous reactive positions on a target polynucleotide placing the photoreactive group in juxtaposition. Activation of the photoreactive functional groups with radiant energy form a probe reaction product in which the probes are bound to each other.Type: GrantFiled: November 10, 1997Date of Patent: October 23, 2001Assignee: Vysis, Inc.Inventors: Garfield P. Royer, Larry E. Morrison, Kenneth A. Cruickshank
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Patent number: 6306589Abstract: Fluorescence-based assay methods for detecting biological analytes in a sample. The fluorescence background in these methods is significantly lower than in conventional assay methods. Also provided are methods of attaching nucleic acids to a metallic or metalloid surface.Type: GrantFiled: May 27, 1998Date of Patent: October 23, 2001Assignee: Vysis, Inc.Inventors: Uwe Richard Müller, Diping Che, Yijia Bao
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Patent number: RE37891Abstract: A method of assay for target polynucleotides includes steps of isolating target polynucleotides from extraneous non-target polynucleotides, debris, and impurities and amplifying the target polynucleotide.Type: GrantFiled: March 8, 2000Date of Patent: October 22, 2002Assignee: Vysis, Inc.Inventors: Mark L. Collins, Donald N. Halbert, Walter King, Jonathan M. Lawrie