Abstract: An assembly for remotely manipulating a patient's spine. A compressor/distractor mechanism attaches to spinal anatomy or vertebral screws on adjacent vertebrae at a spinal surgical site on a patient's spine. A flexible cable is operatively connected to the compressor/distractor mechanism and to a control mechanism. The control mechanism manipulates the flexible cable, controlling the compressor/distractor mechanism to compress or distract the vertebrae. A rotatable surgical table with a remote control can be used in place of the compressor/distractor mechanism and the control mechanism. The rotatable surgical table can rotate the patient to place the spinal surgical site in a desired compressed or distracted position, and to place the patient in a desired orientation with respect to a horizontal reference plane.

Abstract: A surgical system includes a first surgical instrument having a selected configuration and an image guide disposed relative to a sensor to communicate a signal representative of a position of the image guide. A passive image guide is fixed with vertebral tissue and is disposed relative to the sensor to communicate a signal representative of a position of the passive image guide. The passive image guide includes a first surface. A second surgical instrument is connectable with the first surgical instrument and includes a second surface engageable with the first surface in a mating configuration to provide verification of the selected configuration. Surgical instruments, implants, spinal constructs and methods are disclosed.

Abstract: A surgical instrument includes a member including a body engageable with a longitudinal element to fix the longitudinal element with the body. The member further includes a distal portion having a guide including an arcuate surface being engageable with the longitudinal element. An actuator is connected with the member to incrementally tension the longitudinal element. Surgical systems, implants, spinal constructs and methods are disclosed.

Abstract: An osteogenic composition for implantation at or near a target tissue site beneath the skin is provided, the osteogenic composition comprising bone morphogenetic protein and a NEMO binding domain peptide, where the NEMO binding domain peptide reduces soft tissue inflammation at or near the target tissue site. In some embodiments, a method is provided for treating a target tissue site in a patient in need of such treatment, the method comprising implanting an osteogenic composition comprising bone morphogenetic protein and a NEMO binding domain peptide, where the NEMO binding domain peptide reduces soft tissue inflammation at or near the target tissue site.

Abstract: A surgical system comprises at least one implant support including a first implant support that is engageable with a receiver of a first fastener having a shaft fixed with vertebral tissue. At least one adaptor includes a first adaptor extending longitudinally along and being engageable with the first implant support. The first adaptor is rotatable relative to the first implant support to connect the first implant support with a surgical instrument to manipulate the vertebral tissue. Surgical instruments, constructs, implants and methods are disclosed.

Abstract: A drug depot delivery system includes a housing having a cavity. A cartridge is positioned within the cavity and includes a body having a channel. The body includes a first pair of rails and a second pair of rails. A plunger is slidably disposed in the housing and the cartridge. The plunger is configured to move a drug depot through the channel and out of the housing. Kits and methods of use are disclosed.

Abstract: A bone implant for enclosing bone material is provided. The bone implant comprises a nonwoven mesh having an inner surface and an outer surface opposing the inner surface and configured to receive a bone material when the inner surface of the mesh is in an open configuration. A plurality of projections are disposed on or in at least a portion of the inner surface of the mesh, the outer surface of the mesh or both the inner and outer surfaces of the mesh, the plurality of projections extending from at least the portion of the inner surface, the outer surface of the mesh or both the inner and outer surfaces of the mesh and are configured to engage a section of the inner surface of the mesh or a section of the outer surface of the mesh or both in a closed configuration so as to enclose the bone material.

Abstract: A bone implant for enclosing bone material is provided. The bone implant comprises a woven or knit mesh having an inner surface and an outer surface opposing the inner surface and configured to receive a bone material when the inner surface of the mesh is in an open configuration. A plurality of projections are disposed on or in at least a portion of the inner surface of the mesh, the outer surface of the mesh or both the inner and outer surfaces of the mesh, the plurality of projections extending from at least the portion of the inner surface, the outer surface or both the inner and outer surfaces of the mesh and are configured to engage a section of the inner or outer surfaces of the mesh or both in a closed configuration so as to enclose the bone material.

Abstract: A spinal-surgery system having a rod receiver and/or a cap having a generally cylindrical body, a set of opposing splay-resisting flanges, and a set of opposing rotation-preventing/rotation-resisting wings. Each wing has a lateral rotation-preventing portion and a lateral rotation-resisting portion. A receiver proximal end forms a wing-receiving cavity having a lateral rotation-preventing side and a lateral rotation-resisting side. Each flange has a proximal-facing splay-resist surface, and a distal-facing pop-on surface. Each receiver proximal protrusion has a proximal-facing sloped receiver pop-on surface, and a distal-facing sloped receiver splay-resist surface. Each rotation-preventing portion contacts a corresponding rotation-preventing side and each rotation-resisting portion contacts a corresponding rotation-resisting sides when the cap is popped on. The rotation-preventing portions contacting the rotation-preventing sides prevents cap rotation in a first direction.

Abstract: A surgical instrument comprises a member being engageable to a spinal implant configured for connection to a bone fastener shaft. An actuator is connected to the member. A latch is connected to the actuator and the connection is configured to change between at least one non-locked orientation such that the actuator is movable relative to the member and a locked orientation such that the actuator is fixed relative to the member. Systems, spinal constructs, implants and methods are disclosed.

Abstract: A spinal implant comprises an implant body extending between an anterior surface and a posterior surface and includes a first vertebral engaging surface and a second vertebral engaging surface. The implant body includes an inner surface that defines at least one cavity that is oriented to implant a fastener oblique relative to a lateral axis of a subject body and adjacent an intervertebral space of the subject body. At least one indicia is disposed with the implant body to facilitate orientation of the implant body with the subject body. Systems and methods are disclosed.

Abstract: A surgical table for supporting a patient over a floor and including a base assembly, a support column assembly and a patient support structure. The base assembly supported on the floor and including a first end, a second end opposite the first end, and a member extending along a base longitudinal axis between the first and second ends. The support column assembly moveably coupled with the base assembly and configured to translate between the first and second ends of the base assembly along the member extending therebetween, the support column assembly being the only support column assembly coupled with the base assembly. The patient support structure including a first end, a second end opposite the first end, and a longitudinal axis extending between the first and second ends, the second end of the patient support structure supported off of the support column assembly in a cantilevered fashion.

Abstract: Drug depot delivery devices and methods for delivering a drug depot to a site beneath the skin of a patient are provided. In various embodiments the device has a housing having a top housing end, and a bottom housing end. The housing defines a housing channel. The device has a drug cartridge defining a depot channel aligned with the housing channel and configured to slidably accept the drug depot. The drug cartridge has at least a first occluding device configured to occlude the depot channel at a first position such that the drug depot cannot pass through the depot channel without force applied to the drug depot sufficient to deflect the first occluding device. The bottom end of the housing has a coupling configuration for engaging a cannula. A plunger has a push rod to expel the drug depot through the occluding device and the cannula.

Abstract: A patient support apparatus for supporting a patient in a prone position during a surgical procedure is provided, including an open fixed frame suspended above a floor and a pair of spaced opposed radially sliding joints cooperating with the frame, each joint including a virtual pivot point and an arc of motion spaced from the virtual pivot point, the joints being movable along the arc providing a pivot ship mechanism for a pair of pelvic pads attached to the joints. A base for supporting and suspending a patient support structure above the floor, for supporting a patient during a surgical procedure, the base including a pair of spaced opposed vertical translation subassemblies reversibly attachable to a patient support structure, a cross-bar, and a rotation subassembly having two degrees of rotational freedom; wherein a location of each vertical translation subassembly is substantially constant during operation of the patient support structure.

Abstract: Provided is an implant configured to fit at or near a bone defect to promote bone growth. The implant comprises an oxysterol uniformly disposed in an acellular tissue matrix (ATM). The acellular tissue matrix can be porcine collagen, which in some cases is crosslinked. The implant can contain an acellular porcine crosslinked collagen in an amount of about 5 wt. % to about 25 wt. % of the implant and an oxysterol in an amount of about 5 wt. % to about 90 wt. % of the implant. The oxysterol can be Oxy133 monohydrate or an Oxy133 polymorph. Methods of making and using the implant are further provided.

Abstract: A method of treating a spine includes implanting a spinal implant within a patient. The spinal implant includes a first member having a first wall defining an axial passageway and a first opening, the first opening being in communication with the axial passageway. A second member includes a second wall defining an axial channel having the first member disposed therein, the second wall defining a second opening in communication with the axial channel. Bone graft is injected through the first opening and into the axial passageway and through the second opening and into the axial channel after the spinal implant is implanted within the patient.

Abstract: A surgical instrument configured to enable simultaneously driving a bone screw into a boney structure of a patient and delivering of a blade within the patient adjacent the bone screw is disclosed. The surgical instrument may include an elongated outer-sheath extending in a longitudinal direction from a proximal end to a distal end, for example The elongated outer-sheath may include an interior cavity that defines a centrally disposed longitudinal axis that extends in the longitudinal direction, for example. The surgical tool may include a central-sheath disposed within the interior cavity that extends in the longitudinal direction, for example. The surgical instrument may further include an inner-shaft rotatably supported by the central-sheath that extends in the longitudinal direction, for example. The inner-shaft may include a driver configured to selectively drive a bone screw upon rotation of the inner-shaft about the longitudinal axis, for example.

Abstract: A spinal implant comprises an implant body extending between an anterior surface and a posterior surface and includes a first vertebral engaging surface and a second vertebral engaging surface. The implant body includes an inner surface that defines at least one cavity that is oriented to implant a fastener oblique relative to a lateral axis of a subject body and adjacent an intervertebral space of the subject body. At least one indicia is disposed with the implant body to facilitate orientation of the implant body with the subject body. Systems and methods are disclosed.

Abstract: An interbody implant includes an implant body extending between an anterior surface and a posterior surface. The implant body includes a first vertebral engaging surface and a second vertebral engaging surface. At least one of the vertebral engaging surfaces defines a cavity configured for disposal of bone growth detectable via medical imaging. Systems, spinal constructs, surgical instruments and methods are disclosed.

Abstract: A spinal implant package includes a sleeve defining a cavity extending through an end surface of the sleeve. A cap defines an aperture extending through an end surface of the cap. First portions of the end surfaces are joined to define a hinge. The end surface of the sleeve includes a second portion defining a first lip. The end surface of the cap includes a second portion defining a second lip. The package is movable between a closed configuration in which the first lip is adjacent the second lip and a portion of the spinal implant is enclosed within the cavity and the aperture, and an open configuration in which the first lip is spaced farther apart from the second lip and the portion of the spinal implant is positioned outside of the aperture while remaining positioned inside of the cavity.