Abstract: Methods of circulating Fatty Acid Synthase (cFAS) detection, assays, and kits thereof, as well as methods of diagnosis and treatment for cardiovascular-related diseases based on cFAS are provided. Exemplary embodiments of the methods, assays, and kits disclosed herein allow for improved, noninvasive, low-cost, and reliable diagnosis and treatment for cardiovascular-related diseases, particularly in subjects suffering from both symptomatic and asymptomatic Peripheral Arterial Disease (PAD), via detecting and measuring cFAS from LDL-associated cFAS captured from a biological sample.

Abstract: The present disclosure provides methods of selecting a treatment for an inflammatory bowel disease in a subject. In particular, using an indicator of epithelial absorption and metabolism the present disclosure provides method for determining the likelihood a subject is responsive or non-responsive to an inflammatory bowel disease therapeutic agent. The method includes providing a baseline measurement of a microvillus length in the small intestine of a subject, selecting a treatment for the subject according to a treatment criteria, and administering the treatment to the subject.

Abstract: Compositions and formulations of synthetic MXRA8-Fc fusion proteins are provided, as well as methods of use thereof. Methods include neutralizing TSP1/MXRA8 interactions in a subject by administering a synthetic MXRA8-Fc fusion protein, such that the synthetic MXRA8-Fc fusion protein binds to TSP1 to inhibit the TSP1 from binding with MXRA8. Methods also include treating obesity such as high fat diet (HFD)-induced obesity, and treating obesity-associated metabolic diseases such as type 2 diabetes by administering a synthetic MXRA8-Fc fusion protein.

Abstract: Computational refocusing-assisted deep learning methods, apparatus, and systems are described. In certain pathology examples, a representative image is generated using a machine learning model trained with uniformly focused training images generated by a Fourier ptychographic digital refocusing procedure and abnormalities are automatedly identified and/or enumerated based on the representative image.

Abstract: A hyper-excitation hyperspectral imaging (HE-HSI) system. The system represents a technology-empowered expansion of spectroscopy into the imaging domain. The system includes optical components such as tunable filters, light sources, hyperspectral cameras, and advanced data processing algorithms. It addresses one of the major challenges of the traditional hyperspectral imaging approach such as the need to identify specific excitation and/or emission wavelengths where spectral differences are the most pronounced and consistent. The latter is particularly challenging for spectrally complex surfaces of human organs which can be quite variable between individuals. The HE-HSI system collects information across the entire UV-VIS-IR range by collecting both excitation and emission data from each pixel of an image. HE-HSI yields a computationally rich 4D data array that includes both fluorescence and reflectance profiles.

Abstract: A screw locating system including an intramedullary nail, a locating hole at the distal end of the intramedullary nail, a locator pin including a hollow section, and a locating end configured to fit in the locating hole, a cap configured to fill in the locating hole when the locator pin is in the locating hole, a screw configured to securely hold the locator pin, and a jig configured to guide a user to locate at least one distal screw at the distal end of the intramedullary nail.

Abstract: The present disclosure provides the use of fratricide-resistant chimeric antigen receptor T (CAR-T) cells targeting antigens expressed by T cell malignancies.

Abstract: Isolated polypeptides having enhanced affinity for a PDGF receptor and/or a VEGF receptor are provided. Compositions comprising the polypeptides and methods of use thereof are also provided.

Abstract: Systems, catheter and methods for treating Atrial Fibrillation (AF) are provided, which are configure to illuminate a heart tissue having a lesion site; obtain a mitochondrial nicotinamide adenine dinucleotide hydrogen (NADH) fluorescence intensity from the illuminated heart tissue along a first line across the lesion site; create a 2-dimensional (2D) map of the depth of the lesion site along the first line based on the NADH fluorescence intensity; and determine a depth of the lesion site at a selected point along the first line from the 2D map, wherein a lower NADH fluorescence intensity corresponds to a greater depth in the lesion site and a higher NADH fluorescence intensity corresponds to an unablated tissue. The process may be repeated to create a 3 dimensional map of the depth of the lesion.

Abstract: The present disclosure provides molecular methods to improve the rapid diagnosis of respiratory infections. In general, the present disclosure provides method of detecting host gene signatures which aid in determining the etiology of a respiratory infection and thereby improve the treatment.

Abstract: A modular pressurized combustion system for flexible energy generation is provided. The system comprises a plurality of pressurized combustion boilers, at least one compressor configured to provide pressurized oxidizer gas to each of the plurality of pressurized combustion boilers in parallel, and at least one feeder configured to provide fuel to each of the plurality of pressurized combustion boilers in parallel. The system further comprises a flue gas input unit configured to provide recycled flue gas to each of the plurality of pressurized combustion boilers in series, at least one pressurized heat recovery unit configured to receive a flue gas output stream from each of the plurality of pressurized combustion boilers, and at least one particle filter configured to filter a flue gas output stream from the pressurized heat recovery unit. The system also comprises an integrated pollutant removal unit.

Abstract: Various methods and compositions for treating age-associated conditions and other medical conditions, such as muscle diseases, type 2 diabetes, and/or obesity are described. Methods of enhancing cellular uptake of NMN and stimulating NAD+ production are further described. Various mammalian cells and mammalian cell lines are described including those comprising a cDNA encoding a Slc12a8 protein. Gene therapy vectors comprising a nucleic acid encoding Slc12a8 and non-human animals comprising an inactivating mutation in a Slc12a8 gene are also disclosed. Also described are methods for screening a candidate compound to identify compounds that promote NMN transport.

Abstract: Methods and systems for detecting cell states in a biological sample are disclosed. Methods and systems for predicting a therapeutic response, a severe immune-related adverse event (irAE), a symptomatic irAE, and an irAE grade of a subject to be administered an immunotherapy treatment based on cell states detected from a single biological sample from the subject are also disclosed.

Abstract: Methods are disclosed for predicting a likelihood of developing a severe immune-related adverse event (irAE) associated with the administration of an immunotherapy in a melanoma patient based on abundances of activated CD4 memory T cells and/or diversities of T cell receptors (TCR) within a peripheral blood sample obtained from the patient.

Abstract: A sutureless anastomosis device configured to facilitate an anastomosis to a side of a damaged vessel is disclosed. The device includes inner and outer mounting faces configured to attached to the inner and outer vessel walls of the damaged vessel to anchor the device to the damaged vessel. The device further includes an outer cannula attached to the exposed surface of the outer mounting face; the outer cannula is configured to attach to a second vessel to form the side-to end anastomosis.

Abstract: The present disclosure is directed to compositions and methods of treating Triple Negative Breast Cancer (TNBC) in a human subject. A method of treating TNBC in a human subject includes administering a therapeutically effective amount of a neoantigen vaccine composition comprising a fusion protein comprising at least one TNBC-associated neoantigen epitope joined to a mutant ubiquitin protein, or a nucleic acid molecule encoding such a protein.

Abstract: A displacement sensor including an optical whispering gallery mode (WGM) microresonator and a package encasing at least a portion of the WGM microresonator, the package comprising polydimethylsiloxane (PDMS). The WGM microresonator can be configured as a sensor and used in a displacement detection system that can detect displacement with high quality. Artificial intelligence can be implemented in the displacement detection system for improved sensing of different variables and/or pinpointing the location of perturbations.

Abstract: Among the various aspects of the present disclosure is the provision of a noninvasive and localized brain liquid biopsy using focused ultrasound. Briefly, therefore, the present disclosure is directed to methods and systems to identify brain lesion or tumor characteristics without the need for a solid brain biopsy.

Abstract: In various aspects, a photoacoustic endoscopic probe and methods for measuring a hydration of a connective tissue in vivo using the photoacoustic endoscopic probe are disclosed.

Abstract: A mixed reality (MR) visualization system includes an MR device comprising a holographic display configured to display a holographic image to an operator, a hand-held ultrasound imaging device configured to obtain a real-time ultrasound image of a subject's anatomy, and a computing device communicatively coupled to the MR device and the hand-held ultrasound imaging device. The computing device includes a non-volatile memory and a processor. The computing device is configured to receive the real-time ultrasound image, determine a real-time 3D position and orientation of the hand-held ultrasound imaging device, generate a modified real-time ultrasound image by modifying the real-time ultrasound image to correspond to the real-time 3D position and orientation of the hand-held ultrasound imaging device, and transmit the modified real-time ultrasound image to the MR device for display as the holographic image positioned at a predetermined location relative to the hand-held ultrasound imaging device.