Patents Assigned to Wakunaga Pharmaceutical Co., Ltd.
  • Patent number: 6136823
    Abstract: The invention relates to pyridonecarboxylic acid derivatives represented by the general formula (1): ##STR1## wherein R.sup.1 is --OH, a carboxy-protecting group or (alkyl)amino group, R.sup.2 is H, or --NO.sub.2, (protected) amino, (protected) hydroxyl, lower alkyl or lower alkoxyl group, R.sup.3 is a halogen atom, H, or --NO.sub.2, lower alkyl, lower alkoxyl or amino group, R.sup.4 is an azido, (substituted) hydrazino, (substituted) amino, lower alkoxyl or hydroxyl group, R.sup.5, R.sup.6 and R.sup.7 are independently H, --NO.sub.2, halogen atom or lower alkyl group, R.sup.8 is a --NO.sub.2, (substituted) amino, --OH or lower alkoxyl group, A is N or C--R.sup.12, in which R.sup.12 is H, halogen atom, or (substituted) lower alkyl, lower alkenyl, lower alkynyl, lower alkoxyl, lower alkylthio or nitro group, and B is N or C--R.sup.13, in which R.sup.13 is H or halogen atom, or salts thereof, and medicine comprising such a compound as an active ingredient.
    Type: Grant
    Filed: May 28, 1999
    Date of Patent: October 24, 2000
    Assignee: Wakunaga Pharmaceutical Co., Ltd.
    Inventors: Nobuya Sakae, Akira Yazaki, Yasuhiro Kuramoto, Jiro Yoshida, Yoshiko Niino, Yoshihiro Ohshita, Yuzo Hirao, Norihiro Hayashi, Hirotaka Amano
  • Patent number: 6133284
    Abstract: A pyridonecarboxylic acid derivative represented by the following general formula (1): ##STR1## [wherein R.sup.1 represents hydrogen atom or a carboxyl protective group; R.sup.2 represents hydroxyl group, a lower alkoxy group, or a substituted or unsubstituted amino group; R.sup.3 represents hydrogen atom or a halogen atom; R.sup.4 represents hydrogen atom or a halogen atom; R.sup.5 represents a halogen atom or an optionally substituted saturated cyclic amino group; R.sup.6 represents hydrogen atom, a halogen atom, nitro group, or an optionally protected amino group; X, Y and Z may be the same or different and respectively represent nitrogen atom, --CH.dbd. or --CR.sup.7 .dbd. (wherein R.sup.7 represents a lower alkyl group, a halogen atom, or cyano group) (with the proviso that at least one of X, Y and Z represent the nitrogen atom), and W represents nitrogen atom or --CR.sup.8 .dbd. (wherein R.sup.
    Type: Grant
    Filed: June 10, 1999
    Date of Patent: October 17, 2000
    Assignee: Wakunaga Pharmaceutical Co., Ltd.
    Inventors: Akira Yazaki, Yoshiko Niino, Yoshihiro Ohshita, Yuzo Hirao, Hirotaka Amano, Norihiro Hayashi, Yasuhiro Kuramoto
  • Patent number: 5998436
    Abstract: A pyridonecarboxylic acid derivative represented by the following general formula (1): ##STR1## [wherein R.sup.1 represents hydrogen atom or a carboxyl protective group; R.sup.2 represents hydroxyl group, a lower alkoxy group, or a substituted or unsubstituted amino group; R.sup.3 represents hydrogen atom or a halogen atom; R.sup.4 represents hydrogen atom or a halogen atom; R.sup.5 represents a halogen atom or an optionally substituted saturated cyclic amino group; R.sup.6 represents hydrogen atom, a halogen atom, nitro group, or an optionally protected amino group; X, Y and Z may be the same or different and respectively represent nitrogen atom, --CH.dbd. or --CR.sup.7 .dbd. (wherein R.sup.7 represents a lower alkyl group, a halogen atom, or cyano group) (with the proviso that at least one of X, Y and Z represent the nitrogen atom), and W represents nitrogen atom or --CR.sup.8 .dbd. (wherein R.sup.
    Type: Grant
    Filed: March 20, 1998
    Date of Patent: December 7, 1999
    Assignee: Wakunaga Pharmaceuticals Co., Ltd.
    Inventors: Akira Yazaki, Yoshiko Niino, Yoshihiro Ohshita, Yuzo Hirao, Hirotaka Amano, Norihiro Hayashi, Yasuhiro Kuramoto
  • Patent number: 5994575
    Abstract: Phenylenediamines represented by general formula (1): ##STR1## wherein R represents an alkyl group or an optionally substituted aralkyl group, X.sup.1 represents a hydrogen atom or a halogen atom, and X.sup.2 represents a halogen atom; salts thereof, and a process for preparing the same. The compounds are useful as intermediates for synthesis of pyridonecarboxylic acid derivatives useful as antibacterial agents.
    Type: Grant
    Filed: October 15, 1998
    Date of Patent: November 30, 1999
    Assignee: Wakunaga Pharmaceutical Co., Ltd.
    Inventors: Akira Yazaki, Jiro Yoshida, Yoshiko Niino
  • Patent number: 5962480
    Abstract: The present invention discloses a drug for ameliorating brain diseases which comprises as an active ingredient a compound represented by the following formula (1): ##STR1## or a salt thereof. Because of inhibiting a decrease in brain neurons and promoting branching of neurites, this drug is efficacious in the prevention and treatment of dementia, etc. in association with degeneration and sloughing of brain neurons.
    Type: Grant
    Filed: January 9, 1998
    Date of Patent: October 5, 1999
    Assignee: Wakunaga Pharmaceutical Co., Ltd.
    Inventors: Toru Moriguchi, Hiromichi Matsuura, Hiroshi Saito
  • Patent number: 5792609
    Abstract: A method of detecting falciparum, tertian, quartan and ovale malaria parasites by using primers represented by the sequences (SEQ ID NO:1), (SEQ ID NO:3) to (SEQ ID NO:10):5'AAGTCATCTTTCGAGGTGAC3' (SEQ ID NO:4)5'GAATTTTCTCTTCGGAGTTTA3' (SEQ ID NO:5)5'GAGACATTCTTATATATG3' (SEQ ID NO:3)5'GAAAATTCCTTTCGGGGA3' (SEQ ID NO:1)5'CGACTAGGTGTTGGATGA3' (SEQ ID NO:6)5'GAACGAAAGTTAAGGGAGT3' (SEQ ID NO:7)5'ACTGAAGGAAGCAATCTAA3' (SEQ ID NO:8)5'TCAGATACCGTCGTAATCTT3' (SEQ ID NO:9)5'CCAAAGACTTTGATTTCTCAT3' (SEQ ID NO:10)This invention allows all of the plasmodia, which infect the human, to be detected easily, rapidly and with a high sensitivity or distinguished accurately from one another, thus permitting treatment for malaria and large-scale mass examination in the area where malaria is prevalent.
    Type: Grant
    Filed: September 11, 1995
    Date of Patent: August 11, 1998
    Assignee: Wakunaga Pharmaceutical Co., Ltd.
    Inventors: Yusuke Wataya, Akio Yamane
  • Patent number: 5359066
    Abstract: A compound represented by the following general formula: ##STR1## which is useful as an intermediate for production of a clinically excellent synthetic antibacterial, a salt thereof, and a process for producing the same.In said formula,R.sup.1 is a hydrogen atom or a carboxyl-protecting group;R.sup.2 is a hydrogen atom or a lower alkyl group;X.sup.1 is a hydrogen atom or a halogen atom;X.sup.2 is a halogen atom;X.sub.a.sup.5 is a hydrogen atom or a halogen atom;A is a methylene group; a group of >CH--COOR.sup.4, etc.,in which R.sup.4, R.sup.5 and R.sup.6 each are a hydrogen atom or a carboxyl-protecting group;B is a methylene group or a carbonyl group;provided that both A and B must not be methylene groups at the same time.
    Type: Grant
    Filed: June 15, 1993
    Date of Patent: October 25, 1994
    Assignees: Wakunaga Pharmaceutical Co., Ltd., Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Hideo Tsutsumi, Takeshi Terasawa, David Barrett, Masayoshi Murata, Kazuo Sakane, Akira Yazaki, Satoshi Inoue