Abstract: The present invention is directed to various methods of suppressing inflammasome activation. For example, the present invention relates to various methods of treating a disease or condition in which inflammation contributes to the disease or condition state.
Type:
Application
Filed:
January 11, 2021
Publication date:
October 26, 2023
Applicants:
Washington University, Senseion Therapeutics, Inc.
Inventors:
Rajan Sah, Hongzhen Hu, Ashutosh Kumar, Daniel Lerner
Abstract: Disclosed are methods and compositions related to methods of treating, ameliorating, mitigating, slowing, arresting, preventing or reversing various diseases and conditions, including age-related obesity, age-related increases in blood lipid levels, age-related decreases in insulin sensitivity, age-related decreases in memory function, and age-related changes in eye function such as macular degeneration. The methods comprise administering nicotinamide mononucleotide (NMN) to a subject. In some embodiments, the administration can be oral administration. Also disclosed are pharmaceutical compositions comprising NMN.
Abstract: Among the various aspects of the present disclosure is the provision of conjugate systems and methods of use thereof. In an aspect, the conjugate system includes an adenovirus comprising an exterior surface, and at least one polypeptide comprising a first domain and a second domain, and wherein the exterior surface comprises a peptide tag capable of binding to a binding partner.
Abstract: Provided herein are synthetic P. vivax antigens, antibodies and pharmaceutical formulations and vaccines thereof. Also provided herein are methods of treating and/or preventing Plasmodium infection and/or disease by administering the synthetic P. vivax antigens, antibodies and pharmaceutical formulations and vaccines thereof.
Type:
Grant
Filed:
November 24, 2020
Date of Patent:
October 17, 2023
Assignees:
UNIVERSITY OF SOUTH FLORIDA, WASHINGTON UNIVERSITY, CASE WESTERN RESERVE UNIVERSITY
Inventors:
John H. Adams, Christopher L. King, Niraj H. Tolia, Edwin Chen, Nichole Diane Salinas, Miriam Thankam George, Francis B. Ntumngia, Samantha Jones Barnes
Abstract: Systems and methods for monitoring and controlling delivery of a therapeutic compound to a brain of a subject using FUS-BBBD are disclosed. The method includes treating the brain of the subject with focused ultrasound in combination with microbubbles for blood-brain barrier disruption (FUS-BBBD), administering the therapeutic agent to the subject; and obtaining a map of a concentration of the therapeutic agent delivered to the brain of the subject using passive cavitation imaging (PCI). The delivery of focused sound may be modulated to match the map of the concentration of the therapeutic agent delivered to the brain of the subject to a desired spatial distribution of the therapeutic agent.
Type:
Grant
Filed:
January 23, 2020
Date of Patent:
October 17, 2023
Assignee:
Washington University
Inventors:
Hong Chen, Yaoheng Yang, Jeffrey Williamson
Abstract: The present invention is a method or system for acceptance testing and commissioning of a LINAC and treatment planning system (TPS). For a LINAC commissioning, the present invention collects reference data from a fully calibrated LINAC and compares the reference data with machine performance data collected from LINAC. The compared results are analyzed to assess accuracy of the testing LINAC. For a TPS commissioning, the present invention collects standard reference data from standard treatment plans and standard input data and compares the standard reference data with results from standard tests that are performed by a testing treatment plan system. The compares results are analyzed to assess accuracy of the testing treatment plan system.
Type:
Grant
Filed:
January 23, 2023
Date of Patent:
October 17, 2023
Assignees:
Washington University, The Regents of the University of California
Inventors:
Sridhar Yaddanapudi, Sreekrishna M. Goddu, Sasa Mutic, Todd Pawlicki
Abstract: Among the various aspects of the present disclosure is the provision of systems and methods for producing systems and methods for the computational design of CRISPR guide RNAs for strain-specific control of microbiota consortia.
Abstract: Systems and methods for the selection of a treatment for pancreatic adenocarcinoma (PDAC) in a patient in need based on single-cell RNA sequencing data obtained from a tumor biopsy sample obtained prior to treatment are disclosed. Also disclosed are systems and methods for predicting a clinical outcome of a pancreatic adenocarcinoma (PDAC) patient based on the single-cell RNA sequencing data.
Abstract: The present disclosure provides for compositions of, synthetic methods of, and methods for use of dihydrofolate synthase (DHFS) inhibiting agents.
Abstract: Among the various aspects of the present disclosure is the provision of compositions and methods to detect immune system activation and inhibition, including but not limited to a pro-tumor radioresistant tumor microenvironment, including but not limited to overexpressed SERPINB3, and the modulation of this microenvironment with modulators, including but not limited to STAT inhibitors, which can improve radiotherapy in cancer patients.
Abstract: Disclosed herein are methods for reducing expression of Tau mRNA and protein in an animal with Tau antisense compounds. Also disclosed are methods for modulating splicing of Tau mRNA in an animal with Tau antisense compounds. Such methods are useful to treat, prevent, or ameliorate neurodegenerative diseases in an individual in need thereof. Examples of neurodegenerative diseases that can be treated, prevented, and ameliorated with the administration Tau antisense oligonucleotides include Alzheimer's Disease, Fronto-temporal Dementia (FTD), FTDP-17, Progressive Supranuclear Palsy, Chronic Traumatic Encephalopathy, Epilepsy, and Dravet's Syndrome.
Type:
Grant
Filed:
March 11, 2019
Date of Patent:
October 10, 2023
Assignees:
Washington University, Biogen MA Inc.
Inventors:
Timothy M. Miller, Sarah Devos, C. Frank Bennett, Frank Rigo
Abstract: The present invention is directed to various compounds, compositions, and methods for treating bacterial infections such as urinary tract infections.
Type:
Grant
Filed:
November 8, 2018
Date of Patent:
October 3, 2023
Assignee:
Washington University
Inventors:
Vasilios Kalas, James W. Janetka, Scott Hultgren, Jerry Pinkner, Amarendar Maddirala, Vishnu Damalanka
Abstract: Solutions having a solvent and a cold atmospheric plasma dissolved in the solvent are described. Methods and systems of forming cold atmospheric plasma (CAP)-containing solutions are also described. A system for producing (CAP)-containing solutions includes a gas source; a plasma generating device having a hollow body fluidically coupled with the gas source, a closed proximal end and an open distal end, the hollow body receiving gas from the gas source, and at least one electrode in or about the hollow body and ionizing the gas to discharge a cold atmospheric plasma (CAP) from the open distal end; and a container for housing a fluid, the open distal end of the plasma generating device in fluid communication with an inner portion of the container. CAP-containing solutions can be used in treatment of cancer cells, infected tissue sterilization, microorganism inactivation, promotion of wound healing, skin regeneration, and blood coagulation, and teeth bleaching/whitening.
Type:
Grant
Filed:
March 16, 2017
Date of Patent:
October 3, 2023
Assignee:
The George Washington University
Inventors:
Michael Keidar, Zhitong Chen, Xiaoqian Cheng, Li Lin
Abstract: Systems and methods for virtual reality or augmented reality (VR/AR) visualization of 3D medical images using a VR/AR visualization system are disclosed that includes a computing device operatively coupled to a VR/AR device, which includes a holographic display and at least one sensor. The holographic display is configured to display a holographic image to an operator. The computing device is configured to receive at least one stored 3D image of a subject's anatomy and at least one real-time 3D position of at least one surgical instrument, to register the at least one real-time 3D position of the at least one surgical instrument to correspond to the at least one 3D image of the subject's anatomy, and to generate the holographic image comprising the at least one real-time position of the at least one surgical instrument overlaid on the at least one 3D image of the subject's anatomy.
Abstract: In one aspect, a composition for sustained release of oxygen to a tissue is disclosed that includes at least one core-shell oxygen release microsphere (ORM), wherein the core includes a water-soluble polymer-reactive oxygen species (ROS) complex and the shell includes a biodegradable polymer conjugated to a ROS-scavenging enzyme. In some aspects, the reactive oxygen species includes hydrogen peroxide (H2O2), the ROS-scavenging enzyme includes catalase, the water-soluble polymer includes polyvinylpyrrolidone (PVP), and the biodegradable polymer includes poly(N-isopropylacrylamide-co-2-hydroxyethyl methacrylate-co-acrylate-oligolactide-co-Nacryloxysuccinimide)[poly(NIPAAm-co-HEMA-co-AOLA-co-NAS)].
Abstract: A method for selecting a seed region for use in a seed-based cortical functional mapping method includes providing at least one RSN map of at least one subject, each of the at least one RSN maps comprising a plurality of functional voxels within a brain of each of the at least one subjects, each functional voxel of the plurality of functional voxels associated with a probability of membership in an RSN. A subset of the functional voxels characterizing a contiguous region is selected as the seed region, each functional voxel of the seed region having a probability of membership in the RSN above a threshold value.
Type:
Application
Filed:
May 23, 2023
Publication date:
September 28, 2023
Applicant:
Washington University
Inventors:
Eric Leuthardt, Carl Hacker, Shan Siddiqi, Tim Laumann, Andy Daniel
Abstract: Methods of using a foot device are disclosed herein. The foot device includes a generally U-shaped portion having an arcuate portion and first and second legs extending from the arcuate portion. Each leg has an end and a relief area disposed adjacent the respective end. A method of using the foot device comprises engaging the arcuate portion with a heel of a foot to form a first point of contact; positioning the relief area of the first leg proximate a fifth metatarsal head of the foot such that the fifth metatarsal head drops to form a second point of contact; and positioning the relief area of the second leg proximate a first metatarsal head of the foot such that the first metatarsal head drops to form a third point of contact, wherein the first, second, and third points of contact form a triangle-shaped contact surface.
Abstract: Provided herein are methods for the treatment of bone disorders that are associated with kidney disease wherein the methods comprise administration of Activin-ActRIIA inhibitors to a subject in need of the treatment. Also provided herein are methods and compositions for the treatment of low turnover bone disorders wherein the methods comprise administration of Activin-ActRIIA inhibitors to a subject in need of the treatment. Further provided herein are compositions for the treatment of bone disorders that are associated with kidney disease and compositions for the treatment of low turnover bone disorders and vascular calcification.
Type:
Application
Filed:
January 18, 2023
Publication date:
September 21, 2023
Applicants:
Celgene Corporation, Washington University
Inventors:
Victoria Sung, Randall Stevens, William Smith, Victor Schorr Sloan, Keith Hruska, Yifu Fang
Abstract: A goggle system is provided. The goggle system includes a computing device, a goggle device configured to be worn by a user and including a detector configured to simultaneously acquire image data of a subject in a first image mode and a second image mode, at least one eye assembly configured to display at least one of an image in the first image mode, an image in the second image mode, and a hybrid image including pixels of image data from the first image mode and pixels of image data from the second image mode, and a communications module configured to transmit acquired image data from the goggle device to the computing device.
Type:
Grant
Filed:
March 8, 2022
Date of Patent:
September 19, 2023
Assignee:
WASHINGTON UNIVERSITY
Inventors:
Samuel Achilefu, Yang Liu, Viktor Gruev, Joseph P. Culver, Walter Akers, Adam Bauer
Abstract: A thruster has a first stage and a second stage. The first stage is a plasma source that outputs a plasma. The second stage is an accelerator. In one embodiment, the second stage is a plasma accelerator that accelerates the plasma. In another embodiment, the second stage is an ion accelerator that accelerates the ions from the plasma.
Type:
Grant
Filed:
October 10, 2018
Date of Patent:
September 19, 2023
Assignee:
The George Washington University
Inventors:
Michael Keidar, Jonathan Kolbeck, Denis Zolotukhin