Patents Assigned to Washington State University
  • Patent number: 10287600
    Abstract: Aspects of the invention provide methods for differential regulation of fatty acid unsaturation in seed oil and membrane lipids of plants based on modulation of a previously unknown biosynthetic pathway involving a novel phosphatidylcholine:diacylglycerol cholinephosphotransferase (PDCT) that regulates phosphatidylcholine biosynthesis in developing oil seed plants. Specific aspects relate to inventive PDCT polypeptides including, for example, variants, deletions, muteins, fusion proteins, and orthologs thereof (collectively PDCT proteins), to nucleic acids encoding same, to plants comprising such PDCT sequences or proteins or devoid or depleted of such PDCT proteins or sequences, and to methods for generating plants having altered or no PDCT expression and/or activity, including but not limited to methods comprising mutagenesis, recombinant DNA, transgenics, etc.
    Type: Grant
    Filed: November 20, 2015
    Date of Patent: May 14, 2019
    Assignee: Washington State University
    Inventors: John A. Browse, Chaofu Lu, Zhanguo Xin
  • Patent number: 10279578
    Abstract: Techniques of additive deposition for producing articles of manufacture are disclosed herein. In one embodiment, an article of manufacture can include a substrate having a surface and composed of a metal or metal alloy and multiple layers of composite materials deposited on the surface of the substrate. The composite materials is composed of the metal or metal alloy and a ceramic material. The individual composite materials at each of the multiple layers has a composition with a corresponding ratio between the metal or metal alloy material and the ceramic material. The ratios between the metal or metal alloy material and the ceramic material change along at least one dimension of the article of manufacture.
    Type: Grant
    Filed: June 20, 2017
    Date of Patent: May 7, 2019
    Assignee: Washington State University
    Inventors: Amit Bandyopadhyay, Susmita Bose, Thomas Gualtieri, Yanning Zhang
  • Patent number: 10280397
    Abstract: The present invention relates to the production and culture of undifferentiated spermatogonial stem cells that can be maintained long term and are feeder free. The resultant feeder-free populations can be used in any of a number of protocols including the generation of progeny bulls. The present invention includes novel methods required for the successful enrichment of bovine spermatogonial stem cells, novel cell lines and other components used for the same, as well as the resultant stem cell compositions.
    Type: Grant
    Filed: August 25, 2016
    Date of Patent: May 7, 2019
    Assignee: Washington State University
    Inventors: Jon Michael Oatley, Melissa Joan Oatley
  • Patent number: 10267608
    Abstract: Munitions structures comprising one or more high strength reactive alloys, in particular reactive bulk metallic glasses, have significant amounts of inherent chemical energy. This energy may be discharged by subjection of the munitions structure to rapid impulsive loading and fragmentation in the presence of oxygen and/or nitrogen. A munitions structure can be configured in both large and small penetrators, e.g. warheads and bullets, with increased lethality. The lethality of these munitions structures is augmented by means of rapidly and simultaneously imparting both mechanical energy (kinetic energy through impact and fragmentation) and chemical energy (blast and/or fireball) to a target. A high-strength reactive alloy can substitute at least in part one or both of explosives and inert structural materials in conventional munitions systems to improve performance and reduce parasitic weight of structural casing.
    Type: Grant
    Filed: June 7, 2017
    Date of Patent: April 23, 2019
    Assignee: Washington State University
    Inventors: Yogendra M. Gupta, Atakan Peker
  • Patent number: 10258066
    Abstract: The present embodiments are directed to a processing system and transport carrier components for sterilization or pasteurization. In particular, an example embodiment includes a transport carrier for carrying one or more items to be sterilized or pasteurized, wherein the transport carrier includes a carrier base and one or more cross members coupled to and extending between sides of the carrier base. In addition, the transport carrier includes a tray member configured from at least one material of construction selected from a metal, a metal alloy, and a plastic, wherein the tray member extends between ends along the sides of the carrier base, and wherein the tray member further comprises one or more apertures configured to receive the one or more items to be sterilized or pasteurized.
    Type: Grant
    Filed: July 18, 2016
    Date of Patent: April 16, 2019
    Assignee: Washington State University
    Inventors: Juming Tang, Fang Liu
  • Patent number: 10253261
    Abstract: Liquid crystalline network compositions comprising azo-containing aromatic epoxy units cross-linked with alkylene diacid units having alkylene segments containing at least one methylene unit, wherein the azo-containing aromatic epoxy units and alkylene diacid units are connected by ester linkages resulting from ring-opening esterification between the epoxy units and alkylene diacids, and wherein the azo-containing aromatic epoxy units and alkylene diacid units are in a molar ratio that results in the liquid crystalline network composition exhibiting a glass transition temperature (Tg) of at least 25° C. Methods for producing these compositions and their use in light- or thermal-activated physical deformation, shape memory applications, and self-healing, as well as their ability to be recycled and used in additive manufacturing processes are also described.
    Type: Grant
    Filed: January 19, 2017
    Date of Patent: April 9, 2019
    Assignees: UT-BATTELLE, LLC, WASHINGTON STATE UNIVERSITY
    Inventors: Yuzhan Li, Orlando Rios, Michael Richard Kessler
  • Patent number: 10240227
    Abstract: Various embodiments of zirconium based bulk metallic glass with hafnium are described herein. In one embodiment, an alloy composition includes zirconium (Zr), hafnium (Hf), copper (Cu), aluminum (Al), at least one element from a group consisting of niobium (Nb) and titanium (Ti), and at least one element from a group consisting of nickel (Ni), iron (Fe), and cobalt (Co).
    Type: Grant
    Filed: April 29, 2016
    Date of Patent: March 26, 2019
    Assignee: Washington State University
    Inventors: Atakan Peker, Dongchun Qiao
  • Patent number: 10227470
    Abstract: Methods of producing particles of fiber and resin from fiber-resin composite materials are disclosed. The particles may be combined with a resin system and optionally combined with fillers, binders or reinforcements to produce new cured solid composite products.
    Type: Grant
    Filed: August 10, 2017
    Date of Patent: March 12, 2019
    Assignees: Washington State University, GFSI Group LLC
    Inventors: Hui Li, Karl Englund, Don Lilly
  • Patent number: 10220071
    Abstract: Microcin MccPDI and bacteria harboring the mcpM gene which encodes MccPDI limit growth of and/or kill pathogenic bacteria such as pathogenic Escherichia coli (E. coli) and/or Shigella bacteria via proximity-dependent inhibition (PDI).
    Type: Grant
    Filed: May 30, 2018
    Date of Patent: March 5, 2019
    Assignee: Washington State University
    Inventors: Douglas R. Call, Lisa Orfe
  • Patent number: 10221460
    Abstract: Provided herein are methods for the prognosis of prostate cancer progression in a patient by analyzing the gene expression in a tumor sample obtained from the patient the prognosis of prostate cancer progression in a patient by analyzing the gene expression in a tumor sample obtained from the patient. In particular, gene expression levels of GCOM1, MEX3D, TRPM4, ATPAF1, PTRF, GLYATL1, FLNA, OBSCN, STRA13, WHSC1, ARFGAP3, KDM2A, FAM83H, CLDN7, CNOT6, and B3GNT9 are measured. Kits containing means for the measurement of gene expression as described herein and methods for treatment of prostate cancer are also provided.
    Type: Grant
    Filed: March 25, 2015
    Date of Patent: March 5, 2019
    Assignee: Washington State University
    Inventors: Grant D. Trobridge, Arun Kumar Nalla
  • Publication number: 20190040091
    Abstract: Lanthionine ketimine derivatives, and methods of making and using the same, are described. Included are lanthionine ketimine phosphonate (LK-P), lanthionine ketimine ester phosphonate (LKE-P) derivatives, as well as lanthionine ketimine derivatives having a tert-enamide moiety at the 2-position (NVP-LKE).
    Type: Application
    Filed: February 24, 2017
    Publication date: February 7, 2019
    Applicants: The University of Toledo, Washington State University
    Inventors: Kenneth Hensley, Travis Denton
  • Patent number: 10190067
    Abstract: A novel hydraulic (e.g., a biohydraulic) fluid which has high performance attributes is disclosed herein. Such a novel hydraulic fluid includes a contribution of a range of 10% up to about 85% by weight of at least one of: natural esters, synthetic esters, polyols, a vegetable oil, 1% up to about 40% by weight of polyalphaolefin (PAO), 1% up to about 40% by weight of polyalkylene glycol (PAG), and mixtures thereof, and wherein up to about 10% by weight quantity of one or more additives are introduced to provide desired properties that include at least one of: a high viscosity index, a low pour point, a hydrolytic stability, and an oxidative stability, as part of the hydraulic fluid contribution.
    Type: Grant
    Filed: February 24, 2017
    Date of Patent: January 29, 2019
    Assignee: Washington State University
    Inventors: Ray Gunawidjaja, Pranav Nawani, Hergen Eilers
  • Patent number: 10193137
    Abstract: Several embodiments related to lithium-ion batteries having electrodes with nanostructures, compositions of such nanostructures, and associated methods of making such electrodes are disclosed herein. In one embodiment, a method for producing an anode suitable for a lithium-ion battery comprising preparing a surface of a substrate material and forming a plurality of conductive nanostructures on the surface of the substrate material via electrodeposition without using a template. The substrate material is at least partially compliant.
    Type: Grant
    Filed: January 28, 2014
    Date of Patent: January 29, 2019
    Assignee: WASHINGTON STATE UNIVERSITY
    Inventors: David T. Mackay, M. Grant Norton, Sarah Miller
  • Patent number: 10187070
    Abstract: Electronic devices, local oscillator circuits, and methods for operating local oscillators are disclosed herein. In one embodiment, a local oscillator circuit includes a first transistor and a second transistor individually having a base, a collector, and an emitter and a transformer having a first transformer inductor magnetically coupled to a second transformer inductor. The first transformer inductor couples the collector of the first transistor to the base of the second transistor. The second transformer inductor couples the collector of the second transistor to the base of the first transistor.
    Type: Grant
    Filed: November 20, 2014
    Date of Patent: January 22, 2019
    Assignee: Washington State University
    Inventors: Suman P Sah, Deukhyoun Heo
  • Patent number: 10186412
    Abstract: A novel method and mass spectrometer apparatus is introduced to enable collision induced dissociation inside linear ion traps/guides or 3D ion traps based on digital waveform manipulation. In particular, using the device's digitally produced trapping waveforms to trap, isolate and energize the ions of interest creates a simplified and versatile ion trap/guide that is capable tandem mass spectrometry and high sensitivity. Coupling the digitally operated ion trap/guides to a TOF creates a Q-TOF instrument that outperforms any commercial system in terms of sensitivity and capabilities.
    Type: Grant
    Filed: June 12, 2015
    Date of Patent: January 22, 2019
    Assignee: Washington State University
    Inventors: Peter Thomas Aquinas Reilly, Gregory Forrest Brabeck
  • Patent number: 10144874
    Abstract: The thermochemical conversion of biomass material to one or more reaction products includes generating thermal energy with at least one heat source, providing a volume of feedstock, providing a volume of supercritical fluid, transferring a portion of the generated thermal energy to the volume of supercritical fluid, transferring at least a portion of the generated thermal energy from the volume of supercritical fluid to the volume of feedstock, and performing a thermal decomposition process on the volume of feedstock with the thermal energy transferred from the volume of supercritical fluid to the volume of the feedstock in order to form at least one reaction product.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: December 4, 2018
    Assignees: TerraPower, LLC, Washington State University
    Inventors: Joshua C. Walter, Manuel Garcia-Perez
  • Patent number: 10132777
    Abstract: The methods herein provide for analysis of ion populations. Certain aspects include: obtaining a first data set that includes: a first binary On-OFF frequency sweep across a range of frequencies resulting in a first raw data in the time domain and obtaining a second data set that includes: a second binary On-OFF frequency sweep 180° out of phase from the first binary On-OFF frequency sweep so as to result in a second raw data in the time domain from received ion current resulting from the second binary On-OFF frequency sweep. Thereafter the two data sets are combined to provide for raw mobility signals of the ion populations in the time domain for each m/z over a range of selected m/z values. Additional aspects include a hybrid system for performing the methods disclosed herein.
    Type: Grant
    Filed: September 15, 2016
    Date of Patent: November 20, 2018
    Assignee: WASHINGTON STATE UNIVERSITY
    Inventors: Brian H. Clowers, William F. Siems
  • Patent number: 10132853
    Abstract: The embodiments herein are directed to monitoring in real time, power system data so as to provide insights into global operation of a power grid. Such a scheme disclosed herein utilizes rules, which are created by analyzing PMU measurement data, in order to detect the fault location (bus and line) and fault type. Three common types of faults in a power grid, single-line-to-ground (SLG), line-to-line (LL), and three phase faults, can be detected using the methods herein.
    Type: Grant
    Filed: April 11, 2016
    Date of Patent: November 20, 2018
    Assignee: WASHINGTON STATE UNIVERSITY
    Inventors: Xiaodong Liang, Scott Andrew Wallace, Xinghui Zhao
  • Patent number: 10126265
    Abstract: The methods herein provide for analysis of ion populations. Certain aspects include: directing a continuous gas phase ion beam into an entrance of a drift tube configured within an ion mobility spectrometer; perturbing the flow of the continuous gas phase ion beam within a perturbation time range so as to cause one or more configured perturbations; configuring the drift tube to allow the one or more perturbations to separate due to the differences in mobilities; receiving the plurality of ions and the one or more perturbations at the entrance of a mass spectrometer; recording raw data indicative of the plurality of ions; and reconstructing the raw data to obtain one or more mass to charge and one or more ion mobility spectrum of the plurality of ions.
    Type: Grant
    Filed: March 2, 2017
    Date of Patent: November 13, 2018
    Assignee: WASHINGTON STATE UNIVERSITY
    Inventors: Wenjie Liu, Herbert H. Hill, Jr., William F. Siems
  • Patent number: 10119147
    Abstract: The present invention relates to Brassica plants comprising mutant phosphatidylcholine:diacylglycerol cholinephosphotransferase encoding (ROD1) genes, ROD1 nucleic acid sequences and proteins, as well as methods for generating and identifying said plants and alleles, which can be used to plants with increased levels of C18:1 in the seeds.
    Type: Grant
    Filed: July 4, 2013
    Date of Patent: November 6, 2018
    Assignees: Washington State University, Bayer CropScience NV
    Inventors: Peter Denolf, Shuangyi Bai, John Browse